Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Compound/PW C040090/Stoichiometry/1.0
type: Stoichiometry
physical entity: N(6)-(1,2-dicarboxyethyl)AMP
stoichiometric coefficient: 1.0

Reference/ChemSpider 388359
type: UnificationXref
id: 388359
db: ChemSpider

Compound/PW C000936/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17345
type: UnificationXref
id: CHEBI:17345
db: ChEBI

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChEBI CHEBI 18319
type: UnificationXref
id: CHEBI:18319
db: ChEBI

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

ReactionCatalysis1010256
type: Catalysis
controller: adenylosuccinate lyase
controlled: Reaction992902
control type: ACTIVATION

ReactionCatalysis1010258
type: Catalysis
controller: GMP synthetase
controlled: 6.3.5.2
control type: ACTIVATION

Reference/ChEBI CHEBI 16497
type: UnificationXref
id: CHEBI:16497
db: ChEBI

Reference/PubChem-compound 165388
type: UnificationXref
id: 165388
db: PubChem-compound

ReactionCatalysis1010264
type: Catalysis
controller: ribonucleoside diphosphate reductase 1
controlled: 1.17.4.2
control type: ACTIVATION

ReactionCatalysis1010266
type: Catalysis
controller: nucleoside diphosphate kinase
controlled: Reaction992912
control type: ACTIVATION

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ReactionCatalysis1010260
type: Catalysis
controller: guanylate kinase
controlled: 2.7.4.8
control type: ACTIVATION

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

ReactionCatalysis1010262
type: Catalysis
controller: nucleoside diphosphate kinase
controlled: 2.7.4.6
control type: ACTIVATION

Reference/BioCyc 10-FORMYL-THF
type: UnificationXref
id: 10-FORMYL-THF
db: BioCyc

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CAS 85-32-5
type: UnificationXref
id: 85-32-5
db: CAS

Reference/KEGG Compound C00206
type: UnificationXref
id: C00206
db: KEGG Compound

5-Aminoimidazole ribonucleotide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03373
xref: Reference/HMDB HMDB0001235
xref: Reference/ChEBI CHEBI 28843
xref: Reference/ChemSpider 141854
xref: Reference/CAS 25635-88-5
xref: Reference/PubChem-compound 161500
xref: Reference/BioCyc 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL
chemical formula: C8H14N3O7P
molecular weight: 295.05695
structure: ChemicalStructure/PW C000955

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Compound/PW C042960/Stoichiometry/1.0
type: Stoichiometry
physical entity: tetrahydropteroyl mono-L-glutamate
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
entity reference: NAD

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

ReactionCatalysis1010268
type: Catalysis
controller: ribonucleoside-diphosphate reductase 2
controlled: Reaction992914
control type: ACTIVATION

Reference/PathWhiz PW451211
type: UnificationXref
id: PW451211
db: PathWhiz

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Reference/BioCyc 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
type: UnificationXref
id: 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
db: BioCyc

ReactionCatalysis1010275
type: Catalysis
controller: Unknown
controlled: Reaction992921
control type: ACTIVATION

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003379
type: UnificationXref
id: HMDB0003379
db: HMDB

ReactionCatalysis1010277
type: Catalysis
controller: Unknown
controlled: Reaction992923
control type: ACTIVATION

ReactionCatalysis1010270
type: Catalysis
controller: nucleoside diphosphate kinase
controlled: 2.7.4.6
control type: ACTIVATION

Purine Nucleotides De Novo Biosynthesis
type: Pathway
pathway order: PathwaySubPathway/466218
pathway order: PathwaySubPathway/466217
pathway order: PathwayEnzymeReaction/6350319
pathway order: PathwayEnzymeReaction/6350336
pathway order: PathwayEnzymeReaction/6350315
pathway order: PathwayEnzymeReaction/6350365
pathway order: PathwayEnzymeReaction/6350300
pathway order: PathwayEnzymeReaction/6350301
pathway order: PathwayEnzymeReaction/6350345
pathway order: PathwayEnzymeReaction/6350367
pathway order: PathwayEnzymeReaction/6350389
pathway order: PathwayEnzymeReaction/6350302
pathway order: PathwayEnzymeReaction/6350361
pathway order: PathwayEnzymeReaction/6350383
pathway order: PathwayEnzymeReaction/6350384
pathway order: PathwayEnzymeReaction/6350341
pathway order: PathwayEnzymeReaction/6350385
pathway order: PathwayEnzymeReaction/6350386
pathway order: PathwayEnzymeReaction/6350369
pathway order: PathwayEnzymeReaction/6350304
pathway order: PathwayEnzymeReaction/6350306
pathway order: PathwayEnzymeReaction/6350310
pathway order: PathwayEnzymeReaction/6350376
pathway order: PathwayEnzymeReaction/6350355
pathway order: PathwayEnzymeReaction/6350357
pathway order: PathwayEnzymeReaction/6350379
pathway order: PathwayEnzymeReaction/6350350
pathway order: PathwayEnzymeReaction/6350330
pathway order: PathwayEnzymeReaction/6350374
pathway order: PathwayEnzymeReaction/6350390
pathway order: PathwayEnzymeReaction/6350371
pathway component: 1.17.4.1
pathway component: 1.1.1.205
pathway component: Reaction992899
pathway component: 4.3.2.2
pathway component: ReactionCatalysis1010256
pathway component: ReactionCatalysis1010258
pathway component: 6.3.2.6
pathway component: ReactionCatalysis1010264
pathway component: ReactionCatalysis1010266
pathway component: ReactionCatalysis1010260
pathway component: ReactionCatalysis1010262
pathway component: 6.3.4.18
pathway component: Reaction992923
pathway component: Reaction992921
pathway component: 5.4.99.18
pathway component: ReactionCatalysis1010227
pathway component: ReactionCatalysis1010228
pathway component: ReactionCatalysis1010229
pathway component: ReactionCatalysis1010268
pathway component: ReactionCatalysis1010231
pathway component: ReactionCatalysis1010275
pathway component: ReactionCatalysis1010233
pathway component: ReactionCatalysis1010277
pathway component: ReactionCatalysis1010270
pathway component: ReactionCatalysis1010272
pathway component: 3.6.3.14
pathway component: 2.7.4.3
pathway component: Reaction992925
pathway component: 2.1.2.3
pathway component: 1.17.4.2
pathway component: Reaction992928
pathway component: 2.1.2.-
pathway component: 6.3.4.13
pathway component: 2.4.2.14
pathway component: 6.3.3.1
pathway component: Reaction992912
pathway component: PRPP Biosynthesis
pathway component: Folate Biosynthesis
pathway component: 6.3.5.3
pathway component: ReactionCatalysis1010278
pathway component: ReactionCatalysis1010279
pathway component: ReactionCatalysis1010237
pathway component: ReactionCatalysis1010241
pathway component: ReactionCatalysis1010244
pathway component: ReactionCatalysis1010281
pathway component: ReactionCatalysis1010282
pathway component: ReactionCatalysis1010283

Compound/PW C001007/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5'-Phosphoribosyl-N-formylglycinamide
stoichiometric coefficient: 1.0

ReactionCatalysis1010272
type: Catalysis
controller: Unknown
controlled: 2.1.2.3
control type: ACTIVATION

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/HMDB HMDB0003377
type: UnificationXref
id: HMDB0003377
db: HMDB

Reference/ChEBI CHEBI 17202
type: UnificationXref
id: CHEBI:17202
db: ChEBI

Reference/ChEBI CHEBI 18413
type: UnificationXref
id: CHEBI:18413
db: ChEBI

Reference/PubChem-compound 8582
type: UnificationXref
id: 8582
db: PubChem-compound

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChemSpider 2683694
type: UnificationXref
id: 2683694
db: ChemSpider

Reference/BioCyc ITACONATE
type: UnificationXref
id: ITACONATE
db: BioCyc

5-Aminoimidazole ribonucleotide
type: SmallMolecule
entity reference: 5-Aminoimidazole ribonucleotide

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

ReactionCatalysis1010237
type: Catalysis
controller: N5-carboxyaminoimidazole ribonucleotide synthetase
controlled: 6.3.4.18
control type: ACTIVATION

ReactionCatalysis1010241
type: Catalysis
controller: N5-carboxyaminoimidazole ribonucleotide mutase
controlled: 5.4.99.18
control type: ACTIVATION

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

ReactionCatalysis1010244
type: Catalysis
controller: phosphoribosylaminoimidazole-succinocarboxamide synthase
controlled: 6.3.2.6
control type: ACTIVATION

Reference/ChemSpider 17216355
type: UnificationXref
id: 17216355
db: ChemSpider

ChemicalStructure/PW C001080
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0002174
type: UnificationXref
id: HMDB0002174
db: HMDB

N(6)-(1,2-dicarboxyethyl)AMP
type: SmallMolecule
entity reference: N(6)-(1,2-dicarboxyethyl)AMP

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/PubChem-compound 811
type: UnificationXref
id: 811
db: PubChem-compound

Reference/KEGG Compound C04823
type: UnificationXref
id: C04823
db: KEGG Compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ReactionCatalysis1010247
type: Catalysis
controller: adenylosuccinate lyase
controlled: 4.3.2.2
control type: ACTIVATION

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/ChEBI CHEBI 15033
type: UnificationXref
id: CHEBI:15033
db: ChEBI

ReactionCatalysis1010253
type: Catalysis
controller: adenylosuccinate synthase
controlled: Reaction992899
control type: ACTIVATION

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Compound/PW C000092/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

ReactionCatalysis1010250
type: Catalysis
controller: IMP dehydrogenase
controlled: 1.1.1.205
control type: ACTIVATION

adenylosuccinate synthase
type: Complex
component stoichiometry: Protein/40726/Stoichiometry/2.0
component: Clp R domain-containing protein

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/UniProt B7LBZ8
type: UnificationXref
id: B7LBZ8
db: UniProt

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

ChemicalStructure/PW C042960
type: ChemicalStructure
structure format: SMILES

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Itaconyl-CoA
type: SmallMolecule
entity reference: Itaconyl-CoA

Reference/ChEBI CHEBI 16174
type: UnificationXref
id: CHEBI:16174
db: ChEBI

10-Formyltetrahydrofolate
type: SmallMolecule
entity reference: 10-Formyltetrahydrofolate

Triphosphate
type: SmallMolecule
entity reference: Triphosphate

Reference/KEGG Compound C00234
type: UnificationXref
id: C00234
db: KEGG Compound

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/SMPDB SMP0435970
type: UnificationXref
id: SMP0435970
db: SMPDB

Compound/PW C000463/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

amidophosphoribosyl transferase
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/4.0
component: Unknown

Reference/ChemSpider 141854
type: UnificationXref
id: 141854
db: ChemSpider

Reference/PubChem-compound 122347
type: UnificationXref
id: 122347
db: PubChem-compound

Compound/PW C001866/Stoichiometry/1.0
type: Stoichiometry
physical entity: Itaconyl-CoA
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

SAICAR
type: SmallMoleculeReference
xref: Reference/CAS 3031-95-6
xref: Reference/BioCyc P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE
xref: Reference/ChEBI CHEBI 18319
xref: Reference/HMDB HMDB0000797
xref: Reference/KEGG Compound C04823
xref: Reference/PubChem-compound 160666
xref: Reference/ChemSpider 141175
chemical formula: C13H19N4O12P
molecular weight: 454.0737
structure: ChemicalStructure/PW C000637

Compound/PW C001161/Stoichiometry/1.0
type: Stoichiometry
physical entity: dADP
stoichiometric coefficient: 1.0

Compound/PW C001406/Stoichiometry/1.0
type: Stoichiometry
physical entity: Itaconic acid
stoichiometric coefficient: 1.0

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 53477733
type: UnificationXref
id: 53477733
db: PubChem-compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00361
type: UnificationXref
id: C00361
db: KEGG Compound

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

dGDP
type: SmallMolecule
entity reference: dGDP

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

phosphoribosylformylglycinamide cyclo-ligase
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/2.0
component: Unknown

Reference/PubChem-compound 73323
type: UnificationXref
id: 73323
db: PubChem-compound

Reference/ChemSpider 66054
type: UnificationXref
id: 66054
db: ChemSpider

5-Phosphoribosylamine
type: SmallMolecule
entity reference: 5-Phosphoribosylamine

Reference/KEGG Compound C00490
type: UnificationXref
id: C00490
db: KEGG Compound

Compound/PW C000190/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

5-Phosphoribosylamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001128
xref: Reference/ChEBI CHEBI 37737
xref: Reference/BioCyc 5-P-BETA-D-RIBOSYL-AMINE
xref: Reference/ChemSpider 388939
xref: Reference/KEGG Compound C03090
xref: Reference/PubChem-compound 439905
chemical formula: C5H12NO7P
molecular weight: 229.03514
structure: ChemicalStructure/PW C000882

Reference/HMDB HMDB0002086
type: UnificationXref
id: HMDB0002086
db: HMDB

Reference/CAS 6008-93-1
type: UnificationXref
id: 6008-93-1
db: CAS

Reference/HMDB HMDB0002092
type: UnificationXref
id: HMDB0002092
db: HMDB

PRPP Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway466218
pathway component: SubPathwayInteraction466218
xref: Reference/PathWhiz PW000909
xref: Reference/SMPDB SMP0000926
name: SubPathway

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Folate Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway466217
pathway component: SubPathwayInteraction466217
xref: Reference/SMPDB SMP0000925
xref: Reference/PathWhiz PW000908
name: SubPathway

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/KEGG Compound C00130
type: UnificationXref
id: C00130
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

SAICAR
type: SmallMolecule
entity reference: SAICAR

ReactionCatalysis1010278
type: Catalysis
controller: Unknown
controlled: 2.1.2.3
control type: ACTIVATION

Reference/CAS 6157-85-3
type: UnificationXref
id: 6157-85-3
db: CAS

ReactionCatalysis1010279
type: Catalysis
controller: ribonucleoside diphosphate reductase 1
controlled: Reaction992925
control type: ACTIVATION

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

ReactionCatalysis1010281
type: Catalysis
controller: ATP synthase / thiamin triphosphate synthase
controlled: 3.6.3.14
control type: ACTIVATION

ReactionCatalysis1010282
type: Catalysis
controller: ribonucleoside-triphosphate reductase
controlled: Reaction992928
control type: ACTIVATION

ReactionCatalysis1010283
type: Catalysis
controller: ribonucleoside-triphosphate reductase
controlled: 1.17.4.2
control type: ACTIVATION

ReactionCatalysis1010284
type: Catalysis
controller: ribonucleoside-diphosphate reductase 2
controlled: 1.17.4.1
control type: ACTIVATION

ReactionCatalysis1010280
type: Catalysis
controller: Unknown
controlled: 2.7.4.3
control type: ACTIVATION

Reference/HMDB HMDB0006211
type: UnificationXref
id: HMDB0006211
db: HMDB

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/KEGG Compound C00144
type: UnificationXref
id: C00144
db: KEGG Compound

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Guanosine triphosphate
type: SmallMolecule
entity reference: Guanosine triphosphate
name: SubPathwayInput

Reference/BioCyc DGDP
type: UnificationXref
id: DGDP
db: BioCyc

1.1.1.205
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000114/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001196/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: Xanthylic acid
spontaneous: false
EC number: 1.1.1.205
left: Water
left: NAD
left: Inosinic acid
name: Inosinic acid + NAD + Water → Hydrogen Ion + NADH + Xanthylic acid
conversion direction: LEFT_TO_RIGHT

Reference/SMPDB SMP0000925
type: UnificationXref
id: SMP0000925
db: SMPDB

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Reaction992899
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040090/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000114/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: Guanosine diphosphate
right: Hydrogen Ion
right: N(6)-(1,2-dicarboxyethyl)AMP
right: Phosphate
spontaneous: false
left: L-Aspartic acid
left: Inosinic acid
left: Guanosine triphosphate
name: Guanosine triphosphate + Inosinic acid + L-Aspartic acid → Guanosine diphosphate + 2 Hydrogen Ion + N(6)-(1,2-dicarboxyethyl)AMP + Phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C000774/Stoichiometry/1.0
type: Stoichiometry
physical entity: 10-Formyltetrahydrofolate
stoichiometric coefficient: 1.0

guanylate kinase
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/2.0
component: Unknown

nucleoside diphosphate kinase
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/4.0
component: Unknown

Reference/KEGG Compound C04751
type: UnificationXref
id: C04751
db: KEGG Compound

4.3.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001168/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000637/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088/Stoichiometry/1.0
right: AICAR
right: Fumaric acid
spontaneous: false
EC number: 4.3.2.2
left: SAICAR
name: SAICAR → AICAR + Fumaric acid
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 18036
type: UnificationXref
id: CHEBI:18036
db: ChEBI

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

Reference/SMPDB SMP0000926
type: UnificationXref
id: SMP0000926
db: SMPDB

6.3.2.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000637/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002699/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: SAICAR
right: Phosphate
spontaneous: false
EC number: 6.3.2.6
left: L-Aspartic acid
left: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
left: Adenosine triphosphate
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + Adenosine triphosphate + L-Aspartic acid → Adenosine diphosphate + Hydrogen Ion + Phosphate + SAICAR
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

ribonucleoside diphosphate reductase 1
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/2.0
component: Unknown

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

GMP synthetase
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/2.0
component: Unknown

Water
type: SmallMolecule
entity reference: Water

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/PubChem-compound 22833657
type: UnificationXref
id: 22833657
db: PubChem-compound

Reference/BioCyc AICAR
type: UnificationXref
id: AICAR
db: BioCyc

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

6.3.4.18
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000955/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007812/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: N5-Carboxyaminoimidazole ribonucleotide
right: Adenosine diphosphate
right: Hydrogen Ion
right: Phosphate
spontaneous: false
EC number: 6.3.4.18
left: Hydrogen carbonate
left: 5-Aminoimidazole ribonucleotide
left: Adenosine triphosphate
name: 5-Aminoimidazole ribonucleotide + Adenosine triphosphate + Hydrogen carbonate → Adenosine diphosphate + 2 Hydrogen Ion + N5-Carboxyaminoimidazole ribonucleotide + Phosphate
conversion direction: LEFT_TO_RIGHT

5.4.99.18
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002699/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007812/Stoichiometry/1.0
right: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
spontaneous: false
EC number: 5.4.99.18
left: N5-Carboxyaminoimidazole ribonucleotide
name: N5-Carboxyaminoimidazole ribonucleotide → 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
conversion direction: LEFT_TO_RIGHT

Adenosylcobalamin
type: SmallMoleculeReference
xref: Reference/ChemSpider 30791458
xref: Reference/CAS 13870-90-1
xref: Reference/KEGG Compound C00194
xref: Reference/ChEBI CHEBI 18408
xref: Reference/HMDB HMDB0002086
xref: Reference/BioCyc ADENOSYLCOBALAMIN-5-P
chemical formula: C72H100CoN18O17P
molecular weight: 1578.6583
structure: ChemicalStructure/PW C001401

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/KEGG Compound C00286
type: UnificationXref
id: C00286
db: KEGG Compound

ribonucleoside-diphosphate reductase 2
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/2.0
component: Unknown

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

Reference/KEGG Compound C04640
type: UnificationXref
id: C04640
db: KEGG Compound

Reference/KEGG Compound C03794
type: UnificationXref
id: C03794
db: KEGG Compound

Itaconic acid
type: SmallMoleculeReference
xref: Reference/CAS 97-65-4
xref: Reference/HMDB HMDB0002092
xref: Reference/KEGG Compound C00490
xref: Reference/PubChem-compound 811
xref: Reference/ChEBI CHEBI 30838
xref: Reference/BioCyc ITACONATE
xref: Reference/ChemSpider 789
chemical formula: C5H6O4
molecular weight: 130.02661
structure: ChemicalStructure/PW C001406

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

Reference/PubChem-compound 25244572
type: UnificationXref
id: 25244572
db: PubChem-compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001235
type: UnificationXref
id: HMDB0001235
db: HMDB

ChemicalStructure/PW C007812
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C001112/Stoichiometry/1.0
type: Stoichiometry
physical entity: dGTP
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

2.1.2.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042915/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001007/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: Phosphate
right: 5'-Phosphoribosyl-N-formylglycinamide
spontaneous: false
EC number: 2.1.2.-
left: N1-(5-phospho-β-D-ribosyl)glycinamide
left: Formic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Formic acid + N1-(5-phospho-β-D-ribosyl)glycinamide → 5'-Phosphoribosyl-N-formylglycinamide + Adenosine diphosphate + Hydrogen Ion + Phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C001168/Stoichiometry/1.0
type: Stoichiometry
physical entity: AICAR
stoichiometric coefficient: 1.0

6.3.4.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000882/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042915/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: N1-(5-phospho-β-D-ribosyl)glycinamide
right: Phosphate
spontaneous: false
EC number: 6.3.4.13
left: 5-Phosphoribosylamine
left: Glycine
left: Adenosine triphosphate
name: 5-Phosphoribosylamine + Adenosine triphosphate + Glycine → Adenosine diphosphate + Hydrogen Ion + N1-(5-phospho-β-D-ribosyl)glycinamide + Phosphate
conversion direction: LEFT_TO_RIGHT

2.4.2.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000882/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000190/Stoichiometry/1.0
right: L-Glutamic acid
right: 5-Phosphoribosylamine
right: Pyrophosphate
spontaneous: false
EC number: 2.4.2.14
left: Water
left: L-Glutamine
left: Phosphoribosyl pyrophosphate
name: L-Glutamine + Phosphoribosyl pyrophosphate + Water → 5-Phosphoribosylamine + L-Glutamic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

dGDP
type: SmallMoleculeReference
xref: Reference/BioCyc DGDP
xref: Reference/ChEBI CHEBI 28862
xref: Reference/ChemSpider 388359
xref: Reference/HMDB HMDB0000960
xref: Reference/PubChem-compound 439220
xref: Reference/CAS 3493-09-2
xref: Reference/KEGG Compound C00361
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C000767

6.3.3.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002662/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000955/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: 5-Aminoimidazole ribonucleotide
right: Phosphate
spontaneous: false
EC number: 6.3.3.1
left: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
left: Adenosine triphosphate
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine + Adenosine triphosphate → 5-Aminoimidazole ribonucleotide + Adenosine diphosphate + Hydrogen Ion + Phosphate
conversion direction: LEFT_TO_RIGHT

6.3.5.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001007/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002662/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
right: Adenosine diphosphate
right: L-Glutamic acid
right: Hydrogen Ion
right: Phosphate
spontaneous: false
EC number: 6.3.5.3
left: Water
left: L-Glutamine
left: 5'-Phosphoribosyl-N-formylglycinamide
left: Adenosine triphosphate
name: 5'-Phosphoribosyl-N-formylglycinamide + Adenosine triphosphate + L-Glutamine + Water → 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine + Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

N5-carboxyaminoimidazole ribonucleotide synthetase
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/2.0
component: Unknown

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

Itaconic acid
type: SmallMolecule
entity reference: Itaconic acid

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

N5-carboxyaminoimidazole ribonucleotide mutase
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/8.0
component: Unknown

phosphoribosylaminoimidazole-succinocarboxamide synthase
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/3.0
component: Unknown

Adenosylcobalamin
type: SmallMolecule
entity reference: Adenosylcobalamin

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002699
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001128
type: UnificationXref
id: HMDB0001128
db: HMDB

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Unknown
type: ProteinReference

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Reference/HMDB HMDB0012268
type: UnificationXref
id: HMDB0012268
db: HMDB

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

10-Formyltetrahydrofolate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000972
xref: Reference/PubChem-compound 122347
xref: Reference/ChemSpider 109092
xref: Reference/ChEBI CHEBI 15637
xref: Reference/CAS 2800-34-2
xref: Reference/BioCyc 10-FORMYL-THF
xref: Reference/KEGG Compound C00234
chemical formula: C20H23N7O7
molecular weight: 473.1659
structure: ChemicalStructure/PW C000774

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

adenylosuccinate lyase
type: Complex
component stoichiometry: Protein/40730/Stoichiometry/4.0
component: Aspartate ammonia-lyase

ChemicalStructure/PW C001007
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc XANTHOSINE-5-PHOSPHATE
type: UnificationXref
id: XANTHOSINE-5-PHOSPHATE
db: BioCyc

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Itaconyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc 3-METHYLPHENYLITACONYL-COA
xref: Reference/ChemSpider 388390
xref: Reference/PubChem-compound 439254
xref: Reference/ChEBI CHEBI 15528
xref: Reference/CAS 6008-93-1
xref: Reference/HMDB HMDB0003377
xref: Reference/KEGG Compound C00531
chemical formula: C26H40N7O19P3S
molecular weight: 879.1312
structure: ChemicalStructure/PW C001866

IMP dehydrogenase
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/4.0
component: Unknown

Compound/Generic72/Stoichiometry/1.0
type: Stoichiometry
physical entity: oxidized thioredoxin
stoichiometric coefficient: 1.0

Reference/CAS 2800-34-2
type: UnificationXref
id: 2800-34-2
db: CAS

Protein/27297/Stoichiometry/8.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 8.0

Triphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00536
xref: Reference/HMDB HMDB0003379
xref: Reference/CAS 14127-68-5
xref: Reference/ChemSpider 2683694
xref: Reference/PubChem-compound 3440921
xref: Reference/ChEBI CHEBI 18036
chemical formula: H5O10P3
molecular weight: 257.90955
structure: ChemicalStructure/PW C001868

Reference/ChemSpider 789
type: UnificationXref
id: 789
db: ChemSpider

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/ChEBI CHEBI 18381
type: UnificationXref
id: CHEBI:18381
db: ChEBI

Reference/KEGG Compound C00194
type: UnificationXref
id: C00194
db: KEGG Compound

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

Reference/PubChem-compound 3440921
type: UnificationXref
id: 3440921
db: PubChem-compound

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/CAS 2564-35-4
type: UnificationXref
id: 2564-35-4
db: CAS

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Compound/PW C001463/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cobalamin
stoichiometric coefficient: 1.0

Reference/KEGG Compound C04677
type: UnificationXref
id: C04677
db: KEGG Compound

Phosphate
type: SmallMolecule
entity reference: Phosphate

Reference/BioCyc DADP
type: UnificationXref
id: DADP
db: BioCyc

SubPathwayInteraction466218
type: Interaction
name: SubPathwayReaction
name: SubPathway466218Reaction
participant: Phosphoribosyl pyrophosphate

Compound/PW C000882/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Phosphoribosylamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Cobalamin
type: SmallMolecule
entity reference: Cobalamin

SubPathwayInteraction466217
type: Interaction
name: SubPathway466217Reaction
name: SubPathwayReaction
participant: Guanosine triphosphate

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

N(6)-(1,2-dicarboxyethyl)AMP
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0059653
xref: Reference/PubChem-compound 447145
xref: Reference/CAS 19046-78-7
xref: Reference/ChemSpider 394323
xref: Reference/KEGG Compound C03794
chemical formula: C14H18N5O11P
molecular weight: 463.07404
structure: ChemicalStructure/PW C040090

Compound/Generic73/Stoichiometry/1.0
type: Stoichiometry
physical entity: reduced thioredoxin
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/ChemSpider 4942647
type: UnificationXref
id: 4942647
db: ChemSpider

Compound/Generic99/Stoichiometry/1.0
type: Stoichiometry
physical entity: a reduced NrdH glutaredoxin-like protein
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Reference/HMDB HMDB0000175
type: UnificationXref
id: HMDB0000175
db: HMDB

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Inosinic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 8264
xref: Reference/ChEBI CHEBI 17202
xref: Reference/CAS 131-99-7
xref: Reference/PubChem-compound 8582
xref: Reference/BioCyc IMP
xref: Reference/KEGG Compound C00130
xref: Reference/HMDB HMDB0000175
chemical formula: C10H13N4O8P
molecular weight: 348.0471
structure: ChemicalStructure/PW C000114

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reference/KEGG Compound C05776
type: UnificationXref
id: C05776
db: KEGG Compound

2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
type: SmallMolecule
entity reference: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine

ChemicalStructure/PW C001196
type: ChemicalStructure
structure format: SMILES

2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 22833657
xref: Reference/ChEBI CHEBI 18413
xref: Reference/BioCyc 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE
xref: Reference/ChemSpider 17216355
xref: Reference/CAS 6157-85-3
xref: Reference/KEGG Compound C04640
xref: Reference/HMDB HMDB0006211
chemical formula: C6H12N3O8P
molecular weight: 285.0362
structure: ChemicalStructure/PW C002662

L-Aspartic acid
type: SmallMolecule
entity reference: L-Aspartic acid

Escherichia coli (strain 55989 / EAEC)
type: BioSource
xref: Reference/TAXONOMY 585055

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

Reference/PubChem-compound 439905
type: UnificationXref
id: 439905
db: PubChem-compound

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/HMDB HMDB0001397
type: UnificationXref
id: HMDB0001397
db: HMDB

Reference/BioCyc PHOSPHORIBOSYL-CARBOXY-AMINOIMIDAZOLE
type: UnificationXref
id: PHOSPHORIBOSYL-CARBOXY-AMINOIMIDAZOLE
db: BioCyc

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

ChemicalStructure/PW C040844
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Clp R domain-containing protein
type: Protein
entity reference: Clp R domain-containing protein

Inosinic acid
type: SmallMolecule
entity reference: Inosinic acid

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Reference/ChemSpider 144983
type: UnificationXref
id: 144983
db: ChemSpider

Reference/KEGG Compound C03373
type: UnificationXref
id: C03373
db: KEGG Compound

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Compound/PW C000986/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C001168
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388939
type: UnificationXref
id: 388939
db: ChemSpider

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

ChemicalStructure/PW C001161
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

ATP synthase / thiamin triphosphate synthase
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/10.0
component: Unknown

Reference/CAS 25635-88-5
type: UnificationXref
id: 25635-88-5
db: CAS

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

ribonucleoside-triphosphate reductase
type: Complex
component stoichiometry: Protein/27297/Stoichiometry/2.0
component: Unknown

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

ChemicalStructure/PW C042915
type: ChemicalStructure
structure format: SMILES
structure data: [NH3+]CC(=O)NC1OC(COP([O-])([O-])=O)C(O)C1O

ChemicalStructure/PW C042916
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Reference/PathWhiz PW000909
type: UnificationXref
id: PW000909
db: PathWhiz

Reference/PathWhiz PW000908
type: UnificationXref
id: PW000908
db: PathWhiz

Hydrogen carbonate
type: SmallMolecule
entity reference: Hydrogen carbonate

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Reference/BioCyc 5-P-BETA-D-RIBOSYL-AMINE
type: UnificationXref
id: 5-P-BETA-D-RIBOSYL-AMINE
db: BioCyc

Compound/PW C000088/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Aspartate ammonia-lyase
type: Protein
entity reference: Aspartate ammonia-lyase

Reference/BioCyc DGTP
type: UnificationXref
id: DGTP
db: BioCyc

1.17.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000767/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/Generic98/Stoichiometry/1.0
participant stoichiometry: Compound/Generic99/Stoichiometry/1.0
right: Water
right: an oxidized NrdH glutaredoxin-like protein
right: dGDP
spontaneous: false
EC number: 1.17.4.1
left: Guanosine diphosphate
left: a reduced NrdH glutaredoxin-like protein
name: Guanosine diphosphate + a reduced NrdH glutaredoxin-like protein → Water + an oxidized NrdH glutaredoxin-like protein + dGDP
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

FAICAR
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18381
chemical formula: C10H15N4O9P
molecular weight: 366.05768
structure: ChemicalStructure/PW C040844

Reference/PubChem-compound 65110
type: UnificationXref
id: 65110
db: PubChem-compound

Compound/PW C007812/Stoichiometry/1.0
type: Stoichiometry
physical entity: N5-Carboxyaminoimidazole ribonucleotide
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
entity reference: NADH

Reference/CAS 3031-94-5
type: UnificationXref
id: 3031-94-5
db: CAS

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/BioCyc P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE
type: UnificationXref
id: P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE
db: BioCyc

Reaction992923
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001406/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001866/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Adenosine diphosphate
right: Itaconyl-CoA
right: Phosphate
spontaneous: false
left: Coenzyme A
left: Itaconic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Coenzyme A + Itaconic acid → Adenosine diphosphate + Itaconyl-CoA + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 65103
type: UnificationXref
id: 65103
db: PubChem-compound

Reaction992921
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001463/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001868/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001401/Stoichiometry/1.0
right: Triphosphate
right: Adenosylcobalamin
spontaneous: false
left: Cobalamin
left: Adenosine triphosphate
name: Adenosine triphosphate + Cobalamin → Adenosylcobalamin + Triphosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 165388
xref: Reference/BioCyc PHOSPHORIBOSYL-CARBOXY-AMINOIMIDAZOLE
xref: Reference/ChEBI CHEBI 28413
xref: Reference/HMDB HMDB0006273
xref: Reference/KEGG Compound C04751
xref: Reference/ChemSpider 144983
chemical formula: C9H14N3O9P
molecular weight: 339.04675
structure: ChemicalStructure/PW C002699

N1-(5-phospho-β-D-ribosyl)glycinamide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25244572
chemical formula: C7H14N2O8P
molecular weight: 285.04932
structure: ChemicalStructure/PW C042915

5'-Phosphoribosyl-N-formylglycinamide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001308
xref: Reference/CAS 349-34-8
xref: Reference/PubChem-compound 130805
xref: Reference/ChemSpider 115687
xref: Reference/KEGG Compound C04376
xref: Reference/BioCyc 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
chemical formula: C8H15N2O9P
molecular weight: 314.0515
structure: ChemicalStructure/PW C001007

Reference/HMDB HMDB0001508
type: UnificationXref
id: HMDB0001508
db: HMDB

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

dATP
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61404
xref: Reference/PubChem-compound 25320183
chemical formula: C10H12N5O12P3
molecular weight: 486.97174
structure: ChemicalStructure/PW C042916

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 30791458
type: UnificationXref
id: 30791458
db: ChemSpider

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/CAS 131-99-7
type: UnificationXref
id: 131-99-7
db: CAS

Reference/ChEBI CHEBI 28911
type: UnificationXref
id: CHEBI:28911
db: ChEBI

Reference/ChEBI CHEBI 37737
type: UnificationXref
id: CHEBI:37737
db: ChEBI

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

3.6.3.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/3.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/4.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Water
right: Hydrogen Ion
right: Adenosine triphosphate
spontaneous: false
EC number: 3.6.3.14
left: Adenosine diphosphate
left: Hydrogen Ion
left: Phosphate
name: Adenosine diphosphate + 4 Hydrogen Ion + Phosphate ↔ Adenosine triphosphate + 3 Hydrogen Ion + Water
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

2.7.4.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Adenosine triphosphate
spontaneous: false
EC number: 2.7.4.3
left: Adenosine monophosphate
name: Adenosine monophosphate → Adenosine diphosphate + Adenosine triphosphate
conversion direction: LEFT_TO_RIGHT

Reaction992925
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001161/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/Generic73/Stoichiometry/1.0
participant stoichiometry: Compound/Generic72/Stoichiometry/1.0
right: Water
right: oxidized thioredoxin
right: dADP
spontaneous: false
left: Adenosine diphosphate
left: reduced thioredoxin
name: Adenosine diphosphate + reduced thioredoxin ↔ Water + dADP + oxidized thioredoxin
conversion direction: REVERSIBLE

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

2.1.2.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040844/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000114/Stoichiometry/1.0
right: Water
right: Inosinic acid
spontaneous: false
EC number: 2.1.2.3
left: FAICAR
name: FAICAR ↔ Inosinic acid + Water
conversion direction: REVERSIBLE

1.17.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/Generic97/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001112/Stoichiometry/1.0
participant stoichiometry: Compound/Generic96/Stoichiometry/1.0
right: an oxidized flavodoxin
right: dGTP
right: Water
spontaneous: false
EC number: 1.17.4.2
left: a reduced flavodoxin
left: Guanosine triphosphate
name: Guanosine triphosphate + a reduced flavodoxin → Water + an oxidized flavodoxin + dGTP
conversion direction: LEFT_TO_RIGHT

Reaction992928
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/Generic97/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042916/Stoichiometry/1.0
participant stoichiometry: Compound/Generic96/Stoichiometry/1.0
right: an oxidized flavodoxin
right: Water
right: dATP
spontaneous: false
left: a reduced flavodoxin
left: Adenosine triphosphate
name: Adenosine triphosphate + a reduced flavodoxin → Water + an oxidized flavodoxin + dATP
conversion direction: LEFT_TO_RIGHT

Reaction992912
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000767/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001112/Stoichiometry/1.0
right: Adenosine diphosphate
right: dGTP
spontaneous: false
left: dGDP
left: Adenosine triphosphate
name: Adenosine triphosphate + dGDP → Adenosine diphosphate + dGTP
conversion direction: LEFT_TO_RIGHT

1.17.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000767/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/Generic73/Stoichiometry/1.0
participant stoichiometry: Compound/Generic72/Stoichiometry/1.0
right: oxidized thioredoxin
right: Water
right: dGDP
spontaneous: false
EC number: 1.17.4.2
left: Guanosine diphosphate
left: reduced thioredoxin
name: Guanosine diphosphate + reduced thioredoxin → Water + dGDP + oxidized thioredoxin
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001517
type: UnificationXref
id: HMDB0001517
db: HMDB

Reference/CAS 2793-06-8
type: UnificationXref
id: 2793-06-8
db: CAS

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C04376
type: UnificationXref
id: C04376
db: KEGG Compound

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
type: SmallMolecule
entity reference: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

5'-Phosphoribosyl-N-formylglycinamide
type: SmallMolecule
entity reference: 5'-Phosphoribosyl-N-formylglycinamide

Reference/CAS 3031-95-6
type: UnificationXref
id: 3031-95-6
db: CAS

Reference/BioCyc 3-METHYLPHENYLITACONYL-COA
type: UnificationXref
id: 3-METHYLPHENYLITACONYL-COA
db: BioCyc

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Cobalamin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28911
xref: Reference/CAS 13408-78-1
xref: Reference/PubChem-compound 6438156
xref: Reference/HMDB HMDB0002174
xref: Reference/ChemSpider 4942647
xref: Reference/KEGG Compound C05776
xref: Reference/BioCyc ADENOSYLCOBALAMIN-5-P
chemical formula: C62H88CoN13O14P
molecular weight: 1328.5637
structure: ChemicalStructure/PW C001463

ChemicalStructure/PW C001401
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000797
type: UnificationXref
id: HMDB0000797
db: HMDB

Compound/PW C002699/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
stoichiometric coefficient: 1.0

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Reference/BioCyc CPD0-181
type: UnificationXref
id: CPD0-181
db: BioCyc

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001161/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042916/Stoichiometry/1.0
right: Adenosine diphosphate
right: dATP
spontaneous: false
EC number: 2.7.4.6
left: dADP
left: Adenosine triphosphate
name: Adenosine triphosphate + dADP → Adenosine diphosphate + dATP
conversion direction: LEFT_TO_RIGHT

Reaction992914
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001161/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/Generic98/Stoichiometry/1.0
participant stoichiometry: Compound/Generic99/Stoichiometry/1.0
right: Water
right: dADP
right: an oxidized NrdH glutaredoxin-like protein
spontaneous: false
left: Adenosine diphosphate
left: a reduced NrdH glutaredoxin-like protein
name: Adenosine diphosphate + a reduced NrdH glutaredoxin-like protein → Water + an oxidized NrdH glutaredoxin-like protein + dADP
conversion direction: LEFT_TO_RIGHT

2.1.2.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001168/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042960/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040844/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000774/Stoichiometry/1.0
right: tetrahydropteroyl mono-L-glutamate
right: FAICAR
spontaneous: false
EC number: 2.1.2.3
left: AICAR
left: 10-Formyltetrahydrofolate
name: 10-Formyltetrahydrofolate + AICAR → FAICAR + tetrahydropteroyl mono-L-glutamate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/PubChem-compound 25201011
type: UnificationXref
id: 25201011
db: PubChem-compound

Reference/UniProt B7LFQ0
type: UnificationXref
id: B7LFQ0
db: UniProt

Protein/27297/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

ChemicalStructure/PW C001406
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=C)C(O)=O

dGTP
type: SmallMolecule
entity reference: dGTP

dGTP
type: SmallMoleculeReference
xref: Reference/BioCyc DGTP
xref: Reference/ChemSpider 58613
xref: Reference/CAS 2564-35-4
xref: Reference/PubChem-compound 65103
xref: Reference/KEGG Compound C00286
xref: Reference/ChEBI CHEBI 16497
xref: Reference/HMDB HMDB0001440
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C001112

6.3.5.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001196/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001080/Stoichiometry/1.0
right: L-Glutamic acid
right: Hydrogen Ion
right: Adenosine monophosphate
right: Guanosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 6.3.5.2
left: Water
left: Xanthylic acid
left: L-Glutamine
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid → Adenosine monophosphate + Guanosine monophosphate + 2 Hydrogen Ion + L-Glutamic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 61404
type: UnificationXref
id: CHEBI:61404
db: ChEBI

Reaction992902
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040090/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088/Stoichiometry/1.0
right: Fumaric acid
right: Adenosine monophosphate
spontaneous: false
left: N(6)-(1,2-dicarboxyethyl)AMP
name: N(6)-(1,2-dicarboxyethyl)AMP → Adenosine monophosphate + Fumaric acid
conversion direction: LEFT_TO_RIGHT

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000936/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Guanosine triphosphate
spontaneous: false
EC number: 2.7.4.6
left: Guanosine diphosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Guanosine diphosphate → Adenosine diphosphate + Guanosine triphosphate
conversion direction: LEFT_TO_RIGHT

2.7.4.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001080/Stoichiometry/1.0
right: Adenosine diphosphate
right: Guanosine diphosphate
spontaneous: false
EC number: 2.7.4.8
left: Guanosine monophosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Guanosine monophosphate → Adenosine diphosphate + Guanosine diphosphate
conversion direction: LEFT_TO_RIGHT

Unknown
type: Protein
entity reference: Unknown

Compound/PW C000767/Stoichiometry/1.0
type: Stoichiometry
physical entity: dGDP
stoichiometric coefficient: 1.0

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

oxidized thioredoxin
type: SmallMolecule
entity reference: oxidized thioredoxin

reduced thioredoxin
type: SmallMolecule
entity reference: reduced thioredoxin

Aspartate ammonia-lyase
type: ProteinReference
xref: Reference/UniProt B7LBZ8

Reference/PubChem-compound 447145
type: UnificationXref
id: 447145
db: PubChem-compound

Reference/ChemSpider 141175
type: UnificationXref
id: 141175
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C001463
type: ChemicalStructure
structure format: SMILES

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

Reference/ChEBI CHEBI 28843
type: UnificationXref
id: CHEBI:28843
db: ChEBI

Reference/CAS 14127-68-5
type: UnificationXref
id: 14127-68-5
db: CAS

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/BioCyc GMP
type: UnificationXref
id: GMP
db: BioCyc

AICAR
type: SmallMoleculeReference
xref: Reference/CAS 3031-94-5
xref: Reference/ChemSpider 58620
xref: Reference/ChEBI CHEBI 18406
xref: Reference/HMDB HMDB0001517
xref: Reference/KEGG Compound C04677
xref: Reference/PubChem-compound 65110
xref: Reference/BioCyc AICAR
chemical formula: C9H15N4O8P
molecular weight: 338.06274
structure: ChemicalStructure/PW C001168

Reference/ChEBI CHEBI 15637
type: UnificationXref
id: CHEBI:15637
db: ChEBI

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

Formic acid
type: SmallMolecule
entity reference: Formic acid

dADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00206
xref: Reference/PubChem-compound 53477733
xref: Reference/HMDB HMDB0001508
xref: Reference/CAS 2793-06-8
xref: Reference/ChEBI CHEBI 16174
xref: Reference/BioCyc DADP
chemical formula: C10H15N5O9P2
molecular weight: 411.03452
structure: ChemicalStructure/PW C001161

Reference/ChEBI CHEBI 15652
type: UnificationXref
id: CHEBI:15652
db: ChEBI

Compound/PW C000637/Stoichiometry/1.0
type: Stoichiometry
physical entity: SAICAR
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0059653
type: UnificationXref
id: HMDB0059653
db: HMDB

Reference/CAS 13408-78-1
type: UnificationXref
id: 13408-78-1
db: CAS

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/HMDB HMDB0001308
type: UnificationXref
id: HMDB0001308
db: HMDB

a reduced NrdH glutaredoxin-like protein
type: SmallMoleculeReference

Compound/PW C000955/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Aminoimidazole ribonucleotide
stoichiometric coefficient: 1.0

Reference/CAS 19046-78-7
type: UnificationXref
id: 19046-78-7
db: CAS

an oxidized flavodoxin
type: SmallMoleculeReference

Clp R domain-containing protein
type: ProteinReference
xref: Reference/UniProt B7LFQ0

an oxidized NrdH glutaredoxin-like protein
type: SmallMoleculeReference

a reduced flavodoxin
type: SmallMoleculeReference

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

Reference/HMDB HMDB0001554
type: UnificationXref
id: HMDB0001554
db: HMDB

Reference/BioCyc 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE
type: UnificationXref
id: 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE
db: BioCyc

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Fumaric acid
type: SmallMolecule
entity reference: Fumaric acid

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

ChemicalStructure/PW C001112
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15528
type: UnificationXref
id: CHEBI:15528
db: ChEBI

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/ChemSpider 394323
type: UnificationXref
id: 394323
db: ChemSpider

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

an oxidized flavodoxin
type: SmallMolecule
entity reference: an oxidized flavodoxin

Compound/PW C000123/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

a reduced flavodoxin
type: SmallMolecule
entity reference: a reduced flavodoxin

an oxidized NrdH glutaredoxin-like protein
type: SmallMolecule
entity reference: an oxidized NrdH glutaredoxin-like protein

a reduced NrdH glutaredoxin-like protein
type: SmallMolecule
entity reference: a reduced NrdH glutaredoxin-like protein

dATP
type: SmallMolecule
entity reference: dATP

N1-(5-phospho-β-D-ribosyl)glycinamide
type: SmallMolecule
entity reference: N1-(5-phospho-β-D-ribosyl)glycinamide

Reference/ChemSpider 8264
type: UnificationXref
id: 8264
db: ChemSpider

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

AICAR
type: SmallMolecule
entity reference: AICAR

Reference/CAS 13870-90-1
type: UnificationXref
id: 13870-90-1
db: CAS

ChemicalStructure/PW C000114
type: ChemicalStructure
structure format: SMILES

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

dADP
type: SmallMolecule
entity reference: dADP

Glycine
type: SmallMolecule
entity reference: Glycine

Reference/CAS 3493-09-2
type: UnificationXref
id: 3493-09-2
db: CAS

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/PubChem-compound 6804
type: UnificationXref
id: 6804
db: PubChem-compound

Reference/KEGG Compound C03090
type: UnificationXref
id: C03090
db: KEGG Compound

Phosphoribosyl pyrophosphate
type: SmallMolecule
entity reference: Phosphoribosyl pyrophosphate
name: SubPathwayOutput

Reference/HMDB HMDB0001440
type: UnificationXref
id: HMDB0001440
db: HMDB

Reference/TAXONOMY 585055
type: UnificationXref
id: 585055
db: TAXONOMY

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Compound/PW C040844/Stoichiometry/1.0
type: Stoichiometry
physical entity: FAICAR
stoichiometric coefficient: 1.0

reduced thioredoxin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15033

FAICAR
type: SmallMolecule
entity reference: FAICAR

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

N5-Carboxyaminoimidazole ribonucleotide
type: SmallMolecule
entity reference: N5-Carboxyaminoimidazole ribonucleotide

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

N5-Carboxyaminoimidazole ribonucleotide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0012268
xref: Reference/BioCyc CPD0-181
xref: Reference/PubChem-compound 25201011
chemical formula: C9H14N3O9P
molecular weight: 339.04675
structure: ChemicalStructure/PW C007812

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

Compound/Generic98/Stoichiometry/1.0
type: Stoichiometry
physical entity: an oxidized NrdH glutaredoxin-like protein
stoichiometric coefficient: 1.0

ChemicalStructure/PW C002662
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL
type: UnificationXref
id: 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL
db: BioCyc

Protein/40730/Stoichiometry/4.0
type: Stoichiometry
physical entity: Aspartate ammonia-lyase
stoichiometric coefficient: 4.0

Compound/PW C000078/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Reference/ChemSpider 58620
type: UnificationXref
id: 58620
db: ChemSpider

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/PubChem-compound 161500
type: UnificationXref
id: 161500
db: PubChem-compound

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

oxidized thioredoxin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15033

Compound/PW C042916/Stoichiometry/1.0
type: Stoichiometry
physical entity: dATP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30838
type: UnificationXref
id: CHEBI:30838
db: ChEBI

Reference/BioCyc IMP
type: UnificationXref
id: IMP
db: BioCyc

Guanosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 85-32-5
xref: Reference/ChEBI CHEBI 17345
xref: Reference/BioCyc GMP
xref: Reference/PubChem-compound 6804
xref: Reference/KEGG Compound C00144
xref: Reference/ChemSpider 6545
xref: Reference/HMDB HMDB0001397
chemical formula: C10H14N5O8P
molecular weight: 363.058
structure: ChemicalStructure/PW C001080

Compound/PW C001401/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosylcobalamin
stoichiometric coefficient: 1.0

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Compound/PW C042915/Stoichiometry/1.0
type: Stoichiometry
physical entity: N1-(5-phospho-β-D-ribosyl)glycinamide
stoichiometric coefficient: 1.0

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Compound/PW C001080/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine monophosphate
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Compound/Generic97/Stoichiometry/1.0
type: Stoichiometry
physical entity: a reduced flavodoxin
stoichiometric coefficient: 1.0

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Compound/PW C001196/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xanthylic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 28862
type: UnificationXref
id: CHEBI:28862
db: ChEBI

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

ChemicalStructure/PW C040090
type: ChemicalStructure
structure format: SMILES

Guanosine monophosphate
type: SmallMolecule
entity reference: Guanosine monophosphate

Compound/PW C002662/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
stoichiometric coefficient: 1.0

Compound/PW C040034/Stoichiometry/4.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 4.0

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/CAS 349-34-8
type: UnificationXref
id: 349-34-8
db: CAS

Reference/ChemSpider 6545
type: UnificationXref
id: 6545
db: ChemSpider

Compound/PW C000114/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inosinic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 160666
type: UnificationXref
id: 160666
db: PubChem-compound

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ChemicalStructure/PW C000955
type: ChemicalStructure
structure format: SMILES

Xanthylic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15652
xref: Reference/PubChem-compound 73323
xref: Reference/HMDB HMDB0001554
xref: Reference/KEGG Compound C00655
xref: Reference/ChemSpider 66054
xref: Reference/CAS 523-98-8
xref: Reference/BioCyc XANTHOSINE-5-PHOSPHATE
chemical formula: C10H13N4O9P
molecular weight: 364.04202
structure: ChemicalStructure/PW C001196

Reference/HMDB HMDB0000960
type: UnificationXref
id: HMDB0000960
db: HMDB

Xanthylic acid
type: SmallMolecule
entity reference: Xanthylic acid

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

Protein/27297/Stoichiometry/10.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 10.0

Reference/ChemSpider 115687
type: UnificationXref
id: 115687
db: ChemSpider

Guanosine diphosphate
type: SmallMolecule
entity reference: Guanosine diphosphate

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/HMDB HMDB0006273
type: UnificationXref
id: HMDB0006273
db: HMDB

ChemicalStructure/PW C000767
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 25790919
type: UnificationXref
id: 25790919
db: PubChem-compound

Reference/PubChem-compound 130805
type: UnificationXref
id: 130805
db: PubChem-compound

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/HMDB HMDB0000972
type: UnificationXref
id: HMDB0000972
db: HMDB

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

ChemicalStructure/PW C000774
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 25320183
type: UnificationXref
id: 25320183
db: PubChem-compound

Compound/PW C040034/Stoichiometry/3.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 3.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 18408
type: UnificationXref
id: CHEBI:18408
db: ChEBI

Reference/ChEBI CHEBI 18406
type: UnificationXref
id: CHEBI:18406
db: ChEBI

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

tetrahydropteroyl mono-L-glutamate
type: SmallMolecule
entity reference: tetrahydropteroyl mono-L-glutamate

ReactionCatalysis1010227
type: Catalysis
controller: amidophosphoribosyl transferase
controlled: 2.4.2.14
control type: ACTIVATION

ReactionCatalysis1010228
type: Catalysis
controller: Unknown
controlled: 6.3.4.13
control type: ACTIVATION

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001866
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis1010229
type: Catalysis
controller: Unknown
controlled: 2.1.2.-
control type: ACTIVATION

Protein/27297/Stoichiometry/3.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 3.0

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

ChemicalStructure/PW C001868
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(=O)OP(O)(O)=O

ReactionCatalysis1010231
type: Catalysis
controller: Unknown
controlled: 6.3.5.3
control type: ACTIVATION

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ReactionCatalysis1010233
type: Catalysis
controller: phosphoribosylformylglycinamide cyclo-ligase
controlled: 6.3.3.1
control type: ACTIVATION

Reference/PubChem-compound 439220
type: UnificationXref
id: 439220
db: PubChem-compound

Reference/PubChem-compound 6438156
type: UnificationXref
id: 6438156
db: PubChem-compound

tetrahydropteroyl mono-L-glutamate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25790919
chemical formula: C19H21N7O6
molecular weight: 443.15643
structure: ChemicalStructure/PW C042960

Reference/KEGG Compound C00536
type: UnificationXref
id: C00536
db: KEGG Compound

Reference/KEGG Compound C00655
type: UnificationXref
id: C00655
db: KEGG Compound

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

Reference/BioCyc ADENOSYLCOBALAMIN-5-P
type: UnificationXref
id: ADENOSYLCOBALAMIN-5-P
db: BioCyc

Reference/KEGG Compound C00531
type: UnificationXref
id: C00531
db: KEGG Compound

Reference/CAS 97-65-4
type: UnificationXref
id: 97-65-4
db: CAS

Reference/PubChem-compound 439254
type: UnificationXref
id: 439254
db: PubChem-compound

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Compound/Generic96/Stoichiometry/1.0
type: Stoichiometry
physical entity: an oxidized flavodoxin
stoichiometric coefficient: 1.0

Reference/ChemSpider 58613
type: UnificationXref
id: 58613
db: ChemSpider

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/CAS 523-98-8
type: UnificationXref
id: 523-98-8
db: CAS

Reference/ChemSpider 109092
type: UnificationXref
id: 109092
db: ChemSpider

Protein/27297/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000637
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 28413
type: UnificationXref
id: CHEBI:28413
db: ChEBI

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Reference/ChemSpider 388390
type: UnificationXref
id: 388390
db: ChemSpider

ChemicalStructure/PW C000882
type: ChemicalStructure
structure format: SMILES

Protein/40726/Stoichiometry/2.0
type: Stoichiometry
physical entity: Clp R domain-containing protein
stoichiometric coefficient: 2.0

Compound/PW C001868/Stoichiometry/1.0
type: Stoichiometry
physical entity: Triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS