Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/KEGG Compound C02739
type: UnificationXref
id: C02739
db: KEGG Compound

Reference/KEGG Compound C04916
type: UnificationXref
id: C04916
db: KEGG Compound

Compound/PW C040845/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
stoichiometric coefficient: 1.0

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18406
chemical formula: C9H15N4O8P
molecular weight: 338.06274
structure: ChemicalStructure/PW C040845

Reference/ChemSpider 144886
type: UnificationXref
id: 144886
db: ChemSpider

Reference/ChEBI CHEBI 16255
type: UnificationXref
id: CHEBI:16255
db: ChEBI

Reference/PubChem-compound 1012
type: UnificationXref
id: 1012
db: PubChem-compound

NADH
type: SmallMolecule
entity reference: NADH

direct_interaction
type: InteractionVocabulary

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Compound/PW C007780/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histidinal
stoichiometric coefficient: 1.0

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15971
type: UnificationXref
id: CHEBI:15971
db: ChEBI

NAD
type: SmallMolecule
entity reference: NAD

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

5-Aminoimidazole-4-carboxamide
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-3762
xref: Reference/ChEBI CHEBI 2030
xref: Reference/ChemSpider 9298
xref: Reference/PubChem-compound 9679
xref: Reference/HMDB HMDB0003192
xref: Reference/KEGG Compound C04051
xref: Reference/CAS 360-97-4
chemical formula: C4H6N4O
molecular weight: 126.05416
structure: ChemicalStructure/PW C001801

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040919
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC(Cl)=CC=C1C1=CC=CC=C1

Escherichia coli HS
type: BioSource
xref: Reference/TAXONOMY 331112

Reference/CAS 99979-59-6
type: UnificationXref
id: 99979-59-6
db: CAS

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Reference/CAS 4836-52-6
type: UnificationXref
id: 4836-52-6
db: CAS

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/PubChem-compound 1009
type: UnificationXref
id: 1009
db: PubChem-compound

Reference/TAXONOMY 331112
type: UnificationXref
id: 331112
db: TAXONOMY

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/PubChem-compound 9679
type: UnificationXref
id: 9679
db: PubChem-compound

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Compound/PW C007755/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Erythro-imidazole-glycerol-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 6038
type: UnificationXref
id: 6038
db: ChemSpider

5-Aminoimidazole-4-carboxamide
type: SmallMolecule
entity reference: 5-Aminoimidazole-4-carboxamide

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChEBI CHEBI 2030
type: UnificationXref
id: CHEBI:2030
db: ChEBI

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/BioCyc CPD-3762
type: UnificationXref
id: CPD-3762
db: BioCyc

Reference/PubChem-compound 6274
type: UnificationXref
id: 6274
db: PubChem-compound

Reference/ChemSpider 30776608
type: UnificationXref
id: 30776608
db: ChemSpider

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

ChemicalStructure/PW C001889
type: ChemicalStructure
structure format: SMILES
structure data: N[C@H](CO)CC1=CNC=N1

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/ChemSpider 30776607
type: UnificationXref
id: 30776607
db: ChemSpider

Histidine Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/5895028
pathway order: PathwayEnzymeReaction/5895016
pathway order: PathwayEnzymeReaction/5895027
pathway order: PathwayEnzymeReaction/5895018
pathway order: PathwayInteraction/7339
pathway order: PathwayEnzymeReaction/5895020
pathway order: PathwayEnzymeReaction/5895022
pathway order: PathwayEnzymeReaction/5895024
pathway order: PathwayEnzymeReaction/5895023
pathway order: PathwayEnzymeReaction/5895026
pathway order: PathwayEnzymeReaction/5895025
pathway order: PathwaySubPathway/414604
pathway component: ReactionCatalysis789837
pathway component: ReactionCatalysis789836
pathway component: ReactionCatalysis789839
pathway component: ReactionCatalysis789838
pathway component: PRPP Biosynthesis
pathway component: ReactionCatalysis789840
pathway component: Interaction7339
pathway component: ReactionCatalysis789831
pathway component: ReactionCatalysis789842
pathway component: ReactionCatalysis789841
pathway component: ReactionCatalysis789833
pathway component: ReactionCatalysis789835
pathway component: Reaction786420
pathway component: 1.1.1.23
pathway component: 2.4.2.17
pathway component: Reaction786422
pathway component: 2.4.2.-
pathway component: 3.1.3.15
pathway component: 2.6.1.9
pathway component: 3.5.4.19
pathway component: Reaction786415
pathway component: 5.3.1.16
xref: Reference/PathWhiz PW415086
xref: Reference/SMPDB SMP0403670
organism: Escherichia coli HS

ChemicalStructure/PW C007755
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H](COP(O)(O)=O)[C@@H](O)C1=CNC=N1

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/PubChem-compound 165271
type: UnificationXref
id: 165271
db: PubChem-compound

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

Unknown
type: Protein
entity reference: Unknown

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Phosphoribosyl-AMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439795
xref: Reference/ChemSpider 30776608
xref: Reference/BioCyc PHOSPHORIBOSYL-AMP
xref: Reference/HMDB HMDB0012276
chemical formula: C15H23N5O14P2
molecular weight: 559.07166
structure: ChemicalStructure/PW C007817

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Phosphoribosyl-ATP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C02739
xref: Reference/ChemSpider 984
xref: Reference/HMDB HMDB0003665
xref: Reference/PubChem-compound 1009
xref: Reference/ChEBI CHEBI 18263
chemical formula: C15H26N5O20P4
molecular weight: 720.01215
structure: ChemicalStructure/PW C001952

Reference/CAS 71-00-1
type: UnificationXref
id: 71-00-1
db: CAS

Compound/PW C007818/Stoichiometry/1.0
type: Stoichiometry
physical entity: PhosphoribosylformiminoAICAR-phosphate
stoichiometric coefficient: 1.0

Phosphoribulosylformimino-AICAR-P
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0012278
xref: Reference/KEGG Compound C04916
xref: Reference/BioCyc PHOSPHORIBULOSYL-FORMIMINO-AICAR-P
xref: Reference/PubChem-compound 53481398
xref: Reference/ChemSpider 30776607
chemical formula: C15H25N5O15P2
molecular weight: 577.0822
structure: ChemicalStructure/PW C007819

PhosphoribosylformiminoAICAR-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0012277
xref: Reference/BioCyc PHOSPHORIBOSYL-FORMIMINO-AICAR-P
xref: Reference/KEGG Compound C04896
xref: Reference/ChemSpider 987
xref: Reference/PubChem-compound 1012
chemical formula: C15H25N5O15P2
molecular weight: 577.0822
structure: ChemicalStructure/PW C007818

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Compound/PW C007817/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl-AMP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Interaction7339
type: MolecularInteraction
interaction type: direct_interaction
name: L-Histidine inhibits ATP phosphoribosyltransferase
participant: ATP phosphoribosyltransferase
participant: L-Histidine

Reference/BioCyc PHOSPHORIBOSYL-FORMIMINO-AICAR-P
type: UnificationXref
id: PHOSPHORIBOSYL-FORMIMINO-AICAR-P
db: BioCyc

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/PubChem-compound 792
type: UnificationXref
id: 792
db: PubChem-compound

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/KEGG Compound C04051
type: UnificationXref
id: C04051
db: KEGG Compound

Compound/PW C000190/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Compound/PW C000116/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Histidine
stoichiometric coefficient: 1.0

ReactionCatalysis789837
type: Catalysis
controller: Unknown
controlled: 2.4.2.-
control type: ACTIVATION

ReactionCatalysis789836
type: Catalysis
controller: Unknown
controlled: 5.3.1.16
control type: ACTIVATION

ReactionCatalysis789839
type: Catalysis
controller: histidinol-phosphate aminotransferase
controlled: 2.6.1.9
control type: ACTIVATION

ReactionCatalysis789838
type: Catalysis
controller: imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase
controlled: 3.1.3.15
control type: ACTIVATION

PRPP Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway414604
pathway component: SubPathwayInteraction414604
xref: Reference/PathWhiz PW000909
xref: Reference/SMPDB SMP0000926
name: SubPathway

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

ReactionCatalysis789831
type: Catalysis
controller: ATP phosphoribosyltransferase
controlled: 2.4.2.17
control type: ACTIVATION

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

ReactionCatalysis789833
type: Catalysis
controller: Unknown
controlled: 3.5.4.19
control type: ACTIVATION

ReactionCatalysis789835
type: Catalysis
controller: Unknown
controlled: Reaction786415
control type: ACTIVATION

Reference/KEGG Compound C00135
type: UnificationXref
id: C00135
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Protein/28264/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/HMDB HMDB0012208
type: UnificationXref
id: HMDB0012208
db: HMDB

ChemicalStructure/PW C007782
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OCC(=O)CC1=CNC=N1

ChemicalStructure/PW C007780
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC=N1)C=O

Phosphoribosyl pyrophosphate
type: SmallMolecule
entity reference: Phosphoribosyl pyrophosphate
name: SubPathwayOutput

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/HMDB HMDB0003192
type: UnificationXref
id: HMDB0003192
db: HMDB

Phosphoribulosylformimino-AICAR-P
type: SmallMolecule
entity reference: Phosphoribulosylformimino-AICAR-P

ReactionCatalysis789840
type: Catalysis
controller: imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase
controlled: Reaction786420
control type: ACTIVATION

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

Phosphoribosyl-AMP
type: SmallMolecule
entity reference: Phosphoribosyl-AMP

ReactionCatalysis789842
type: Catalysis
controller: histidinal dehydrogenase / histidinol dehydrogenase
controlled: Reaction786422
control type: ACTIVATION

ChemicalStructure/PW C000116
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CN=CN1)C(O)=O

PhosphoribosylformiminoAICAR-phosphate
type: SmallMolecule
entity reference: PhosphoribosylformiminoAICAR-phosphate

ReactionCatalysis789841
type: Catalysis
controller: histidinal dehydrogenase / histidinol dehydrogenase
controlled: 1.1.1.23
control type: ACTIVATION

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Phosphoribosyl-ATP
type: SmallMolecule
entity reference: Phosphoribosyl-ATP

1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
type: SmallMolecule
entity reference: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/BioCyc PHOSPHORIBOSYL-AMP
type: UnificationXref
id: PHOSPHORIBOSYL-AMP
db: BioCyc

Reference/ChEBI CHEBI 17805
type: UnificationXref
id: CHEBI:17805
db: ChEBI

Reference/HMDB HMDB0012234
type: UnificationXref
id: HMDB0012234
db: HMDB

Reference/HMDB HMDB0012236
type: UnificationXref
id: HMDB0012236
db: HMDB

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/SMPDB SMP0000926
type: UnificationXref
id: SMP0000926
db: SMPDB

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 439795
type: UnificationXref
id: 439795
db: PubChem-compound

Water
type: SmallMolecule
entity reference: Water

Reference/BioCyc PHOSPHORIBULOSYL-FORMIMINO-AICAR-P
type: UnificationXref
id: PHOSPHORIBULOSYL-FORMIMINO-AICAR-P
db: BioCyc

Reference/ChemSpider 770
type: UnificationXref
id: 770
db: ChemSpider

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Compound/PW C040919/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-histidinol-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 23784-15-8
type: UnificationXref
id: 23784-15-8
db: CAS

Reference/ChEBI CHEBI 16426
type: UnificationXref
id: CHEBI:16426
db: ChEBI

L-Histidinol
type: SmallMoleculeReference
xref: Reference/BioCyc L-HISTIDINOL-P
xref: Reference/CAS 4836-52-6
xref: Reference/PubChem-compound 165271
xref: Reference/ChemSpider 144886
xref: Reference/HMDB HMDB0003431
xref: Reference/ChEBI CHEBI 16255
xref: Reference/KEGG Compound C00860
chemical formula: C6H11N3O
molecular weight: 141.09021
structure: ChemicalStructure/PW C001889

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

D-Erythro-imidazole-glycerol-phosphate
type: SmallMolecule
entity reference: D-Erythro-imidazole-glycerol-phosphate

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

D-Erythro-imidazole-glycerol-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440431
xref: Reference/HMDB HMDB0012208
xref: Reference/KEGG Compound C04666
xref: Reference/ChemSpider 389372
xref: Reference/CAS 36244-87-8
xref: Reference/BioCyc D-ERYTHRO-IMIDAZOLE-GLYCEROL-P
xref: Reference/ChEBI CHEBI 17805
chemical formula: C6H11N2O6P
molecular weight: 238.03548
structure: ChemicalStructure/PW C007755

Reference/BioCyc D-ERYTHRO-IMIDAZOLE-GLYCEROL-P
type: UnificationXref
id: D-ERYTHRO-IMIDAZOLE-GLYCEROL-P
db: BioCyc

L-Histidinol
type: SmallMolecule
entity reference: L-Histidinol

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Compound/PW C001952/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl-ATP
stoichiometric coefficient: 1.0

Reference/KEGG Compound C04896
type: UnificationXref
id: C04896
db: KEGG Compound

Reference/KEGG Compound C01267
type: UnificationXref
id: C01267
db: KEGG Compound

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase
type: Complex
component stoichiometry: Protein/28264/Stoichiometry/2.0
component: Unknown

Reference/HMDB HMDB0003665
type: UnificationXref
id: HMDB0003665
db: HMDB

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/CAS 360-97-4
type: UnificationXref
id: 360-97-4
db: CAS

Compound/PW C001889/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Histidinol
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference

histidinal dehydrogenase / histidinol dehydrogenase
type: Complex
component stoichiometry: Protein/28264/Stoichiometry/2.0
component: Unknown

Reference/BioCyc HIS
type: UnificationXref
id: HIS
db: BioCyc

histidinol-phosphate aminotransferase
type: Complex
component stoichiometry: Protein/28264/Stoichiometry/2.0
component: Unknown

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/PubChem-compound 775
type: UnificationXref
id: 775
db: PubChem-compound

Reference/ChEBI CHEBI 18263
type: UnificationXref
id: CHEBI:18263
db: ChEBI

ChemicalStructure/PW C001801
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)C1=C(N)N=CN1

Reference/KEGG Compound C04666
type: UnificationXref
id: C04666
db: KEGG Compound

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00860
type: UnificationXref
id: C00860
db: KEGG Compound

Reference/BioCyc HISTIDINAL
type: UnificationXref
id: HISTIDINAL
db: BioCyc

L-histidinol-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 6242
chemical formula: C12H9ClO
molecular weight: 204.0342
structure: ChemicalStructure/PW C040919

Reference/PubChem-compound 440431
type: UnificationXref
id: 440431
db: PubChem-compound

ATP phosphoribosyltransferase
type: Complex
component stoichiometry: Protein/28264/Stoichiometry/2.0
component: Unknown

Reference/ChEBI CHEBI 6242
type: UnificationXref
id: CHEBI:6242
db: ChEBI

L-histidinol-phosphate
type: SmallMolecule
entity reference: L-histidinol-phosphate

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

Reference/HMDB HMDB0003431
type: UnificationXref
id: HMDB0003431
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/HMDB HMDB0012277
type: UnificationXref
id: HMDB0012277
db: HMDB

Reference/HMDB HMDB0012278
type: UnificationXref
id: HMDB0012278
db: HMDB

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Phosphate
type: SmallMolecule
entity reference: Phosphate

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/HMDB HMDB0012276
type: UnificationXref
id: HMDB0012276
db: HMDB

Reference/ChemSpider 9298
type: UnificationXref
id: 9298
db: ChemSpider

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/HMDB HMDB0000177
type: UnificationXref
id: HMDB0000177
db: HMDB

Oxoglutaric acid
type: SmallMolecule
entity reference: Oxoglutaric acid

Reference/BioCyc L-HISTIDINOL-P
type: UnificationXref
id: L-HISTIDINOL-P
db: BioCyc

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Imidazole acetol-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0012236
xref: Reference/CAS 99979-59-6
xref: Reference/ChEBI CHEBI 16426
xref: Reference/ChemSpider 770
xref: Reference/BioCyc IMIDAZOLE-ACETOL-P
xref: Reference/KEGG Compound C01267
xref: Reference/PubChem-compound 792
chemical formula: C6H9N2O5P
molecular weight: 220.0249
structure: ChemicalStructure/PW C007782

Histidinal
type: SmallMoleculeReference
xref: Reference/PubChem-compound 775
xref: Reference/ChemSpider 754
xref: Reference/HMDB HMDB0012234
xref: Reference/CAS 23784-15-8
xref: Reference/BioCyc HISTIDINAL
chemical formula: C6H9N3O
molecular weight: 139.07455
structure: ChemicalStructure/PW C007780

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

L-Histidine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15971
xref: Reference/HMDB HMDB0000177
xref: Reference/PubChem-compound 6274
xref: Reference/ChemSpider 6038
xref: Reference/CAS 71-00-1
xref: Reference/BioCyc HIS
xref: Reference/KEGG Compound C00135
chemical formula: C6H9N3O2
molecular weight: 155.06947
structure: ChemicalStructure/PW C000116

Reference/ChEBI CHEBI 18406
type: UnificationXref
id: CHEBI:18406
db: ChEBI

Reference/ChemSpider 389372
type: UnificationXref
id: 389372
db: ChemSpider

Reference/CAS 36244-87-8
type: UnificationXref
id: 36244-87-8
db: CAS

Reaction786420
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001889/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040919/Stoichiometry/1.0
right: L-Histidinol
right: Phosphate
spontaneous: false
left: Water
left: L-histidinol-phosphate
name: L-histidinol-phosphate + Water → L-Histidinol + Phosphate
conversion direction: LEFT_TO_RIGHT

1.1.1.23
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001889/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007780/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: Histidinal
spontaneous: false
EC number: 1.1.1.23
left: NAD
left: L-Histidinol
name: L-Histidinol + NAD → Histidinal + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reaction786422
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000116/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007780/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: NADH
right: Hydrogen Ion
right: L-Histidine
spontaneous: false
left: Water
left: NAD
left: Histidinal
name: Histidinal + NAD + Water → 2 Hydrogen Ion + L-Histidine + NADH
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 53481398
type: UnificationXref
id: 53481398
db: PubChem-compound

Compound/PW C007819/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribulosylformimino-AICAR-P
stoichiometric coefficient: 1.0

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Compound/PW C007782/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imidazole acetol-phosphate
stoichiometric coefficient: 1.0

L-Histidine
type: SmallMolecule
entity reference: L-Histidine

ChemicalStructure/PW C007819
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001952
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040845
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

ChemicalStructure/PW C007817
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C007818
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

Reference/PathWhiz PW415086
type: UnificationXref
id: PW415086
db: PathWhiz

Reference/ChemSpider 754
type: UnificationXref
id: 754
db: ChemSpider

2.4.2.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000190/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001952/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Pyrophosphate
right: Phosphoribosyl-ATP
spontaneous: false
EC number: 2.4.2.17
left: Hydrogen Ion
left: Phosphoribosyl pyrophosphate
name: Hydrogen Ion + Phosphoribosyl pyrophosphate → Phosphoribosyl-ATP + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

2.4.2.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007755/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001801/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007819/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: L-Glutamic acid
right: D-Erythro-imidazole-glycerol-phosphate
right: Hydrogen Ion
right: 5-Aminoimidazole-4-carboxamide
spontaneous: false
EC number: 2.4.2.-
left: Phosphoribulosylformimino-AICAR-P
left: L-Glutamine
name: L-Glutamine + Phosphoribulosylformimino-AICAR-P → 5-Aminoimidazole-4-carboxamide + D-Erythro-imidazole-glycerol-phosphate + Hydrogen Ion + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

3.1.3.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007782/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007755/Stoichiometry/1.0
right: Water
right: Imidazole acetol-phosphate
spontaneous: false
EC number: 3.1.3.15
left: D-Erythro-imidazole-glycerol-phosphate
name: D-Erythro-imidazole-glycerol-phosphate → Imidazole acetol-phosphate + Water
conversion direction: LEFT_TO_RIGHT

Imidazole acetol-phosphate
type: SmallMolecule
entity reference: Imidazole acetol-phosphate

2.6.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007782/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040919/Stoichiometry/1.0
right: Oxoglutaric acid
right: L-histidinol-phosphate
spontaneous: false
EC number: 2.6.1.9
left: L-Glutamic acid
left: Imidazole acetol-phosphate
name: Imidazole acetol-phosphate + L-Glutamic acid → L-histidinol-phosphate + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Histidinal
type: SmallMolecule
entity reference: Histidinal

3.5.4.19
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007817/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001952/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: Phosphoribosyl-AMP
right: Pyrophosphate
spontaneous: false
EC number: 3.5.4.19
left: Water
left: Phosphoribosyl-ATP
name: Phosphoribosyl-ATP + Water → Hydrogen Ion + Phosphoribosyl-AMP + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reaction786415
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040845/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007817/Stoichiometry/1.0
right: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
spontaneous: false
left: Water
left: Phosphoribosyl-AMP
name: Phosphoribosyl-AMP + Water → 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
conversion direction: LEFT_TO_RIGHT

5.3.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040845/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007818/Stoichiometry/1.0
right: PhosphoribosylformiminoAICAR-phosphate
spontaneous: false
EC number: 5.3.1.16
left: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
name: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide → PhosphoribosylformiminoAICAR-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/SMPDB SMP0403670
type: UnificationXref
id: SMP0403670
db: SMPDB

SubPathwayInteraction414604
type: Interaction
name: SubPathwayReaction
name: SubPathway414604Reaction
participant: Phosphoribosyl pyrophosphate

Reference/ChemSpider 987
type: UnificationXref
id: 987
db: ChemSpider

Reference/PathWhiz PW000909
type: UnificationXref
id: PW000909
db: PathWhiz

Reference/ChemSpider 984
type: UnificationXref
id: 984
db: ChemSpider

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Reference/BioCyc IMIDAZOLE-ACETOL-P
type: UnificationXref
id: IMIDAZOLE-ACETOL-P
db: BioCyc

Compound/PW C001801/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Aminoimidazole-4-carboxamide
stoichiometric coefficient: 1.0