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Pathway Description
beta-Alanine Metabolism
Escherichia coli
Metabolic Pathway
Beta-Alanine metabolism starts as a product of aspartate metabolism. Aspartate is decarboxylated by aspartate 1-decarboxylase, releasing carbon dioxide and beta-alanine. Beta-Alanine is then metabolized through a pantothenate synthease resulting in pantothenic acid. Pantothenic acid then undergoes phosphorylation through an ATP-driven pantothenate kinase, resulting in D-4-phosphopantothenate. Pantothenate, vitamin B5, is a precursor for synthesis of 4'-phosphopantetheine moiety of coenzyme A and acyl carrier protein. Plants and microorganisms can synthesize pantothenate de novo, but animals must obtain it from diet. Enzymes of beta-alanine metabolism are targets for anti-microbial drugs.
References
beta-Alanine Metabolism References
Cronan JE Jr, Littel KJ, Jackowski S: Genetic and biochemical analyses of pantothenate biosynthesis in Escherichia coli and Salmonella typhimurium. J Bacteriol. 1982 Mar;149(3):916-22.
Pubmed: 7037743
Cronan JE Jr: Beta-alanine synthesis in Escherichia coli. J Bacteriol. 1980 Mar;141(3):1291-7.
Pubmed: 6767707
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from PW000896
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