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Pathway Description
Trehalose Biosynthesis I
Escherichia coli
Metabolic Pathway
Trehalose is a disaccharide made of two glucose molecules that can be used as a store of energy, as well as water retention and protection from freezing at low temperatures. In this pathway, glucose-6-phosphate from the galactose metabolism pathway combines with uridine diphosphate glucose to form alpha,alpha-trehalose 6-phosphate, as well as uridine 5’-diphosphate and a hydrogen ion as byroducts in a reaction catalyzed by alpha,alpha-trehalose-phosphate synthase [UDP-forming]. Following this, alpha,alpha-trehalose 6-phosphate is converted to alpha,alpha-trehalose following the hydrolytic cleavage of its phosphate group by trehalose-phosphate phosphatase. Alpha,alpha-trehalose can then function as energy stores until it is broken down as a part of the trehalose degradation pathway when needed.
References
Trehalose Biosynthesis I References
Giaever HM, Styrvold OB, Kaasen I, Strom AR: Biochemical and genetic characterization of osmoregulatory trehalose synthesis in Escherichia coli. J Bacteriol. 1988 Jun;170(6):2841-9.
Pubmed: 3131312
Strom AR, Kaasen I: Trehalose metabolism in Escherichia coli: stress protection and stress regulation of gene expression. Mol Microbiol. 1993 Apr;8(2):205-10. doi: 10.1111/j.1365-2958.1993.tb01564.x.
Pubmed: 8391102
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