Reference/PubChem-compound 44229140
type: UnificationXref
id: 44229140
db: PubChem-compound

aldehydo-L-galactonate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44229140
xref: Reference/ChEBI CHEBI 53071
chemical formula: C6H11O7
molecular weight: 195.05048
structure: ChemicalStructure/PW C044521

Compound/PW C001064/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Keto-3-deoxy-6-phosphogluconic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/KEGG Compound C00556
type: UnificationXref
id: C00556
db: KEGG Compound

Compound/PW C041006/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Altronate
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 244
type: UnificationXref
id: 244
db: PubChem-compound

ChemicalStructure/PW C001782
type: ChemicalStructure
structure format: SMILES
structure data: OCC1=CC=CC=C1

NADH
type: SmallMolecule
entity reference: NADH

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Escherichia coli IAI39
type: BioSource
xref: Reference/TAXONOMY 585057

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C041005/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-mannonate
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
entity reference: NAD

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/BioCyc 34-DIMETHYLBENZYL-ALCOHOL
type: UnificationXref
id: 34-DIMETHYLBENZYL-ALCOHOL
db: BioCyc

2-Keto-3-deoxy-D-gluconic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Keto-3-deoxy-D-gluconic acid

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 4126
type: UnificationXref
id: CHEBI:4126
db: ChEBI

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid

Reference/PubChem-compound 194024
type: UnificationXref
id: 194024
db: PubChem-compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/PW C041004/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-fructuronate
stoichiometric coefficient: 1.0

Reference/ChemSpider 2338483
type: UnificationXref
id: 2338483
db: ChemSpider

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Bilirubin diglucuronide
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Bilirubin diglucuronide

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/BioCyc 2-DEHYDRO-3-DEOXY-D-GLUCONATE
type: UnificationXref
id: 2-DEHYDRO-3-DEOXY-D-GLUCONATE
db: BioCyc

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Compound/PW C041002 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-glucopyranuronate
stoichiometric coefficient: 1.0

Reference/BioCyc 2-KETO-3-DEOXY-6-P-GLUCONATE
type: UnificationXref
id: 2-KETO-3-DEOXY-6-P-GLUCONATE
db: BioCyc

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Compound/PW C041002/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-glucopyranuronate
stoichiometric coefficient: 1.0

Unknown
type: Protein
entity reference: Unknown

Reference/ChemSpider 709
type: UnificationXref
id: 709
db: ChemSpider

aldehydo-L-galactonate
type: SmallMolecule
cellular location: Cytosol
entity reference: aldehydo-L-galactonate

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Compound/PW C041007/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-tagaturonate
stoichiometric coefficient: 1.0

Protein/28273 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Compound/PW C001838 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Bilirubin diglucuronide
stoichiometric coefficient: 1.0

D-fructuronate
type: SmallMolecule
entity reference: D-fructuronate

Reference/ChEBI CHEBI 17028
type: UnificationXref
id: CHEBI:17028
db: ChEBI

D-Glyceraldehyde 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GAP
xref: Reference/ChEBI CHEBI 17138
xref: Reference/HMDB HMDB0001112
xref: Reference/ChemSpider 709
xref: Reference/KEGG Compound C00661
xref: Reference/PubChem-compound 729
xref: Reference/CAS 591-59-3
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C000869

Bilirubin diglucuronide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003325
xref: Reference/PubChem-compound 5459911
xref: Reference/ChemSpider 4573640
xref: Reference/ChEBI CHEBI 18392
xref: Reference/CAS 17459-92-6
xref: Reference/BioCyc BILIRUBIN-BISGLUCURONOSIDE
xref: Reference/KEGG Compound C05787
chemical formula: C45H52N4O18
molecular weight: 936.32764
structure: ChemicalStructure/PW C001838

D-mannonate
type: SmallMolecule
entity reference: D-mannonate

D-Altronate
type: SmallMolecule
entity reference: D-Altronate

D-tagaturonate
type: SmallMolecule
entity reference: D-tagaturonate

aldehydo-D-galacturonate
type: SmallMolecule
cellular location: Cytosol
entity reference: aldehydo-D-galacturonate

Compound/PW C001044/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Keto-3-deoxy-D-gluconic acid
stoichiometric coefficient: 1.0

D-glucopyranuronate
type: SmallMolecule
entity reference: D-glucopyranuronate

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/PathWhiz PW000785
type: UnificationXref
id: PW000785
db: PathWhiz

aldehydo-D-glucuronate
type: SmallMolecule
entity reference: aldehydo-D-glucuronate

Compound/PW C041004 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-fructuronate
stoichiometric coefficient: 1.0

5.3.1.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041003/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041004/Stoichiometry/1.0
right: D-fructuronate
spontaneous: false
EC number: 5.3.1.12
left: aldehydo-D-glucuronate
name: aldehydo-D-glucuronate → D-fructuronate
conversion direction: LEFT_TO_RIGHT

SubPathwayInteraction467034
type: Interaction
name: SubPathway467034Reaction
name: SubPathwayReaction
participant: Pyruvic acid

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

SubPathwayInteraction467033
type: Interaction
name: SubPathway467033Reaction
name: SubPathwayReaction
participant: D-Glyceraldehyde 3-phosphate

aldehydo-D-galacturonate
type: SmallMolecule
entity reference: aldehydo-D-galacturonate

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Transport63983
type: Transport
participant stoichiometry: Compound/PW C001838 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001838 Extracellular Space/Stoichiometry/1.0
right: Bilirubin diglucuronide
spontaneous: false
left: Bilirubin diglucuronide
name: Bilirubin diglucuronide (→) Transport: Escherichia coli IAI39, Extracellular Space to Escherichia coli IAI39, Periplasmic Space
conversion direction: LEFT_TO_RIGHT

2-Keto-3-deoxy-D-gluconic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17028
xref: Reference/KEGG Compound C01216
xref: Reference/CAS 17510-99-5
xref: Reference/ChemSpider 168361
xref: Reference/PubChem-compound 194024
xref: Reference/HMDB HMDB0001353
xref: Reference/BioCyc 2-DEHYDRO-3-DEOXY-D-GLUCONATE
chemical formula: C6H10O6
molecular weight: 178.04774
structure: ChemicalStructure/PW C001044

2-Keto-3-deoxy-6-phosphogluconic acid
type: SmallMolecule
entity reference: 2-Keto-3-deoxy-6-phosphogluconic acid

Transport63982
type: Transport
participant stoichiometry: Compound/PW C001838 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001838 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: Bilirubin diglucuronide
spontaneous: false
left: Hydrogen Ion
left: Bilirubin diglucuronide
name: Bilirubin diglucuronide (→), Hydrogen Ion (→) Transport: Escherichia coli IAI39, Periplasmic Space to Escherichia coli IAI39, Cytosol
conversion direction: LEFT_TO_RIGHT

TransportCatalysis44565
type: Catalysis
controller: Unknown
controlled: Transport63993
control type: ACTIVATION

Transport63987
type: Transport
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044521 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044521 Periplasmic Space/Stoichiometry/1.0
right: Hydrogen Ion
right: aldehydo-L-galactonate
spontaneous: false
left: aldehydo-L-galactonate
left: Hydrogen Ion
name: aldehydo-L-galactonate (→), Hydrogen Ion (→) Transport: Escherichia coli IAI39, Periplasmic Space to Escherichia coli IAI39, Cytosol
conversion direction: LEFT_TO_RIGHT

TransportCatalysis44568
type: Catalysis
controller: Unknown
controlled: Transport63996
control type: ACTIVATION

Transport63989
type: Transport
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001044 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001044 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: 2-Keto-3-deoxy-D-gluconic acid
spontaneous: false
left: 2-Keto-3-deoxy-D-gluconic acid
left: Hydrogen Ion
name: 2-Keto-3-deoxy-D-gluconic acid (→), Hydrogen Ion (→) Transport: Escherichia coli IAI39, Periplasmic Space to Escherichia coli IAI39, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C01216
type: UnificationXref
id: C01216
db: KEGG Compound

TransportCatalysis44561
type: Catalysis
controller: Unknown
controlled: Transport63989
control type: ACTIVATION

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

aldehydo-D-galacturonate
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: aldehydo-D-galacturonate

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C041008 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: aldehydo-D-galacturonate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

TransportCatalysis44559
type: Catalysis
controller: Unknown
controlled: Transport63987
control type: ACTIVATION

Transport63996
type: Transport
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041004 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041004 Periplasmic Space/Stoichiometry/1.0
right: Hydrogen Ion
right: D-fructuronate
spontaneous: false
left: Hydrogen Ion
left: D-fructuronate
name: D-fructuronate (→), Hydrogen Ion (→) Transport: Escherichia coli IAI39, Periplasmic Space to Escherichia coli IAI39, Cytosol
conversion direction: LEFT_TO_RIGHT

aldehydo-L-galactonate
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: aldehydo-L-galactonate

Transport63993
type: Transport
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041008 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041008 Cytosol/Stoichiometry/1.0
right: aldehydo-D-galacturonate
right: Hydrogen Ion
spontaneous: false
left: Hydrogen Ion
left: aldehydo-D-galacturonate
name: Hydrogen Ion (→), aldehydo-D-galacturonate (→) Transport: Escherichia coli IAI39, Periplasmic Space to Escherichia coli IAI39, Cytosol
conversion direction: LEFT_TO_RIGHT

TransportCatalysis44554
type: Catalysis
controller: Unknown
controlled: Transport63982
control type: ACTIVATION

TransportCatalysis44555
type: Catalysis
controller: Unknown
controlled: Transport63983
control type: ACTIVATION

β-D-glucuronidase
type: Complex
component stoichiometry: Protein/28273 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Unknown

Glycolysis and Pyruvate Dehydrogenase
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway467034
pathway order: SubPathwayInteractionSteps/SubPathway467033
pathway component: SubPathwayInteraction467034
pathway component: SubPathwayInteraction467033
xref: Reference/PathWhiz PW000785
xref: Reference/SMPDB SMP0000807
name: SubPathway

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Pyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvic acid
name: SubPathwayInput

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/PubChem-compound 3080745
type: UnificationXref
id: 3080745
db: PubChem-compound

D-fructuronate
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: D-fructuronate

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/ChEBI CHEBI 17360
type: UnificationXref
id: CHEBI:17360
db: ChEBI

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Compound/PW C041008 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: aldehydo-D-galacturonate
stoichiometric coefficient: 1.0

2-Keto-3-deoxy-D-gluconic acid
type: SmallMolecule
entity reference: 2-Keto-3-deoxy-D-gluconic acid

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005620
type: UnificationXref
id: GO:0005620
db: GENE ONTOLOGY

Reference/CAS 17459-92-6
type: UnificationXref
id: 17459-92-6
db: CAS

Compound/PW C001044 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Keto-3-deoxy-D-gluconic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17138
type: UnificationXref
id: CHEBI:17138
db: ChEBI

D-glucopyranuronate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 47952
chemical formula: C6H10O7
molecular weight: 194.04265
structure: ChemicalStructure/PW C041002

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

aldehydo-D-glucuronate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 47953
chemical formula: C6H10O7
molecular weight: 194.04265
structure: ChemicalStructure/PW C041003

D-fructuronate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 4126
chemical formula: C6H10O7
molecular weight: 194.04265
structure: ChemicalStructure/PW C041004

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
entity reference: D-Glyceraldehyde 3-phosphate

D-mannonate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17767
chemical formula: C6H11O7
molecular weight: 195.05103
structure: ChemicalStructure/PW C041005

aldehydo-L-galactonate
type: SmallMolecule
entity reference: aldehydo-L-galactonate

D-Altronate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17360
chemical formula: C6H11O7
molecular weight: 195.05103
structure: ChemicalStructure/PW C041006

D-tagaturonate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17886
chemical formula: C6H9O7
molecular weight: 193.03537
structure: ChemicalStructure/PW C041007

Compound/PW C044521 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: aldehydo-L-galactonate
stoichiometric coefficient: 1.0

aldehydo-D-galacturonate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 12952
chemical formula: C6H9O7
molecular weight: 193.03537
structure: ChemicalStructure/PW C041008

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/TAXONOMY 585057
type: UnificationXref
id: 585057
db: TAXONOMY

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Compound/PW C041008/Stoichiometry/1.0
type: Stoichiometry
physical entity: aldehydo-D-galacturonate
stoichiometric coefficient: 1.0

Compound/PW C044521/Stoichiometry/1.0
type: Stoichiometry
physical entity: aldehydo-L-galactonate
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

ReactionCatalysis1014098
type: Catalysis
controller: Unknown
controlled: 1.1.1.-
control type: ACTIVATION

ReactionCatalysis1014099
type: Catalysis
controller: β-D-glucuronidase
controlled: 3.2.1.31
control type: ACTIVATION

ReactionCatalysis1014096
type: Catalysis
controller: Unknown
controlled: 2.7.1.45
control type: ACTIVATION

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glyceraldehyde 3-phosphate
name: SubPathwayInput

ReactionCatalysis1014097
type: Catalysis
controller: multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase and oxaloacetate decarboxylase
controlled: 4.1.3.16
control type: ACTIVATION

ReactionCatalysis1014094
type: Catalysis
controller: Unknown
controlled: 1.1.1.58
control type: ACTIVATION

Protein/28273/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

ReactionCatalysis1014092
type: Catalysis
controller: Unknown
controlled: 4.2.1.8
control type: ACTIVATION

ReactionCatalysis1014093
type: Catalysis
controller: Unknown
controlled: 4.2.1.7
control type: ACTIVATION

ReactionCatalysis1014090
type: Catalysis
controller: Unknown
controlled: 5.3.1.12
control type: ACTIVATION

ReactionCatalysis1014091
type: Catalysis
controller: Unknown
controlled: 1.1.1.57
control type: ACTIVATION

2-Keto-3-deoxy-D-gluconic acid
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: 2-Keto-3-deoxy-D-gluconic acid

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17987
type: UnificationXref
id: CHEBI:17987
db: ChEBI

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Compound/PW C001782 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Benzyl alcohol
stoichiometric coefficient: 1.0

Compound/PW C001044 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Keto-3-deoxy-D-gluconic acid
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000807
type: UnificationXref
id: SMP0000807
db: SMPDB

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
entity reference: Water

D-glucopyranuronate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-glucopyranuronate

Reference/ChEBI CHEBI 18392
type: UnificationXref
id: CHEBI:18392
db: ChEBI

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001112
type: UnificationXref
id: HMDB0001112
db: HMDB

Compound/PW C001838 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Bilirubin diglucuronide
stoichiometric coefficient: 1.0

Compound/PW C001838 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Bilirubin diglucuronide
stoichiometric coefficient: 1.0

Reference/CAS 27244-54-8
type: UnificationXref
id: 27244-54-8
db: CAS

Reference/HMDB HMDB0001353
type: UnificationXref
id: HMDB0001353
db: HMDB

Reference/PubChem-compound 5459911
type: UnificationXref
id: 5459911
db: PubChem-compound

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChEBI CHEBI 12952
type: UnificationXref
id: CHEBI:12952
db: ChEBI

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/BioCyc BILIRUBIN-BISGLUCURONOSIDE
type: UnificationXref
id: BILIRUBIN-BISGLUCURONOSIDE
db: BioCyc

Benzyl alcohol
type: SmallMolecule
cellular location: Cytosol
entity reference: Benzyl alcohol

Reference/CAS 591-59-3
type: UnificationXref
id: 591-59-3
db: CAS

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reaction3057
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041002/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041003/Stoichiometry/1.0
right: aldehydo-D-glucuronate
spontaneous: true
left: D-glucopyranuronate
name: D-glucopyranuronate → aldehydo-D-glucuronate
conversion direction: LEFT_TO_RIGHT

2-Keto-3-deoxy-6-phosphogluconic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001376
xref: Reference/CAS 27244-54-8
xref: Reference/PubChem-compound 3080745
xref: Reference/ChEBI CHEBI 15925
xref: Reference/BioCyc 2-KETO-3-DEOXY-6-P-GLUCONATE
xref: Reference/ChemSpider 2338483
xref: Reference/KEGG Compound C04442
chemical formula: C6H11O9P
molecular weight: 258.01407
structure: ChemicalStructure/PW C001064

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/CAS 17510-99-5
type: UnificationXref
id: 17510-99-5
db: CAS

Bilirubin diglucuronide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Bilirubin diglucuronide

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 53071
type: UnificationXref
id: CHEBI:53071
db: ChEBI

Reference/PathWhiz PW451753
type: UnificationXref
id: PW451753
db: PathWhiz

Bilirubin diglucuronide
type: SmallMolecule
cellular location: Cytosol
entity reference: Bilirubin diglucuronide

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/HMDB HMDB0001376
type: UnificationXref
id: HMDB0001376
db: HMDB

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Hexuronide and Hexuronate Degradation
type: Pathway
pathway order: PathwayTransport/6359225
pathway order: PathwayEnzymeReaction/6359220
pathway order: PathwayTransport/6359226
pathway order: PathwayEnzymeReaction/6359210
pathway order: PathwayTransport/6359223
pathway order: PathwayEnzymeReaction/6359211
pathway order: PathwayTransport/6359224
pathway order: PathwayEnzymeReaction/6359212
pathway order: PathwayTransport/6359221
pathway order: PathwayEnzymeReaction/6359213
pathway order: PathwayTransport/6359222
pathway order: PathwayEnzymeReaction/6359214
pathway order: PathwayEnzymeReaction/6359215
pathway order: PathwayEnzymeReaction/6359216
pathway order: PathwayEnzymeReaction/6359217
pathway order: PathwayEnzymeReaction/6359218
pathway order: PathwayEnzymeReaction/6359219
pathway order: PathwaySubPathway/467034
pathway order: PathwaySubPathway/467033
pathway component: Glycolysis and Pyruvate Dehydrogenase
pathway component: 5.3.1.12
pathway component: Transport63983
pathway component: Reaction3057
pathway component: Transport63982
pathway component: TransportCatalysis44565
pathway component: Transport63987
pathway component: TransportCatalysis44568
pathway component: Transport63989
pathway component: 4.1.3.16
pathway component: 1.1.1.-
pathway component: 3.2.1.31
pathway component: 4.2.1.7
pathway component: 1.1.1.58
pathway component: TransportCatalysis44561
pathway component: Reaction996504
pathway component: 2.7.1.45
pathway component: 1.1.1.57
pathway component: 4.2.1.8
pathway component: TransportCatalysis44559
pathway component: Transport63996
pathway component: ReactionCatalysis1014098
pathway component: ReactionCatalysis1014099
pathway component: Transport63993
pathway component: ReactionCatalysis1014096
pathway component: ReactionCatalysis1014097
pathway component: TransportCatalysis44554
pathway component: ReactionCatalysis1014094
pathway component: ReactionCatalysis1014092
pathway component: ReactionCatalysis1014093
pathway component: ReactionCatalysis1014090
pathway component: TransportCatalysis44555
pathway component: ReactionCatalysis1014091
xref: Reference/SMPDB SMP0436443
xref: Reference/PathWhiz PW451753
organism: Escherichia coli IAI39

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 4573640
type: UnificationXref
id: 4573640
db: ChemSpider

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/HMDB HMDB0003325
type: UnificationXref
id: HMDB0003325
db: HMDB

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001064
type: ChemicalStructure
structure format: SMILES

Periplasmic Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005620

multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase and oxaloacetate decarboxylase
type: Complex
component stoichiometry: Protein/28273/Stoichiometry/4.0
component: Unknown

Reference/PubChem-compound 729
type: UnificationXref
id: 729
db: PubChem-compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

D-fructuronate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-fructuronate

ChemicalStructure/PW C041005
type: ChemicalStructure
structure format: SMILES
structure data: OCC(O)C(O)C(O)C(O)C([O-])=O

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

ChemicalStructure/PW C041004
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C041003
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C041002
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

ChemicalStructure/PW C041008
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

ChemicalStructure/PW C041007
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)C(O)C(O)C(O)C([O-])=O

ChemicalStructure/PW C041006
type: ChemicalStructure
structure format: SMILES
structure data: OCC(O)C(O)C(O)C(O)C([O-])=O

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C04442
type: UnificationXref
id: C04442
db: KEGG Compound

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C044521
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15925
type: UnificationXref
id: CHEBI:15925
db: ChEBI

Compound/PW C000869/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde 3-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17886
type: UnificationXref
id: CHEBI:17886
db: ChEBI

Reference/ChEBI CHEBI 17767
type: UnificationXref
id: CHEBI:17767
db: ChEBI

ChemicalStructure/PW C001838
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000869
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C=O

Reference/KEGG Compound C05787
type: UnificationXref
id: C05787
db: KEGG Compound

Compound/PW C041004 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-fructuronate
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0436443
type: UnificationXref
id: SMP0436443
db: SMPDB

ChemicalStructure/PW C001044
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](O)[C@H](O)CC(=O)C(O)=O

Benzyl alcohol
type: SmallMoleculeReference
xref: Reference/CAS 100-51-6
xref: Reference/KEGG Compound C00556
xref: Reference/ChemSpider 13860335
xref: Reference/ChEBI CHEBI 17987
xref: Reference/HMDB HMDB0003119
xref: Reference/BioCyc 34-DIMETHYLBENZYL-ALCOHOL
xref: Reference/PubChem-compound 244
chemical formula: C7H8O
molecular weight: 108.05752
structure: ChemicalStructure/PW C001782

Compound/PW C041003/Stoichiometry/1.0
type: Stoichiometry
physical entity: aldehydo-D-glucuronate
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C044521 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: aldehydo-L-galactonate
stoichiometric coefficient: 1.0

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

4.1.3.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001064/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869/Stoichiometry/1.0
right: D-Glyceraldehyde 3-phosphate
right: Pyruvic acid
spontaneous: false
EC number: 4.1.3.16
left: 2-Keto-3-deoxy-6-phosphogluconic acid
name: 2-Keto-3-deoxy-6-phosphogluconic acid → D-Glyceraldehyde 3-phosphate + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc GAP
type: UnificationXref
id: GAP
db: BioCyc

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

1.1.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041007/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044521/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: D-tagaturonate
right: Hydrogen Ion
spontaneous: false
EC number: 1.1.1.-
left: aldehydo-L-galactonate
left: NAD
name: NAD + aldehydo-L-galactonate → D-tagaturonate + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

3.2.1.31
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041002 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001782 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001838 Cytosol/Stoichiometry/1.0
right: D-glucopyranuronate
right: Benzyl alcohol
spontaneous: false
EC number: 3.2.1.31
left: Bilirubin diglucuronide
left: Water
name: Bilirubin diglucuronide + Water → Benzyl alcohol + D-glucopyranuronate
conversion direction: LEFT_TO_RIGHT

4.2.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001044/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041006/Stoichiometry/1.0
right: 2-Keto-3-deoxy-D-gluconic acid
right: Water
spontaneous: false
EC number: 4.2.1.7
left: D-Altronate
name: D-Altronate → 2-Keto-3-deoxy-D-gluconic acid + Water
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

1.1.1.58
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041007/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041006/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: D-Altronate
right: NAD
spontaneous: false
EC number: 1.1.1.58
left: NADH
left: D-tagaturonate
left: Hydrogen Ion
name: D-tagaturonate + Hydrogen Ion + NADH → D-Altronate + NAD
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 168361
type: UnificationXref
id: 168361
db: ChemSpider

Reaction996504
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041007/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041008/Stoichiometry/1.0
right: D-tagaturonate
spontaneous: false
left: aldehydo-D-galacturonate
name: aldehydo-D-galacturonate → D-tagaturonate
conversion direction: LEFT_TO_RIGHT

Hydrogen Ion
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Hydrogen Ion

2.7.1.45
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001064/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001044/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: 2-Keto-3-deoxy-6-phosphogluconic acid
spontaneous: false
EC number: 2.7.1.45
left: 2-Keto-3-deoxy-D-gluconic acid
left: Adenosine triphosphate
name: 2-Keto-3-deoxy-D-gluconic acid + Adenosine triphosphate → 2-Keto-3-deoxy-6-phosphogluconic acid + Adenosine diphosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00661
type: UnificationXref
id: C00661
db: KEGG Compound

1.1.1.57
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041005/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041004/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: D-mannonate
right: NAD
spontaneous: false
EC number: 1.1.1.57
left: D-fructuronate
left: NADH
left: Hydrogen Ion
name: D-fructuronate + Hydrogen Ion + NADH → D-mannonate + NAD
conversion direction: LEFT_TO_RIGHT

4.2.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041005/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001044/Stoichiometry/1.0
right: 2-Keto-3-deoxy-D-gluconic acid
right: Water
spontaneous: false
EC number: 4.2.1.8
left: D-mannonate
name: D-mannonate → 2-Keto-3-deoxy-D-gluconic acid + Water
conversion direction: LEFT_TO_RIGHT

Reference/CAS 100-51-6
type: UnificationXref
id: 100-51-6
db: CAS

Reference/ChemSpider 13860335
type: UnificationXref
id: 13860335
db: ChemSpider

Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003119
type: UnificationXref
id: HMDB0003119
db: HMDB

Reference/ChEBI CHEBI 47952
type: UnificationXref
id: CHEBI:47952
db: ChEBI

Reference/ChEBI CHEBI 47953
type: UnificationXref
id: CHEBI:47953
db: ChEBI