PathWhiz

Pathway Description

N-Acetylneuraminate, N-Acetylmannosamine, and N-Acetylglucosamine Degradation

Escherichia coli

Metabolic Pathway

The degradation of N-acetylneuraminate begins with its incorporation into the cytosol through a hydrogen symporter. Once inside the cytosol it is degraded by a N-acetylneuraminate lyase resulting in a release of a pyruvic acid and N-acetymannosamine. The latter compound is phosphorylated by an ATP driven N-Acetylmannosamine kinase resulting in the release of an ADP, a hydrogen ion and a N-Acetyl-D-mannosamine 6-phosphate. This phosphorylated compound is then metabolized by a putative N-acetylmannosamine-6-phosphate 2-epimerase resulting in the release of a N-Acetyl-D-glucosamine 6-phosphate. This compound is then deacetylated through a N-acetylglucosamine-6-phosphate deacetylase resulting in the release of an Acetic acid and a glucosamine 6-phosphate This compound can then be deaminated through a glucosamine-6-phosphate deaminase resulting in the release of an ammonium and a beta-D-fructofuranose 6-phosphate which can then be incorporated into the glycolysis pathway.

References

N-Acetylneuraminate, N-Acetylmannosamine, and N-Acetylglucosamine Degradation References

Kalivoda KA, Steenbergen SM, Vimr ER, Plumbridge J: Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli. J Bacteriol. 2003 Aug;185(16):4806-15.

Pubmed: 12897000

Plumbridge J, Vimr E: Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli. J Bacteriol. 1999 Jan;181(1):47-54.

Pubmed: 9864311

Vimr ER, Kalivoda KA, Deszo EL, Steenbergen SM: Diversity of microbial sialic acid metabolism. Microbiol Mol Biol Rev. 2004 Mar;68(1):132-53.

Pubmed: 15007099

Vimr ER, Troy FA: Identification of an inducible catabolic system for sialic acids (nan) in Escherichia coli. J Bacteriol. 1985 Nov;164(2):845-53.

Pubmed: 3902799

Alvarez-Anorve LI, Calcagno ML, Plumbridge J: Why does Escherichia coli grow more slowly on glucosamine than on N-acetylglucosamine? Effects of enzyme levels and allosteric activation of GlcN6P deaminase (NagB) on growth rates. J Bacteriol. 2005 May;187(9):2974-82. doi: 10.1128/JB.187.9.2974-2982.2005.

Pubmed: 15838023

Escherichia coli and Salmonella: Cellular and Molecular Biology (EcoSal). Online edition.

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from PW002030

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Acetic acid
		Adenosine diphosphate
		Adenosine triphosphate
		Ammonium
		D-glucosamine 6-phosphate
		Glucosamine 6-phosphate
		Hydrogen Ion
		N-Acetyl-D-Glucosamine 6-Phosphate
		N-Acetyl-D-mannosamine 6-phosphate
		N-Acetylmannosamine
		N-Acetylneuraminic acid
		Pyruvic acid
		Water
		β-D-fructofuranose 6-phosphate

Visualize Protein Data

		Glucosamine-6-phosphate deaminase
		N-acetylglucosamine-6-phosphate deacetylase
		N-acetylmannosamine kinase
		N-acetylneuraminate lyase
		Putative N-acetylmannosamine-6-phosphate 2-epimerase
		Putative sialic acid transporter

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