Loading Pathway... 
Error: Pathway image not found.
Hide 
    Pathway Description
      O-Antigen Building Blocks Biosynthesis
Escherichia coli
          Metabolic Pathway
          
        
          Lipopolysaccharide (LPS) is a major component of outer membrane which is consisted of lipid A-core (oligosaccharide) on both inner and outer region and O-antigen (known as distal repeating unit with four sugars: N-acetylglucosamine, glucose, rhamnose and galactose). O-antigen is part of three domains of LPS, which is attached to lipid A-core; however, O-antigen and lipid A-core are synthesized separately. In this pathway, synthesis of three of O-antigen sugars is demonstrated. UDP-α-D-galactose is converted to UDP-D-Galacto-1,4-furanose by facilitation of UDP-galactopyranose mutase. dTTP glucose-1-phosphate is derivatized to dTDP-rhamnose. Fructose-6-phosphate gains an amino group, incorporates an acetate moiety and then acquires a nucleoside diphosphate resulting in UDP-N-acetyl-D-glucosamine.
        
      References
      
      O-Antigen Building Blocks Biosynthesis References
Liu D, Reeves PR: Escherichia coli K12 regains its O antigen. Microbiology. 1994 Jan;140 ( Pt 1):49-57. doi: 10.1099/13500872-140-1-49.
                  Pubmed: 7512872
              This pathway was propagated using PathWhiz - 
                Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
              
            Propagated from PW002089
        Highlighted elements will appear in red.
        
          
          
        
      
      Highlight Compounds
      Highlight Proteins
      Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
        
          
          
        
      
      Visualize Compound Data
      Visualize Protein Data
      Downloads
      
    Settings