Cyclic pyranopterin monophosphate
type: SmallMolecule
entity reference: Cyclic pyranopterin monophosphate

Reference/ChEBI CHEBI 71308
type: UnificationXref
id: CHEBI:71308
db: ChEBI

ChemicalStructure/PW C001537
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)CO)N1

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C042896/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidylyl molybdenum cofactor
stoichiometric coefficient: 1.0

Molybdate
type: SmallMolecule
entity reference: Molybdate

Compound/Generic235/Stoichiometry/1.0
type: Stoichiometry
physical entity: thiocarboxylated small subunit of molybdopterin synthase
stoichiometric coefficient: 1.0

Cytidine triphosphate
type: SmallMolecule
entity reference: Cytidine triphosphate

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/ChemSpider 26332851
type: UnificationXref
id: 26332851
db: ChemSpider

molybdopterin molybdenumtransferase
type: Complex
component stoichiometry: Protein/29295/Stoichiometry/2.0
component: Unknown

molybdopterin adenylyltransferase
type: Complex
component stoichiometry: Protein/29295/Stoichiometry/3.0
component: Unknown

Reference/KEGG Compound C19848
type: UnificationXref
id: C19848
db: KEGG Compound

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Unknown
type: ProteinReference

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

molybdopterin synthase
type: Complex
component stoichiometry: Protein/29295/Stoichiometry/2.0
component: Unknown

Reference/HMDB HMDB0002275
type: UnificationXref
id: HMDB0002275
db: HMDB

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/ChemSpider 4883416
type: UnificationXref
id: 4883416
db: ChemSpider

Adenylyl-molybdopterin
type: SmallMolecule
entity reference: Adenylyl-molybdopterin

ChemicalStructure/PW C042896
type: ChemicalStructure
structure format: SMILES

7,8-dihydroneopterin 3'-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25245170
chemical formula: C9H12N5O7P
molecular weight: 333.04742
structure: ChemicalStructure/PW C042913

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

7,8-dihydroneopterin 3'-triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25201779
chemical formula: C9H12N5O13P3
molecular weight: 490.96664
structure: ChemicalStructure/PW C042912

Reference/BioCyc DIHYDROXYPHENYLGLYCOLALDEHYDE
type: UnificationXref
id: DIHYDROXYPHENYLGLYCOLALDEHYDE
db: BioCyc

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Molybdopterin
type: SmallMolecule
entity reference: Molybdopterin

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Molybdopterin
type: SmallMoleculeReference
xref: Reference/ChemSpider 4883416
xref: Reference/KEGG Compound C05924
xref: Reference/BioCyc CPD0-1882
xref: Reference/ChEBI CHEBI 21437
xref: Reference/HMDB HMDB0002206
xref: Reference/PubChem-compound 23304237
xref: Reference/CAS 73508-07-3
chemical formula: C10H16MoN5O8PS2
molecular weight: 526.9232
structure: ChemicalStructure/PW C001491

Adenylyl-molybdopterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 62728
xref: Reference/PubChem-compound 53356705
xref: Reference/ChemSpider 26332851
xref: Reference/KEGG Compound C19848
xref: Reference/HMDB HMDB0059628
chemical formula: C20H26N10O12P2S2
molecular weight: 724.0648
structure: ChemicalStructure/PW C040065

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
type: SmallMolecule
entity reference: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate

6-hydroxymethyl-7,8-dihydropterin
type: SmallMolecule
entity reference: 6-hydroxymethyl-7,8-dihydropterin

Compound/PW C040065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenylyl-molybdopterin
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Protein/29295/Stoichiometry/10.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 10.0

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Reference/ChEBI CHEBI 62728
type: UnificationXref
id: CHEBI:62728
db: ChEBI

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Reference/PubChem-compound 25245170
type: UnificationXref
id: 25245170
db: PubChem-compound

Reference/SMPDB SMP0457224
type: UnificationXref
id: SMP0457224
db: SMPDB

Compound/PW C001850/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycolaldehyde
stoichiometric coefficient: 1.0

Cyclic pyranopterin monophosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 17221217
xref: Reference/HMDB HMDB0059639
xref: Reference/ChEBI CHEBI 60210
xref: Reference/KEGG Compound C18239
xref: Reference/PubChem-compound 16061579
chemical formula: C10H14N5O8P
molecular weight: 363.058
structure: ChemicalStructure/PW C040076

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/BioCyc DIHYDRONEOPTERIN-P3
type: UnificationXref
id: DIHYDRONEOPTERIN-P3
db: BioCyc

Compound/PW C000092/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Reference/KEGG Compound C05924
type: UnificationXref
id: C05924
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/PubChem-compound 23304237
type: UnificationXref
id: 23304237
db: PubChem-compound

Compound/PW C007805/Stoichiometry/1.0
type: Stoichiometry
physical entity: Molybdate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Compound/PW C000057/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 2137
type: UnificationXref
id: CHEBI:2137
db: ChEBI

Formic acid
type: SmallMolecule
entity reference: Formic acid

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/ChemSpider 17221217
type: UnificationXref
id: 17221217
db: ChemSpider

Reference/BioCyc CTP
type: UnificationXref
id: CTP
db: BioCyc

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/CAS 141-46-8
type: UnificationXref
id: 141-46-8
db: CAS

molybdenum cofactor
type: SmallMolecule
entity reference: molybdenum cofactor

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Glycolaldehyde
type: SmallMolecule
entity reference: Glycolaldehyde

Reference/KEGG Compound C06232
type: UnificationXref
id: C06232
db: KEGG Compound

Reference/PubChem-compound 46173482
type: UnificationXref
id: 46173482
db: PubChem-compound

Glycolaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17071
xref: Reference/PubChem-compound 756
xref: Reference/BioCyc DIHYDROXYPHENYLGLYCOLALDEHYDE
xref: Reference/ChemSpider 736
xref: Reference/HMDB HMDB0003344
xref: Reference/CAS 141-46-8
xref: Reference/KEGG Compound C00266
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C001850

thiocarboxylated small subunit of molybdopterin synthase
type: SmallMolecule
entity reference: thiocarboxylated small subunit of molybdopterin synthase

Weissella cibaria KACC 11862
type: BioSource
xref: Reference/TAXONOMY 911104

Protein/29295/Stoichiometry/3.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 3.0

molybdenum cofactor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 2137
chemical formula: C10H18MoN5O8PS2
molecular weight: 528.93884
structure: ChemicalStructure/PW C044506

Reference/CAS 7782-91-4
type: UnificationXref
id: 7782-91-4
db: CAS

7,8-dihydroneopterin 3'-triphosphate
type: SmallMolecule
entity reference: 7,8-dihydroneopterin 3'-triphosphate

Reference/HMDB HMDB0059628
type: UnificationXref
id: HMDB0059628
db: HMDB

2.7.7.76
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044506/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042896/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Cytidylyl molybdenum cofactor
right: Pyrophosphate
spontaneous: false
EC number: 2.7.7.76
left: Cytidine triphosphate
left: Hydrogen Ion
left: molybdenum cofactor
name: Cytidine triphosphate + Hydrogen Ion + molybdenum cofactor → Cytidylyl molybdenum cofactor + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

7,8-dihydroneopterin 3'-phosphate
type: SmallMolecule
entity reference: 7,8-dihydroneopterin 3'-phosphate

Reference/ChEBI CHEBI 17001
type: UnificationXref
id: CHEBI:17001
db: ChEBI

Compound/Generic235/Stoichiometry/2.0
type: Stoichiometry
physical entity: thiocarboxylated small subunit of molybdopterin synthase
stoichiometric coefficient: 2.0

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Compound/PW C040774/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-hydroxymethyl-7,8-dihydropterin
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Cytidine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17677
xref: Reference/CAS 65-47-4
xref: Reference/PubChem-compound 6176
xref: Reference/KEGG Compound C00063
xref: Reference/ChemSpider 5941
xref: Reference/HMDB HMDB0000082
xref: Reference/BioCyc CTP
chemical formula: C9H16N3O14P3
molecular weight: 482.9845
structure: ChemicalStructure/PW C000057

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Molybdate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C06232
xref: Reference/ChEBI CHEBI 25371
xref: Reference/ChemSpider 74188
xref: Reference/CAS 7782-91-4
xref: Reference/HMDB HMDB0012260
xref: Reference/PubChem-compound 82208
chemical formula: H2MoO4
molecular weight: 163.89961
structure: ChemicalStructure/PW C007805

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/HMDB HMDB0059639
type: UnificationXref
id: HMDB0059639
db: HMDB

Guanosine triphosphate
type: SmallMolecule
entity reference: Guanosine triphosphate

Reference/KEGG Compound C00266
type: UnificationXref
id: C00266
db: KEGG Compound

Reference/PathWhiz PW475735
type: UnificationXref
id: PW475735
db: PathWhiz

Compound/PW C040076/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cyclic pyranopterin monophosphate
stoichiometric coefficient: 1.0

Reference/TAXONOMY 911104
type: UnificationXref
id: 911104
db: TAXONOMY

Reference/BioCyc CPD0-1882
type: UnificationXref
id: CPD0-1882
db: BioCyc

Cytidylyl molybdenum cofactor
type: SmallMolecule
entity reference: Cytidylyl molybdenum cofactor

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

4.1.2.25
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001537/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040774/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001850/Stoichiometry/1.0
right: 6-hydroxymethyl-7,8-dihydropterin
right: Glycolaldehyde
spontaneous: false
EC number: 4.1.2.25
left: 7,8-Dihydroneopterin
name: 7,8-Dihydroneopterin → 6-hydroxymethyl-7,8-dihydropterin + Glycolaldehyde
conversion direction: LEFT_TO_RIGHT

GTP cyclohydrolase I
type: Complex
component stoichiometry: Protein/29295/Stoichiometry/10.0
component: Unknown

3.6.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042913/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042912/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: Pyrophosphate
right: 7,8-dihydroneopterin 3'-phosphate
spontaneous: false
EC number: 3.6.1.-
left: Water
left: 7,8-dihydroneopterin 3'-triphosphate
name: 7,8-dihydroneopterin 3'-triphosphate + Water → 7,8-dihydroneopterin 3'-phosphate + Hydrogen Ion + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C04874
type: UnificationXref
id: C04874
db: KEGG Compound

dihydroneopterin aldolase
type: Complex
component stoichiometry: Protein/29295/Stoichiometry/8.0
component: Unknown

Reference/CAS 73508-07-3
type: UnificationXref
id: 73508-07-3
db: CAS

Reaction3398
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001537/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042913/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: 7,8-Dihydroneopterin
right: Phosphate
spontaneous: false
left: Water
left: 7,8-dihydroneopterin 3'-phosphate
name: 7,8-dihydroneopterin 3'-phosphate + Water → 7,8-Dihydroneopterin + Phosphate
conversion direction: LEFT_TO_RIGHT

Water
type: SmallMolecule
entity reference: Water

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/ChEBI CHEBI 25371
type: UnificationXref
id: CHEBI:25371
db: ChEBI

ChemicalStructure/PW C000057
type: ChemicalStructure
structure format: SMILES

2.7.6.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040773/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040774/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
right: Hydrogen Ion
right: Adenosine monophosphate
spontaneous: false
EC number: 2.7.6.3
left: 6-hydroxymethyl-7,8-dihydropterin
left: Adenosine triphosphate
name: 6-hydroxymethyl-7,8-dihydropterin + Adenosine triphosphate → (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + Adenosine monophosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C040076
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/KEGG Compound C18239
type: UnificationXref
id: C18239
db: KEGG Compound

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

ReactionCatalysis1184963
type: Catalysis
controller: molybdopterin adenylyltransferase
controlled: 2.7.7.75
control type: ACTIVATION

Reference/CAS 1218-98-0
type: UnificationXref
id: 1218-98-0
db: CAS

ReactionCatalysis1184965
type: Catalysis
controller: molybdopterin molybdenumtransferase
controlled: 2.10.1.1
control type: ACTIVATION

Reference/ChEBI CHEBI 21437
type: UnificationXref
id: CHEBI:21437
db: ChEBI

Reference/PubChem-compound 756
type: UnificationXref
id: 756
db: PubChem-compound

ReactionCatalysis1184960
type: Catalysis
controller: molybdopterin synthase
controlled: 2.8.1.12
control type: ACTIVATION

2.7.7.75
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001491/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenylyl-molybdopterin
right: Pyrophosphate
spontaneous: false
EC number: 2.7.7.75
left: Molybdopterin
left: Hydrogen Ion
left: Adenosine triphosphate
name: Adenosine triphosphate + Hydrogen Ion + Molybdopterin → Adenylyl-molybdopterin + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

7,8-Dihydroneopterin
type: SmallMolecule
entity reference: 7,8-Dihydroneopterin

2.8.1.12
type: BiochemicalReaction
participant stoichiometry: Compound/Generic235/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/Generic235/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001491/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040076/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/4.0
right: Molybdopterin
right: Hydrogen Ion
right: thiocarboxylated small subunit of molybdopterin synthase
spontaneous: false
EC number: 2.8.1.12
left: Water
left: Cyclic pyranopterin monophosphate
left: thiocarboxylated small subunit of molybdopterin synthase
name: Cyclic pyranopterin monophosphate + Water + thiocarboxylated small subunit of molybdopterin synthase → 4 Hydrogen Ion + Molybdopterin + 2 thiocarboxylated small subunit of molybdopterin synthase
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1184967
type: Catalysis
controller: Unknown
controlled: 2.7.7.76
control type: ACTIVATION

4.1.99.18
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040076/Stoichiometry/1.0
right: Cyclic pyranopterin monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 4.1.99.18
left: Guanosine triphosphate
name: Guanosine triphosphate → Cyclic pyranopterin monophosphate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C007805
type: ChemicalStructure
structure format: SMILES
structure data: O[Mo++](O)(=O)=O

GTP Degradation and Molybdenum Cofactor Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/6728839
pathway order: PathwayEnzymeReaction/6728816
pathway order: PathwayEnzymeReaction/6728808
pathway order: PathwayEnzymeReaction/6728830
pathway order: PathwayEnzymeReaction/6728811
pathway order: PathwayEnzymeReaction/6728821
pathway order: PathwayEnzymeReaction/6728812
pathway order: PathwayEnzymeReaction/6728823
pathway order: PathwayEnzymeReaction/6728834
pathway order: PathwayEnzymeReaction/6728804
pathway component: ReactionCatalysis1184963
pathway component: ReactionCatalysis1184965
pathway component: ReactionCatalysis1184953
pathway component: ReactionCatalysis1184950
pathway component: ReactionCatalysis1184960
pathway component: 2.7.7.75
pathway component: 2.8.1.12
pathway component: 4.1.2.25
pathway component: ReactionCatalysis1184945
pathway component: ReactionCatalysis1184967
pathway component: 3.6.1.-
pathway component: ReactionCatalysis1184947
pathway component: 2.7.7.76
pathway component: 4.1.99.18
pathway component: ReactionCatalysis1184957
pathway component: Reaction3398
pathway component: 3.5.4.16
pathway component: 2.7.6.3
pathway component: 2.10.1.1
xref: Reference/PathWhiz PW475735
xref: Reference/SMPDB SMP0457224
organism: Weissella cibaria KACC 11862

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17071
type: UnificationXref
id: CHEBI:17071
db: ChEBI

Reference/HMDB HMDB0002206
type: UnificationXref
id: HMDB0002206
db: HMDB

2.10.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044506/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007805/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Water
right: Adenosine monophosphate
right: molybdenum cofactor
spontaneous: false
EC number: 2.10.1.1
left: Adenylyl-molybdopterin
left: Hydrogen Ion
left: Molybdate
name: Adenylyl-molybdopterin + Hydrogen Ion + Molybdate → Adenosine monophosphate + Water + molybdenum cofactor
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

ReactionCatalysis1184953
type: Catalysis
controller: Unknown
controlled: 2.7.6.3
control type: ACTIVATION

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

ReactionCatalysis1184950
type: Catalysis
controller: dihydroneopterin aldolase
controlled: 4.1.2.25
control type: ACTIVATION

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

ReactionCatalysis1184957
type: Catalysis
controller: Unknown
controlled: 4.1.99.18
control type: ACTIVATION

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Reference/KEGG Compound C00063
type: UnificationXref
id: C00063
db: KEGG Compound

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Compound/PW C040034/Stoichiometry/4.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 4.0

ChemicalStructure/PW C040774
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC2=C(N=C(CO)CN2)C(=O)N1

Compound/PW C040773/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040773
type: ChemicalStructure
structure format: SMILES
structure data: OP(=O)(OCC1=NC2=C(NC1)NC(=N)N=C2[O-])OP([O-])([O-])=O

Cytidylyl molybdenum cofactor
type: SmallMoleculeReference
xref: Reference/PubChem-compound 46173482
xref: Reference/ChEBI CHEBI 71308
chemical formula: C19H24MoN8O15P2S2
molecular weight: 827.93317
structure: ChemicalStructure/PW C042896

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C042912/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-dihydroneopterin 3'-triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 659
type: UnificationXref
id: 659
db: PubChem-compound

Reference/PubChem-compound 53356705
type: UnificationXref
id: 53356705
db: PubChem-compound

Reference/HMDB HMDB0012260
type: UnificationXref
id: HMDB0012260
db: HMDB

ReactionCatalysis1184945
type: Catalysis
controller: GTP cyclohydrolase I
controlled: 3.5.4.16
control type: ACTIVATION

ReactionCatalysis1184947
type: Catalysis
controller: Unknown
controlled: 3.6.1.-
control type: ACTIVATION

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/CAS 65-47-4
type: UnificationXref
id: 65-47-4
db: CAS

3.5.4.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042912/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: 7,8-dihydroneopterin 3'-triphosphate
right: Formic acid
spontaneous: false
EC number: 3.5.4.16
left: Water
left: Guanosine triphosphate
name: Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 25201779
type: UnificationXref
id: 25201779
db: PubChem-compound

ChemicalStructure/PW C001491
type: ChemicalStructure
structure format: SMILES

Protein/29295/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

ChemicalStructure/PW C044506
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 736
type: UnificationXref
id: 736
db: ChemSpider

Phosphate
type: SmallMolecule
entity reference: Phosphate

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Compound/PW C001491/Stoichiometry/1.0
type: Stoichiometry
physical entity: Molybdopterin
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 17677
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 57602
chemical formula: C7H8N5O8P2
molecular weight: 351.9848
structure: ChemicalStructure/PW C040773

Reference/PubChem-compound 6176
type: UnificationXref
id: 6176
db: PubChem-compound

6-hydroxymethyl-7,8-dihydropterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17083
chemical formula: C7H9N5O2
molecular weight: 195.07562
structure: ChemicalStructure/PW C040774

Reference/ChemSpider 74188
type: UnificationXref
id: 74188
db: ChemSpider

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C001537/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-Dihydroneopterin
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 57602
type: UnificationXref
id: CHEBI:57602
db: ChEBI

Reference/ChEBI CHEBI 60210
type: UnificationXref
id: CHEBI:60210
db: ChEBI

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

thiocarboxylated small subunit of molybdopterin synthase
type: SmallMoleculeReference

Reference/ChemSpider 5941
type: UnificationXref
id: 5941
db: ChemSpider

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Unknown
type: Protein
entity reference: Unknown

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 639
type: UnificationXref
id: 639
db: ChemSpider

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

7,8-Dihydroneopterin
type: SmallMoleculeReference
xref: Reference/CAS 1218-98-0
xref: Reference/PubChem-compound 659
xref: Reference/ChemSpider 639
xref: Reference/KEGG Compound C04874
xref: Reference/BioCyc DIHYDRONEOPTERIN-P3
xref: Reference/HMDB HMDB0002275
xref: Reference/ChEBI CHEBI 17001
chemical formula: C9H13N5O4
molecular weight: 255.09676
structure: ChemicalStructure/PW C001537

Compound/PW C000986/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C042913/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-dihydroneopterin 3'-phosphate
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/ChEBI CHEBI 17083
type: UnificationXref
id: CHEBI:17083
db: ChEBI

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/HMDB HMDB0003344
type: UnificationXref
id: HMDB0003344
db: HMDB

Protein/29295/Stoichiometry/8.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 8.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

ChemicalStructure/PW C042912
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

ChemicalStructure/PW C042913
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 16061579
type: UnificationXref
id: 16061579
db: PubChem-compound

ChemicalStructure/PW C001850
type: ChemicalStructure
structure format: SMILES
structure data: OCC=O

Compound/PW C044506/Stoichiometry/1.0
type: Stoichiometry
physical entity: molybdenum cofactor
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000082
type: UnificationXref
id: HMDB0000082
db: HMDB

ChemicalStructure/PW C040065
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 82208
type: UnificationXref
id: 82208
db: PubChem-compound