Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/ChEBI CHEBI 15961
type: UnificationXref
id: CHEBI:15961
db: ChEBI

Reference/BioCyc O-PHOSPHO-L-HOMOSERINE
type: UnificationXref
id: O-PHOSPHO-L-HOMOSERINE
db: BioCyc

Reference/PathWhiz PW474321
type: UnificationXref
id: PW474321
db: PathWhiz

ReactionCatalysis782624
type: Catalysis
controller: aspartate kinase / homoserine dehydrogenase
controlled: 2.7.2.4
control type: ACTIVATION

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/CAS 22138-53-0
type: UnificationXref
id: 22138-53-0
db: CAS

ChemicalStructure/PW C000570
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCO)C(O)=O

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003484
type: UnificationXref
id: HMDB0003484
db: HMDB

Reference/ChemSpider 809
type: UnificationXref
id: 809
db: ChemSpider

Propanoate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway500099
pathway component: SubPathwayInteraction500099
xref: Reference/SMPDB SMP0000957
xref: Reference/PathWhiz PW000940
name: SubPathway

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/KEGG Compound C00441
type: UnificationXref
id: C00441
db: KEGG Compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C001905/Stoichiometry/1.0
type: Stoichiometry
physical entity: O-Phosphohomoserine
stoichiometric coefficient: 1.0

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reference/SMPDB SMP0456107
type: UnificationXref
id: SMP0456107
db: SMPDB

Reference/PubChem-compound 6288
type: UnificationXref
id: 6288
db: PubChem-compound

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Reference/BioCyc THR
type: UnificationXref
id: THR
db: BioCyc

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

2.7.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007795/Stoichiometry/1.0
right: Adenosine diphosphate
right: L-Aspartyl-4-phosphate
spontaneous: false
EC number: 2.7.2.4
left: L-Aspartic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Aspartic acid → Adenosine diphosphate + L-Aspartyl-4-phosphate
conversion direction: LEFT_TO_RIGHT

O-Phosphohomoserine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 151187
xref: Reference/CAS 4210-66-6
xref: Reference/ChEBI CHEBI 15961
xref: Reference/BioCyc O-PHOSPHO-L-HOMOSERINE
xref: Reference/ChemSpider 133252
xref: Reference/HMDB HMDB0003484
xref: Reference/KEGG Compound C01102
chemical formula: C4H10NO6P
molecular weight: 199.02457
structure: ChemicalStructure/PW C001905

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

NADP
type: SmallMolecule
entity reference: NADP

aspartate kinase / homoserine dehydrogenase
type: Complex
component stoichiometry: Protein/28020/Stoichiometry/2.0
component: Unknown

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

ReactionCatalysis782661
type: Catalysis
controller: homoserine kinase
controlled: 2.7.1.39
control type: ACTIVATION

ReactionCatalysis782660
type: Catalysis
controller: aspartate semialdehyde dehydrogenase
controlled: Reaction779767
control type: ACTIVATION

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Unknown
type: Protein
entity reference: Unknown

Reference/PathWhiz PW000787
type: UnificationXref
id: PW000787
db: PathWhiz

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 16857
type: UnificationXref
id: CHEBI:16857
db: ChEBI

Reference/CAS 672-15-1
type: UnificationXref
id: 672-15-1
db: CAS

ReactionCatalysis782664
type: Catalysis
controller: Unknown
controlled: 4.2.3.1
control type: ACTIVATION

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/CAS 72-19-5
type: UnificationXref
id: 72-19-5
db: CAS

Reference/CAS 4210-66-6
type: UnificationXref
id: 4210-66-6
db: CAS

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/ChEBI CHEBI 48052
type: UnificationXref
id: CHEBI:48052
db: ChEBI

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

ChemicalStructure/PW C001905
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCOP(O)(O)=O)C(O)=O

Reference/PubChem-compound 17
type: UnificationXref
id: 17
db: PubChem-compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

2.7.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000570/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007794/Stoichiometry/1.0
right: L-Homoserine
right: NADP
spontaneous: false
EC number: 2.7.2.4
left: L-Aspartate-semialdehyde
left: Hydrogen Ion
left: NADPH
name: Hydrogen Ion + L-Aspartate-semialdehyde + NADPH → L-Homoserine + NADP
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/ChemSpider 6051
type: UnificationXref
id: 6051
db: ChemSpider

Reference/KEGG Compound C03082
type: UnificationXref
id: C03082
db: KEGG Compound

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Aspartate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway500098
pathway component: SubPathwayInteraction500098
xref: Reference/PathWhiz PW000787
xref: Reference/SMPDB SMP0000809
name: SubPathway

Compound/PW C000123/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

ChemicalStructure/PW C000109
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@H](O)[C@H](N)C(O)=O

Reference/KEGG Compound C01102
type: UnificationXref
id: C01102
db: KEGG Compound

Compound/PW C000570/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Homoserine
stoichiometric coefficient: 1.0

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/ChemSpider 12126
type: UnificationXref
id: 12126
db: ChemSpider

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00263
type: UnificationXref
id: C00263
db: KEGG Compound

Compound/PW C007794/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartate-semialdehyde
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

Protein/28020/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

ChemicalStructure/PW C007794
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC=O)C(O)=O

Prevotella copri
type: BioSource
xref: Reference/TAXONOMY 165179

ChemicalStructure/PW C007795
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)OP(O)(O)=O)C(O)=O

ChemicalStructure/PW C007792
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1CC=CC(=N1)C(O)=O

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/SMPDB SMP0000809
type: UnificationXref
id: SMP0000809
db: SMPDB

L-Homoserine
type: SmallMolecule
entity reference: L-Homoserine

Water
type: SmallMolecule
entity reference: Water

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/HMDB HMDB0012247
type: UnificationXref
id: HMDB0012247
db: HMDB

Reference/HMDB HMDB0012249
type: UnificationXref
id: HMDB0012249
db: HMDB

Reference/ChEBI CHEBI 15699
type: UnificationXref
id: CHEBI:15699
db: ChEBI

SubPathwayInteraction500098
type: Interaction
name: SubPathway500098Reaction
name: SubPathwayReaction
participant: L-Aspartic acid

SubPathwayInteraction500099
type: Interaction
name: SubPathway500099Reaction
name: SubPathwayReaction
participant: L-Threonine

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Compound/PW C007792/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-2,3-Dihydrodipicolinate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/PubChem-compound 12647
type: UnificationXref
id: 12647
db: PubChem-compound

homoserine kinase
type: Complex
component stoichiometry: Protein/28020/Stoichiometry/2.0
component: Unknown

Reference/HMDB HMDB0012250
type: UnificationXref
id: HMDB0012250
db: HMDB

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reaction779767
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007795/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007794/Stoichiometry/1.0
right: NADP
right: L-Aspartate-semialdehyde
right: Phosphate
spontaneous: false
left: Hydrogen Ion
left: L-Aspartyl-4-phosphate
left: NADPH
name: Hydrogen Ion + L-Aspartyl-4-phosphate + NADPH → L-Aspartate-semialdehyde + NADP + Phosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.39
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000570/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001905/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: O-Phosphohomoserine
spontaneous: false
EC number: 2.7.1.39
left: L-Homoserine
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Homoserine → Adenosine diphosphate + Hydrogen Ion + O-Phosphohomoserine
conversion direction: LEFT_TO_RIGHT

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/BioCyc L-BETA-ASPARTYL-P
type: UnificationXref
id: L-BETA-ASPARTYL-P
db: BioCyc

4.2.3.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000109/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001905/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: L-Threonine
right: Phosphate
spontaneous: false
EC number: 4.2.3.1
left: Water
left: O-Phosphohomoserine
name: O-Phosphohomoserine + Water → L-Threonine + Phosphate
conversion direction: LEFT_TO_RIGHT

Unknown
type: ProteinReference

Reference/SMPDB SMP0000957
type: UnificationXref
id: SMP0000957
db: SMPDB

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Reference/KEGG Compound C00188
type: UnificationXref
id: C00188
db: KEGG Compound

Reference/BioCyc ALPHA-N-ACETYLNEURAMINYL-ETCETERA
type: UnificationXref
id: ALPHA-N-ACETYLNEURAMINYL-ETCETERA
db: BioCyc

Reference/CAS 16052-12-3
type: UnificationXref
id: 16052-12-3
db: CAS

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/HMDB HMDB0000719
type: UnificationXref
id: HMDB0000719
db: HMDB

Reference/HMDB HMDB0000167
type: UnificationXref
id: HMDB0000167
db: HMDB

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Compound/PW C000109/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Threonine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03340
type: UnificationXref
id: C03340
db: KEGG Compound

Protein/28020/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/TAXONOMY 165179
type: UnificationXref
id: 165179
db: TAXONOMY

Compound/PW C007795/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartyl-4-phosphate
stoichiometric coefficient: 1.0

Reaction1149430
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/2.0
participant stoichiometry: Compound/PW C007792/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007794/Stoichiometry/1.0
right: Water
right: L-2,3-Dihydrodipicolinate
spontaneous: false
left: L-Aspartate-semialdehyde
left: Pyruvic acid
name: L-Aspartate-semialdehyde + Pyruvic acid ↔ L-2,3-Dihydrodipicolinate + 2 Water
conversion direction: REVERSIBLE

Reference/ChemSpider 133252
type: UnificationXref
id: 133252
db: ChemSpider

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/PubChem-compound 151187
type: UnificationXref
id: 151187
db: PubChem-compound

L-Threonine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000167
xref: Reference/PubChem-compound 6288
xref: Reference/CAS 72-19-5
xref: Reference/ChemSpider 6051
xref: Reference/ChEBI CHEBI 16857
xref: Reference/KEGG Compound C00188
xref: Reference/BioCyc THR
chemical formula: C4H9NO3
molecular weight: 119.05824
structure: ChemicalStructure/PW C000109

ReactionCatalysis594516
type: Catalysis
controller: Aspartate kinase
controlled: 2.7.2.4
control type: ACTIVATION

Reference/PathWhiz PW000940
type: UnificationXref
id: PW000940
db: PathWhiz

O-Phosphohomoserine
type: SmallMolecule
entity reference: O-Phosphohomoserine

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Phosphate
type: SmallMolecule
entity reference: Phosphate

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439235
type: UnificationXref
id: 439235
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/ChemSpider 16
type: UnificationXref
id: 16
db: ChemSpider

Reference/CAS 15106-57-7
type: UnificationXref
id: 15106-57-7
db: CAS

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Secondary Metabolites: Threonine Biosynthesis from Aspartate
type: Pathway
pathway order: PathwayEnzymeReaction/6710269
pathway order: PathwaySubPathway/500098
pathway order: PathwayEnzymeReaction/6710265
pathway order: PathwayEnzymeReaction/6710263
pathway order: PathwayEnzymeReaction/6710274
pathway order: PathwayEnzymeReaction/6710271
pathway order: PathwaySubPathway/500099
pathway order: PathwayEnzymeReaction/6710259
pathway component: 2.7.2.4
pathway component: ReactionCatalysis782661
pathway component: Aspartate Metabolism
pathway component: ReactionCatalysis782660
pathway component: ReactionCatalysis594516
pathway component: Propanoate Metabolism
pathway component: ReactionCatalysis782624
pathway component: ReactionCatalysis782664
pathway component: Reaction779767
pathway component: 2.7.1.39
pathway component: 4.2.3.1
pathway component: Reaction1149430
pathway component: ReactionCatalysis1176108
xref: Reference/PathWhiz PW474321
xref: Reference/SMPDB SMP0456107
organism: Prevotella copri

ReactionCatalysis1176108
type: Catalysis
controller: 4-hydroxy-tetrahydrodipicolinate synthase
controlled: Reaction1149430
control type: ACTIVATION

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/PubChem-compound 832
type: UnificationXref
id: 832
db: PubChem-compound

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

L-Aspartyl-4-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc L-BETA-ASPARTYL-P
xref: Reference/KEGG Compound C03082
xref: Reference/ChemSpider 809
xref: Reference/PubChem-compound 832
xref: Reference/CAS 22138-53-0
xref: Reference/HMDB HMDB0012250
chemical formula: C4H8NO7P
molecular weight: 213.00385
structure: ChemicalStructure/PW C007795

L-Aspartic acid
type: SmallMolecule
entity reference: L-Aspartic acid
name: SubPathwayOutput

L-Aspartate-semialdehyde
type: SmallMolecule
entity reference: L-Aspartate-semialdehyde

L-Aspartyl-4-phosphate
type: SmallMolecule
entity reference: L-Aspartyl-4-phosphate

L-2,3-Dihydrodipicolinate
type: SmallMolecule
entity reference: L-2,3-Dihydrodipicolinate

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

L-Aspartate-semialdehyde
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439235
xref: Reference/HMDB HMDB0012249
xref: Reference/ChEBI CHEBI 18051
xref: Reference/KEGG Compound C00441
xref: Reference/ChemSpider 388372
xref: Reference/CAS 15106-57-7
xref: Reference/BioCyc L-ASPARTATE-SEMIALDEHYDE
chemical formula: C4H7NO3
molecular weight: 117.042595
structure: ChemicalStructure/PW C007794

L-2,3-Dihydrodipicolinate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03340
xref: Reference/HMDB HMDB0012247
xref: Reference/PubChem-compound 17
xref: Reference/ChemSpider 16
xref: Reference/ChEBI CHEBI 48052
xref: Reference/BioCyc ALPHA-N-ACETYLNEURAMINYL-ETCETERA
xref: Reference/CAS 16052-12-3
chemical formula: C7H7NO4
molecular weight: 169.0375
structure: ChemicalStructure/PW C007792

Reference/ChemSpider 388372
type: UnificationXref
id: 388372
db: ChemSpider

Aspartate kinase
type: Complex
component stoichiometry: Protein/28020/Stoichiometry/2.0
component: Unknown

aspartate semialdehyde dehydrogenase
type: Complex
component stoichiometry: Protein/28020/Stoichiometry/2.0
component: Unknown

Reference/BioCyc L-ASPARTATE-SEMIALDEHYDE
type: UnificationXref
id: L-ASPARTATE-SEMIALDEHYDE
db: BioCyc

4-hydroxy-tetrahydrodipicolinate synthase
type: Complex
component stoichiometry: Protein/28020/Stoichiometry/4.0
component: Unknown

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc HOMO-SER
type: UnificationXref
id: HOMO-SER
db: BioCyc

Reference/ChEBI CHEBI 18051
type: UnificationXref
id: CHEBI:18051
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

L-Homoserine
type: SmallMoleculeReference
xref: Reference/BioCyc HOMO-SER
xref: Reference/ChEBI CHEBI 15699
xref: Reference/CAS 672-15-1
xref: Reference/KEGG Compound C00263
xref: Reference/PubChem-compound 12647
xref: Reference/HMDB HMDB0000719
xref: Reference/ChemSpider 12126
chemical formula: C4H9NO3
molecular weight: 119.05824
structure: ChemicalStructure/PW C000570

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

L-Threonine
type: SmallMolecule
entity reference: L-Threonine
name: SubPathwayInput

Compound/PW C001420/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0