1-Deoxy-D-xylulose 5-phosphate + Hydrogen Ion + NADPH → 2-C-methyl-D-erythritol 4-phosphate + NADP
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
2-C-methyl-D-erythritol 4-phosphate + Cytidine triphosphate + Hydrogen Ion → 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Pyrophosphate
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine triphosphate → 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine diphosphate + Hydrogen Ion
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol → 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + Cytidine monophosphate
2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + a reduced flavodoxin → 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + Water + an oxidized flavodoxin
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + NADPH → Isopentenyl pyrophosphate + NADPH + Water
Isopentenyl pyrophosphate ↔ Dimethylallylpyrophosphate
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + NADPH → Dimethylallylpyrophosphate + NADP + Water
Secondary Metabolites: Methylerythritol Phosphate and Polyisoprenoid Biosynthesis
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D-Glyceraldehyde 3-phosphate + Hydrogen Ion → 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Secondary Metabolites: Isoprenoid Biosynthesis (Nonmevalonate Pathway)
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
4-diphosphocytidyl-2-C-methylerythritol kinase
4-diphosphocytidyl-2C-methyl-D-erythritol synthase