Reference/KEGG Compound C00318
type: UnificationXref
id: C00318
db: KEGG Compound

L-carnitine dehydratase
type: Dna
cellular location: Cytosol
entity reference: L-carnitine dehydratase

direct_interaction
type: InteractionVocabulary

Protein/84216 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peptide synthetase
stoichiometric coefficient: 1.0

L-Carnitine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Carnitine

Reference/HMDB HMDB0003364
type: UnificationXref
id: HMDB0003364
db: HMDB

DNA-directed RNA polymerase
type: ProteinReference
xref: Reference/UniProt Q4VPM6
organism: Streptococcus pneumoniae

2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase
type: Protein
entity reference: 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase
name: SubPathwayInput

histidine kinase
type: ProteinReference
xref: Reference/UniProt Q9X4S9
organism: Streptococcus pneumoniae

DNA-directed RNA polymerase subunit alpha
type: ProteinReference
xref: Reference/UniProt B1I8M4
organism: Streptococcus pneumoniae

RNA polymerase sigma factor RpoD
type: ProteinReference
organism: Streptococcus pneumoniae

DNA-directed RNA polymerase subunit
type: ProteinReference
organism: Streptococcus pneumoniae

Dehydrogenase
type: ProteinReference
organism: Streptococcus pneumoniae

Crp/Fnr family transcriptional regulator
type: ProteinReference
organism: Streptococcus pneumoniae

Signal recognition particle protein
type: ProteinReference

Transport72429
type: Transport
participant stoichiometry: Compound/PW C000044 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Extracellular Space/Stoichiometry/1.0
right: L-Carnitine
spontaneous: false
left: L-Carnitine
name: L-Carnitine (→) Transport: Streptococcus pneumoniae, Extracellular Space to Streptococcus pneumoniae, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Transport72428
type: Transport
participant stoichiometry: Protein/84214 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/84214 Cytoplasm/Stoichiometry/1.0
right: Uncharacterized protein
spontaneous: false
left: Uncharacterized protein
name: L-carnitine/gamma-butyrobetaine antiporter (→) Transport: Streptococcus pneumoniae, Cytoplasm to Streptococcus pneumoniae, Cell Membrane
conversion direction: LEFT_TO_RIGHT

terminator
type: DnaReference
organism: Streptococcus pneumoniae

Reference/UniProt Q9X4S9
type: UnificationXref
id: Q9X4S9
db: UniProt

Transcriptional regulatory protein WalR
type: Protein
cellular location: Cytoplasm
entity reference: Transcriptional regulatory protein WalR

carnitine operon protein CaiE
type: Dna
cellular location: Cytosol
entity reference: carnitine operon protein CaiE

Uncharacterized protein
type: Protein
entity reference: Uncharacterized protein

L-Carnitine
type: SmallMoleculeReference
xref: Reference/BioCyc CARNITINE
xref: Reference/ChEBI CHEBI 16347
xref: Reference/PubChem-compound 10917
xref: Reference/CAS 541-15-1
xref: Reference/KEGG Compound C00318
xref: Reference/HMDB HMDB0000062
xref: Reference/ChemSpider 10455
chemical formula: C7H15NO3
molecular weight: 161.1052
structure: ChemicalStructure/PW C000044

Glutaryl-CoA dehydrogenase
type: Protein
entity reference: Glutaryl-CoA dehydrogenase
name: SubPathwayInput

Peptide synthetase
type: Protein
entity reference: Peptide synthetase
name: SubPathwayInput

DNA/86 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-carnitine dehydratase
stoichiometric coefficient: 1.0

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Transcriptional regulatory protein WalR
type: ProteinReference
organism: Streptococcus pneumoniae

Enoyl-CoA hydratase/isomerase family protein
type: Protein
entity reference: Enoyl-CoA hydratase/isomerase family protein
name: SubPathwayInput

Interaction8530
type: MolecularInteraction
interaction type: direct_interaction
name: Transcriptional activatory protein CaiF activates Promoter
participant: Dehydrogenase
participant: Promoter

cAMP-activated global transcriptional regulator CRP
type: Complex
component stoichiometry: Protein/84227 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Crp/Fnr family transcriptional regulator

Protein/24412/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Glutaryl-CoA dehydrogenase
type: ProteinReference
organism: Streptococcus pneumoniae

Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
organism: Streptococcus pneumoniae

Enoyl-CoA hydratase/isomerase family protein
type: ProteinReference
organism: Streptococcus pneumoniae

Peptide synthetase
type: ProteinReference
organism: Streptococcus pneumoniae

2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase
type: ProteinReference
organism: Streptococcus pneumoniae

Promoter
type: DnaReference
organism: Streptococcus pneumoniae

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

ProteinComplex/303762 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-butyrobetainyl-CoA:carnitine CoA transferase
stoichiometric coefficient: 1.0

TransportCatalysis52941
type: Catalysis
controller: Signal recognition particle protein
controlled: Transport72428
control type: ACTIVATION

TransportCatalysis52942
type: Catalysis
controller: Uncharacterized protein
controlled: Transport72429
control type: ACTIVATION

Interaction8527
type: MolecularInteraction
interaction type: direct_interaction
name: ArcB activates ArcA
participant: ArcB
participant: Transcriptional regulatory protein WalR

Interaction8528
type: MolecularInteraction
interaction type: direct_interaction
name: RNA polymerase sigma 70 activates Promoter
participant: Promoter
participant: RNA polymerase sigma 70

DNA/89 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: carnitine operon protein CaiE
stoichiometric coefficient: 1.0

Interaction8525
type: MolecularInteraction
interaction type: direct_interaction
name: ArcA-Phosphorylated DNA-binding transcriptional dual regulator activates Promoter
participant: Promoter
participant: Transcriptional regulatory protein WalR

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Interaction8526
type: MolecularInteraction
interaction type: direct_interaction
name: Quinone activates ArcB
participant: ArcB
participant: Quinone

Reference/PubChem-compound 4650
type: UnificationXref
id: 4650
db: PubChem-compound

ArcB
type: Complex
component stoichiometry: Protein/84221 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: histidine kinase

Reference/SMPDB SMP0002051
type: UnificationXref
id: SMP0002051
db: SMPDB

Reference/SMPDB SMP0461273
type: UnificationXref
id: SMP0461273
db: SMPDB

Interaction8529
type: MolecularInteraction
interaction type: direct_interaction
name: CRP-cAMP DNA-binding transcriptional dual regulator activates Promoter
participant: CRP-cAMP DNA-binding transcriptional dual regulator
participant: Promoter

terminator
type: Dna
cellular location: Cytosol
entity reference: terminator

DNA-directed RNA polymerase
type: Protein
cellular location: Cytoplasm
entity reference: DNA-directed RNA polymerase

carnitine racemase
type: Dna
cellular location: Cytosol
entity reference: carnitine racemase

DNA/143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: terminator
stoichiometric coefficient: 1.0

Reference/CAS 541-15-1
type: UnificationXref
id: 541-15-1
db: CAS

Protein/84221 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: histidine kinase
stoichiometric coefficient: 2.0

2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase
type: Protein
cellular location: Cytosol
entity reference: 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00472
type: UnificationXref
id: C00472
db: KEGG Compound

DNA/559 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: caiF
stoichiometric coefficient: 1.0

Reaction1034480
type: BiochemicalReaction
participant stoichiometry: DNA/559 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: DNA/47 Cytoplasm/Stoichiometry/1.0
right: caiF
spontaneous: true
left: Promoter
name: Promoter → caiF
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Protein/84219 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase
stoichiometric coefficient: 1.0

Reaction1184463
type: BiochemicalReaction
participant stoichiometry: DNA/559 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/84228 Cytoplasm/Stoichiometry/1.0
right: Dehydrogenase
spontaneous: false
left: caiF
name: caiF → Transcriptional activatory protein CaiF
conversion direction: LEFT_TO_RIGHT

Reaction1184461
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/303767 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: ProteinComplex/303768 Cytoplasm/Stoichiometry/1.0
right: CRP-cAMP DNA-binding transcriptional dual regulator
spontaneous: false
left: cAMP-activated global transcriptional regulator CRP
left: cAMP
name: cAMP + 2 cAMP-activated global transcriptional regulator CRP → CRP-cAMP DNA-binding transcriptional dual regulator
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW002037
type: UnificationXref
id: PW002037
db: PathWhiz

DNA/85 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: probable carnitine operon oxidoreductase CaiA
stoichiometric coefficient: 1.0

Protein/24412 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Protein/84217 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Enoyl-CoA hydratase/isomerase family protein
stoichiometric coefficient: 1.0

Uncharacterized protein
type: Protein
cellular location: Cytoplasm
entity reference: Uncharacterized protein

Promoter
type: Dna
cellular location: Cytoplasm
entity reference: Promoter

Quinone
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Quinone

Protein/84214 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uncharacterized protein
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

probable carnitine operon oxidoreductase CaiA
type: Dna
cellular location: Cytosol
entity reference: probable carnitine operon oxidoreductase CaiA

Peptide synthetase
type: Protein
cellular location: Cytosol
entity reference: Peptide synthetase

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

histidine kinase
type: Protein
cellular location: Cytoplasm
entity reference: histidine kinase

Reaction1184459
type: BiochemicalReaction
participant stoichiometry: Protein/84219 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/89 Cytosol/Stoichiometry/1.0
right: 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase
spontaneous: false
left: carnitine operon protein CaiE
name: carnitine operon protein CaiE → Putative transferase
conversion direction: LEFT_TO_RIGHT

Reaction1184458
type: BiochemicalReaction
participant stoichiometry: Protein/84217 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/88 Cytosol/Stoichiometry/1.0
right: Enoyl-CoA hydratase/isomerase family protein
spontaneous: false
left: carnitine racemase
name: carnitine racemase → crotonobetainyl-CoA hydratase
conversion direction: LEFT_TO_RIGHT

Reaction1184457
type: BiochemicalReaction
participant stoichiometry: Protein/84216 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/87 Cytosol/Stoichiometry/1.0
right: Peptide synthetase
spontaneous: false
left: probable crotonoβine/carnitine-CoA ligase
name: probable crotonoβine/carnitine-CoA ligase → carnitine-CoA ligase
conversion direction: LEFT_TO_RIGHT

Reaction1184456
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/303762 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/86 Cytosol/Stoichiometry/1.0
right: γ-butyrobetainyl-CoA:carnitine CoA transferase
spontaneous: false
left: L-carnitine dehydratase
name: L-carnitine dehydratase → γ-butyrobetainyl-CoA:carnitine CoA transferase
conversion direction: LEFT_TO_RIGHT

Reaction1184455
type: BiochemicalReaction
participant stoichiometry: Protein/84215 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/85 Cytosol/Stoichiometry/1.0
right: Glutaryl-CoA dehydrogenase
spontaneous: false
left: probable carnitine operon oxidoreductase CaiA
name: probable carnitine operon oxidoreductase CaiA → crotonobetainyl-CoA reductase
conversion direction: LEFT_TO_RIGHT

Reaction1184454
type: BiochemicalReaction
participant stoichiometry: Protein/84214 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/84 Cytosol/Stoichiometry/1.0
right: Uncharacterized protein
spontaneous: false
left: probable carnitine transporter
name: probable carnitine transporter → L-carnitine/gamma-butyrobetaine antiporter
conversion direction: LEFT_TO_RIGHT

Signal recognition particle protein
type: Protein
entity reference: Signal recognition particle protein

Reference/BioCyc CARNITINE
type: UnificationXref
id: CARNITINE
db: BioCyc

RNA polymerase sigma factor RpoD
type: Protein
cellular location: Cytoplasm
entity reference: RNA polymerase sigma factor RpoD

Protein/84223 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: DNA-directed RNA polymerase subunit alpha
stoichiometric coefficient: 2.0

Protein/84215 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutaryl-CoA dehydrogenase
stoichiometric coefficient: 1.0

Reference/UniProt B1I8M4
type: UnificationXref
id: B1I8M4
db: UniProt

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Protein/84214 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uncharacterized protein
stoichiometric coefficient: 1.0

histidine kinase
type: Protein
cellular location: Cell Membrane
entity reference: histidine kinase

γ-butyrobetainyl-CoA:carnitine CoA transferase
type: Complex
component stoichiometry: Protein/24412 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

cAMP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: cAMP

Enoyl-CoA hydratase/isomerase family protein
type: Protein
cellular location: Cytosol
entity reference: Enoyl-CoA hydratase/isomerase family protein

DNA/47 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

L-Carnitine Degradation I
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway508050
pathway order: SubPathwayInteractionSteps/SubPathway508051
pathway order: SubPathwayInteractionSteps/SubPathway508049
pathway order: SubPathwayInteractionSteps/SubPathway508048
pathway order: SubPathwayInteractionSteps/SubPathway508052
pathway component: SubPathwayInteraction508048
pathway component: SubPathwayInteraction508049
pathway component: SubPathwayInteraction508050
pathway component: SubPathwayInteraction508051
pathway component: SubPathwayInteraction508052
xref: Reference/SMPDB SMP0002051
xref: Reference/PathWhiz PW002037
name: SubPathway

Unknown
type: Protein
entity reference: Unknown

DNA/84 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: probable carnitine transporter
stoichiometric coefficient: 1.0

Protein/84221 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: histidine kinase
stoichiometric coefficient: 2.0

Compound/PW C000044 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

Protein/84228 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydrogenase
stoichiometric coefficient: 1.0

Reference/PubChem-compound 10917
type: UnificationXref
id: 10917
db: PubChem-compound

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Protein/84214 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uncharacterized protein
stoichiometric coefficient: 1.0

ArcB
type: Complex
component stoichiometry: Protein/84221 Cell Membrane/Stoichiometry/2.0
cellular location: Cell Membrane
component: histidine kinase

Reference/ChemSpider 10455
type: UnificationXref
id: 10455
db: ChemSpider

caiF
type: Dna
cellular location: Cytoplasm
entity reference: caiF

Crp/Fnr family transcriptional regulator
type: Protein
cellular location: Cytoplasm
entity reference: Crp/Fnr family transcriptional regulator

DNA-directed RNA polymerase subunit
type: Protein
cellular location: Cytoplasm
entity reference: DNA-directed RNA polymerase subunit

probable crotonoβine/carnitine-CoA ligase
type: Dna
cellular location: Cytosol
entity reference: probable crotonoβine/carnitine-CoA ligase

Uncharacterized protein
type: Protein
cellular location: Cytosol
entity reference: Uncharacterized protein

RNA polymerase sigma 70
type: Complex
component stoichiometry: Protein/84223 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: DNA-directed RNA polymerase subunit
component: RNA polymerase sigma factor RpoD
component: DNA-directed RNA polymerase subunit alpha
component: DNA-directed RNA polymerase

DNA/87 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: probable crotonoβine/carnitine-CoA ligase
stoichiometric coefficient: 1.0

Dehydrogenase
type: Protein
cellular location: Cytoplasm
entity reference: Dehydrogenase

Quinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4489
xref: Reference/CAS 106-51-4
xref: Reference/KEGG Compound C00472
xref: Reference/ChEBI CHEBI 16509
xref: Reference/BioCyc CPD-8130
xref: Reference/PubChem-compound 4650
xref: Reference/HMDB HMDB0003364
chemical formula: C6H4O2
molecular weight: 108.021126
structure: ChemicalStructure/PW C001860

DNA/88 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: carnitine racemase
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16509
type: UnificationXref
id: CHEBI:16509
db: ChEBI

Transcriptional regulatory protein WalR
type: Protein
cellular location: Cytosol
entity reference: Transcriptional regulatory protein WalR

Reference/ChemSpider 4489
type: UnificationXref
id: 4489
db: ChemSpider

Reference/BioCyc CPD-8130
type: UnificationXref
id: CPD-8130
db: BioCyc

ChemicalStructure/PW C000044
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)C[C@H](O)CC([O-])=O

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

DNA-directed RNA polymerase subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: DNA-directed RNA polymerase subunit alpha

Glutaryl-CoA dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: Glutaryl-CoA dehydrogenase

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Reference/UniProt Q4VPM6
type: UnificationXref
id: Q4VPM6
db: UniProt

ProteinComplex/303767 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: cAMP-activated global transcriptional regulator CRP
stoichiometric coefficient: 2.0

ChemicalStructure/PW C001860
type: ChemicalStructure
structure format: SMILES
structure data: O=C1C=CC(=O)C=C1

probable carnitine transporter
type: Dna
cellular location: Cytosol
entity reference: probable carnitine transporter

Reaction180770
type: BiochemicalReaction
participant stoichiometry: DNA/143 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/89 Cytosol/Stoichiometry/1.0
right: terminator
spontaneous: false
left: carnitine operon protein CaiE
name: carnitine operon protein CaiE → terminator
conversion direction: LEFT_TO_RIGHT

Uncharacterized protein
type: Protein
cellular location: Cell Membrane
entity reference: Uncharacterized protein

Streptococcus pneumoniae
type: BioSource
xref: Reference/TAXONOMY 1313

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Protein/84227 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Crp/Fnr family transcriptional regulator
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 16347
type: UnificationXref
id: CHEBI:16347
db: ChEBI

SubPathwayInteraction508050
type: Interaction
name: SubPathwayReaction
name: SubPathway508050Reaction
participant: Peptide synthetase

SubPathwayInteraction508051
type: Interaction
name: SubPathway508051Reaction
name: SubPathwayReaction
participant: Enoyl-CoA hydratase/isomerase family protein

SubPathwayInteraction508052
type: Interaction
name: SubPathway508052Reaction
name: SubPathwayReaction
participant: 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase

Reference/TAXONOMY 1313
type: UnificationXref
id: 1313
db: TAXONOMY

Reaction180769
type: BiochemicalReaction
participant stoichiometry: DNA/84 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/47 Cytosol/Stoichiometry/1.0
right: probable carnitine transporter
spontaneous: false
left: Promoter
name: Promoter → probable carnitine transporter
conversion direction: LEFT_TO_RIGHT

Unknown
type: ProteinReference
organism: Streptococcus pneumoniae

Reference/HMDB HMDB0000062
type: UnificationXref
id: HMDB0000062
db: HMDB

SubPathwayInteraction508048
type: Interaction
name: SubPathwayReaction
name: SubPathway508048Reaction
participant: Glutaryl-CoA dehydrogenase

SubPathwayInteraction508049
type: Interaction
name: SubPathway508049Reaction
name: SubPathwayReaction
participant: γ-butyrobetainyl-CoA:carnitine CoA transferase

probable carnitine transporter
type: DnaReference
organism: Streptococcus pneumoniae

L-carnitine dehydratase
type: DnaReference
organism: Streptococcus pneumoniae

probable carnitine operon oxidoreductase CaiA
type: DnaReference
organism: Streptococcus pneumoniae

Reference/PathWhiz PW479956
type: UnificationXref
id: PW479956
db: PathWhiz

carnitine racemase
type: DnaReference
organism: Streptococcus pneumoniae

L-Carnitine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Carnitine

probable crotonoβine/carnitine-CoA ligase
type: DnaReference
organism: Streptococcus pneumoniae

carnitine operon protein CaiE
type: DnaReference
organism: Streptococcus pneumoniae

Operon: Carnitine Operon
type: Pathway
pathway order: PathwayEnzymeReaction/6796920
pathway order: PathwayTransport/6796937
pathway order: PathwayTransport/6796938
pathway order: PathwaySubPathway/508050
pathway order: PathwayEnzymeReaction/6796923
pathway order: PathwayInteraction/8525
pathway order: PathwaySubPathway/508051
pathway order: PathwayEnzymeReaction/6796924
pathway order: PathwaySubPathway/508052
pathway order: PathwayEnzymeReaction/6796921
pathway order: PathwayInteraction/8527
pathway order: PathwayEnzymeReaction/6796922
pathway order: PathwayEnzymeReaction/6796933
pathway order: PathwayInteraction/8526
pathway order: PathwayInteraction/8529
pathway order: PathwayInteraction/8528
pathway order: PathwayEnzymeReaction/6796927
pathway order: PathwayEnzymeReaction/6796925
pathway order: PathwayEnzymeReaction/6796926
pathway order: PathwaySubPathway/508048
pathway order: PathwaySubPathway/508049
pathway order: PathwayEnzymeReaction/6796929
pathway order: PathwayInteraction/8530
pathway order: PathwayEnzymeReaction/6796919
pathway component: TransportCatalysis52941
pathway component: Interaction8530
pathway component: Reaction1184463
pathway component: TransportCatalysis52942
pathway component: Reaction1184461
pathway component: Interaction8527
pathway component: Interaction8528
pathway component: Interaction8525
pathway component: Interaction8526
pathway component: Transport72429
pathway component: Reaction180769
pathway component: Transport72428
pathway component: Reaction1034480
pathway component: Interaction8529
pathway component: L-Carnitine Degradation I
pathway component: Reaction1184459
pathway component: Reaction1184458
pathway component: Reaction180770
pathway component: Reaction1184457
pathway component: Reaction1184456
pathway component: Reaction1184455
pathway component: Reaction1184454
xref: Reference/SMPDB SMP0461273
xref: Reference/PathWhiz PW479956
organism: Streptococcus pneumoniae

γ-butyrobetainyl-CoA:carnitine CoA transferase
type: Complex
component stoichiometry: Protein/24412/Stoichiometry/2.0
component: Unknown
name: SubPathwayInput

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

CRP-cAMP DNA-binding transcriptional dual regulator
type: Complex
component stoichiometry: Protein/84227 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Crp/Fnr family transcriptional regulator

ProteinComplex/303768 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: CRP-cAMP DNA-binding transcriptional dual regulator
stoichiometric coefficient: 1.0

Promoter
type: Dna
cellular location: Cytosol
entity reference: Promoter

Reference/CAS 106-51-4
type: UnificationXref
id: 106-51-4
db: CAS

DNA/47 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

Compound/PW C000044 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

caiF
type: DnaReference
organism: Streptococcus pneumoniae