Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Compound/PW C001134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine monophosphate

Acinetobacter johnsonii SH046
type: BioSource
xref: Reference/TAXONOMY 575586

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Quinolinic acid
type: SmallMoleculeReference
xref: Reference/CAS 89-00-9
xref: Reference/ChEBI CHEBI 16675
xref: Reference/HMDB HMDB0000232
xref: Reference/ChemSpider 1037
xref: Reference/BioCyc QUINOLINATE
xref: Reference/KEGG Compound C03722
xref: Reference/PubChem-compound 1066
chemical formula: C7H5NO4
molecular weight: 167.02185
structure: ChemicalStructure/PW C000156

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

succinate dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: succinate dehydrogenase

Reference/ChemSpider 145043
type: UnificationXref
id: 145043
db: ChemSpider

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/ChEBI CHEBI 50616
type: UnificationXref
id: CHEBI:50616
db: ChEBI

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

NAD synthetase, NH3-dependent
type: Complex
component stoichiometry: Protein/62366 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Glutamine-dependent NAD(+) synthetase

Quinolinate synthase
type: ProteinReference
xref: Reference/UniProt D0SHB5
organism: Acinetobacter johnsonii SH046

Dihydroxyacetone phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
xref: Reference/PubChem-compound 668
xref: Reference/ChEBI CHEBI 16108
xref: Reference/KEGG Compound C00111
xref: Reference/CAS 57-04-5
xref: Reference/ChemSpider 648
xref: Reference/HMDB HMDB0001473
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C001134

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

SubPathwayInteraction420825
type: Interaction
name: SubPathway420825Reaction
name: SubPathwayReaction
participant: L-Aspartic acid

Reference/PubChem-compound 165491
type: UnificationXref
id: 165491
db: PubChem-compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

2.7.7.18
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000915 Cytosol/Stoichiometry/1.0
right: Pyrophosphate
right: Nicotinic acid adenine dinucleotide
spontaneous: false
EC number: 2.7.7.18
left: nicotinate β-D-ribonucleotide
left: Adenosine triphosphate
left: Hydrogen Ion
name: Adenosine triphosphate + Hydrogen Ion + nicotinate β-D-ribonucleotide → Nicotinic acid adenine dinucleotide + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03722
type: UnificationXref
id: C03722
db: KEGG Compound

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Compound/PW C000915 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nicotinic acid adenine dinucleotide
stoichiometric coefficient: 1.0

Reaction818816
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000884 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: Hydrogen peroxide
right: Iminoaspartic acid
spontaneous: false
left: L-Aspartic acid
left: Oxygen
name: L-Aspartic acid + Oxygen → Hydrogen Ion + Hydrogen peroxide + Iminoaspartic acid
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

2.5.1.72
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000156 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000884 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Quinolinic acid
right: Water
spontaneous: false
EC number: 2.5.1.72
left: Dihydroxyacetone phosphate
left: Iminoaspartic acid
name: Dihydroxyacetone phosphate + Iminoaspartic acid → Phosphate + Quinolinic acid + 2 Water
conversion direction: LEFT_TO_RIGHT

2.4.2.19
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000156 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: nicotinate β-D-ribonucleotide
right: Pyrophosphate
right: Carbon dioxide
spontaneous: false
EC number: 2.4.2.19
left: Hydrogen Ion
left: Phosphoribosyl pyrophosphate
left: Quinolinic acid
name: Hydrogen Ion + Phosphoribosyl pyrophosphate + Quinolinic acid → Carbon dioxide + Pyrophosphate + nicotinate β-D-ribonucleotide
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

6.3.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022608 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000915 Cytosol/Stoichiometry/1.0
right: NAD
right: Adenosine monophosphate
right: Hydrogen Ion
right: Pyrophosphate
spontaneous: false
EC number: 6.3.1.5
left: Adenosine triphosphate
left: Nicotinic acid adenine dinucleotide
left: Ammonium
name: Adenosine triphosphate + Ammonium + Nicotinic acid adenine dinucleotide → Adenosine monophosphate + Hydrogen Ion + NAD + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

6.3.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000915 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: Adenosine monophosphate
right: L-Glutamic acid
right: NAD
right: Pyrophosphate
spontaneous: false
EC number: 6.3.1.5
left: Water
left: Nicotinic acid adenine dinucleotide
left: Adenosine triphosphate
left: L-Glutamine
name: Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water → Adenosine monophosphate + Hydrogen Ion + L-Glutamic acid + NAD + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

succinate dehydrogenase
type: ProteinReference
xref: Reference/UniProt D0SBJ9
organism: Acinetobacter johnsonii SH046

Reference/ChEBI CHEBI 18304
type: UnificationXref
id: CHEBI:18304
db: ChEBI

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Protein/62364 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: nicotinate-nucleotide diphosphorylase (carboxylating)
stoichiometric coefficient: 2.0

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Nicotinic acid adenine dinucleotide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Nicotinic acid adenine dinucleotide

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

nicotinate β-D-ribonucleotide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15763
xref: Reference/KEGG Compound C01185
xref: Reference/ChemSpider 108822
xref: Reference/HMDB HMDB0059646
xref: Reference/PubChem-compound 121992
chemical formula: C11H15NO9P
molecular weight: 336.04843
structure: ChemicalStructure/PW C040083

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

Reference/ChEBI CHEBI 15763
type: UnificationXref
id: CHEBI:15763
db: ChEBI

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000787
type: UnificationXref
id: PW000787
db: PathWhiz

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Reference/KEGG Compound C00111
type: UnificationXref
id: C00111
db: KEGG Compound

Reference/HMDB HMDB0059646
type: UnificationXref
id: HMDB0059646
db: HMDB

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

L-Glutamic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamic acid

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

nicotinate-nucleotide diphosphorylase (carboxylating)
type: Protein
cellular location: Cytosol
entity reference: nicotinate-nucleotide diphosphorylase (carboxylating)

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Iminoaspartic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Iminoaspartic acid

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

Glutamine-dependent NAD(+) synthetase
type: Protein
cellular location: Cytoplasm
entity reference: Glutamine-dependent NAD(+) synthetase

Quinolinate synthase
type: Protein
cellular location: Cytosol
entity reference: Quinolinate synthase

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/UniProt D0SHB5
type: UnificationXref
id: D0SHB5
db: UniProt

Reference/BioCyc IMINOASPARTATE
type: UnificationXref
id: IMINOASPARTATE
db: BioCyc

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/ChemSpider 1037
type: UnificationXref
id: 1037
db: ChemSpider

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/PubChem-compound 796
type: UnificationXref
id: 796
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 57-04-5
type: UnificationXref
id: 57-04-5
db: CAS

Aspartate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway420825
pathway component: SubPathwayInteraction420825
xref: Reference/PathWhiz PW000787
xref: Reference/SMPDB SMP0000809
name: SubPathway

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/HMDB HMDB0000232
type: UnificationXref
id: HMDB0000232
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/BioCyc QUINOLINATE
type: UnificationXref
id: QUINOLINATE
db: BioCyc

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Compound/PW C000190 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

Protein/62366 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutamine-dependent NAD(+) synthetase
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000915
type: ChemicalStructure
structure format: SMILES

Reference/UniProt D0SBJ9
type: UnificationXref
id: D0SBJ9
db: UniProt

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/UniProt D0SBJ1
type: UnificationXref
id: D0SBJ1
db: UniProt

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

nicotinate β-D-ribonucleotide
type: SmallMolecule
cellular location: Cytosol
entity reference: nicotinate β-D-ribonucleotide

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/SMPDB SMP0000809
type: UnificationXref
id: SMP0000809
db: SMPDB

Reference/KEGG Compound C05840
type: UnificationXref
id: C05840
db: KEGG Compound

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroxyacetone phosphate

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/ChemSpider 108822
type: UnificationXref
id: 108822
db: ChemSpider

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Glutamine-dependent NAD(+) synthetase
type: Protein
cellular location: Cytosol
entity reference: Glutamine-dependent NAD(+) synthetase

L-Glutamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamine

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

Reference/ChemSpider 648
type: UnificationXref
id: 648
db: ChemSpider

Reference/SMPDB SMP0407330
type: UnificationXref
id: SMP0407330
db: SMPDB

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

Reference/UniProt D0SG55
type: UnificationXref
id: D0SG55
db: UniProt

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C000156 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Quinolinic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040083
type: ChemicalStructure
structure format: SMILES

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C001420 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Compound/PW C000032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Protein/62366 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutamine-dependent NAD(+) synthetase
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0001473
type: UnificationXref
id: HMDB0001473
db: HMDB

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Iminoaspartic acid
type: SmallMoleculeReference
xref: Reference/CAS 79067-61-1
xref: Reference/PubChem-compound 796
xref: Reference/ChEBI CHEBI 50616
xref: Reference/HMDB HMDB0001131
xref: Reference/KEGG Compound C05840
xref: Reference/ChemSpider 13628208
xref: Reference/BioCyc IMINOASPARTATE
chemical formula: C4H5NO4
molecular weight: 131.02185
structure: ChemicalStructure/PW C000884

Reference/PubChem-compound 668
type: UnificationXref
id: 668
db: PubChem-compound

Reference/KEGG Compound C00857
type: UnificationXref
id: C00857
db: KEGG Compound

Reference/PubChem-compound 121992
type: UnificationXref
id: 121992
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/CAS 89-00-9
type: UnificationXref
id: 89-00-9
db: CAS

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

ChemicalStructure/PW C000156
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC=CN=C1C(O)=O

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
type: UnificationXref
id: DIHYDROXY-ACETONE-PHOSPHATE
db: BioCyc

quinolinate phosphoribosyltransferase
type: Complex
component stoichiometry: Protein/62364 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: nicotinate-nucleotide diphosphorylase (carboxylating)

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Compound/PW C000915 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nicotinic acid adenine dinucleotide
stoichiometric coefficient: 1.0

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

ChemicalStructure/PW C001134
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)COP(O)(O)=O

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

Nicotinic acid adenine dinucleotide
type: SmallMolecule
cellular location: Cytosol
entity reference: Nicotinic acid adenine dinucleotide

Reference/TAXONOMY 575586
type: UnificationXref
id: 575586
db: TAXONOMY

Reference/HMDB HMDB0001131
type: UnificationXref
id: HMDB0001131
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

nicotinate-nucleotide diphosphorylase (carboxylating)
type: ProteinReference
xref: Reference/UniProt D0SFZ4
organism: Acinetobacter johnsonii SH046

Site-specific recombinase, phage integrase family
type: ProteinReference
xref: Reference/UniProt D0SG55
organism: Acinetobacter johnsonii SH046

Glutamine-dependent NAD(+) synthetase
type: ProteinReference
xref: Reference/UniProt D0SBJ1
organism: Acinetobacter johnsonii SH046

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/CAS 6450-77-7
type: UnificationXref
id: 6450-77-7
db: CAS

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Compound/PW C040083 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: nicotinate β-D-ribonucleotide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

NAD synthetase, NH3-dependent
type: Complex
component stoichiometry: Protein/62366 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Glutamine-dependent NAD(+) synthetase

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

quinolinate synthase
type: Complex
component stoichiometry: Protein/48364 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Quinolinate synthase

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 79067-61-1
type: UnificationXref
id: 79067-61-1
db: CAS

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 16108
type: UnificationXref
id: CHEBI:16108
db: ChEBI

Quinolinic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Quinolinic acid

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Nicotinic acid adenine dinucleotide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001179
xref: Reference/ChEBI CHEBI 18304
xref: Reference/CAS 6450-77-7
xref: Reference/ChemSpider 145043
xref: Reference/BioCyc DEAMIDO-NAD
xref: Reference/KEGG Compound C00857
xref: Reference/PubChem-compound 165491
chemical formula: C21H27N6O15P2
molecular weight: 665.10095
structure: ChemicalStructure/PW C000915

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/KEGG Compound C01185
type: UnificationXref
id: C01185
db: KEGG Compound

NAD Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/5943459
pathway order: PathwayEnzymeReaction/5943466
pathway order: PathwayEnzymeReaction/5943463
pathway order: PathwayEnzymeReaction/5943464
pathway order: PathwayEnzymeReaction/5943462
pathway order: PathwaySubPathway/420825
pathway order: PathwayEnzymeReaction/5943460
pathway component: 2.7.7.18
pathway component: Aspartate Metabolism
pathway component: ReactionCatalysis824159
pathway component: Reaction818816
pathway component: 2.5.1.72
pathway component: 2.4.2.19
pathway component: ReactionCatalysis824160
pathway component: 6.3.1.5
pathway component: ReactionCatalysis824158
pathway component: ReactionCatalysis824157
pathway component: ReactionCatalysis824156
pathway component: ReactionCatalysis824155
xref: Reference/PathWhiz PW419229
xref: Reference/SMPDB SMP0407330
organism: Acinetobacter johnsonii SH046

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Phosphoribosyl pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoribosyl pyrophosphate

Reference/PathWhiz PW419229
type: UnificationXref
id: PW419229
db: PathWhiz

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

Reference/ChEBI CHEBI 16675
type: UnificationXref
id: CHEBI:16675
db: ChEBI

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

L-Aspartic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Aspartic acid
name: SubPathwayOutput

ReactionCatalysis824160
type: Catalysis
controller: NAD synthetase, NH3-dependent
controlled: 6.3.1.5
control type: ACTIVATION

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Site-specific recombinase, phage integrase family
type: Protein
cellular location: Cytosol
entity reference: Site-specific recombinase, phage integrase family

Ammonium
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonium

Compound/PW C000884 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Iminoaspartic acid
stoichiometric coefficient: 1.0

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

ReactionCatalysis824159
type: Catalysis
controller: NAD synthetase, NH3-dependent
controlled: 6.3.1.5
control type: ACTIVATION

Protein/48364 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Quinolinate synthase
stoichiometric coefficient: 2.0

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C022608 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1066
type: UnificationXref
id: 1066
db: PubChem-compound

Reference/HMDB HMDB0001179
type: UnificationXref
id: HMDB0001179
db: HMDB

Compound/PW C000123 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

ChemicalStructure/PW C000884
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=N)C(O)=O

Reference/BioCyc DEAMIDO-NAD
type: UnificationXref
id: DEAMIDO-NAD
db: BioCyc

ReactionCatalysis824158
type: Catalysis
controller: Site-specific recombinase, phage integrase family
controlled: 2.7.7.18
control type: ACTIVATION

Reference/UniProt D0SFZ4
type: UnificationXref
id: D0SFZ4
db: UniProt

ReactionCatalysis824157
type: Catalysis
controller: quinolinate phosphoribosyltransferase
controlled: 2.4.2.19
control type: ACTIVATION

ReactionCatalysis824156
type: Catalysis
controller: quinolinate synthase
controlled: 2.5.1.72
control type: ACTIVATION

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

ReactionCatalysis824155
type: Catalysis
controller: succinate dehydrogenase
controlled: Reaction818816
control type: ACTIVATION

Reference/ChemSpider 13628208
type: UnificationXref
id: 13628208
db: ChemSpider