Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

ChemicalStructure/PW C001537
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)CO)N1

Reference/PubChem-compound 7057990
type: UnificationXref
id: 7057990
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Chorismate
type: SmallMolecule
cellular location: Cytosol
entity reference: Chorismate
name: SubPathwayOutput

Reference/HMDB HMDB0012199
type: UnificationXref
id: HMDB0012199
db: HMDB

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002275
type: UnificationXref
id: HMDB0002275
db: HMDB

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
type: ProteinReference
xref: Reference/UniProt C3QRC3

Reference/KEGG Compound C00568
type: UnificationXref
id: C00568
db: KEGG Compound

Reference/ChEBI CHEBI 20506
type: UnificationXref
id: CHEBI:20506
db: ChEBI

7,8-dihydroneopterin aldolase
type: ProteinReference
xref: Reference/UniProt C3QWL6

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

NAD(+) diphosphatase
type: ProteinReference
xref: Reference/UniProt C3QN96

Anthranilate synthase component 1
type: Protein
entity reference: Anthranilate synthase component 1

Chorismate Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway468449
pathway component: SubPathwayInteraction468449
xref: Reference/SMPDB SMP0000836
xref: Reference/PathWhiz PW000816
name: SubPathway

7,8-dihydroneopterin 3'-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25245170
chemical formula: C9H12N5O7P
molecular weight: 333.04742
structure: ChemicalStructure/PW C042913

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

7,8-dihydroneopterin 3'-triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25201779
chemical formula: C9H12N5O13P3
molecular weight: 490.96664
structure: ChemicalStructure/PW C042912

Reference/BioCyc DIHYDROXYPHENYLGLYCOLALDEHYDE
type: UnificationXref
id: DIHYDROXYPHENYLGLYCOLALDEHYDE
db: BioCyc

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

7,8-dihydrofolate monoglutamate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 40480038
chemical formula: C19H19N7O6
molecular weight: 441.14078
structure: ChemicalStructure/PW C042914

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Glutamine amidotransferase, class I
type: ProteinReference
xref: Reference/UniProt C3QYJ7

Compound/PW C001090/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-Dihydropteroic acid
stoichiometric coefficient: 1.0

dihydropteroate synthase
type: ProteinReference
xref: Reference/UniProt C3QXF3

Reference/PubChem-compound 40480038
type: UnificationXref
id: 40480038
db: PubChem-compound

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

SubPathwayInteraction468449
type: Interaction
name: SubPathway468449Reaction
name: SubPathwayReaction
participant: Chorismate

Reference/ChemSpider 18714427
type: UnificationXref
id: 18714427
db: ChemSpider

SubPathwayInteraction468448
type: Interaction
name: SubPathwayReaction
name: SubPathway468448Reaction
participant: Guanosine triphosphate

SubPathwayInteraction468447
type: Interaction
name: SubPathwayReaction
name: SubPathway468447Reaction
participant: Tetrahydrofolic acid

Compound/PW C007748/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chorismate
stoichiometric coefficient: 1.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

GTP cyclohydrolase 1
type: Protein
entity reference: GTP cyclohydrolase 1

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
type: SmallMolecule
entity reference: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate

6-hydroxymethyl-7,8-dihydropterin
type: SmallMolecule
entity reference: 6-hydroxymethyl-7,8-dihydropterin

Tetrahydrofolic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrofolic acid
name: SubPathwayInput

3-deoxy-D-manno-octulosonic acid transferase
type: Protein
entity reference: 3-deoxy-D-manno-octulosonic acid transferase

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

4-amino-4-deoxychorismate
type: SmallMolecule
entity reference: 4-amino-4-deoxychorismate

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChemSpider 953
type: UnificationXref
id: 953
db: ChemSpider

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

ChemicalStructure/PW C007748
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/UniProt C3QWY6
type: UnificationXref
id: C3QWY6
db: UniProt

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Tetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 20506
xref: Reference/ChemSpider 18714427
xref: Reference/HMDB HMDB0001846
xref: Reference/PubChem-compound 13781857
xref: Reference/BioCyc THF
xref: Reference/CAS 135-16-0
xref: Reference/KEGG Compound C00101
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C001221

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Reference/PubChem-compound 25245170
type: UnificationXref
id: 25245170
db: PubChem-compound

GTP cyclohydrolase I
type: Complex
component stoichiometry: Protein/65599/Stoichiometry/10.0
component: GTP cyclohydrolase 1

Compound/PW C001850/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycolaldehyde
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0001750
type: UnificationXref
id: SMP0001750
db: SMPDB

dihydroneopterin aldolase
type: Complex
component stoichiometry: Protein/65603/Stoichiometry/8.0
component: 7,8-dihydroneopterin aldolase

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine triphosphate
name: SubPathwayInput

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

dihydropteroate synthase
type: Complex
component stoichiometry: Protein/65607/Stoichiometry/2.0
component: dihydropteroate synthase

Folate Biosynthesis
type: Pathway
pathway order: PathwaySubPathway/468449
pathway order: PathwayEnzymeReaction/6373359
pathway order: PathwayEnzymeReaction/6373363
pathway order: PathwayEnzymeReaction/6373362
pathway order: PathwayEnzymeReaction/6373373
pathway order: PathwayEnzymeReaction/6373365
pathway order: PathwaySubPathway/468447
pathway order: PathwayEnzymeReaction/6373368
pathway order: PathwaySubPathway/468448
pathway order: PathwayEnzymeReaction/6373370
pathway order: PathwayEnzymeReaction/6373361
pathway order: PathwayEnzymeReaction/6373372
pathway order: PathwayEnzymeReaction/6373360
pathway order: PathwayEnzymeReaction/6373371
pathway component: 4.1.2.25
pathway component: 3.6.1.-
pathway component: 2.7.6.3
pathway component: Purine Nucleotides De Novo Biosynthesis
pathway component: 2.5.1.15
pathway component: Chorismate Biosynthesis
pathway component: 4.1.3.38
pathway component: 3.5.4.16
pathway component: ReactionCatalysis1021607
pathway component: ReactionCatalysis1021618
pathway component: Reaction3398
pathway component: ReactionCatalysis1021608
pathway component: ReactionCatalysis1021616
pathway component: ReactionCatalysis1021606
pathway component: ReactionCatalysis1021617
pathway component: ReactionCatalysis1021609
pathway component: 6.3.2.17
pathway component: ReactionCatalysis1021611
pathway component: 2.6.1.85
pathway component: 1.5.1.3
pathway component: ReactionCatalysis1021615
pathway component: ReactionCatalysis1021613
pathway component: One Carbon Pool by Folate
xref: Reference/PathWhiz PW452692
xref: Reference/SMPDB SMP0437251
organism: Bacteroides sp. 2_2_4

3-deoxy-D-manno-octulosonic acid transferase
type: ProteinReference
xref: Reference/UniProt C3R0F6

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Reference/ChEBI CHEBI 17333
type: UnificationXref
id: CHEBI:17333
db: ChEBI

Protein/65599/Stoichiometry/10.0
type: Stoichiometry
physical entity: GTP cyclohydrolase 1
stoichiometric coefficient: 10.0

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/BioCyc DIHYDRONEOPTERIN-P3
type: UnificationXref
id: DIHYDRONEOPTERIN-P3
db: BioCyc

Reference/KEGG Compound C00101
type: UnificationXref
id: C00101
db: KEGG Compound

Compound/PW C000092/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001412
type: UnificationXref
id: HMDB0001412
db: HMDB

Reference/ChEBI CHEBI 4581
type: UnificationXref
id: CHEBI:4581
db: ChEBI

NADP
type: SmallMolecule
entity reference: NADP

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

ChemicalStructure/PW C001090
type: ChemicalStructure
structure format: SMILES

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

4-amino-4-deoxychorismate synthase
type: Complex
component: Anthranilate synthase component 1
component: Glutamine amidotransferase, class I

Reference/BioCyc THF
type: UnificationXref
id: THF
db: BioCyc

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

dihydropteroate synthase
type: Protein
entity reference: dihydropteroate synthase

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

GTP cyclohydrolase 1
type: ProteinReference
xref: Reference/UniProt C3QZD4

Glutamine amidotransferase, class I
type: Protein
entity reference: Glutamine amidotransferase, class I

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Anthranilate synthase component 1
type: ProteinReference
xref: Reference/UniProt C3QYJ8

ChemicalStructure/PW C001221
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 58406
type: UnificationXref
id: CHEBI:58406
db: ChEBI

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Compound/PW C001221/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

7,8-dihydroneopterin aldolase
type: Protein
entity reference: 7,8-dihydroneopterin aldolase

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
type: Protein
entity reference: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

Formic acid
type: SmallMolecule
entity reference: Formic acid

NAD(+) diphosphatase
type: Protein
entity reference: NAD(+) diphosphatase

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/UniProt C3QXF3
type: UnificationXref
id: C3QXF3
db: UniProt

Reference/KEGG Compound C00921
type: UnificationXref
id: C00921
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/CAS 141-46-8
type: UnificationXref
id: 141-46-8
db: CAS

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/CAS 135-16-0
type: UnificationXref
id: 135-16-0
db: CAS

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Bacteroides sp. 2_2_4
type: BioSource
xref: Reference/TAXONOMY 469590

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Glycolaldehyde
type: SmallMolecule
entity reference: Glycolaldehyde

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Glycolaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17071
xref: Reference/PubChem-compound 756
xref: Reference/BioCyc DIHYDROXYPHENYLGLYCOLALDEHYDE
xref: Reference/ChemSpider 736
xref: Reference/HMDB HMDB0003344
xref: Reference/CAS 141-46-8
xref: Reference/KEGG Compound C00266
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C001850

Reference/CAS 150-13-0
type: UnificationXref
id: 150-13-0
db: CAS

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/PathWhiz PW001735
type: UnificationXref
id: PW001735
db: PathWhiz

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Purine Nucleotides De Novo Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway468448
pathway component: SubPathwayInteraction468448
xref: Reference/PathWhiz PW000910
xref: Reference/SMPDB SMP0000927
name: SubPathway

Protein/65603/Stoichiometry/8.0
type: Stoichiometry
physical entity: 7,8-dihydroneopterin aldolase
stoichiometric coefficient: 8.0

4.1.3.38
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040772/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001077/Stoichiometry/1.0
right: p-Aminobenzoic acid
right: Hydrogen Ion
right: Pyruvic acid
spontaneous: false
EC number: 4.1.3.38
left: 4-amino-4-deoxychorismate
name: 4-amino-4-deoxychorismate → Hydrogen Ion + Pyruvic acid + p-Aminobenzoic acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00251
type: UnificationXref
id: C00251
db: KEGG Compound

7,8-dihydroneopterin 3'-triphosphate
type: SmallMolecule
entity reference: 7,8-dihydroneopterin 3'-triphosphate

7,8-dihydrofolate monoglutamate
type: SmallMolecule
entity reference: 7,8-dihydrofolate monoglutamate

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

7,8-dihydroneopterin 3'-phosphate
type: SmallMolecule
entity reference: 7,8-dihydroneopterin 3'-phosphate

Reference/ChEBI CHEBI 17001
type: UnificationXref
id: CHEBI:17001
db: ChEBI

ReactionCatalysis1021607
type: Catalysis
controller: NAD(+) diphosphatase
controlled: 3.6.1.-
control type: ACTIVATION

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

ReactionCatalysis1021608
type: Catalysis
controller: dihydroneopterin aldolase
controlled: 4.1.2.25
control type: ACTIVATION

ReactionCatalysis1021606
type: Catalysis
controller: GTP cyclohydrolase I
controlled: 3.5.4.16
control type: ACTIVATION

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/SMPDB SMP0437251
type: UnificationXref
id: SMP0437251
db: SMPDB

ReactionCatalysis1021609
type: Catalysis
controller: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
controlled: 2.7.6.3
control type: ACTIVATION

Compound/PW C040774/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-hydroxymethyl-7,8-dihydropterin
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

6.3.2.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001090/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042914/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: Phosphate
right: 7,8-dihydrofolate monoglutamate
spontaneous: false
EC number: 6.3.2.17
left: L-Glutamic acid
left: 7,8-Dihydropteroic acid
left: Adenosine triphosphate
name: 7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid → 7,8-dihydrofolate monoglutamate + Adenosine diphosphate + Hydrogen Ion + Phosphate
conversion direction: LEFT_TO_RIGHT

2.6.1.85
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007748/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040772/Stoichiometry/1.0
right: L-Glutamic acid
right: 4-amino-4-deoxychorismate
spontaneous: false
EC number: 2.6.1.85
left: L-Glutamine
left: Chorismate
name: Chorismate + L-Glutamine → 4-amino-4-deoxychorismate + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

1.5.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042914/Stoichiometry/1.0
right: Tetrahydrofolic acid
right: NADP
spontaneous: false
EC number: 1.5.1.3
left: Hydrogen Ion
left: NADPH
left: 7,8-dihydrofolate monoglutamate
name: 7,8-dihydrofolate monoglutamate + Hydrogen Ion + NADPH → NADP + Tetrahydrofolic acid
conversion direction: LEFT_TO_RIGHT

Reference/UniProt C3QYJ7
type: UnificationXref
id: C3QYJ7
db: UniProt

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/UniProt C3QYJ8
type: UnificationXref
id: C3QYJ8
db: UniProt

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Guanosine triphosphate
type: SmallMolecule
entity reference: Guanosine triphosphate

Reference/KEGG Compound C00266
type: UnificationXref
id: C00266
db: KEGG Compound

ReactionCatalysis1021618
type: Catalysis
controller: Dihydrofolate reductase
controlled: 1.5.1.3
control type: ACTIVATION

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

ReactionCatalysis1021616
type: Catalysis
controller: tetrahydrofolate synthase
controlled: 6.3.2.17
control type: ACTIVATION

ReactionCatalysis1021617
type: Catalysis
controller: Oxidoreductase, short chain dehydrogenase/reductase family protein
controlled: 1.5.1.3
control type: ACTIVATION

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ReactionCatalysis1021611
type: Catalysis
controller: dihydropteroate synthase
controlled: 2.5.1.15
control type: ACTIVATION

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

tetrahydrofolate synthase
type: Protein
entity reference: tetrahydrofolate synthase

ReactionCatalysis1021615
type: Catalysis
controller: 4-amino-4-deoxychorismate synthase
controlled: 2.6.1.85
control type: ACTIVATION

Oxidoreductase, short chain dehydrogenase/reductase family protein
type: Protein
entity reference: Oxidoreductase, short chain dehydrogenase/reductase family protein

Reference/UniProt C3R0F6
type: UnificationXref
id: C3R0F6
db: UniProt

ReactionCatalysis1021613
type: Catalysis
controller: 3-deoxy-D-manno-octulosonic acid transferase
controlled: 4.1.3.38
control type: ACTIVATION

Dihydrofolate reductase
type: Protein
entity reference: Dihydrofolate reductase

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/KEGG Compound C04874
type: UnificationXref
id: C04874
db: KEGG Compound

Reference/SMPDB SMP0000927
type: UnificationXref
id: SMP0000927
db: SMPDB

Reaction3398
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001537/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042913/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: 7,8-Dihydroneopterin
right: Phosphate
spontaneous: false
left: Water
left: 7,8-dihydroneopterin 3'-phosphate
name: 7,8-dihydroneopterin 3'-phosphate + Water → 7,8-Dihydroneopterin + Phosphate
conversion direction: LEFT_TO_RIGHT

Water
type: SmallMolecule
entity reference: Water

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/BioCyc 7,8-dihydropteroate
type: UnificationXref
id: 7,8-dihydropteroate
db: BioCyc

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/CAS 1218-98-0
type: UnificationXref
id: 1218-98-0
db: CAS

Reference/PubChem-compound 756
type: UnificationXref
id: 756
db: PubChem-compound

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

7,8-Dihydroneopterin
type: SmallMolecule
entity reference: 7,8-Dihydroneopterin

Chorismate
type: SmallMoleculeReference
xref: Reference/CAS 617-12-9
xref: Reference/BioCyc CPD-9517
xref: Reference/KEGG Compound C00251
xref: Reference/PubChem-compound 12039
xref: Reference/ChEBI CHEBI 17333
xref: Reference/ChemSpider 11542
xref: Reference/HMDB HMDB0012199
chemical formula: C10H10O6
molecular weight: 226.04774
structure: ChemicalStructure/PW C007748

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17071
type: UnificationXref
id: CHEBI:17071
db: ChEBI

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

7,8-Dihydropteroic acid
type: SmallMoleculeReference
xref: Reference/CAS 2134-76-1
xref: Reference/KEGG Compound C00921
xref: Reference/HMDB HMDB0001412
xref: Reference/ChEBI CHEBI 4581
xref: Reference/PubChem-compound 170
xref: Reference/ChemSpider 165
xref: Reference/BioCyc 7,8-dihydropteroate
chemical formula: C14H14N6O3
molecular weight: 314.11273
structure: ChemicalStructure/PW C001090

Compound/PW C001077/Stoichiometry/1.0
type: Stoichiometry
physical entity: p-Aminobenzoic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 11542
type: UnificationXref
id: 11542
db: ChemSpider

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

7,8-Dihydropteroic acid
type: SmallMolecule
entity reference: 7,8-Dihydropteroic acid

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Chorismate
type: SmallMolecule
entity reference: Chorismate

Compound/PW C042914/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-dihydrofolate monoglutamate
stoichiometric coefficient: 1.0

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/CAS 617-12-9
type: UnificationXref
id: 617-12-9
db: CAS

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

ChemicalStructure/PW C040774
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC2=C(N=C(CO)CN2)C(=O)N1

Compound/PW C040773/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/SMPDB SMP0000836
type: UnificationXref
id: SMP0000836
db: SMPDB

ChemicalStructure/PW C040773
type: ChemicalStructure
structure format: SMILES
structure data: OP(=O)(OCC1=NC2=C(NC1)NC(=N)N=C2[O-])OP([O-])([O-])=O

ChemicalStructure/PW C040772
type: ChemicalStructure
structure format: SMILES

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C042912/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-dihydroneopterin 3'-triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 659
type: UnificationXref
id: 659
db: PubChem-compound

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

p-Aminobenzoic acid
type: SmallMolecule
entity reference: p-Aminobenzoic acid

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

p-Aminobenzoic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30753
xref: Reference/KEGG Compound C00568
xref: Reference/BioCyc P-AMINO-BENZOATE
xref: Reference/CAS 150-13-0
xref: Reference/PubChem-compound 7057990
xref: Reference/HMDB HMDB0001392
xref: Reference/ChemSpider 953
chemical formula: C7H7NO2
molecular weight: 137.04768
structure: ChemicalStructure/PW C001077

Reference/BioCyc P-AMINO-BENZOATE
type: UnificationXref
id: P-AMINO-BENZOATE
db: BioCyc

Reference/PubChem-compound 25201779
type: UnificationXref
id: 25201779
db: PubChem-compound

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/PathWhiz PW452692
type: UnificationXref
id: PW452692
db: PathWhiz

Reference/BioCyc CPD-9517
type: UnificationXref
id: CPD-9517
db: BioCyc

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/UniProt C3QN96
type: UnificationXref
id: C3QN96
db: UniProt

Reference/ChemSpider 736
type: UnificationXref
id: 736
db: ChemSpider

Phosphate
type: SmallMolecule
entity reference: Phosphate

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/ChEBI CHEBI 30753
type: UnificationXref
id: CHEBI:30753
db: ChEBI

Tetrahydrofolic acid
type: SmallMolecule
entity reference: Tetrahydrofolic acid

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Reference/PubChem-compound 170
type: UnificationXref
id: 170
db: PubChem-compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/PathWhiz PW000816
type: UnificationXref
id: PW000816
db: PathWhiz

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

4.1.2.25
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001537/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040774/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001850/Stoichiometry/1.0
right: 6-hydroxymethyl-7,8-dihydropterin
right: Glycolaldehyde
spontaneous: false
EC number: 4.1.2.25
left: 7,8-Dihydroneopterin
name: 7,8-Dihydroneopterin → 6-hydroxymethyl-7,8-dihydropterin + Glycolaldehyde
conversion direction: LEFT_TO_RIGHT

3.6.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042913/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042912/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: Pyrophosphate
right: 7,8-dihydroneopterin 3'-phosphate
spontaneous: false
EC number: 3.6.1.-
left: Water
left: 7,8-dihydroneopterin 3'-triphosphate
name: 7,8-dihydroneopterin 3'-triphosphate + Water → 7,8-dihydroneopterin 3'-phosphate + Hydrogen Ion + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

4-amino-4-deoxychorismate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58406
chemical formula: C10H10NO5
molecular weight: 224.05644
structure: ChemicalStructure/PW C040772

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

2.7.6.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040773/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040774/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
right: Hydrogen Ion
right: Adenosine monophosphate
spontaneous: false
EC number: 2.7.6.3
left: 6-hydroxymethyl-7,8-dihydropterin
left: Adenosine triphosphate
name: 6-hydroxymethyl-7,8-dihydropterin + Adenosine triphosphate → (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + Adenosine monophosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 57602
chemical formula: C7H8N5O8P2
molecular weight: 351.9848
structure: ChemicalStructure/PW C040773

6-hydroxymethyl-7,8-dihydropterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17083
chemical formula: C7H9N5O2
molecular weight: 195.07562
structure: ChemicalStructure/PW C040774

2.5.1.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040773/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001077/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001090/Stoichiometry/1.0
right: Pyrophosphate
right: 7,8-Dihydropteroic acid
spontaneous: false
EC number: 2.5.1.15
left: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
left: p-Aminobenzoic acid
name: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + p-Aminobenzoic acid → 7,8-Dihydropteroic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

3.5.4.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042912/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: 7,8-dihydroneopterin 3'-triphosphate
right: Formic acid
spontaneous: false
EC number: 3.5.4.16
left: Water
left: Guanosine triphosphate
name: Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Reference/UniProt C3QS36
type: UnificationXref
id: C3QS36
db: UniProt

ChemicalStructure/PW C001077
type: ChemicalStructure
structure format: SMILES
structure data: NC1=CC=C(C=C1)C(O)=O

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C001537/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-Dihydroneopterin
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 57602
type: UnificationXref
id: CHEBI:57602
db: ChEBI

Reference/ChemSpider 165
type: UnificationXref
id: 165
db: ChemSpider

Reference/HMDB HMDB0001392
type: UnificationXref
id: HMDB0001392
db: HMDB

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/UniProt C3QWL6
type: UnificationXref
id: C3QWL6
db: UniProt

Oxidoreductase, short chain dehydrogenase/reductase family protein
type: ProteinReference
xref: Reference/UniProt C3QS36

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

tetrahydrofolate synthase
type: ProteinReference
xref: Reference/UniProt C3R1P1

Dihydrofolate reductase
type: ProteinReference
xref: Reference/UniProt C3QWY6

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 639
type: UnificationXref
id: 639
db: ChemSpider

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

7,8-Dihydroneopterin
type: SmallMoleculeReference
xref: Reference/CAS 1218-98-0
xref: Reference/PubChem-compound 659
xref: Reference/ChemSpider 639
xref: Reference/KEGG Compound C04874
xref: Reference/BioCyc DIHYDRONEOPTERIN-P3
xref: Reference/HMDB HMDB0002275
xref: Reference/ChEBI CHEBI 17001
chemical formula: C9H13N5O4
molecular weight: 255.09676
structure: ChemicalStructure/PW C001537

Reference/UniProt C3R1P1
type: UnificationXref
id: C3R1P1
db: UniProt

Reference/TAXONOMY 469590
type: UnificationXref
id: 469590
db: TAXONOMY

Reference/CAS 2134-76-1
type: UnificationXref
id: 2134-76-1
db: CAS

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Compound/PW C000986/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C042913/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-dihydroneopterin 3'-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/ChEBI CHEBI 17083
type: UnificationXref
id: CHEBI:17083
db: ChEBI

Reference/PathWhiz PW000910
type: UnificationXref
id: PW000910
db: PathWhiz

Reference/UniProt C3QRC3
type: UnificationXref
id: C3QRC3
db: UniProt

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/HMDB HMDB0003344
type: UnificationXref
id: HMDB0003344
db: HMDB

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

ChemicalStructure/PW C042912
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1

Reference/UniProt C3QZD4
type: UnificationXref
id: C3QZD4
db: UniProt

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Protein/65607/Stoichiometry/2.0
type: Stoichiometry
physical entity: dihydropteroate synthase
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0001846
type: UnificationXref
id: HMDB0001846
db: HMDB

ChemicalStructure/PW C042913
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 12039
type: UnificationXref
id: 12039
db: PubChem-compound

ChemicalStructure/PW C042914
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

ChemicalStructure/PW C001850
type: ChemicalStructure
structure format: SMILES
structure data: OCC=O

Reference/PubChem-compound 13781857
type: UnificationXref
id: 13781857
db: PubChem-compound

Compound/PW C040772/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-amino-4-deoxychorismate
stoichiometric coefficient: 1.0

One Carbon Pool by Folate
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway468447
pathway component: SubPathwayInteraction468447
xref: Reference/SMPDB SMP0001750
xref: Reference/PathWhiz PW001735
name: SubPathway