2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Secondary Metabolites: Enterobacterial Common Antigen Biosynthesis
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
Secondary Metabolites: Methylerythritol Phosphate and Polyisoprenoid Biosynthesis
Prevotella corporis DSM 18810 = JCM 8529
2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + a reduced flavodoxin → 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + Water + an oxidized flavodoxin
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol → 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + Cytidine monophosphate
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine triphosphate → 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine diphosphate + Hydrogen Ion
4-diphosphocytidyl-2-C-methylerythritol kinase
2-C-methyl-D-erythritol 4-phosphate + Cytidine triphosphate + Hydrogen Ion → 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Pyrophosphate
1-Deoxy-D-xylulose 5-phosphate + Hydrogen Ion + NADPH → 2-C-methyl-D-erythritol 4-phosphate + NADP
1-deoxy-D-xylulose 5-phosphate reductoisomerase
4-diphosphocytidyl-2C-methyl-D-erythritol synthase
D-Glyceraldehyde 3-phosphate + Hydrogen Ion → 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide
Geranyl-PP + Isopentenyl pyrophosphate → Farnesyl pyrophosphate + Pyrophosphate
di-trans,octa-cis-undecaprenyl diphosphate
Farnesyl pyrophosphate + 5 Isopentenyl pyrophosphate → Octaprenyl diphosphate + 5 Pyrophosphate
Secondary Metabolites: Ubiquinol Biosynthesis
Farnesyl pyrophosphate + 8 Isopentenyl pyrophosphate → 8 Pyrophosphate + di-trans,octa-cis-undecaprenyl diphosphate
Dimethylallylpyrophosphate + Isopentenyl pyrophosphate → Geranyl-PP + Pyrophosphate
Isopentenyl pyrophosphate ↔ Dimethylallylpyrophosphate
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + NADPH → Isopentenyl pyrophosphate + NADPH + Water
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + NADPH → Dimethylallylpyrophosphate + NADP + Water