cis-Aconitic acid → trans-Aconitic acid
Acetyl-CoA + Glyoxylic acid + Water → Coenzyme A + Hydrogen Ion + L-Malic acid
Hydroxypropanedioic acid inhibits isocitrate lyase
Citrate hydro-lyase (cis-aconitate-forming)
Isocitric acid ↔ Glyoxylic acid + Succinic acid
L-Malic acid + NAD → Hydrogen Ion + NADH + Oxalacetic acid
Water + cis-Aconitic acid ↔ Isocitric acid
Acetyl-CoA + Oxalacetic acid + Water → Citric acid + Coenzyme A + Hydrogen Ion
Citric acid → Water + cis-Aconitic acid