Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 388356
type: UnificationXref
id: 388356
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/UniProt C4ZUM4
type: UnificationXref
id: C4ZUM4
db: UniProt

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

UDP-N-acetyl-α-D-muramate
type: SmallMolecule
cellular location: Cytosol
entity reference: UDP-N-acetyl-α-D-muramate
name: SubPathwayInput

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/UniProt C4ZY54
type: UnificationXref
id: C4ZY54
db: UniProt

Reference/HMDB HMDB0003362
type: UnificationXref
id: HMDB0003362
db: HMDB

Reference/HMDB HMDB0001062
type: UnificationXref
id: HMDB0001062
db: HMDB

Reference/BioCyc UDP-MANNAC
type: UnificationXref
id: UDP-MANNAC
db: BioCyc

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6133
type: UnificationXref
id: 6133
db: PubChem-compound

Glucosamine 6-phosphate
type: SmallMolecule
entity reference: Glucosamine 6-phosphate

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/ChEBI CHEBI 16264
type: UnificationXref
id: CHEBI:16264
db: ChEBI

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15784
xref: Reference/ChemSpider 389821
xref: Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-6-P
xref: Reference/HMDB HMDB0001062
xref: Reference/KEGG Compound C00357
xref: Reference/CAS 102029-88-9
xref: Reference/PubChem-compound 440996
chemical formula: C8H16NO9P
molecular weight: 301.05627
structure: ChemicalStructure/PW C000837

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

Chitobiose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003556
xref: Reference/ChemSpider 17216232
xref: Reference/CAS 577-76-4
xref: Reference/PubChem-compound 22833609
xref: Reference/KEGG Compound C01674
xref: Reference/BioCyc CHITOBIOSE
chemical formula: C15H26N2O12
molecular weight: 426.14856
structure: ChemicalStructure/PW C001925

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

UDP-N-acetyl-D-mannosamine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01170
xref: Reference/PubChem-compound 53481607
xref: Reference/BioCyc UDP-MANNAC
xref: Reference/HMDB HMDB0013112
xref: Reference/ChEBI CHEBI 16287
chemical formula: C17H27N3O17P2
molecular weight: 607.08154
structure: ChemicalStructure/PW C008203

UDP-N-acetyl-D-mannosamine
type: SmallMolecule
entity reference: UDP-N-acetyl-D-mannosamine

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Voltage-gated ClC-type chloride channel ClcB
type: Protein
cellular location: Inner Membrane
entity reference: Voltage-gated ClC-type chloride channel ClcB

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Reference/BioCyc D-LACTATE
type: UnificationXref
id: D-LACTATE
db: BioCyc

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Compound/PW C000837 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-Glucosamine 6-Phosphate
stoichiometric coefficient: 1.0

Glucosamine-1P
type: SmallMolecule
cellular location: Cytosol
entity reference: Glucosamine-1P

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

N-acetylmannosamine kinase
type: ProteinReference
xref: Reference/UniProt C4ZSW0
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

Protein/48829 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
stoichiometric coefficient: 2.0

Reference/ChemSpider 17216232
type: UnificationXref
id: 17216232
db: ChemSpider

Secondary Metabolites: Enterobacterial Common Antigen Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway464299
pathway component: SubPathwayInteraction464299
xref: Reference/SMPDB SMP0000975
xref: Reference/PathWhiz PW000959
name: SubPathway

Glucosamine 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glucosamine 6-phosphate

2.7.1.69
type: TransportWithBiochemicalReaction
participant stoichiometry: Protein/40835 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000837 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000141 Inner Membrane/Stoichiometry/1.0
right: N-Acetyl-D-Glucosamine 6-Phosphate
right: UPF0181 protein YoaH
spontaneous: false
EC number: 2.7.1.69
left: N-Acetyl-D-glucosamine
left: UPF0181 protein YoaH
name: HPr - phosphorylated + N-Acetyl-D-glucosamine → HPr + N-Acetyl-D-Glucosamine 6-Phosphate
conversion direction: LEFT_TO_RIGHT

MurNAc-6-P
type: SmallMolecule
cellular location: Inner Membrane
entity reference: MurNAc-6-P

Reference/ChemSpider 8140645
type: UnificationXref
id: 8140645
db: ChemSpider

Reference/UniProt C4ZW19
type: UnificationXref
id: C4ZW19
db: UniProt

ReactionCoupledTransport13820
type: TransportWithBiochemicalReaction
participant stoichiometry: Protein/40835 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041109 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041110 Inner Membrane/Stoichiometry/1.0
right: UPF0181 protein YoaH
right: MurNAc-6-P
spontaneous: false
left: UPF0181 protein YoaH
left: MurNAc
name: HPr - phosphorylated + MurNAc → HPr + MurNAc-6-P
conversion direction: LEFT_TO_RIGHT

Glycine cleavage system H protein
type: ProteinReference
xref: Reference/UniProt C5A0H6
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

3-phosphoshikimate 1-carboxyvinyltransferase
type: Protein
cellular location: Cytosol
entity reference: 3-phosphoshikimate 1-carboxyvinyltransferase

Reference/PubChem-compound 439174
type: UnificationXref
id: 439174
db: PubChem-compound

Reference/KEGG Compound C00461
type: UnificationXref
id: C00461
db: KEGG Compound

ChemicalStructure/PW C041109
type: ChemicalStructure
structure format: SMILES

glucosamine-6-phosphate deaminase
type: Complex
component stoichiometry: Protein/64345 Cytosol/Stoichiometry/6.0
cellular location: Cytosol
component: 3-phosphoshikimate 1-carboxyvinyltransferase

Protein/64350/Stoichiometry/2.0
type: Stoichiometry
physical entity: Siroheme synthase
stoichiometric coefficient: 2.0

Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
type: ProteinReference
xref: Reference/UniProt C4ZU96
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CAS 10326-41-7
type: UnificationXref
id: 10326-41-7
db: CAS

Reference/KEGG Compound C01674
type: UnificationXref
id: C01674
db: KEGG Compound

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Compound/PW C001144 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 2.0

Reference/BioCyc GLUCOSAMINE-1P
type: UnificationXref
id: GLUCOSAMINE-1P
db: BioCyc

Reference/PubChem-compound 440272
type: UnificationXref
id: 440272
db: PubChem-compound

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

ChemicalStructure/PW C041110
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O[C@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@@H](O)[C@@H]1NC(C)=O)C([O-])=O

Reference/SMPDB SMP0000792
type: UnificationXref
id: SMP0000792
db: SMPDB

Amino Sugar and Nucleotide Sugar Metabolism I
type: Pathway
pathway order: PathwayEnzymeReaction/6329352
pathway order: PathwayEnzymeReaction/6329363
pathway order: PathwayEnzymeReaction/6329353
pathway order: PathwayEnzymeReaction/6329364
pathway order: PathwayEnzymeReaction/6329361
pathway order: PathwayEnzymeReaction/6329351
pathway order: PathwayEnzymeReaction/6329362
pathway order: PathwayEnzymeReaction/6329360
pathway order: PathwayEnzymeReaction/6329358
pathway order: PathwayEnzymeReaction/6329369
pathway order: PathwayEnzymeReaction/6329359
pathway order: PathwayEnzymeReaction/6329356
pathway order: PathwayEnzymeReaction/6329357
pathway order: PathwayEnzymeReaction/6329354
pathway order: PathwayEnzymeReaction/6329365
pathway order: PathwayEnzymeReaction/6329355
pathway order: PathwayEnzymeReaction/6329366
pathway order: PathwaySubPathway/464298
pathway order: PathwaySubPathway/464299
pathway component: 3.2.1.14
pathway component: 3.2.1.52
pathway component: 1.1.1.336
pathway component: ReactionCatalysis1000990
pathway component: 5.1.3.14
pathway component: 3.5.99.6
pathway component: 2.7.1.59
pathway component: 2.6.1.16
pathway component: D-Glutamine and D-Glutamate Metabolism
pathway component: ReactionCatalysis1000989
pathway component: ReactionCatalysis1000987
pathway component: Secondary Metabolites: Enterobacterial Common Antigen Biosynthesis
pathway component: ReactionCatalysis1000988
pathway component: ReactionCatalysis1000985
pathway component: ReactionCatalysis1000986
pathway component: 3.5.1.25
pathway component: ReactionCatalysis1000983
pathway component: 1.3.1.98
pathway component: 2.7.1.69
pathway component: ReactionCatalysis1000984
pathway component: ReactionCatalysis1000981
pathway component: ReactionCatalysis1000982
pathway component: ReactionCoupledTransportCatalysis13881
pathway component: ReactionCoupledTransportCatalysis13882
pathway component: ReactionCatalysis1000980
pathway component: ReactionCoupledTransport13820
pathway component: ReactionCatalysis767717
pathway component: ReactionCatalysis767712
pathway component: ReactionCatalysis767714
pathway component: ReactionCatalysis1000979
pathway component: 5.4.2.10
pathway component: 2.7.7.23
pathway component: Reaction984098
pathway component: 2.5.1.7
pathway component: Reaction765588
pathway component: Reaction984099
xref: Reference/PathWhiz PW449868
xref: Reference/SMPDB SMP0434788
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

Reference/ChEBI CHEBI 17029
type: UnificationXref
id: CHEBI:17029
db: ChEBI

Glucosamine-1P
type: SmallMoleculeReference
xref: Reference/PubChem-compound 9965052
xref: Reference/BioCyc GLUCOSAMINE-1P
xref: Reference/HMDB HMDB0001109
xref: Reference/ChemSpider 8140645
chemical formula: C6H14NO8P
molecular weight: 259.04572
structure: ChemicalStructure/PW C000868

Compound/PW C000192 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 388319
type: UnificationXref
id: 388319
db: ChemSpider

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/KEGG Compound C00352
type: UnificationXref
id: C00352
db: KEGG Compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00357
type: UnificationXref
id: C00357
db: KEGG Compound

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C041114/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetyl-α-D-glucosamine-enolpyruvate
stoichiometric coefficient: 1.0

Chitin
type: SmallMolecule
cellular location: Cytosol
entity reference: Chitin

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

UDP-N-acetyl-α-D-glucosamine-enolpyruvate
type: SmallMolecule
entity reference: UDP-N-acetyl-α-D-glucosamine-enolpyruvate

Reference/CAS 3616-42-0
type: UnificationXref
id: 3616-42-0
db: CAS

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

UDP-N-acetyl-α-D-muramate
type: SmallMolecule
entity reference: UDP-N-acetyl-α-D-muramate

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/SMPDB SMP0000975
type: UnificationXref
id: SMP0000975
db: SMPDB

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

MurNAc
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 7212
chemical formula: C11H18NO8
molecular weight: 292.1038
structure: ChemicalStructure/PW C041109

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

HTH-type transcriptional regulator MurR
type: ProteinReference
xref: Reference/UniProt C4ZVV8
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

Compound/PW C041115/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetyl-α-D-muramate
stoichiometric coefficient: 1.0

5.4.2.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000868 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969 Cytosol/Stoichiometry/1.0
right: Glucosamine-1P
spontaneous: false
EC number: 5.4.2.10
left: Glucosamine 6-phosphate
name: Glucosamine 6-phosphate ↔ Glucosamine-1P
conversion direction: REVERSIBLE

2.7.7.23
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000868 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001055 Cytosol/Stoichiometry/1.0
right: Coenzyme A
right: Hydrogen Ion
right: N-Acetyl-glucosamine 1-phosphate
spontaneous: false
EC number: 2.7.7.23
left: Acetyl-CoA
left: Glucosamine-1P
name: Acetyl-CoA + Glucosamine-1P → Coenzyme A + Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate
conversion direction: LEFT_TO_RIGHT

Reaction765588
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000196 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000192 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001055 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Uridine diphosphate-N-acetylglucosamine
right: Pyrophosphate
spontaneous: false
left: Hydrogen Ion
left: Uridine triphosphate
left: N-Acetyl-glucosamine 1-phosphate
name: Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine
conversion direction: LEFT_TO_RIGHT

MurNAc-6-P
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58721
chemical formula: C11H17NO11P
molecular weight: 370.05557
structure: ChemicalStructure/PW C041110

Probable malate:quinone oxidoreductase
type: Protein
cellular location: Cytosol
entity reference: Probable malate:quinone oxidoreductase

UDP-N-acetyl-α-D-mannosaminuronate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 70731
chemical formula: C17H22N3O18P2
molecular weight: 618.039
structure: ChemicalStructure/PW C041113

UDP-N-acetyl-α-D-glucosamine-enolpyruvate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 68483
chemical formula: C20H26N3O19P2
molecular weight: 674.06525
structure: ChemicalStructure/PW C041114

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

UDP-N-acetyl-α-D-muramate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 70757
chemical formula: C20H28N3O19P2
molecular weight: 676.0809
structure: ChemicalStructure/PW C041115

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Chitobiose
type: SmallMolecule
cellular location: Cytosol
entity reference: Chitobiose

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/KEGG Compound C00256
type: UnificationXref
id: C00256
db: KEGG Compound

Glucosamine 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 3616-42-0
xref: Reference/ChemSpider 388356
xref: Reference/ChEBI CHEBI 15873
xref: Reference/KEGG Compound C00352
xref: Reference/BioCyc D-GLUCOSAMINE-6-P
xref: Reference/PubChem-compound 439217
xref: Reference/HMDB HMDB0001254
chemical formula: C6H14NO8P
molecular weight: 259.04572
structure: ChemicalStructure/PW C000969

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/ChEBI CHEBI 7125
type: UnificationXref
id: CHEBI:7125
db: ChEBI

Reference/KEGG Compound C00140
type: UnificationXref
id: C00140
db: KEGG Compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/BioCyc D-GLUCOSAMINE-6-P
type: UnificationXref
id: D-GLUCOSAMINE-6-P
db: BioCyc

Compound/PW C001055 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-glucosamine 1-phosphate
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0434788
type: UnificationXref
id: SMP0434788
db: SMPDB

Compound/PW C000837 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-Glucosamine 6-Phosphate
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

ReactionCatalysis767717
type: Catalysis
controller: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
controlled: Reaction765588
control type: ACTIVATION

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

ReactionCatalysis767712
type: Catalysis
controller: Glycerol-3-phosphate dehydrogenase [NAD(P)+]
controlled: 5.4.2.10
control type: ACTIVATION

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Compound/PW C001925 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chitobiose
stoichiometric coefficient: 1.0

ReactionCatalysis767714
type: Catalysis
controller: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
controlled: 2.7.7.23
control type: ACTIVATION

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/ChEBI CHEBI 16287
type: UnificationXref
id: CHEBI:16287
db: ChEBI

D-fructose-6-phosphate aminotransferase
type: Complex
component stoichiometry: Protein/55173/Stoichiometry/2.0
component: N-acetylmuramic acid 6-phosphate etherase

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
type: Protein
cellular location: Cytosol
entity reference: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Sulfur carrier protein TusA
type: Protein
cellular location: Cytosol
entity reference: Sulfur carrier protein TusA

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: Reference/UniProt C4ZQ34
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

Cell division protein ZipA
type: ProteinReference
xref: Reference/UniProt C4ZVU3
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

Reference/UniProt C4ZXK0
type: UnificationXref
id: C4ZXK0
db: UniProt

Reference/CAS 577-76-4
type: UnificationXref
id: 577-76-4
db: CAS

Protein/55445 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: HTH-type transcriptional regulator MurR
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-1-P
type: UnificationXref
id: N-ACETYL-D-GLUCOSAMINE-1-P
db: BioCyc

Reference/ChEBI CHEBI 70731
type: UnificationXref
id: CHEBI:70731
db: ChEBI

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

N-acetylmuramic acid 6-phosphate etherase
type: Protein
entity reference: N-acetylmuramic acid 6-phosphate etherase

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/HMDB HMDB0001109
type: UnificationXref
id: HMDB0001109
db: HMDB

Reference/KEGG Compound C00043
type: UnificationXref
id: C00043
db: KEGG Compound

UPF0181 protein YoaH
type: Protein
cellular location: Inner Membrane
entity reference: UPF0181 protein YoaH

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

Sulfur carrier protein TusA
type: ProteinReference
xref: Reference/UniProt C4ZW19
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

HTH-type transcriptional regulator MurR
type: Protein
cellular location: Cytoplasm
entity reference: HTH-type transcriptional regulator MurR

Dihydroorotase
type: ProteinReference
xref: Reference/UniProt C4ZS02
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

Siroheme synthase
type: ProteinReference
xref: Reference/UniProt C4ZUM4

Reference/BioCyc UTP
type: UnificationXref
id: UTP
db: BioCyc

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

Reference/ChemSpider 389821
type: UnificationXref
id: 389821
db: ChemSpider

Reference/ChEBI CHEBI 70757
type: UnificationXref
id: CHEBI:70757
db: ChEBI

Reference/ChemSpider 5903
type: UnificationXref
id: 5903
db: ChemSpider

Reference/ChemSpider 399508
type: UnificationXref
id: 399508
db: ChemSpider

3-deoxy-manno-octulosonate cytidylyltransferase
type: ProteinReference
xref: Reference/UniProt C4ZQ44
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

N-acetylmuramic acid PTS permease
type: Complex
cellular location: Inner Membrane
component: Voltage-gated ClC-type chloride channel ClcB
component: Glycine cleavage system H protein

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Chitin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17029
xref: Reference/ChemSpider 399508
xref: Reference/HMDB HMDB0003362
xref: Reference/CAS 1398-61-4
xref: Reference/KEGG Compound C00461
xref: Reference/PubChem-compound 21252321
xref: Reference/BioCyc 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1
chemical formula: C24H41N3O16
molecular weight: 627.24866
structure: ChemicalStructure/PW C001858

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/HMDB HMDB0001367
type: UnificationXref
id: HMDB0001367
db: HMDB

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Voltage-gated ClC-type chloride channel ClcB
type: ProteinReference
xref: Reference/UniProt C4ZY54
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

Reference/BioCyc 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1
type: UnificationXref
id: 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1
db: BioCyc

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/PubChem-compound 445675
type: UnificationXref
id: 445675
db: PubChem-compound

Compound/PW C000721 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/UniProt C4ZSB3
type: UnificationXref
id: C4ZSB3
db: UniProt

Reference/CAS 6866-69-9
type: UnificationXref
id: 6866-69-9
db: CAS

Reference/HMDB HMDB0013112
type: UnificationXref
id: HMDB0013112
db: HMDB

Reference/HMDB HMDB0003556
type: UnificationXref
id: HMDB0003556
db: HMDB

Reference/ChEBI CHEBI 7212
type: UnificationXref
id: CHEBI:7212
db: ChEBI

ChemicalStructure/PW C001010
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](O)C(O)=O

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: N-Acetyl-D-Glucosamine 6-Phosphate

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

Glycine cleavage system H protein
type: Protein
cellular location: Inner Membrane
entity reference: Glycine cleavage system H protein

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Compound/PW C000837 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-Glucosamine 6-Phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001254
type: UnificationXref
id: HMDB0001254
db: HMDB

Reference/HMDB HMDB0000285
type: UnificationXref
id: HMDB0000285
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

UDP-N-acetyl-α-D-mannosaminuronate
type: SmallMolecule
cellular location: Cytosol
entity reference: UDP-N-acetyl-α-D-mannosaminuronate
name: SubPathwayInput

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Acetyl-D-Glucosamine 6-Phosphate

N-Acetyl-D-glucosamine
type: SmallMolecule
cellular location: Inner Membrane
entity reference: N-Acetyl-D-glucosamine

ChemicalStructure/PW C040941
type: ChemicalStructure
structure format: SMILES
structure data: OCC1(O)OC(COP([O-])([O-])=O)C(O)C1O

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/KEGG Compound C00075
type: UnificationXref
id: C00075
db: KEGG Compound

Reference/KEGG Compound C01170
type: UnificationXref
id: C01170
db: KEGG Compound

D-Lactic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-Lactic acid

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/PubChem-compound 9965052
type: UnificationXref
id: 9965052
db: PubChem-compound

Reference/HMDB HMDB0000290
type: UnificationXref
id: HMDB0000290
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

N-Acetyl-glucosamine 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Acetyl-glucosamine 1-phosphate

Reference/ChEBI CHEBI 42111
type: UnificationXref
id: CHEBI:42111
db: ChEBI

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/PubChem-compound 22833609
type: UnificationXref
id: 22833609
db: PubChem-compound

Escherichia coli (strain K12 / MC4100 / BW2952)
type: BioSource
xref: Reference/TAXONOMY 595496

Acetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetic acid

3.2.1.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001925 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001858 Cytosol/Stoichiometry/1.0
right: Chitin
right: Chitobiose
spontaneous: false
EC number: 3.2.1.14
left: Chitin
left: Water
name: Chitin + Water → Chitin + Chitobiose
conversion direction: LEFT_TO_RIGHT

3.2.1.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001925 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000141 Cytosol/Stoichiometry/2.0
right: N-Acetyl-D-glucosamine
spontaneous: false
EC number: 3.2.1.52
left: Chitobiose
left: Water
name: Chitobiose + Water → 2 N-Acetyl-D-glucosamine
conversion direction: LEFT_TO_RIGHT

1.1.1.336
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C041113 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008203 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/3.0
right: UDP-N-acetyl-α-D-mannosaminuronate
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.1.1.336
left: NAD
left: UDP-N-acetyl-D-mannosamine
left: Water
name: 2 NAD + UDP-N-acetyl-D-mannosamine + Water → 3 Hydrogen Ion + 2 NADH + UDP-N-acetyl-α-D-mannosaminuronate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

5.1.3.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000196/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008203/Stoichiometry/1.0
right: UDP-N-acetyl-D-mannosamine
spontaneous: false
EC number: 5.1.3.14
left: Uridine diphosphate-N-acetylglucosamine
name: Uridine diphosphate-N-acetylglucosamine ↔ UDP-N-acetyl-D-mannosamine
conversion direction: REVERSIBLE

3.5.99.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000969 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022608 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040941 Cytosol/Stoichiometry/1.0
right: Ammonium
right: β-D-fructofuranose 6-phosphate
spontaneous: false
EC number: 3.5.99.6
left: Glucosamine 6-phosphate
left: Water
name: Glucosamine 6-phosphate + Water → Ammonium + β-D-fructofuranose 6-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Uridine diphosphate-N-acetylglucosamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine diphosphate-N-acetylglucosamine

2.7.1.59
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000837 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000141 Cytosol/Stoichiometry/1.0
right: N-Acetyl-D-Glucosamine 6-Phosphate
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.1.59
left: N-Acetyl-D-glucosamine
left: Adenosine triphosphate
name: Adenosine triphosphate + N-Acetyl-D-glucosamine → Adenosine diphosphate + Hydrogen Ion + N-Acetyl-D-Glucosamine 6-Phosphate
conversion direction: LEFT_TO_RIGHT

2.6.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040941/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969/Stoichiometry/1.0
right: Glucosamine 6-phosphate
right: L-Glutamic acid
spontaneous: false
EC number: 2.6.1.16
left: β-D-fructofuranose 6-phosphate
left: L-Glutamine
name: L-Glutamine + β-D-fructofuranose 6-phosphate ↔ Glucosamine 6-phosphate + L-Glutamic acid
conversion direction: REVERSIBLE

Reference/PathWhiz PW449868
type: UnificationXref
id: PW449868
db: PathWhiz

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

N-acetylmannosamine kinase
type: Protein
cellular location: Cytosol
entity reference: N-acetylmannosamine kinase

ChemicalStructure/PW C000196
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

SubPathwayInteraction464299
type: Interaction
name: SubPathway464299Reaction
name: SubPathwayReaction
participant: UDP-N-acetyl-α-D-mannosaminuronate

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

SubPathwayInteraction464298
type: Interaction
name: SubPathwayReaction
name: SubPathway464298Reaction
participant: UDP-N-acetyl-α-D-muramate

Ammonium
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonium

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

3.5.1.25
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000969 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000837 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000029 Cytosol/Stoichiometry/1.0
right: Acetic acid
right: Glucosamine 6-phosphate
spontaneous: false
EC number: 3.5.1.25
left: N-Acetyl-D-Glucosamine 6-Phosphate
left: Water
name: N-Acetyl-D-Glucosamine 6-Phosphate + Water → Acetic acid + Glucosamine 6-phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000192
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Cell division protein ZipA
type: Protein
cellular location: Cytosol
entity reference: Cell division protein ZipA

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N-Acetyl-D-Glucosamine 6-Phosphate

UDP-N-acetylglucosamine 2-epimerase
type: Complex
component stoichiometry: Protein/64350/Stoichiometry/2.0
component: Siroheme synthase

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/CAS 102029-88-9
type: UnificationXref
id: 102029-88-9
db: CAS

Compound/PW C022608 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 57634
type: UnificationXref
id: CHEBI:57634
db: ChEBI

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

MurNAc
type: SmallMolecule
cellular location: Inner Membrane
entity reference: MurNAc

Reference/ChEBI CHEBI 58721
type: UnificationXref
id: CHEBI:58721
db: ChEBI

ChemicalStructure/PW C001055
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

Reference/UniProt C5A0H6
type: UnificationXref
id: C5A0H6
db: UniProt

Reference/TAXONOMY 595496
type: UnificationXref
id: 595496
db: TAXONOMY

Reaction984098
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041110 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001010 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000837 Cytoplasm/Stoichiometry/1.0
right: D-Lactic acid
right: N-Acetyl-D-Glucosamine 6-Phosphate
spontaneous: false
left: MurNAc-6-P
left: Water
name: MurNAc-6-P + Water → D-Lactic acid + N-Acetyl-D-Glucosamine 6-Phosphate
conversion direction: LEFT_TO_RIGHT

2.5.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000196 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041114 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: UDP-N-acetyl-α-D-glucosamine-enolpyruvate
spontaneous: false
EC number: 2.5.1.7
left: Uridine diphosphate-N-acetylglucosamine
left: Phosphoenolpyruvic acid
name: Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine → Phosphate + UDP-N-acetyl-α-D-glucosamine-enolpyruvate
conversion direction: LEFT_TO_RIGHT

Reaction984099
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001858 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000141 Cytosol/Stoichiometry/1.0
right: N-Acetyl-D-glucosamine
right: Chitin
spontaneous: false
left: Chitin
left: Water
name: Chitin + Water → Chitin + N-Acetyl-D-glucosamine
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

Reference/UniProt C4ZZG7
type: UnificationXref
id: C4ZZG7
db: UniProt

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA

Reference/PubChem-compound 21252321
type: UnificationXref
id: 21252321
db: PubChem-compound

Compound/PW C000180 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

N-acetylglucosamine PTS permease
type: Complex
component stoichiometry: Protein/48829 Inner Membrane/Stoichiometry/2.0
cellular location: Inner Membrane
component: Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase

D-Lactic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001311
xref: Reference/ChemSpider 55423
xref: Reference/BioCyc D-LACTATE
xref: Reference/CAS 10326-41-7
xref: Reference/KEGG Compound C00256
xref: Reference/PubChem-compound 61503
xref: Reference/ChEBI CHEBI 42111
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C001010

Reference/UniProt C4ZQ44
type: UnificationXref
id: C4ZQ44
db: UniProt

Reference/CAS 528-04-1
type: UnificationXref
id: 528-04-1
db: CAS

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/PW C008203/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetyl-D-mannosamine
stoichiometric coefficient: 1.0

Reference/BioCyc ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
type: UnificationXref
id: ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
db: BioCyc

Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-6-P
type: UnificationXref
id: N-ACETYL-D-GLUCOSAMINE-6-P
db: BioCyc

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C04256
type: UnificationXref
id: C04256
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

3-deoxy-manno-octulosonate cytidylyltransferase
type: Protein
cellular location: Cytosol
entity reference: 3-deoxy-manno-octulosonate cytidylyltransferase

Compound/PW C040941 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-fructofuranose 6-phosphate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000959
type: UnificationXref
id: PW000959
db: PathWhiz

Reference/ChemSpider 393240
type: UnificationXref
id: 393240
db: ChemSpider

Reference/BioCyc CHITOBIOSE
type: UnificationXref
id: CHITOBIOSE
db: BioCyc

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Compound/PW C041110 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: MurNAc-6-P
stoichiometric coefficient: 1.0

Reference/ChemSpider 55423
type: UnificationXref
id: 55423
db: ChemSpider

N-Acetyl-D-glucosamine
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Acetyl-D-glucosamine

Reference/ChEBI CHEBI 15713
type: UnificationXref
id: CHEBI:15713
db: ChEBI

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

NADP
type: SmallMolecule
entity reference: NADP

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

N-Acetyl-D-glucosamine
type: SmallMoleculeReference
xref: Reference/BioCyc ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
xref: Reference/ChEBI CHEBI 506227
xref: Reference/HMDB HMDB0000215
xref: Reference/KEGG Compound C00140
xref: Reference/ChemSpider 388319
xref: Reference/PubChem-compound 439174
xref: Reference/CAS 7512-17-6
chemical formula: C8H15NO6
molecular weight: 221.08994
structure: ChemicalStructure/PW C000141

Compound/PW C000141 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-glucosamine
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Phosphoenolpyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoenolpyruvic acid

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

Compound/PW C000029 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Uridine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6133
xref: Reference/CAS 63-39-8
xref: Reference/ChemSpider 5903
xref: Reference/ChEBI CHEBI 15713
xref: Reference/KEGG Compound C00075
xref: Reference/HMDB HMDB0000285
xref: Reference/BioCyc UTP
chemical formula: C9H15N2O15P3
molecular weight: 483.96854
structure: ChemicalStructure/PW C000192

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/UniProt C4ZU96
type: UnificationXref
id: C4ZU96
db: UniProt

Protein/40835 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: UPF0181 protein YoaH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000215
type: UnificationXref
id: HMDB0000215
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/CAS 1398-61-4
type: UnificationXref
id: 1398-61-4
db: CAS

Compound/PW C041110 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: MurNAc-6-P
stoichiometric coefficient: 1.0

Uridine diphosphate-N-acetylglucosamine
type: SmallMoleculeReference
xref: Reference/CAS 528-04-1
xref: Reference/PubChem-compound 445675
xref: Reference/HMDB HMDB0000290
xref: Reference/BioCyc UDP-N-ACETYL-D-GLUCOSAMINE
xref: Reference/KEGG Compound C00043
xref: Reference/ChEBI CHEBI 16264
xref: Reference/ChemSpider 393240
chemical formula: C17H27N3O17P2
molecular weight: 607.08154
structure: ChemicalStructure/PW C000196

UDP-N-acetyl-D-mannosamine dehydrogenase
type: Complex
component stoichiometry: Protein/64352 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Sulfur carrier protein TusA

β-D-fructofuranose 6-phosphate
type: SmallMolecule
entity reference: β-D-fructofuranose 6-phosphate

Compound/PW C000940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

Reference/HMDB HMDB0001311
type: UnificationXref
id: HMDB0001311
db: HMDB

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000141
type: ChemicalStructure
structure format: SMILES

N-Acetyl-glucosamine 1-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 7125
xref: Reference/ChemSpider 389248
xref: Reference/HMDB HMDB0001367
xref: Reference/PubChem-compound 440272
xref: Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-1-P
xref: Reference/CAS 6866-69-9
xref: Reference/KEGG Compound C04256
chemical formula: C8H16NO9P
molecular weight: 301.05627
structure: ChemicalStructure/PW C001055

Compound/PW C040941/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-fructofuranose 6-phosphate
stoichiometric coefficient: 1.0

Protein/51494 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: 3-deoxy-manno-octulosonate cytidylyltransferase
stoichiometric coefficient: 3.0

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/PathWhiz PW000769
type: UnificationXref
id: PW000769
db: PathWhiz

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

UDP-N-acetyl-α-D-glucosamine-enolpyruvate
type: SmallMolecule
cellular location: Cytosol
entity reference: UDP-N-acetyl-α-D-glucosamine-enolpyruvate

Compound/PW C041114 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetyl-α-D-glucosamine-enolpyruvate
stoichiometric coefficient: 1.0

β-D-fructofuranose 6-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 57634
chemical formula: C6H11O9P
molecular weight: 258.01517
structure: ChemicalStructure/PW C040941

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

Uridine diphosphate-N-acetylglucosamine
type: SmallMolecule
entity reference: Uridine diphosphate-N-acetylglucosamine

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Protein/64352 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Sulfur carrier protein TusA
stoichiometric coefficient: 2.0

Reference/UniProt C4ZQ34
type: UnificationXref
id: C4ZQ34
db: UniProt

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/ChEBI CHEBI 68483
type: UnificationXref
id: CHEBI:68483
db: ChEBI

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

ReactionCoupledTransportCatalysis13881
type: Catalysis
controller: N-acetylglucosamine PTS permease
controlled: 2.7.1.69
control type: ACTIVATION

ReactionCoupledTransportCatalysis13882
type: Catalysis
controller: N-acetylmuramic acid PTS permease
controlled: ReactionCoupledTransport13820
control type: ACTIVATION

Reference/ChEBI CHEBI 15873
type: UnificationXref
id: CHEBI:15873
db: ChEBI

MurNAc-6-P
type: SmallMolecule
cellular location: Cytoplasm
entity reference: MurNAc-6-P

Reference/PubChem-compound 440996
type: UnificationXref
id: 440996
db: PubChem-compound

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/UniProt C4ZSW0
type: UnificationXref
id: C4ZSW0
db: UniProt

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000969
type: ChemicalStructure
structure format: SMILES

Compound/PW C000141 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: N-Acetyl-D-glucosamine
stoichiometric coefficient: 2.0

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

D-Glutamine and D-Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway464298
pathway component: SubPathwayInteraction464298
xref: Reference/PathWhiz PW000769
xref: Reference/SMPDB SMP0000792
name: SubPathway

Glycerol-3-phosphate dehydrogenase [NAD(P)+]
type: ProteinReference
xref: Reference/UniProt C4ZXK0
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

Reference/UniProt C4ZU53
type: UnificationXref
id: C4ZU53
db: UniProt

1.3.1.98
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041114/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041115/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: UDP-N-acetyl-α-D-muramate
right: NADP
spontaneous: false
EC number: 1.3.1.98
left: UDP-N-acetyl-α-D-glucosamine-enolpyruvate
left: Hydrogen Ion
left: NADPH
name: Hydrogen Ion + NADPH + UDP-N-acetyl-α-D-glucosamine-enolpyruvate → NADP + UDP-N-acetyl-α-D-muramate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Protein/55173/Stoichiometry/2.0
type: Stoichiometry
physical entity: N-acetylmuramic acid 6-phosphate etherase
stoichiometric coefficient: 2.0

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

N-acetylglucosamine-6-phosphate deacetylase
type: Complex
component stoichiometry: Protein/48744 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Compound/PW C000196/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate-N-acetylglucosamine
stoichiometric coefficient: 1.0

Compound/PW C000868 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine-1P
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Compound/PW C041113 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetyl-α-D-mannosaminuronate
stoichiometric coefficient: 1.0

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Uridine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine triphosphate

Reference/UniProt C4ZS02
type: UnificationXref
id: C4ZS02
db: UniProt

Reference/ChEBI CHEBI 15784
type: UnificationXref
id: CHEBI:15784
db: ChEBI

Compound/PW C000196 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate-N-acetylglucosamine
stoichiometric coefficient: 1.0

ReactionCatalysis1000990
type: Catalysis
controller: Dihydroorotase
controlled: 1.3.1.98
control type: ACTIVATION

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

β-D-fructofuranose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: β-D-fructofuranose 6-phosphate

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Compound/PW C040034 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 3.0

UPF0181 protein YoaH
type: ProteinReference
xref: Reference/UniProt C4ZZG7
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

N-acetylmuramic acid 6-phosphate etherase
type: ProteinReference
xref: Reference/UniProt C4ZVV9

ReactionCatalysis1000989
type: Catalysis
controller: Cell division protein ZipA
controlled: Reaction984099
control type: ACTIVATION

N-acetylmuramic acid 6-phosphate etherase
type: Complex
component stoichiometry: Protein/55445 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: HTH-type transcriptional regulator MurR

ReactionCatalysis1000987
type: Catalysis
controller: 3-phosphoshikimate 1-carboxyvinyltransferase
controlled: 2.5.1.7
control type: ACTIVATION

ReactionCatalysis1000988
type: Catalysis
controller: N-acetylmuramic acid 6-phosphate etherase
controlled: Reaction984098
control type: ACTIVATION

Reference/PubChem-compound 439217
type: UnificationXref
id: 439217
db: PubChem-compound

ReactionCatalysis1000985
type: Catalysis
controller: UDP-N-acetylglucosamine 2-epimerase
controlled: 5.1.3.14
control type: ACTIVATION

ReactionCatalysis1000986
type: Catalysis
controller: UDP-N-acetyl-D-mannosamine dehydrogenase
controlled: 1.1.1.336
control type: ACTIVATION

ReactionCatalysis1000983
type: Catalysis
controller: Probable malate:quinone oxidoreductase
controlled: 3.2.1.52
control type: ACTIVATION

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

ReactionCatalysis1000984
type: Catalysis
controller: Cell division protein ZipA
controlled: 3.2.1.14
control type: ACTIVATION

ReactionCatalysis1000981
type: Catalysis
controller: D-fructose-6-phosphate aminotransferase
controlled: 2.6.1.16
control type: ACTIVATION

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

ReactionCatalysis1000982
type: Catalysis
controller: N-acetylmannosamine kinase
controlled: 2.7.1.59
control type: ACTIVATION

ReactionCatalysis1000980
type: Catalysis
controller: glucosamine-6-phosphate deaminase
controlled: 3.5.99.6
control type: ACTIVATION

Reference/BioCyc UDP-N-ACETYL-D-GLUCOSAMINE
type: UnificationXref
id: UDP-N-ACETYL-D-GLUCOSAMINE
db: BioCyc

ChemicalStructure/PW C000837
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001925
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/ChEBI CHEBI 506227
type: UnificationXref
id: CHEBI:506227
db: ChEBI

Glycerol-3-phosphate dehydrogenase [NAD(P)+]
type: Protein
cellular location: Cytosol
entity reference: Glycerol-3-phosphate dehydrogenase [NAD(P)+]

ChemicalStructure/PW C008203
type: ChemicalStructure
structure format: SMILES

UDP-N-acetyl-D-mannosamine
type: SmallMolecule
cellular location: Cytosol
entity reference: UDP-N-acetyl-D-mannosamine

ReactionCatalysis1000979
type: Catalysis
controller: N-acetylglucosamine-6-phosphate deacetylase
controlled: 3.5.1.25
control type: ACTIVATION

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

ChemicalStructure/PW C041115
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C041114
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 389248
type: UnificationXref
id: 389248
db: ChemSpider

ChemicalStructure/PW C041113
type: ChemicalStructure
structure format: SMILES

Compound/PW C000969/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine 6-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Protein/48744 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
stoichiometric coefficient: 4.0

Reference/PubChem-compound 53481607
type: UnificationXref
id: 53481607
db: PubChem-compound

ChemicalStructure/PW C001858
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Dihydroorotase
type: Protein
entity reference: Dihydroorotase

Siroheme synthase
type: Protein
entity reference: Siroheme synthase

Compound/PW C000969 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine 6-phosphate
stoichiometric coefficient: 1.0

Protein/64345 Cytosol/Stoichiometry/6.0
type: Stoichiometry
physical entity: 3-phosphoshikimate 1-carboxyvinyltransferase
stoichiometric coefficient: 6.0

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
type: Protein
cellular location: Inner Membrane
entity reference: Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Probable malate:quinone oxidoreductase
type: ProteinReference
xref: Reference/UniProt C4ZU53
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Compound/PW C008203 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetyl-D-mannosamine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 61503
type: UnificationXref
id: 61503
db: PubChem-compound

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

ChemicalStructure/PW C000868
type: ChemicalStructure
structure format: SMILES

Compound/PW C000141 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-glucosamine
stoichiometric coefficient: 1.0

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/UniProt C4ZVV8
type: UnificationXref
id: C4ZVV8
db: UniProt

Reference/UniProt C4ZVV9
type: UnificationXref
id: C4ZVV9
db: UniProt

Compound/PW C001858 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chitin
stoichiometric coefficient: 1.0

Reference/CAS 63-39-8
type: UnificationXref
id: 63-39-8
db: CAS

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Compound/PW C001010 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Lactic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
type: ProteinReference
xref: Reference/UniProt C4ZSB3
organism: Escherichia coli (strain K12 / MC4100 / BW2952)

Compound/PW C041109 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: MurNAc
stoichiometric coefficient: 1.0

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
type: Complex
component stoichiometry: Protein/51494 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: 3-deoxy-manno-octulosonate cytidylyltransferase

Reference/UniProt C4ZVU3
type: UnificationXref
id: C4ZVU3
db: UniProt

Reference/CAS 7512-17-6
type: UnificationXref
id: 7512-17-6
db: CAS