7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid → 7,8-dihydrofolate monoglutamate + Adenosine diphosphate + Hydrogen Ion + Phosphate
Chorismate + L-Glutamine → 4-amino-4-deoxychorismate + L-Glutamic acid
7,8-dihydrofolate monoglutamate + Hydrogen Ion + NADPH → NADP + Tetrahydrofolic acid
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
7,8-dihydroneopterin 3'-phosphate + Water → 7,8-Dihydroneopterin + Phosphate
7,8-Dihydroneopterin → 6-hydroxymethyl-7,8-dihydropterin + Glycolaldehyde
Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion
7,8-dihydroneopterin 3'-triphosphate + Water → 7,8-dihydroneopterin 3'-phosphate + Hydrogen Ion + Pyrophosphate
4-amino-4-deoxychorismate → Hydrogen Ion + Pyruvic acid + p-Aminobenzoic acid
6-hydroxymethyl-7,8-dihydropterin + Adenosine triphosphate → (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + Adenosine monophosphate + Hydrogen Ion
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + p-Aminobenzoic acid → 7,8-Dihydropteroic acid + Pyrophosphate