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Pathway Description
L-Cysteine Degradation
Escherichia coli IAI39
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2025-02-22
Last Updated: 2025-02-22
The degradation of cysteine starts with L-cysteine reacting with l-cysteine desulfhydrase resulting in the release of a hydrogen sulfide, a hydrogen ion and a a 2-aminoprop-2-enoate. The latter compound in turn reacts spontaneously to form a 2-iminopropanoate. This compound in turn reacts spontaneously with water and a hydrogen ion resulting in the release of ammonium and pyruvate.
References
L-Cysteine Degradation References
Deeley MC, Yanofsky C: Nucleotide sequence of the structural gene for tryptophanase of Escherichia coli K-12. J Bacteriol. 1981 Sep;147(3):787-96.
Pubmed: 6268608
Tokushige M, Tsujimoto N, Oda T, Honda T, Yumoto N, Ito S, Yamamoto M, Kim EH, Hiragi Y: Role of cysteine residues in tryptophanase for monovalent cation-induced activation. Biochimie. 1989 Jun;71(6):711-20. doi: 10.1016/0300-9084(89)90087-4.
Pubmed: 2502187
Burland V, Plunkett G 3rd, Daniels DL, Blattner FR: DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication. Genomics. 1993 Jun;16(3):551-61. doi: 10.1006/geno.1993.1230.
Pubmed: 7686882
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0002122
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