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Pathway Description
Tyrosine Biosynthesis
Escherichia coli
Metabolic Pathway
Tyrosine is one of the amino acid used in protein synthesis. The tyrosine biosynthesis pathways is connected with the chorismate biosynthesis pathway. Chorismate biosynthesis produce the chorismate, which can further be converted to prephenate by T-protein. Combined with cofactor, NAD, prephenate has been further converted to 4-Hydroxyphenylpyruvic acid by T-protein with generated NADH and carbon dioxide. Tyrosine aminotransferase catalyzes 4-Hydroxyphenylpyruvic acid to tyrosine, and also converts glutamic acid to oxoglutaric acid. Tyrosine will be further catalyzed into various molecules such as 2-iminoacetate, p-Cresol, 5'Deoxyadenosine and L-Methionine; or it will be exported from cell via the lysine exporter.
References
Tyrosine Biosynthesis References
Gelfand DH, Steinberg RA: Escherichia coli mutants deficient in the aspartate and aromatic amino acid aminotransferases. J Bacteriol. 1977 Apr;130(1):429-40.
Pubmed: 15983
Tsirka SA, Sklaviadis TK, Kyriakidis DA: Non-competitive inhibition of ornithine decarboxylase by a phosphopeptide and phosphoamino acids. Biochim Biophys Acta. 1986 Dec 10;884(3):482-9.
Pubmed: 3096379
Kim SC, Min BE, Hwang HG, Seo SW, Jung GY: Pathway optimization by re-design of untranslated regions for L-tyrosine production in Escherichia coli. Sci Rep. 2015 Sep 8;5:13853. doi: 10.1038/srep13853.
Pubmed: 26346938
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from PW000806
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