PathWhiz

Pathway Description

Tetrahydromonapterin Biosynthesis

Escherichia coli

Metabolic Pathway

This pathway demonstrates the biosynthesis of tetrahydromonapterin in E.coli. However, it is still unclear about biological role of tetrahydromonapterin. GTP cyclohydrolase 1 generates formic acid and 7,8-dihydroneopterin 3'-triphosphate with cofactor GTP and water. 7,8-dihydroneopterin 3'-triphosphate is converted to dihydromonapterin-triphosphate by d-erythro-7,8-dihydroneopterin triphosphate epimerase (folX). Later, dihydromonapterin-triphosphate is hydroxylated to dihydromethysticin, and eventually form tetrahydromonapterin via dihydromonapterin reductase (folM) with cofactor NADPH.

References

Tetrahydromonapterin Biosynthesis References

Ikemoto K, Sugimoto T, Murata S, Tazawa M, Nomura T, Ichinose H, Nagatsu T: (6R)-5,6,7,8-tetrahydro-L-monapterin from Escherichia coli, a novel natural unconjugated tetrahydropterin. Biol Chem. 2002 Feb;383(2):325-30. doi: 10.1515/BC.2002.035.

Pubmed: 11934271

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from PW002043

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		7,8-dihydroneopterin 3'-triphosphate
		Dihydromethysticin
		Dihydromonapterin-triphosphate
		Formic acid
		Guanosine triphosphate
		Hydrogen Ion
		NADP
		NADPH
		Phosphate
		Tetrahydromonapterin
		Water