trimethylamine-N-oxide reductase
type: ProteinReference
xref: Reference/UniProt D4F7F2
organism: Edwardsiella tarda ATCC 23685

menaquinone-8
type: SmallMolecule
entity reference: menaquinone-8
name: SubPathwayOutput

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Formate dehydrogenase, gamma subunit
type: Protein
cellular location: Inner Membrane
entity reference: Formate dehydrogenase, gamma subunit

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/UniProt D4F7F2
type: UnificationXref
id: D4F7F2
db: UniProt

Putative dimethylsulfoxide reductase, chain B
type: ProteinReference
xref: Reference/UniProt D4F740
organism: Edwardsiella tarda ATCC 23685

Reference/ChemSpider 659
type: UnificationXref
id: 659
db: ChemSpider

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Dimethylsulfide
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Dimethylsulfide

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

ReactionCoupledTransportCatalysis26034
type: Catalysis
controller: formate dehydrogenase-O
controlled: 1.2.1.2
control type: ACTIVATION

ReactionCoupledTransportCatalysis26033
type: Catalysis
controller: hydrogenase 1, oxygen tolerant hydrogenase
controlled: 1.12.99.6
control type: ACTIVATION

ReactionCoupledTransportCatalysis26031
type: Catalysis
controller: NADH:quinone oxidoreductase I
controlled: 1.6.99.5
control type: ACTIVATION

Putative dimethylsulfoxide reductase, chain B
type: Protein
cellular location: Inner Membrane
entity reference: Putative dimethylsulfoxide reductase, chain B

ReactionCoupledTransportCatalysis26038
type: Catalysis
controller: dimethyl sulfoxide reductase
controlled: 1.8.5.3
control type: ACTIVATION

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/HMDB HMDB0002151
type: UnificationXref
id: HMDB0002151
db: HMDB

Formate dehydrogenase iron-sulfur subunit
type: ProteinReference
xref: Reference/UniProt D4FAF6
organism: Edwardsiella tarda ATCC 23685

ChemicalStructure/PW C041683
type: ChemicalStructure
structure format: SMILES

Formate dehydrogenase, gamma subunit
type: ProteinReference
xref: Reference/UniProt D4FAF7
organism: Edwardsiella tarda ATCC 23685

Respiratory-chain NADH dehydrogenase, 30 Kd subunit
type: Protein
cellular location: Inner Membrane
entity reference: Respiratory-chain NADH dehydrogenase, 30 Kd subunit

Ni/Fe-hydrogenase, b-type cytochrome subunit
type: ProteinReference
xref: Reference/UniProt D4F1X4
organism: Edwardsiella tarda ATCC 23685

Reference/UniProt D4F1K5
type: UnificationXref
id: D4F1K5
db: UniProt

Reference/CAS 67-68-5
type: UnificationXref
id: 67-68-5
db: CAS

Menaquinol 8
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Menaquinol 8

hydrogenase (acceptor)
type: ProteinReference
xref: Reference/UniProt D4F7P7
organism: Edwardsiella tarda ATCC 23685

Reference/UniProt D4F1K6
type: UnificationXref
id: D4F1K6
db: UniProt

Reference/UniProt D4F1K9
type: UnificationXref
id: D4F1K9
db: UniProt

Formic acid
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Formic acid

ChemicalStructure/PW C001554
type: ChemicalStructure
structure format: SMILES
structure data: CSC

Dimethyl sulfoxide
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Dimethyl sulfoxide

Unknown
type: ProteinReference
organism: Edwardsiella tarda ATCC 23685

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/PubChem-compound 45479636
type: UnificationXref
id: 45479636
db: PubChem-compound

NADH-quinone oxidoreductase subunit J
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit J

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Water
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Water

Reference/UniProt D4F738
type: UnificationXref
id: D4F738
db: UniProt

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Protein/29224 Inner Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

NADH ubiquinone oxidoreductase, 20 Kd subunit
type: Protein
cellular location: Inner Membrane
entity reference: NADH ubiquinone oxidoreductase, 20 Kd subunit

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Reference/UniProt D4F1X4
type: UnificationXref
id: D4F1X4
db: UniProt

Reference/KEGG Compound C00580
type: UnificationXref
id: C00580
db: KEGG Compound

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Carbon dioxide
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Carbon dioxide

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

menaquinone-8
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5376507
xref: Reference/ChEBI CHEBI 44027
chemical formula: C51H72O2
molecular weight: 716.5532
structure: ChemicalStructure/PW C041683

NADH dehydrogenase subunit L
type: Protein
cellular location: Inner Membrane
entity reference: NADH dehydrogenase subunit L

NAD
type: SmallMolecule
cellular location: Inner Membrane
entity reference: NAD

Compound/PW C001144 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Ni/Fe-hydrogenase, b-type cytochrome subunit
type: Protein
cellular location: Inner Membrane
entity reference: Ni/Fe-hydrogenase, b-type cytochrome subunit

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/SMPDB SMP0466310
type: UnificationXref
id: SMP0466310
db: SMPDB

trimethylamine-N-oxide reductase
type: Protein
cellular location: Inner Membrane
entity reference: trimethylamine-N-oxide reductase

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

Protein/86488 Inner Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: hydrogenase (acceptor)
stoichiometric coefficient: 4.0

Compound/PW C041100 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Electron
stoichiometric coefficient: 2.0

Compound/PW C040034 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

dimethyl sulfoxide reductase
type: Complex
cellular location: Inner Membrane
component: Putative dimethylsulfoxide reductase, chain B
component: DMSO reductase, anchor subunit DmsC
component: trimethylamine-N-oxide reductase

NADH dehydrogenase
type: Protein
cellular location: Inner Membrane
entity reference: NADH dehydrogenase

Reference/UniProt D4F740
type: UnificationXref
id: D4F740
db: UniProt

ChemicalStructure/PW C041590
type: ChemicalStructure
structure format: SMILES

Reference/UniProt D4F7R4
type: UnificationXref
id: D4F7R4
db: UniProt

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/PubChem-compound 5376507
type: UnificationXref
id: 5376507
db: PubChem-compound

Reference/UniProt D4F7R7
type: UnificationXref
id: D4F7R7
db: UniProt

Compound/PW C001554 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dimethylsulfide
stoichiometric coefficient: 1.0

Formate dehydrogenase-O major subunit
type: Protein
cellular location: Inner Membrane
entity reference: Formate dehydrogenase-O major subunit

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

NADH-quinone oxidoreductase subunit K
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit K

Edwardsiella tarda ATCC 23685
type: BioSource
xref: Reference/TAXONOMY 500638

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/PW C041683 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: menaquinone-8
stoichiometric coefficient: 1.0

1.8.5.3
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C041100 Inner Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C041683 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001554 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041590 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001447 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
right: Water
right: menaquinone-8
right: Hydrogen Ion
right: Dimethylsulfide
spontaneous: false
EC number: 1.8.5.3
left: Electron
left: Menaquinol 8
left: Dimethyl sulfoxide
left: Hydrogen Ion
name: Dimethyl sulfoxide + 2 Electron + 2 Hydrogen Ion + Menaquinol 8 → Dimethylsulfide + 2 Hydrogen Ion + Water + menaquinone-8
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

DMSO reductase, anchor subunit DmsC
type: Protein
cellular location: Inner Membrane
entity reference: DMSO reductase, anchor subunit DmsC

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/UniProt D4F7R0
type: UnificationXref
id: D4F7R0
db: UniProt

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

NADH
type: SmallMolecule
cellular location: Inner Membrane
entity reference: NADH

Hydrogen Ion
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Hydrogen Ion

NADH-quinone oxidoreductase subunit A
type: ProteinReference
xref: Reference/UniProt D4F7R7
organism: Edwardsiella tarda ATCC 23685

1.2.1.2
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C041100 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041683 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041590 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092 Inner Membrane/Stoichiometry/1.0
right: Menaquinol 8
right: Carbon dioxide
right: Hydrogen Ion
spontaneous: false
EC number: 1.2.1.2
left: Formic acid
left: Electron
left: menaquinone-8
left: Hydrogen Ion
name: Electron + Formic acid + Hydrogen Ion + menaquinone-8 → Carbon dioxide + Hydrogen Ion + Menaquinol 8
conversion direction: LEFT_TO_RIGHT

NADH dehydrogenase
type: ProteinReference
xref: Reference/UniProt D4F1K5
organism: Edwardsiella tarda ATCC 23685

1.12.99.6
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C041100 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041683 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041590 Inner Membrane/Stoichiometry/1.0
right: Menaquinol 8
right: Hydrogen Ion
spontaneous: false
EC number: 1.12.99.6
left: Electron
left: menaquinone-8
left: Hydrogen Ion
name: Electron + Hydrogen Ion + 2 Hydrogen Ion + menaquinone-8 → Hydrogen Ion + Menaquinol 8
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Electron
type: SmallMoleculeReference

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Compound/PW C001316 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Protein/86489 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ni/Fe-hydrogenase, b-type cytochrome subunit
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 17437
type: UnificationXref
id: CHEBI:17437
db: ChEBI

Reference/PubChem-compound 679
type: UnificationXref
id: 679
db: PubChem-compound

Reference/ChemSpider 1039
type: UnificationXref
id: 1039
db: ChemSpider

Compound/PW C041590 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Menaquinol 8
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Dimethyl sulfoxide
type: SmallMoleculeReference
xref: Reference/CAS 67-68-5
xref: Reference/PubChem-compound 679
xref: Reference/HMDB HMDB0002151
xref: Reference/ChEBI CHEBI 28262
xref: Reference/KEGG Compound C11143
xref: Reference/ChemSpider 659
chemical formula: C2H6OS
molecular weight: 78.01394
structure: ChemicalStructure/PW C001447

NADH-quinone oxidoreductase subunit I
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit I

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Compound/PW C041100 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Electron
stoichiometric coefficient: 1.0

Reference/CAS 75-18-3
type: UnificationXref
id: 75-18-3
db: CAS

Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/UniProt D4FAF4
type: UnificationXref
id: D4FAF4
db: UniProt

Reference/UniProt D4FAF6
type: UnificationXref
id: D4FAF6
db: UniProt

Menaquinol 8
type: SmallMoleculeReference
xref: Reference/PubChem-compound 45479636
xref: Reference/ChEBI CHEBI 61684
chemical formula: C51H74O2
molecular weight: 718.5689
structure: ChemicalStructure/PW C041590

Reference/UniProt D4FAF7
type: UnificationXref
id: D4FAF7
db: UniProt

Reference/ChEBI CHEBI 44027
type: UnificationXref
id: CHEBI:44027
db: ChEBI

Formate dehydrogenase iron-sulfur subunit
type: Protein
cellular location: Inner Membrane
entity reference: Formate dehydrogenase iron-sulfur subunit

hydrogenase 1, oxygen tolerant hydrogenase
type: Complex
component stoichiometry: Protein/86489 Inner Membrane/Stoichiometry/2.0
component stoichiometry: Protein/29224 Inner Membrane/Stoichiometry/4.0
component stoichiometry: Protein/86488 Inner Membrane/Stoichiometry/4.0
cellular location: Inner Membrane
component: Ni/Fe-hydrogenase, b-type cytochrome subunit
component: hydrogenase (acceptor)
component: Unknown

SubPathwayInteraction513394
type: Interaction
name: SubPathway513394Reaction
name: SubPathwayReaction
participant: menaquinone-8

Reference/TAXONOMY 500638
type: UnificationXref
id: 500638
db: TAXONOMY

menaquinone-8
type: SmallMolecule
cellular location: Inner Membrane
entity reference: menaquinone-8

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/UniProt D4F7P7
type: UnificationXref
id: D4F7P7
db: UniProt

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

formate dehydrogenase-O
type: Complex
cellular location: Inner Membrane
component: Formate dehydrogenase, gamma subunit
component: Formate dehydrogenase-O major subunit
component: Formate dehydrogenase iron-sulfur subunit

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Formate dehydrogenase-O major subunit
type: ProteinReference
xref: Reference/UniProt D4FAF4
organism: Edwardsiella tarda ATCC 23685

Unknown
type: Protein
cellular location: Inner Membrane
entity reference: Unknown

NADH-quinone oxidoreductase subunit M
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit M

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

hydrogenase (acceptor)
type: Protein
cellular location: Inner Membrane
entity reference: hydrogenase (acceptor)

NADH-quinone oxidoreductase subunit A
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit A

Reference/ChEBI CHEBI 28262
type: UnificationXref
id: CHEBI:28262
db: ChEBI

Reference/KEGG Compound C11143
type: UnificationXref
id: C11143
db: KEGG Compound

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Compound/PW C000092 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

NADH-quinone oxidoreductase subunit J
type: ProteinReference
xref: Reference/UniProt D4F7Q9
organism: Edwardsiella tarda ATCC 23685

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Electron
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Electron

NADH dehydrogenase subunit L
type: ProteinReference
xref: Reference/UniProt D4F7Q7
organism: Edwardsiella tarda ATCC 23685

Reference/UniProt D4F7Q7
type: UnificationXref
id: D4F7Q7
db: UniProt

Reference/UniProt D4F7Q6
type: UnificationXref
id: D4F7Q6
db: UniProt

NADH-quinone oxidoreductase subunit E
type: ProteinReference
xref: Reference/UniProt D4F7R4
organism: Edwardsiella tarda ATCC 23685

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Dimethyl Sulfoxide Electron Transfer
type: Pathway
pathway order: PathwaySubPathway/513394
pathway order: PathwayEnzymeReaction/6858085
pathway order: PathwayEnzymeReaction/6858086
pathway order: PathwayEnzymeReaction/6858090
pathway order: PathwayEnzymeReaction/6858082
pathway component: ReactionCoupledTransportCatalysis26034
pathway component: ReactionCoupledTransportCatalysis26033
pathway component: 1.8.5.3
pathway component: Endocytosis
pathway component: ReactionCoupledTransportCatalysis26031
pathway component: ReactionCoupledTransportCatalysis26038
pathway component: 1.6.99.5
pathway component: 1.2.1.2
pathway component: 1.12.99.6
xref: Reference/SMPDB SMP0466310
xref: Reference/PathWhiz PW485776
organism: Edwardsiella tarda ATCC 23685

Reference/UniProt D4F7Q9
type: UnificationXref
id: D4F7Q9
db: UniProt

NADH-quinone oxidoreductase subunit K
type: ProteinReference
xref: Reference/UniProt D4F7Q8
organism: Edwardsiella tarda ATCC 23685

Reference/UniProt D4F7Q8
type: UnificationXref
id: D4F7Q8
db: UniProt

NADH-quinone oxidoreductase subunit M
type: ProteinReference
xref: Reference/UniProt D4F7Q6
organism: Edwardsiella tarda ATCC 23685

Reference/PubChem-compound 1068
type: UnificationXref
id: 1068
db: PubChem-compound

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

ChemicalStructure/PW C001447
type: ChemicalStructure
structure format: SMILES
structure data: CS(C)=O

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C040034 Inner Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0002303
type: UnificationXref
id: HMDB0002303
db: HMDB

Endocytosis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway513394
pathway component: SubPathwayInteraction513394
name: SubPathway

Reference/BioCyc REDUCED-DMSO
type: UnificationXref
id: REDUCED-DMSO
db: BioCyc

1.6.99.5
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/4.0
participant stoichiometry: Compound/PW C041100 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041683 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041590 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Inner Membrane/Stoichiometry/1.0
right: Electron
right: NAD
right: Menaquinol 8
right: Hydrogen Ion
spontaneous: false
EC number: 1.6.99.5
left: menaquinone-8
left: NADH
left: Hydrogen Ion
name: 4 Hydrogen Ion + 2 Hydrogen Ion + NADH + menaquinone-8 ? Electron + Hydrogen Ion + 4 Hydrogen Ion + Menaquinol 8 + NAD

Dimethylsulfide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002303
xref: Reference/CAS 75-18-3
xref: Reference/KEGG Compound C00580
xref: Reference/BioCyc REDUCED-DMSO
xref: Reference/ChEBI CHEBI 17437
xref: Reference/ChemSpider 1039
xref: Reference/PubChem-compound 1068
chemical formula: C2H6S
molecular weight: 62.01902
structure: ChemicalStructure/PW C001554

NADH-quinone oxidoreductase subunit I
type: ProteinReference
xref: Reference/UniProt D4F7R0
organism: Edwardsiella tarda ATCC 23685

Compound/PW C001447 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dimethyl sulfoxide
stoichiometric coefficient: 1.0

NADH ubiquinone oxidoreductase, 20 Kd subunit
type: ProteinReference
xref: Reference/UniProt D4F1K9
organism: Edwardsiella tarda ATCC 23685

Respiratory-chain NADH dehydrogenase, 30 Kd subunit
type: ProteinReference
xref: Reference/UniProt D4F1K6
organism: Edwardsiella tarda ATCC 23685

Reference/PathWhiz PW485776
type: UnificationXref
id: PW485776
db: PathWhiz

NADH:quinone oxidoreductase I
type: Complex
cellular location: Inner Membrane
component: NADH-quinone oxidoreductase subunit M
component: NADH dehydrogenase subunit L
component: NADH dehydrogenase
component: NADH-quinone oxidoreductase subunit A
component: NADH-quinone oxidoreductase subunit J
component: NADH-quinone oxidoreductase subunit K
component: NADH-quinone oxidoreductase subunit E
component: NADH-quinone oxidoreductase subunit I
component: Respiratory-chain NADH dehydrogenase, 30 Kd subunit
component: Unknown
component: NADH ubiquinone oxidoreductase, 20 Kd subunit

NADH-quinone oxidoreductase subunit E
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit E

DMSO reductase, anchor subunit DmsC
type: ProteinReference
xref: Reference/UniProt D4F738
organism: Edwardsiella tarda ATCC 23685

Compound/PW C000721 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 61684
type: UnificationXref
id: CHEBI:61684
db: ChEBI