1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide → PhosphoribosylformiminoAICAR-phosphate
Phosphoribosyl-AMP + Water → 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
Phosphoribosyl-ATP + Water → Hydrogen Ion + Phosphoribosyl-AMP + Pyrophosphate
Hydrogen Ion + Phosphoribosyl pyrophosphate → Phosphoribosyl-ATP + Pyrophosphate
Imidazole acetol-phosphate + L-Glutamic acid → L-histidinol-phosphate + Oxoglutaric acid
L-histidinol-phosphate + Water → L-Histidinol + Phosphate
L-Histidine inhibits ATP phosphoribosyltransferase
D-Erythro-imidazole-glycerol-phosphate → Imidazole acetol-phosphate + Water
L-Glutamine + PhosphoribosylformiminoAICAR-phosphate → 5-Aminoimidazole-4-carboxamide + D-Erythro-imidazole-glycerol-phosphate + Hydrogen Ion + L-Glutamic acid
Imidazole glycerol phosphate synthase subunit HisH
histidinal dehydrogenase / histidinol dehydrogenase
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
D,D-heptose 1,7-bisphosphate phosphatase
Histidinal + NAD + Water → 2 Hydrogen Ion + L-Histidine + NADH
L-Histidinol + NAD → Histidinal + Hydrogen Ion + NADH
imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase
Secondary Metabolites: Histidine Biosynthesis