Reference/SMPDB SMP0448972
type: UnificationXref
id: SMP0448972
db: SMPDB

Reference/KEGG Compound C00315
type: UnificationXref
id: C00315
db: KEGG Compound

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/CAS 23656-67-9
type: UnificationXref
id: 23656-67-9
db: CAS

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Compound/PW C001092/Stoichiometry/1.0
type: Stoichiometry
physical entity: Putrescine
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Spermidine
type: SmallMolecule
entity reference: Spermidine

5-Methylthioribose
type: SmallMolecule
entity reference: 5-Methylthioribose

Reference/ChemSpider 13837702
type: UnificationXref
id: 13837702
db: ChemSpider

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Methionine Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway489595
pathway component: SubPathwayInteraction489595
xref: Reference/SMPDB SMP0000834
xref: Reference/PathWhiz PW000814
name: SubPathway

Escherichia coli IAI1
type: BioSource
xref: Reference/TAXONOMY 585034

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Reference/PathWhiz PW465973
type: UnificationXref
id: PW465973
db: PathWhiz

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 6137
type: UnificationXref
id: 6137
db: PubChem-compound

Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc S-ADENOSYLMETHIONINAMINE
type: UnificationXref
id: S-ADENOSYLMETHIONINAMINE
db: BioCyc

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/CAS 124-20-9
type: UnificationXref
id: 124-20-9
db: CAS

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Water
type: SmallMolecule
cellular location: Outer Membrane
entity reference: Water

Protein/28270/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Protein/28270 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Compound/PW C000548 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000548
type: ChemicalStructure
structure format: SMILES
structure data: CSCC[C@H](N)C(O)=O

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/HMDB HMDB0001087
type: UnificationXref
id: HMDB0001087
db: HMDB

Pyrophosphate
type: SmallMolecule
cellular location: Outer Membrane
entity reference: Pyrophosphate

Adenosine diphosphate
type: SmallMolecule
cellular location: Outer Membrane
entity reference: Adenosine diphosphate

ChemicalStructure/PW C042677
type: ChemicalStructure
structure format: SMILES
structure data: CSCC1OC(C(O)C1O)N1C=NC2=C(N)N=CN=C12

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Unknown
type: Protein
entity reference: Unknown

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

Compound/PW C000414 Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Outer Membrane
entity reference: Adenosine triphosphate

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

N8-Acetylspermidine
type: SmallMolecule
entity reference: N8-Acetylspermidine

Reference/HMDB HMDB0001414
type: UnificationXref
id: HMDB0001414
db: HMDB

Adenine
type: SmallMolecule
entity reference: Adenine

N8-Acetylspermidine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01029
xref: Reference/CAS 13431-24-8
xref: Reference/PubChem-compound 123689
xref: Reference/ChEBI CHEBI 27911
xref: Reference/HMDB HMDB0002189
xref: Reference/BioCyc CPD-3462
xref: Reference/ChemSpider 110264
chemical formula: C9H21N3O
molecular weight: 187.16846
structure: ChemicalStructure/PW C001476

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

ChemicalStructure/PW C001092
type: ChemicalStructure
structure format: SMILES
structure data: NCCCCN

Adenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000034
xref: Reference/BioCyc ADENINE
xref: Reference/PubChem-compound 190
xref: Reference/ChemSpider 185
xref: Reference/KEGG Compound C00147
xref: Reference/ChEBI CHEBI 16708
xref: Reference/CAS 73-24-5
chemical formula: C5H5N5
molecular weight: 135.05449
structure: ChemicalStructure/PW C000024

Reference/HMDB HMDB0002189
type: UnificationXref
id: HMDB0002189
db: HMDB

L-Methionine
type: SmallMolecule
cellular location: Inner Membrane
entity reference: L-Methionine

Reference/ChEBI CHEBI 17148
type: UnificationXref
id: CHEBI:17148
db: ChEBI

Reference/ChEBI CHEBI 16610
type: UnificationXref
id: CHEBI:16610
db: ChEBI

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C000855/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Methylthioribose
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/HMDB HMDB0000696
type: UnificationXref
id: HMDB0000696
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

spermidine acetyltransferase
type: Complex
component stoichiometry: Protein/28270/Stoichiometry/4.0
component: Unknown

Reference/ChemSpider 110264
type: UnificationXref
id: 110264
db: ChemSpider

Hydrogen Ion
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Hydrogen Ion

5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
type: Complex
component stoichiometry: Protein/28270/Stoichiometry/2.0
component: Unknown

Spermidine synthase
type: Complex
component stoichiometry: Protein/28270/Stoichiometry/2.0
component: Unknown

adenosylmethionine decarboxylase
type: Complex
component stoichiometry: Protein/28270/Stoichiometry/8.0
component: Unknown

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/CAS 110-60-1
type: UnificationXref
id: 110-60-1
db: CAS

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

5'-S-methyl-5'-thioadenosine
type: SmallMoleculeReference
chemical formula: C11H15N5O3S
molecular weight: 297.08957
structure: ChemicalStructure/PW C042677

Reference/BioCyc ADENINE
type: UnificationXref
id: ADENINE
db: BioCyc

Protein/28270 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C000024
type: ChemicalStructure
structure format: SMILES
structure data: NC1=C2NC=NC2=NC=N1

Reference/PubChem-compound 123689
type: UnificationXref
id: 123689
db: PubChem-compound

ChemicalStructure/PW C001476
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)NCCCCNCCCN

Compound/PW C001476/Stoichiometry/1.0
type: Stoichiometry
physical entity: N8-Acetylspermidine
stoichiometric coefficient: 1.0

Protein/28270/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

3.6.3.-
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
right: Phosphate
right: Adenosine diphosphate
right: Hydrogen Ion
right: L-Methionine
spontaneous: false
EC number: 3.6.3.-
left: Water
left: Adenosine triphosphate
left: L-Methionine
name: Adenosine triphosphate + L-Methionine + Water → Adenosine diphosphate + Hydrogen Ion + L-Methionine + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Reference/ChEBI CHEBI 15625
type: UnificationXref
id: CHEBI:15625
db: ChEBI

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/KEGG Compound C03089
type: UnificationXref
id: C03089
db: KEGG Compound

Reference/KEGG Compound C00134
type: UnificationXref
id: C00134
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

ReactionCoupledTransportCatalysis8217
type: Catalysis
controller: L-methionine / D-methionine ABC transporter
controlled: 3.6.3.-
control type: ACTIVATION

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

methionine adenosyltransferase
type: Complex
component stoichiometry: Protein/28270 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Unknown

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Spermidine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00315
xref: Reference/HMDB HMDB0001257
xref: Reference/ChEBI CHEBI 16610
xref: Reference/CAS 124-20-9
xref: Reference/BioCyc SPERMIDINE
xref: Reference/PubChem-compound 1102
xref: Reference/ChemSpider 1071
chemical formula: C7H19N3
molecular weight: 145.1579
structure: ChemicalStructure/PW C000971

Reference/PubChem-compound 439415
type: UnificationXref
id: 439415
db: PubChem-compound

Reference/ChEBI CHEBI 16708
type: UnificationXref
id: CHEBI:16708
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/CAS 22365-13-5
type: UnificationXref
id: 22365-13-5
db: CAS

5-Methylthioribose
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16895
xref: Reference/CAS 23656-67-9
xref: Reference/ChemSpider 388938
xref: Reference/BioCyc CPD-560
xref: Reference/PubChem-compound 439904
xref: Reference/HMDB HMDB0001087
xref: Reference/KEGG Compound C03089
chemical formula: C6H12O4S
molecular weight: 180.04562
structure: ChemicalStructure/PW C000855

Reference/PubChem-compound 1102
type: UnificationXref
id: 1102
db: PubChem-compound

L-Methionine
type: SmallMolecule
cellular location: Outer Membrane
entity reference: L-Methionine

Reference/BioCyc MET
type: UnificationXref
id: MET
db: BioCyc

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/BioCyc CPD-560
type: UnificationXref
id: CPD-560
db: BioCyc

Reference/KEGG Compound C00147
type: UnificationXref
id: C00147
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Protein/28270 Outer Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Compound/PW C000921/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Compound/PW C000548 Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

Compound/PW C000971/Stoichiometry/1.0
type: Stoichiometry
physical entity: Spermidine
stoichiometric coefficient: 1.0

Reference/CAS 73-24-5
type: UnificationXref
id: 73-24-5
db: CAS

Reference/ChEBI CHEBI 16895
type: UnificationXref
id: CHEBI:16895
db: ChEBI

L-Methionine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000696
xref: Reference/ChEBI CHEBI 16643
xref: Reference/KEGG Compound C00073
xref: Reference/CAS 63-68-3
xref: Reference/BioCyc MET
xref: Reference/PubChem-compound 6137
xref: Reference/ChemSpider 5907
chemical formula: C5H11NO2S
molecular weight: 149.05106
structure: ChemicalStructure/PW C000548

Hydrogen Ion
type: SmallMolecule
cellular location: Outer Membrane
entity reference: Hydrogen Ion

Reference/BioCyc PUTRESCINE
type: UnificationXref
id: PUTRESCINE
db: BioCyc

4.1.1.50
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: S-Adenosylmethioninamine
right: Carbon dioxide
spontaneous: false
EC number: 4.1.1.50
left: Hydrogen Ion
left: S-Adenosylmethionine
name: Hydrogen Ion + S-Adenosylmethionine → Carbon dioxide + S-Adenosylmethioninamine
conversion direction: LEFT_TO_RIGHT

2.5.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042677/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001092/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000971/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: 5'-S-methyl-5'-thioadenosine
right: Hydrogen Ion
right: Spermidine
spontaneous: false
EC number: 2.5.1.-
left: S-Adenosylmethioninamine
left: Putrescine
name: Putrescine + S-Adenosylmethioninamine → 5'-S-methyl-5'-thioadenosine + Hydrogen Ion + Spermidine
conversion direction: LEFT_TO_RIGHT

Adenosine triphosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Adenosine triphosphate

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Water
type: SmallMolecule
entity reference: Water

Compound/PW C000024/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenine
stoichiometric coefficient: 1.0

Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0043165

Reference/GENE ONTOLOGY GO 0043165
type: UnificationXref
id: GO:0043165
db: GENE ONTOLOGY

L-methionine / D-methionine ABC transporter
type: Complex
component stoichiometry: Protein/28270 Inner Membrane/Stoichiometry/2.0
cellular location: Inner Membrane
component: Unknown

ChemicalStructure/PW C000971
type: ChemicalStructure
structure format: SMILES
structure data: NCCCCNCCCN

2.5.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000548 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Pyrophosphate
right: S-Adenosylmethionine
spontaneous: false
EC number: 2.5.1.6
left: Adenosine triphosphate
left: L-Methionine
left: Water
name: Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine
conversion direction: LEFT_TO_RIGHT

3.2.2.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000024/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042677/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000855/Stoichiometry/1.0
right: Adenine
right: 5-Methylthioribose
spontaneous: false
EC number: 3.2.2.9
left: 5'-S-methyl-5'-thioadenosine
left: Water
name: 5'-S-methyl-5'-thioadenosine + Water → 5-Methylthioribose + Adenine
conversion direction: LEFT_TO_RIGHT

2.3.1.57
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001476/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000971/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Coenzyme A
right: N8-Acetylspermidine
right: Hydrogen Ion
spontaneous: false
EC number: 2.3.1.57
left: Acetyl-CoA
left: Spermidine
name: Acetyl-CoA + Spermidine → Coenzyme A + Hydrogen Ion + N8-Acetylspermidine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Phosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Phosphate

Reference/TAXONOMY 585034
type: UnificationXref
id: 585034
db: TAXONOMY

Protein/28270/Stoichiometry/8.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 8.0

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Compound/PW C001420 Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000855
type: ChemicalStructure
structure format: SMILES
structure data: CSC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O

Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 1071
type: UnificationXref
id: 1071
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/KEGG Compound C01137
type: UnificationXref
id: C01137
db: KEGG Compound

Reference/BioCyc CPD-3462
type: UnificationXref
id: CPD-3462
db: BioCyc

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Putrescine
type: SmallMolecule
entity reference: Putrescine

Reference/ChemSpider 388529
type: UnificationXref
id: 388529
db: ChemSpider

Unknown
type: Protein
cellular location: Outer Membrane
entity reference: Unknown

Putrescine
type: SmallMoleculeReference
xref: Reference/CAS 110-60-1
xref: Reference/BioCyc PUTRESCINE
xref: Reference/ChEBI CHEBI 17148
xref: Reference/HMDB HMDB0001414
xref: Reference/ChemSpider 13837702
xref: Reference/KEGG Compound C00134
xref: Reference/PubChem-compound 1045
chemical formula: C4H12N2
molecular weight: 88.10005
structure: ChemicalStructure/PW C001092

Water
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Water

5'-S-methyl-5'-thioadenosine
type: SmallMolecule
entity reference: 5'-S-methyl-5'-thioadenosine

Reference/KEGG Compound C01029
type: UnificationXref
id: C01029
db: KEGG Compound

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Compound/PW C001034 Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Compound/PW C042677/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5'-S-methyl-5'-thioadenosine
stoichiometric coefficient: 1.0

ReactionCatalysis1121739
type: Catalysis
controller: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
controlled: 3.2.2.9
control type: ACTIVATION

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

ReactionCatalysis1121738
type: Catalysis
controller: Spermidine synthase
controlled: 2.5.1.-
control type: ACTIVATION

ReactionCatalysis1121737
type: Catalysis
controller: adenosylmethionine decarboxylase
controlled: 4.1.1.50
control type: ACTIVATION

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

ReactionCatalysis1121740
type: Catalysis
controller: spermidine acetyltransferase
controlled: 2.3.1.57
control type: ACTIVATION

Reference/HMDB HMDB0000034
type: UnificationXref
id: HMDB0000034
db: HMDB

Compound/PW C000170 Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Unknown
type: Protein
cellular location: Inner Membrane
entity reference: Unknown

Reference/CAS 63-68-3
type: UnificationXref
id: 63-68-3
db: CAS

Reference/ChemSpider 5907
type: UnificationXref
id: 5907
db: ChemSpider

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/SMPDB SMP0000834
type: UnificationXref
id: SMP0000834
db: SMPDB

Reference/ChEBI CHEBI 16643
type: UnificationXref
id: CHEBI:16643
db: ChEBI

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ReactionCatalysis1121741
type: Catalysis
controller: methionine adenosyltransferase
controlled: 2.5.1.6
control type: ACTIVATION

Reference/HMDB HMDB0001257
type: UnificationXref
id: HMDB0001257
db: HMDB

S-Adenosylmethioninamine
type: SmallMolecule
entity reference: S-Adenosylmethioninamine

Reference/KEGG Compound C00073
type: UnificationXref
id: C00073
db: KEGG Compound

S-Adenosylmethioninamine
type: SmallMoleculeReference
xref: Reference/CAS 22365-13-5
xref: Reference/ChEBI CHEBI 15625
xref: Reference/HMDB HMDB0000988
xref: Reference/ChemSpider 388529
xref: Reference/PubChem-compound 439415
xref: Reference/KEGG Compound C01137
xref: Reference/BioCyc S-ADENOSYLMETHIONINAMINE
chemical formula: C14H23N6O3S
molecular weight: 355.15524
structure: ChemicalStructure/PW C000783

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

L-Methionine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Methionine
name: SubPathwayOutput

L-methionine / D-methionine ABC transporter
type: Complex
component stoichiometry: Protein/28270 Outer Membrane/Stoichiometry/2.0
cellular location: Outer Membrane
component: Unknown

ReactionCoupledTransport14287
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000170 Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Outer Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: L-Methionine
right: Pyrophosphate
spontaneous: false
left: Adenosine triphosphate
left: Water
left: L-Methionine
name: Adenosine triphosphate + L-Methionine + Water → Adenosine diphosphate + Hydrogen Ion + L-Methionine + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/ChEBI CHEBI 27911
type: UnificationXref
id: CHEBI:27911
db: ChEBI

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/PathWhiz PW000814
type: UnificationXref
id: PW000814
db: PathWhiz

Compound/PW C000783/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethioninamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

S-Adenosylmethionine
type: SmallMolecule
entity reference: S-Adenosylmethionine

Reference/PubChem-compound 1045
type: UnificationXref
id: 1045
db: PubChem-compound

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

ChemicalStructure/PW C000783
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 439904
type: UnificationXref
id: 439904
db: PubChem-compound

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

S-Adenosyl-L-Methionine Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/6597905
pathway order: PathwayEnzymeReaction/6597904
pathway order: PathwayEnzymeReaction/6597907
pathway order: PathwayEnzymeReaction/6597906
pathway order: PathwayEnzymeReaction/6597909
pathway order: PathwayEnzymeReaction/6597908
pathway order: PathwayEnzymeReaction/6597910
pathway order: PathwaySubPathway/489595
pathway component: 3.6.3.-
pathway component: 4.1.1.50
pathway component: 2.5.1.-
pathway component: ReactionCatalysis1121739
pathway component: ReactionCatalysis1121738
pathway component: ReactionCatalysis1121737
pathway component: ReactionCatalysis1121741
pathway component: ReactionCoupledTransportCatalysis8217
pathway component: ReactionCoupledTransport14287
pathway component: ReactionCoupledTransportCatalysis14349
pathway component: ReactionCatalysis1121740
pathway component: 2.5.1.6
pathway component: Methionine Biosynthesis
pathway component: 3.2.2.9
pathway component: 2.3.1.57
xref: Reference/SMPDB SMP0448972
xref: Reference/PathWhiz PW465973
organism: Escherichia coli IAI1

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/HMDB HMDB0000988
type: UnificationXref
id: HMDB0000988
db: HMDB

ReactionCoupledTransportCatalysis14349
type: Catalysis
controller: L-methionine / D-methionine ABC transporter
controlled: ReactionCoupledTransport14287
control type: ACTIVATION

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/PubChem-compound 190
type: UnificationXref
id: 190
db: PubChem-compound

Reference/ChemSpider 388938
type: UnificationXref
id: 388938
db: ChemSpider

Compound/PW C000548 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/BioCyc SPERMIDINE
type: UnificationXref
id: SPERMIDINE
db: BioCyc

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

SubPathwayInteraction489595
type: Interaction
name: SubPathway489595Reaction
name: SubPathwayReaction
participant: L-Methionine

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Compound/PW C040034 Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Reference/CAS 13431-24-8
type: UnificationXref
id: 13431-24-8
db: CAS

Reference/ChemSpider 185
type: UnificationXref
id: 185
db: ChemSpider

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Adenosine diphosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Adenosine diphosphate

Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0