Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChEBI CHEBI 16136
type: UnificationXref
id: CHEBI:16136
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

2.6.1.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000810/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001214/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134/Stoichiometry/1.0
right: Oxoglutaric acid
right: DL-O-Phosphoserine
spontaneous: false
EC number: 2.6.1.52
left: L-Glutamic acid
left: Phosphohydroxypyruvic acid
name: L-Glutamic acid + Phosphohydroxypyruvic acid → DL-O-Phosphoserine + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

2.3.1.30
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001755/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000120/Stoichiometry/1.0
right: Coenzyme A
right: O-Acetylserine
spontaneous: false
EC number: 2.3.1.30
left: L-Serine
left: Acetyl-CoA
name: Acetyl-CoA + L-Serine → Coenzyme A + O-Acetylserine
conversion direction: LEFT_TO_RIGHT

Protein/28262/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Hydrogen sulfide
type: SmallMolecule
entity reference: Hydrogen sulfide

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

2.5.1.47
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001755/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001827/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: L-Cysteine
right: Acetic acid
spontaneous: false
EC number: 2.5.1.47
left: Hydrogen sulfide
left: O-Acetylserine
name: Hydrogen sulfide + O-Acetylserine → Acetic acid + Hydrogen Ion + L-Cysteine
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

1.1.1.95
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000810/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000644/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: Phosphohydroxypyruvic acid
spontaneous: false
EC number: 1.1.1.95
left: 3-Phosphoglyceric acid
left: NAD
name: 3-Phosphoglyceric acid + NAD → Hydrogen Ion + NADH + Phosphohydroxypyruvic acid
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

NADH
type: SmallMolecule
entity reference: NADH

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/PubChem-compound 18779926
type: UnificationXref
id: 18779926
db: PubChem-compound

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Protein/6419/Stoichiometry/2.0
type: Stoichiometry
physical entity: Phosphoserine aminotransferase
stoichiometric coefficient: 2.0

Reference/CAS 5147-00-2
type: UnificationXref
id: 5147-00-2
db: CAS

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17115
type: UnificationXref
id: CHEBI:17115
db: ChEBI

NAD
type: SmallMolecule
entity reference: NAD

Compound/PW C001214/Stoichiometry/1.0
type: Stoichiometry
physical entity: DL-O-Phosphoserine
stoichiometric coefficient: 1.0

O-acetylserine sulfhydrylase A
type: Complex
component stoichiometry: Protein/28262/Stoichiometry/2.0
component: Unknown

cysteine synthase
type: Complex
component stoichiometry: Protein/28262/Stoichiometry/2.0
component: Unknown

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Reference/ChemSpider 89874
type: UnificationXref
id: 89874
db: ChemSpider

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Escherichia coli APEC O1
type: BioSource
xref: Reference/TAXONOMY 405955

Compound/PW C043169/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Aminomalonate semialdehyde
stoichiometric coefficient: 1.0

D-3-phosphoglycerate dehydrogenase
type: Protein
entity reference: D-3-phosphoglycerate dehydrogenase

Reference/HMDB HMDB0003011
type: UnificationXref
id: HMDB0003011
db: HMDB

3-hydroxy acid dehydrogenase
type: Complex
component stoichiometry: Protein/28262/Stoichiometry/4.0
component: Unknown

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Glycolate and Glyoxylate Degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway511696
pathway component: SubPathwayInteraction511696
xref: Reference/SMPDB SMP0000847
xref: Reference/PathWhiz PW000827
name: SubPathway

DL-O-Phosphoserine
type: SmallMoleculeReference
xref: Reference/ChemSpider 104
xref: Reference/BioCyc 3-P-SERINE
xref: Reference/HMDB HMDB0001721
xref: Reference/PubChem-compound 106
xref: Reference/ChEBI CHEBI 37712
xref: Reference/CAS 17885-08-4
xref: Reference/KEGG Compound C01005
chemical formula: C3H8NO6P
molecular weight: 185.00893
structure: ChemicalStructure/PW C001214

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001755
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)OC[C@H](N)C(O)=O

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/CAS 17885-08-4
type: UnificationXref
id: 17885-08-4
db: CAS

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Protein/6142/Stoichiometry/4.0
type: Stoichiometry
physical entity: D-3-phosphoglycerate dehydrogenase
stoichiometric coefficient: 4.0

Compound/PW C001755/Stoichiometry/1.0
type: Stoichiometry
physical entity: O-Acetylserine
stoichiometric coefficient: 1.0

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChemSpider 391
type: UnificationXref
id: 391
db: ChemSpider

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/ChemSpider 5736
type: UnificationXref
id: 5736
db: ChemSpider

Phosphohydroxypyruvic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001024
xref: Reference/PubChem-compound 105
xref: Reference/ChemSpider 103
xref: Reference/CAS 3913-50-6
xref: Reference/ChEBI CHEBI 30933
xref: Reference/KEGG Compound C03232
xref: Reference/BioCyc 3-P-HYDROXYPYRUVATE
chemical formula: C3H5O7P
molecular weight: 183.9773
structure: ChemicalStructure/PW C000810

Compound/PW C000448/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Reference/ChemSpider 704
type: UnificationXref
id: 704
db: ChemSpider

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/BioCyc SER
type: UnificationXref
id: SER
db: BioCyc

Acetic acid
type: SmallMolecule
entity reference: Acetic acid

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

NADP
type: SmallMolecule
entity reference: NADP

1.1.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043169/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000120/Stoichiometry/1.0
right: NADP
right: L-Serine
spontaneous: false
EC number: 1.1.1.-
left: Hydrogen Ion
left: 2-Aminomalonate semialdehyde
left: NADPH
name: 2-Aminomalonate semialdehyde + Hydrogen Ion + NADPH ↔ L-Serine + NADP
conversion direction: REVERSIBLE

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/PathWhiz PW000827
type: UnificationXref
id: PW000827
db: PathWhiz

Reference/HMDB HMDB0003276
type: UnificationXref
id: HMDB0003276
db: HMDB

Reference/SMPDB SMP0000847
type: UnificationXref
id: SMP0000847
db: SMPDB

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Unknown
type: Protein
entity reference: Unknown

Reference/PathWhiz PW483912
type: UnificationXref
id: PW483912
db: PathWhiz

Reference/CAS 3913-50-6
type: UnificationXref
id: 3913-50-6
db: CAS

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/KEGG Compound C00597
type: UnificationXref
id: C00597
db: KEGG Compound

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

3-Phosphoglyceric acid
type: SmallMolecule
entity reference: 3-Phosphoglyceric acid
name: SubPathwayOutput

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

ChemicalStructure/PW C000810
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=O)COP(O)(O)=O

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

D-3-phosphoglycerate dehydrogenase
type: ProteinReference
xref: Reference/UniProt P0A9T0

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/PubChem-compound 6971051
type: UnificationXref
id: 6971051
db: PubChem-compound

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 7783-06-4
type: UnificationXref
id: 7783-06-4
db: CAS

Compound/PW C000120/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Serine
stoichiometric coefficient: 1.0

ReactionCatalysis733034
type: Catalysis
controller: cysteine synthase
controlled: 2.5.1.47
control type: ACTIVATION

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/PubChem-compound 105
type: UnificationXref
id: 105
db: PubChem-compound

ReactionCatalysis733033
type: Catalysis
controller: serine acetyltransferase
controlled: 2.3.1.30
control type: ACTIVATION

ReactionCatalysis733032
type: Catalysis
controller: 3-phosphoserine aminotransferase / phosphohydroxythreonine aminotransferase
controlled: 2.6.1.52
control type: ACTIVATION

ReactionCatalysis733031
type: Catalysis
controller: D-3-phosphoglycerate dehydrogenase / α-ketoglutarate reductase
controlled: 1.1.1.95
control type: ACTIVATION

Reference/ChEBI CHEBI 58671
type: UnificationXref
id: CHEBI:58671
db: ChEBI

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/PubChem-compound 106
type: UnificationXref
id: 106
db: PubChem-compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

3-phosphoserine aminotransferase / phosphohydroxythreonine aminotransferase
type: Complex
component stoichiometry: Protein/6419/Stoichiometry/2.0
component: Phosphoserine aminotransferase

Reference/PubChem-compound 5951
type: UnificationXref
id: 5951
db: PubChem-compound

D-3-phosphoglycerate dehydrogenase / α-ketoglutarate reductase
type: Complex
component stoichiometry: Protein/6142/Stoichiometry/4.0
component: D-3-phosphoglycerate dehydrogenase

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

serine acetyltransferase
type: Complex
component stoichiometry: Protein/28262/Stoichiometry/6.0
component: Unknown

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

ReactionCatalysis733035
type: Catalysis
controller: O-acetylserine sulfhydrylase A
controlled: 2.5.1.47
control type: ACTIVATION

Hydrogen sulfide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16136
xref: Reference/BioCyc HS
xref: Reference/KEGG Compound C00283
xref: Reference/PubChem-compound 18779926
xref: Reference/CAS 7783-06-4
xref: Reference/ChemSpider 391
xref: Reference/HMDB HMDB0003276
chemical formula: H2S
molecular weight: 33.98772
structure: ChemicalStructure/PW C001827

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

ChemicalStructure/PW C043169
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@](N)(C=O)C([O-])=O

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

Reference/BioCyc 3-P-HYDROXYPYRUVATE
type: UnificationXref
id: 3-P-HYDROXYPYRUVATE
db: BioCyc

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Compound/PW C000644/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Phosphoglyceric acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/ChemSpider 104
type: UnificationXref
id: 104
db: ChemSpider

ChemicalStructure/PW C000120
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CO)C(O)=O

Reference/ChemSpider 103
type: UnificationXref
id: 103
db: ChemSpider

ChemicalStructure/PW C001214
type: ChemicalStructure
structure format: SMILES
structure data: NC(COP(O)(O)=O)C(O)=O

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

ReactionCatalysis474759
type: Catalysis
controller: Unknown
controlled: 3.1.3.3
control type: ACTIVATION

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Secondary Metabolites: Cysteine Biosynthesis from Serine
type: Pathway
pathway order: PathwayEnzymeReaction/6839101
pathway order: PathwayEnzymeReaction/6839104
pathway order: PathwayEnzymeReaction/6839097
pathway order: PathwayEnzymeReaction/6839120
pathway order: PathwayEnzymeReaction/6839110
pathway order: PathwayEnzymeReaction/6839100
pathway order: PathwayEnzymeReaction/6839109
pathway order: PathwaySubPathway/511696
pathway component: ReactionCatalysis733034
pathway component: ReactionCatalysis733033
pathway component: ReactionCatalysis733032
pathway component: ReactionCatalysis733031
pathway component: 2.6.1.52
pathway component: 3.1.3.3
pathway component: 2.3.1.30
pathway component: 2.5.1.47
pathway component: Glycolate and Glyoxylate Degradation
pathway component: 1.1.1.95
pathway component: ReactionCatalysis474759
pathway component: ReactionCatalysis1233759
pathway component: 1.1.1.-
pathway component: ReactionCatalysis733035
xref: Reference/PathWhiz PW483912
xref: Reference/SMPDB SMP0464682
organism: Escherichia coli APEC O1

3.1.3.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001214/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000120/Stoichiometry/1.0
right: L-Serine
right: Phosphate
spontaneous: false
EC number: 3.1.3.3
left: Water
left: DL-O-Phosphoserine
name: DL-O-Phosphoserine + Water → L-Serine + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

O-Acetylserine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6971051
xref: Reference/ChemSpider 89874
xref: Reference/KEGG Compound C00979
xref: Reference/BioCyc ACETYLSERINE
xref: Reference/CAS 5147-00-2
xref: Reference/ChEBI CHEBI 17981
xref: Reference/HMDB HMDB0003011
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C001755

Reference/ChEBI CHEBI 17981
type: UnificationXref
id: CHEBI:17981
db: ChEBI

Reference/KEGG Compound C01005
type: UnificationXref
id: C01005
db: KEGG Compound

Phosphoserine aminotransferase
type: Protein
entity reference: Phosphoserine aminotransferase

Reference/HMDB HMDB0000807
type: UnificationXref
id: HMDB0000807
db: HMDB

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
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structure format: SMILES

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Water
type: SmallMolecule
entity reference: Water

Reference/KEGG Compound C00283
type: UnificationXref
id: C00283
db: KEGG Compound

Protein/28262/Stoichiometry/6.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 6.0

2-Aminomalonate semialdehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58671
xref: Reference/PubChem-compound 25244138
chemical formula: C3H4NO3
molecular weight: 102.01967
structure: ChemicalStructure/PW C043169

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

ChemicalStructure/PW C001827
type: ChemicalStructure
structure format: SMILES
structure data: S

L-Cysteine
type: SmallMolecule
entity reference: L-Cysteine

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

SubPathwayInteraction511696
type: Interaction
name: SubPathway511696Reaction
name: SubPathwayReaction
participant: 3-Phosphoglyceric acid

3-Phosphoglyceric acid
type: SmallMoleculeReference
xref: Reference/BioCyc G3P
xref: Reference/PubChem-compound 724
xref: Reference/ChEBI CHEBI 17050
xref: Reference/ChemSpider 704
xref: Reference/CAS 820-11-1
xref: Reference/KEGG Compound C00597
xref: Reference/HMDB HMDB0000807
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C000644

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/KEGG Compound C00979
type: UnificationXref
id: C00979
db: KEGG Compound

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/HMDB HMDB0001487
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id: HMDB0001487
db: HMDB

Reference/ChEBI CHEBI 30933
type: UnificationXref
id: CHEBI:30933
db: ChEBI

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Unknown
type: ProteinReference

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Compound/PW C000029/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Compound/PW C000810/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphohydroxypyruvic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00065
type: UnificationXref
id: C00065
db: KEGG Compound

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

O-Acetylserine
type: SmallMolecule
entity reference: O-Acetylserine

Reference/ChEBI CHEBI 17050
type: UnificationXref
id: CHEBI:17050
db: ChEBI

Compound/PW C001827/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen sulfide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Reference/PubChem-compound 724
type: UnificationXref
id: 724
db: PubChem-compound

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Protein/28262/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 37712
type: UnificationXref
id: CHEBI:37712
db: ChEBI

ChemicalStructure/PW C000644
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C(O)=O

Phosphate
type: SmallMolecule
entity reference: Phosphate

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Phosphohydroxypyruvic acid
type: SmallMolecule
entity reference: Phosphohydroxypyruvic acid

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/HMDB HMDB0001024
type: UnificationXref
id: HMDB0001024
db: HMDB

Oxoglutaric acid
type: SmallMolecule
entity reference: Oxoglutaric acid

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Phosphoserine aminotransferase
type: ProteinReference
xref: Reference/UniProt P23721

Reference/CAS 56-45-1
type: UnificationXref
id: 56-45-1
db: CAS

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/KEGG Compound C03232
type: UnificationXref
id: C03232
db: KEGG Compound

DL-O-Phosphoserine
type: SmallMolecule
entity reference: DL-O-Phosphoserine

Reference/PubChem-compound 25244138
type: UnificationXref
id: 25244138
db: PubChem-compound

Reference/UniProt P0A9T0
type: UnificationXref
id: P0A9T0
db: UniProt

Reference/BioCyc G3P
type: UnificationXref
id: G3P
db: BioCyc

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ReactionCatalysis1233759
type: Catalysis
controller: 3-hydroxy acid dehydrogenase
controlled: 1.1.1.-
control type: ACTIVATION

L-Serine
type: SmallMolecule
entity reference: L-Serine

Reference/BioCyc ACETYLSERINE
type: UnificationXref
id: ACETYLSERINE
db: BioCyc

L-Serine
type: SmallMoleculeReference
xref: Reference/ChemSpider 5736
xref: Reference/ChEBI CHEBI 17115
xref: Reference/CAS 56-45-1
xref: Reference/KEGG Compound C00065
xref: Reference/PubChem-compound 5951
xref: Reference/HMDB HMDB0000187
xref: Reference/BioCyc SER
chemical formula: C3H7NO3
molecular weight: 105.042595
structure: ChemicalStructure/PW C000120

Reference/HMDB HMDB0000187
type: UnificationXref
id: HMDB0000187
db: HMDB

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

2-Aminomalonate semialdehyde
type: SmallMolecule
entity reference: 2-Aminomalonate semialdehyde

Reference/SMPDB SMP0464682
type: UnificationXref
id: SMP0464682
db: SMPDB

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

Reference/BioCyc HS
type: UnificationXref
id: HS
db: BioCyc

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reference/TAXONOMY 405955
type: UnificationXref
id: 405955
db: TAXONOMY

Reference/HMDB HMDB0001721
type: UnificationXref
id: HMDB0001721
db: HMDB

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Reference/BioCyc 3-P-SERINE
type: UnificationXref
id: 3-P-SERINE
db: BioCyc

Reference/UniProt P23721
type: UnificationXref
id: P23721
db: UniProt

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/CAS 820-11-1
type: UnificationXref
id: 820-11-1
db: CAS