Reference/ChemSpider 82579
type: UnificationXref
id: 82579
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Nucleus
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Compound/PW C040034 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Adenylate cyclase type 10
type: ProteinReference
xref: Reference/UniProt Q96PN6
organism: BiologicalState13711

ProteinComplex/416721 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: CREB (phosphorylated)
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C000273 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17-Hydroxyprogesterone
stoichiometric coefficient: 1.0

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP

Reference/UniProt Q02930
type: UnificationXref
id: Q02930
db: UniProt

direct_interaction
type: InteractionVocabulary

Reference/BioCyc CHOLESTEROL
type: UnificationXref
id: CHOLESTEROL
db: BioCyc

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Compound/PW C000054 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroepiandrosterone
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

ReactionCatalysis944
type: Catalysis
controller: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
controlled: Reaction51
control type: ACTIVATION

17-Hydroxyprogesterone
type: SmallMoleculeReference
xref: Reference/CAS 68-96-2
xref: Reference/ChEBI CHEBI 17252
xref: Reference/KEGG Compound C01176
xref: Reference/PubChem-compound 6238
xref: Reference/ChemSpider 6002
xref: Reference/HMDB HMDB0000374
chemical formula: C21H30O3
molecular weight: 330.21948
structure: ChemicalStructure/PW C000273

G protein complex
type: Complex
cellular location: Cytosol
component: Guanine nucleotide-binding protein G(i) subunit alpha-1
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Gγ

Cytochrome P450 19A1
type: ProteinReference
xref: Reference/UniProt P11511
organism: BiologicalState13716

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P63096
organism: BiologicalState13711

Reference/BioCyc 3-BETA-HYDROXYANDROST-5-EN-17-ONE
type: UnificationXref
id: 3-BETA-HYDROXYANDROST-5-EN-17-ONE
db: BioCyc

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
type: ProteinReference
xref: Reference/UniProt P14060
organism: BiologicalState13711

Compound/PW C000721 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Compound/PW C000094/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estrone
stoichiometric coefficient: 1.0

Androstenedione
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16422
xref: Reference/ChemSpider 5898
xref: Reference/KEGG Compound C00280
xref: Reference/PubChem-compound 6128
xref: Reference/HMDB HMDB0000053
xref: Reference/BioCyc ANDROST4ENE
xref: Reference/CAS 63-05-8
chemical formula: C19H26O2
molecular weight: 286.19327
structure: ChemicalStructure/PW C000037

Protein/22679 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Steroidogenic acute regulatory protein, mitochondrial
stoichiometric coefficient: 1.0

Reference/ChemSpider 6002
type: UnificationXref
id: 6002
db: ChemSpider

ReactionCatalysis24
type: Catalysis
controller: Steroid 17-alpha-hydroxylase/17,20 lyase
controlled: Reaction24
control type: ACTIVATION

Steroidogenic acute regulatory protein, mitochondrial
type: ProteinReference
xref: Reference/UniProt P49675
organism: BiologicalState13711

Reaction179451
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000047 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000173 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Pregnenolone
spontaneous: false
left: Cholesterol
name: Cholesterol → Pregnenolone
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis22
type: Catalysis
controller: Steroid 17-alpha-hydroxylase/17,20 lyase
controlled: Reaction21
control type: ACTIVATION

ProteinComplex/416349 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

Protein/22679 Mitochondrial membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Steroidogenic acute regulatory protein, mitochondrial
stoichiometric coefficient: 1.0

Cholesterol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000067
xref: Reference/ChEBI CHEBI 16113
xref: Reference/BioCyc CHOLESTEROL
xref: Reference/KEGG Compound C00187
xref: Reference/ChemSpider 5775
xref: Reference/PubChem-compound 5997
xref: Reference/CAS 57-88-5
chemical formula: C27H46O
molecular weight: 386.35486
structure: ChemicalStructure/PW C000047

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/UniProt P01215
type: UnificationXref
id: P01215
db: UniProt

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/UniProt P59768
type: UnificationXref
id: P59768
db: UniProt

Reference/ChEBI CHEBI 16113
type: UnificationXref
id: CHEBI:16113
db: ChEBI

Reference/PubChem-compound 5870
type: UnificationXref
id: 5870
db: PubChem-compound

Reduced acceptor
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Reduced acceptor

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/PubChem-compound 5757
type: UnificationXref
id: 5757
db: PubChem-compound

Progesterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001830
xref: Reference/ChEBI CHEBI 17026
xref: Reference/CAS 57-83-0
xref: Reference/ChemSpider 5773
xref: Reference/PubChem-compound 5994
xref: Reference/BioCyc CPD-272
xref: Reference/KEGG Compound C00410
chemical formula: C21H30O2
molecular weight: 314.22458
structure: ChemicalStructure/PW C001216

Reference/PubChem-compound 5997
type: UnificationXref
id: 5997
db: PubChem-compound

Reference/BioCyc PREGNENOLONE
type: UnificationXref
id: PREGNENOLONE
db: BioCyc

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/PubChem-compound 5994
type: UnificationXref
id: 5994
db: PubChem-compound

Gγ
type: Protein
cellular location: Membrane
entity reference: Gγ

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Transport13777
type: Transport
participant stoichiometry: Compound/PW C000047 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000047 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Cholesterol
spontaneous: false
left: Cholesterol
name: Cholesterol (→) Transport: Homo sapiens, Ovary, Theca Cell, Mitochondrial Outer Membrane to Homo sapiens, Ovary, Theca Cell, Mitochondrial Inner Membrane
conversion direction: LEFT_TO_RIGHT

Compound/PW C000263 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17a-Hydroxypregnenolone
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15022
type: UnificationXref
id: CHEBI:15022
db: ChEBI

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Steroidogenic acute regulatory protein, mitochondrial
type: Protein
cellular location: Nucleus
entity reference: Steroidogenic acute regulatory protein, mitochondrial

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

17-Hydroxyprogesterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 17-Hydroxyprogesterone

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Interaction15667
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates PKA
participant: PKA
participant: cAMP

ProteinComplex/416349 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

Compound/PW C000037 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Androstenedione
stoichiometric coefficient: 1.0

Reaction1279
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001216 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000273 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
right: 17-Hydroxyprogesterone
right: Acceptor
right: Water
spontaneous: false
left: Reduced acceptor
left: Progesterone
left: Oxygen
name: Oxygen + Progesterone + Reduced acceptor → 17-Hydroxyprogesterone + Acceptor + Water
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P01229
type: UnificationXref
id: P01229
db: UniProt

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/KEGG Compound C00468
type: UnificationXref
id: C00468
db: KEGG Compound

Steroidogenic acute regulatory protein, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: Steroidogenic acute regulatory protein, mitochondrial

Reference/PubChem-compound 53477678
type: UnificationXref
id: 53477678
db: PubChem-compound

Reference/UniProt Q96PN6
type: UnificationXref
id: Q96PN6
db: UniProt

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState13711

ReactionCatalysis46
type: Catalysis
controller: Estradiol 17-beta-dehydrogenase 1
controlled: 1.1.1.62
control type: ACTIVATION

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Cyclic AMP-responsive element-binding protein 3
type: Protein
cellular location: Nucleus
entity reference: Cyclic AMP-responsive element-binding protein 3

Compound/PW C001144 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000503
type: UnificationXref
id: CL:0000503
db: CELL TYPE ONTOLOGY

Compound/PW C000047 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reaction2039137
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/416349 Nucleus/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/416721 Nucleus/Stoichiometry/1.0
right: CREB (phosphorylated)
spontaneous: false
left: PKA
left: Phosphate
name: PKA + Phosphate → CREB (phosphorylated)
conversion direction: LEFT_TO_RIGHT

Reference/CELL TYPE ONTOLOGY CL 0000501
type: UnificationXref
id: CL:0000501
db: CELL TYPE ONTOLOGY

Glycoprotein hormones alpha chain
type: Protein
cellular location: Membrane
entity reference: Glycoprotein hormones alpha chain

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Hydrogen Ion

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Compound/PW C000037 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Androstenedione
stoichiometric coefficient: 1.0

Estradiol 17-beta-dehydrogenase 1
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Estradiol 17-beta-dehydrogenase 1

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

17a-Hydroxypregnenolone
type: SmallMoleculeReference
xref: Reference/ChemSpider 82579
xref: Reference/PubChem-compound 91451
xref: Reference/CAS 387-79-1
xref: Reference/HMDB HMDB0000363
xref: Reference/KEGG Compound C05138
xref: Reference/ChEBI CHEBI 28750
chemical formula: C21H32O3
molecular weight: 332.23514
structure: ChemicalStructure/PW C000263

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState13711

Mitochondrial membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0031966

ReactionCatalysis2177014
type: Catalysis
controller: Steroid 17-alpha-hydroxylase/17,20 lyase
controlled: Reaction2145475
control type: ACTIVATION

Reference/ChEBI CHEBI 17026
type: UnificationXref
id: CHEBI:17026
db: ChEBI

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/ChEBI CHEBI 17263
type: UnificationXref
id: CHEBI:17263
db: ChEBI

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

ChemicalStructure/PW C001216
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Gγ
type: ProteinReference
xref: Reference/UniProt P59768
organism: BiologicalState13711

Reference/BioCyc ANDROST4ENE
type: UnificationXref
id: ANDROST4ENE
db: BioCyc

Compound/PW C000173 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pregnenolone
stoichiometric coefficient: 1.0

Lutropin subunit beta
type: ProteinReference
xref: Reference/UniProt P01229
organism: BiologicalState13711

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Estrone
type: SmallMolecule
entity reference: Estrone

Ovary
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000975

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

NAD
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NAD

Estradiol
type: SmallMolecule
entity reference: Estradiol

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Cyclic AMP-responsive element-binding protein 1
type: ProteinReference
xref: Reference/UniProt P16220
organism: BiologicalState13711

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

ReactionCatalysis981
type: Catalysis
controller: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
controlled: Reaction52
control type: ACTIVATION

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/CAS 50-28-2
type: UnificationXref
id: 50-28-2
db: CAS

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADP

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADPH

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C05138
type: UnificationXref
id: C05138
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/UniProt P16220
type: UnificationXref
id: P16220
db: UniProt

Acceptor
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Acceptor

ReactionCatalysis207333
type: Catalysis
controller: Cytochrome P450 19A1
controlled: Reaction217801
control type: ACTIVATION

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000263
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

Reference/BRENDA TISSUE ONTOLOGY BTO 0000975
type: UnificationXref
id: BTO:0000975
db: BRENDA TISSUE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Reference/PubChem-compound 91451
type: UnificationXref
id: 91451
db: PubChem-compound

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Oxygen

Reference/CAS 57-88-5
type: UnificationXref
id: 57-88-5
db: CAS

NADH
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADH

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Lutropin-choriogonadotropic hormone receptor
type: ProteinReference
xref: Reference/UniProt P22888
organism: BiologicalState13711

Reaction217801
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000094 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000037 Endoplasmic Reticulum/Stoichiometry/1.0
right: Estrone
spontaneous: false
left: Androstenedione
name: Androstenedione → Estrone
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/KEGG Compound C01227
type: UnificationXref
id: C01227
db: KEGG Compound

Compound/PW C001216 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Progesterone
stoichiometric coefficient: 1.0

Cholesterol
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Cholesterol

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

PKA
type: Complex
cellular location: Nucleus
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase catalytic subunit alpha

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

ReactionCatalysis169348
type: Catalysis
controller: Cholesterol side-chain cleavage enzyme, mitochondrial
controlled: Reaction179451
control type: ACTIVATION

Reaction51
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000054 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000037 Endoplasmic Reticulum/Stoichiometry/1.0
right: Hydrogen Ion
right: NADH
right: Androstenedione
spontaneous: false
left: Dehydroepiandrosterone
left: NAD
name: Dehydroepiandrosterone + NAD → Androstenedione + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: Membrane
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: Reference/UniProt P22612
organism: BiologicalState13711

Reference/PubChem-compound 6128
type: UnificationXref
id: 6128
db: PubChem-compound

Compound/PW C000173 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pregnenolone
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reaction52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001216 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000173 Endoplasmic Reticulum/Stoichiometry/1.0
right: Progesterone
right: Hydrogen Ion
right: NADH
spontaneous: false
left: Pregnenolone
left: NAD
name: NAD + Pregnenolone → Hydrogen Ion + NADH + Progesterone
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5660
type: UnificationXref
id: 5660
db: ChemSpider

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Ovarian Steroidogenesis
type: Pathway
pathway order: PathwayTransport/9851219
pathway order: PathwayTransport/9851215
pathway order: PathwayEnzymeReaction/9851220
pathway order: PathwayTransport/9851214
pathway order: PathwayInteraction/2834
pathway order: PathwayTransport/9851216
pathway order: PathwayTransport/9851211
pathway order: PathwayEnzymeReaction/9851228
pathway order: PathwayTransport/9851231
pathway order: PathwayEnzymeReaction/9851225
pathway order: PathwayTransport/9851230
pathway order: PathwayEnzymeReaction/9851224
pathway order: PathwayEnzymeReaction/9851223
pathway order: PathwayEnzymeReaction/9851222
pathway order: PathwayEnzymeReaction/9851221
pathway order: PathwayEnzymeReaction/9851229
pathway order: PathwayInteraction/15667
pathway order: PathwayTransport/9851226
pathway order: PathwayTransport/9851227
pathway order: PathwayInteraction/3679
pathway order: PathwayInteraction/3678
pathway order: PathwayInteraction/3676
pathway order: PathwayEnzymeReaction/9851217
pathway order: PathwayEnzymeReaction/9851213
pathway order: PathwayEnzymeReaction/9851212
pathway component: Transport100588
pathway component: ReactionCatalysis2177014
pathway component: Transport100585
pathway component: Reaction217801
pathway component: Transport100586
pathway component: Transport100584
pathway component: ReactionCatalysis169348
pathway component: Reaction51
pathway component: Transport100589
pathway component: Transport13777
pathway component: Reaction52
pathway component: Interaction15667
pathway component: Reaction2145475
pathway component: Interaction2834
pathway component: Reaction2145474
pathway component: Transport100590
pathway component: Transport100591
pathway component: ReactionCatalysis944
pathway component: Reaction1279
pathway component: Reaction24
pathway component: 1.1.1.62
pathway component: ReactionCatalysis981
pathway component: Transport100592
pathway component: Interaction3676
pathway component: Reaction21
pathway component: ReactionCatalysis24
pathway component: ReactionCatalysis46
pathway component: TransportCatalysis4825
pathway component: Reaction179451
pathway component: ReactionCatalysis22
pathway component: ReactionCatalysis207333
pathway component: Interaction3678
pathway component: Interaction3679
pathway component: Reaction2039137
pathway component: ReactionCatalysis995
xref: Reference/PathWhiz PW766123
xref: Reference/SMPDB SMP0728344
organism: Homo sapiens

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Reference/UniProt P05108
type: UnificationXref
id: P05108
db: UniProt

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Dehydroepiandrosterone
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5881
xref: Reference/KEGG Compound C01227
xref: Reference/ChEBI CHEBI 28689
xref: Reference/BioCyc 3-BETA-HYDROXYANDROST-5-EN-17-ONE
xref: Reference/CAS 53-43-0
xref: Reference/ChemSpider 5670
xref: Reference/HMDB HMDB0000077
chemical formula: C19H28O2
molecular weight: 288.20892
structure: ChemicalStructure/PW C000054

Pregnenolone
type: SmallMoleculeReference
xref: Reference/CAS 145-13-1
xref: Reference/KEGG Compound C01953
xref: Reference/PubChem-compound 53477678
xref: Reference/ChEBI CHEBI 16581
xref: Reference/BioCyc PREGNENOLONE
xref: Reference/HMDB HMDB0000253
chemical formula: C21H32O2
molecular weight: 316.24023
structure: ChemicalStructure/PW C000173

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 5898
type: UnificationXref
id: 5898
db: ChemSpider

Androstenedione
type: SmallMolecule
cellular location: Cytosol
entity reference: Androstenedione

Reference/ChemSpider 5773
type: UnificationXref
id: 5773
db: ChemSpider

Reference/ChEBI CHEBI 17252
type: UnificationXref
id: CHEBI:17252
db: ChEBI

Interaction3676
type: MolecularInteraction
interaction type: direct_interaction
name: Luteinizing Hormone activates Lutropin-choriogonadotropic hormone receptor
participant: Lutropin-choriogonadotropic hormone receptor
participant: Luteinizing Hormone

Reference/ChemSpider 5775
type: UnificationXref
id: 5775
db: ChemSpider

Reference/PubChem-compound 6238
type: UnificationXref
id: 6238
db: PubChem-compound

Granulosa Cell
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000501

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Cyclic AMP-responsive element-binding protein 5
type: Protein
cellular location: Nucleus
entity reference: Cyclic AMP-responsive element-binding protein 5

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612
organism: BiologicalState13711

TransportCatalysis4825
type: Catalysis
controller: Steroidogenic acute regulatory protein, mitochondrial
controlled: Transport13777
control type: ACTIVATION

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Interaction3678
type: MolecularInteraction
interaction type: direct_interaction
name: Lutropin-choriogonadotropic hormone receptor activates G protein complex
participant: G protein complex
participant: Lutropin-choriogonadotropic hormone receptor

Interaction3679
type: MolecularInteraction
interaction type: direct_interaction
name: G protein complex activates Adenylate Cyclase
participant: G protein complex
participant: Adenylate cyclase type 10

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Reference/UniProt P14060
type: UnificationXref
id: P14060
db: UniProt

Reference/HMDB HMDB0000363
type: UnificationXref
id: HMDB0000363
db: HMDB

ReactionCatalysis995
type: Catalysis
controller: Steroid 17-alpha-hydroxylase/17,20 lyase
controlled: Reaction1279
control type: ACTIVATION

Reference/UniProt P14061
type: UnificationXref
id: P14061
db: UniProt

G protein complex
type: Complex
cellular location: Membrane
component: Guanine nucleotide-binding protein G(i) subunit alpha-1
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Gγ

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Luteinizing Hormone
type: Complex
cellular location: Membrane
component: Glycoprotein hormones alpha chain
component: Lutropin subunit beta

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Pregnenolone
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Pregnenolone

Reference/SMPDB SMP0728344
type: UnificationXref
id: SMP0728344
db: SMPDB

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00951
type: UnificationXref
id: C00951
db: KEGG Compound

Androstenedione
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Androstenedione

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Steroid 17-alpha-hydroxylase/17,20 lyase
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Steroid 17-alpha-hydroxylase/17,20 lyase

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000054
type: ChemicalStructure
structure format: SMILES

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

ChemicalStructure/PW C000173
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00280
type: UnificationXref
id: C00280
db: KEGG Compound

Compound/Generic40 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced acceptor
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000253
type: UnificationXref
id: HMDB0000253
db: HMDB

Reference/HMDB HMDB0000374
type: UnificationXref
id: HMDB0000374
db: HMDB

CREB (phosphorylated)
type: Complex
cellular location: Nucleus
component: Cyclic AMP-responsive element-binding protein 3
component: Cyclic AMP-responsive element-binding protein 1
component: Cyclic AMP-responsive element-binding protein 5

Reference/ChEBI CHEBI 16422
type: UnificationXref
id: CHEBI:16422
db: ChEBI

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Nucleus
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

1.1.1.62
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000098 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000094 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum/Stoichiometry/1.0
right: Estrone
right: NADPH
spontaneous: false
EC number: 1.1.1.62
left: NADP
left: Estradiol
name: Estradiol + NADP ↔ Estrone + NADPH
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 15339
type: UnificationXref
id: CHEBI:15339
db: ChEBI

Compound/PW C000094 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estrone
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Phosphate

Compound/PW C000047 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

Reference/UniProt P05093
type: UnificationXref
id: P05093
db: UniProt

Reference/ChemSpider 5554
type: UnificationXref
id: 5554
db: ChemSpider

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/ChemSpider 5670
type: UnificationXref
id: 5670
db: ChemSpider

Cyclic AMP-responsive element-binding protein 3
type: ProteinReference
xref: Reference/UniProt O43889
organism: BiologicalState13711

Reference/UniProt P63096
type: UnificationXref
id: P63096
db: UniProt

Reference/HMDB HMDB0000145
type: UnificationXref
id: HMDB0000145
db: HMDB

Reference/UniProt O43889
type: UnificationXref
id: O43889
db: UniProt

Progesterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Progesterone

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Water

17a-Hydroxypregnenolone
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 17a-Hydroxypregnenolone

Estradiol 17-beta-dehydrogenase 1
type: ProteinReference
xref: Reference/UniProt P14061
organism: BiologicalState13716

Estradiol
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Estradiol

Lutropin subunit beta
type: Protein
cellular location: Membrane
entity reference: Lutropin subunit beta

Reference/ChEBI CHEBI 28750
type: UnificationXref
id: CHEBI:28750
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Glycoprotein hormones alpha chain
type: ProteinReference
xref: Reference/UniProt P01215
organism: BiologicalState13711

Reference/BioCyc CPD-352
type: UnificationXref
id: CPD-352
db: BioCyc

Reference/BioCyc ESTRONE
type: UnificationXref
id: ESTRONE
db: BioCyc

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15339

Cholesterol side-chain cleavage enzyme, mitochondrial
type: ProteinReference
xref: Reference/UniProt P05108
organism: BiologicalState13711

Reduced acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15022

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Estrone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000145
xref: Reference/PubChem-compound 5870
xref: Reference/KEGG Compound C00468
xref: Reference/CAS 53-16-7
xref: Reference/ChEBI CHEBI 17263
xref: Reference/BioCyc ESTRONE
xref: Reference/ChemSpider 5660
chemical formula: C18H22O2
molecular weight: 270.162
structure: ChemicalStructure/PW C000094

Cholesterol
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Cholesterol

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

ChemicalStructure/PW C000273
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000037
type: ChemicalStructure
structure format: SMILES

Interaction2834
type: MolecularInteraction
interaction type: direct_interaction
name: Adenylate Cyclase activates cAMP
participant: Adenylate cyclase type 10
participant: cAMP

Pregnenolone
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Pregnenolone

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Estradiol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16469
xref: Reference/CAS 50-28-2
xref: Reference/BioCyc CPD-352
xref: Reference/PubChem-compound 5757
xref: Reference/ChemSpider 5554
xref: Reference/KEGG Compound C00951
xref: Reference/HMDB HMDB0000151
chemical formula: C18H24O2
molecular weight: 272.17764
structure: ChemicalStructure/PW C000098

Reference/HMDB HMDB0000151
type: UnificationXref
id: HMDB0000151
db: HMDB

Reaction24
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000037 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000273 Endoplasmic Reticulum/Stoichiometry/1.0
right: Androstenedione
spontaneous: false
left: 17-Hydroxyprogesterone
name: 17-Hydroxyprogesterone → Androstenedione
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C01953
type: UnificationXref
id: C01953
db: KEGG Compound

Compound/PW C000143 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/CAS 68-96-2
type: UnificationXref
id: 68-96-2
db: CAS

Reference/KEGG Compound C00187
type: UnificationXref
id: C00187
db: KEGG Compound

Gγ
type: Protein
cellular location: Cytosol
entity reference: Gγ

Reaction21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000054 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000263 Endoplasmic Reticulum/Stoichiometry/1.0
right: Dehydroepiandrosterone
spontaneous: false
left: 17a-Hydroxypregnenolone
name: 17a-Hydroxypregnenolone → Dehydroepiandrosterone
conversion direction: LEFT_TO_RIGHT

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/GENE ONTOLOGY GO 0016020
type: UnificationXref
id: GO:0016020
db: GENE ONTOLOGY

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000047
type: ChemicalStructure
structure format: SMILES

Estrone
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Estrone

Theca Cell
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000503

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/CAS 57-83-0
type: UnificationXref
id: 57-83-0
db: CAS

Reference/CAS 53-16-7
type: UnificationXref
id: 53-16-7
db: CAS

Dehydroepiandrosterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Dehydroepiandrosterone

Compound/PW C001065 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Compound/PW C000146 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

PKA
type: Complex
cellular location: Cytosol
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase catalytic subunit gamma

Protein/22679 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Steroidogenic acute regulatory protein, mitochondrial
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/PathWhiz PW766123
type: UnificationXref
id: PW766123
db: PathWhiz

Steroidogenic acute regulatory protein, mitochondrial
type: Protein
cellular location: Mitochondrial membrane
entity reference: Steroidogenic acute regulatory protein, mitochondrial

Steroidogenic acute regulatory protein, mitochondrial
type: Protein
entity reference: Steroidogenic acute regulatory protein, mitochondrial

Steroid 17-alpha-hydroxylase/17,20 lyase
type: ProteinReference
xref: Reference/UniProt P05093
organism: BiologicalState13711

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C000098
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Lutropin-choriogonadotropic hormone receptor
type: Protein
cellular location: Membrane
entity reference: Lutropin-choriogonadotropic hormone receptor

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Reference/ChEBI CHEBI 28689
type: UnificationXref
id: CHEBI:28689
db: ChEBI

Reaction2145475
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000173 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000263 Endoplasmic Reticulum/Stoichiometry/1.0
right: 17a-Hydroxypregnenolone
spontaneous: false
left: Pregnenolone
name: Pregnenolone → 17a-Hydroxypregnenolone
conversion direction: LEFT_TO_RIGHT

Reaction2145474
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/416721 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/22679 Nucleus/Stoichiometry/1.0
right: Steroidogenic acute regulatory protein, mitochondrial
spontaneous: false
left: CREB (phosphorylated)
name: CREB (phosphorylated) → StAR
conversion direction: LEFT_TO_RIGHT

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Reference/HMDB HMDB0000053
type: UnificationXref
id: HMDB0000053
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000094
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cytochrome P450 19A1
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Cytochrome P450 19A1

Reference/PubChem-compound 5881
type: UnificationXref
id: 5881
db: PubChem-compound

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Compound/PW C000098 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estradiol
stoichiometric coefficient: 1.0

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 16469
type: UnificationXref
id: CHEBI:16469
db: ChEBI

Reference/UniProt P49675
type: UnificationXref
id: P49675
db: UniProt

Reference/ChEBI CHEBI 16581
type: UnificationXref
id: CHEBI:16581
db: ChEBI

Reference/KEGG Compound C01176
type: UnificationXref
id: C01176
db: KEGG Compound

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/CAS 53-43-0
type: UnificationXref
id: 53-43-0
db: CAS

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Reference/HMDB HMDB0000067
type: UnificationXref
id: HMDB0000067
db: HMDB

Reference/CAS 145-13-1
type: UnificationXref
id: 145-13-1
db: CAS

Reference/HMDB HMDB0001830
type: UnificationXref
id: HMDB0001830
db: HMDB

Reference/UniProt P22612
type: UnificationXref
id: P22612
db: UniProt

Compound/Generic41 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acceptor
stoichiometric coefficient: 1.0

Reference/CAS 387-79-1
type: UnificationXref
id: 387-79-1
db: CAS

Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016020

Transport100588
type: Transport
participant stoichiometry: Compound/PW C000173 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000173 Endoplasmic Reticulum/Stoichiometry/1.0
right: Pregnenolone
spontaneous: false
left: Pregnenolone
name: Pregnenolone (→) Transport: Homo sapiens, Ovary, Theca Cell, Mitochondrial Inner Membrane to Homo sapiens, Ovary, Theca Cell, Endoplasmic Reticulum
conversion direction: LEFT_TO_RIGHT

Transport100585
type: Transport
participant stoichiometry: Protein/22679 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/22679 Cytosol/Stoichiometry/1.0
right: Steroidogenic acute regulatory protein, mitochondrial
spontaneous: false
left: Steroidogenic acute regulatory protein, mitochondrial
name: StAR (→) Transport: Homo sapiens, Ovary, Theca Cell, Nucleus to Homo sapiens, Ovary, Theca Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport100586
type: Transport
participant stoichiometry: Protein/22679 Mitochondrial membrane/Stoichiometry/1.0
participant stoichiometry: Protein/22679 Cytosol/Stoichiometry/1.0
right: Steroidogenic acute regulatory protein, mitochondrial
spontaneous: false
left: Steroidogenic acute regulatory protein, mitochondrial
name: StAR (→) Transport: Homo sapiens, Ovary, Theca Cell, Cytosol to Homo sapiens, Ovary, Theca Cell, Mitochondrial membrane
conversion direction: LEFT_TO_RIGHT

Cyclic AMP-responsive element-binding protein 5
type: ProteinReference
xref: Reference/UniProt Q02930
organism: BiologicalState13711

Transport100584
type: Transport
participant stoichiometry: ProteinComplex/416349 Nucleus/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/416349 Cytosol/Stoichiometry/1.0
right: PKA
spontaneous: false
left: PKA
name: PKA (→) Transport: Homo sapiens, Ovary, Theca Cell, Cytosol to Homo sapiens, Ovary, Theca Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-272
type: UnificationXref
id: CPD-272
db: BioCyc

Reference/KEGG Compound C00410
type: UnificationXref
id: C00410
db: KEGG Compound

Transport100589
type: Transport
participant stoichiometry: Compound/PW C000037 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000037 Cytosol/Stoichiometry/1.0
right: Androstenedione
spontaneous: false
left: Androstenedione
name: Androstenedione (→) Transport: Homo sapiens, Ovary, Theca Cell, Endoplasmic Reticulum to Homo sapiens, Ovary, Granulosa Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P22888
type: UnificationXref
id: P22888
db: UniProt

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Cyclic AMP-responsive element-binding protein 1
type: Protein
cellular location: Nucleus
entity reference: Cyclic AMP-responsive element-binding protein 1

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/GENE ONTOLOGY GO 0031966
type: UnificationXref
id: GO:0031966
db: GENE ONTOLOGY

Transport100590
type: Transport
participant stoichiometry: Compound/PW C000037 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000037 Cytosol/Stoichiometry/1.0
right: Androstenedione
spontaneous: false
left: Androstenedione
name: Androstenedione (→) Transport: Homo sapiens, Ovary, Granulosa Cell, Cytosol to Homo sapiens, Ovary, Granulosa Cell, Endoplasmic Reticulum
conversion direction: LEFT_TO_RIGHT

Transport100591
type: Transport
participant stoichiometry: Compound/PW C000094/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000094 Endoplasmic Reticulum/Stoichiometry/1.0
right: Estrone
spontaneous: false
left: Estrone
name: Estrone (→) Transport: Homo sapiens, Ovary, Granulosa Cell, Endoplasmic Reticulum to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/HMDB HMDB0000077
type: UnificationXref
id: HMDB0000077
db: HMDB

Reference/CAS 63-05-8
type: UnificationXref
id: 63-05-8
db: CAS

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

BiologicalState13711
type: BioSource
cell type: Theca Cell
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Ovary, Theca Cell
tissue: Ovary

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Nucleus
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Compound/PW C001104 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/UniProt P11511
type: UnificationXref
id: P11511
db: UniProt

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Transport100592
type: Transport
participant stoichiometry: Compound/PW C000098 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000098/Stoichiometry/1.0
right: Estradiol
spontaneous: false
left: Estradiol
name: Estradiol (→) Transport: Homo sapiens, Ovary, Granulosa Cell, Endoplasmic Reticulum to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Cholesterol side-chain cleavage enzyme, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cholesterol side-chain cleavage enzyme, mitochondrial

BiologicalState13716
type: BioSource
cell type: Granulosa Cell
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Ovary, Granulosa Cell
tissue: Ovary

Adenylate cyclase type 10
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 10

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Compound/PW C000098/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estradiol
stoichiometric coefficient: 1.0