PathWhiz

Pathway Description

Phosphatidylcholine Biosynthesis

Saccharomyces cerevisiae

Metabolic Pathway

Phosphatidyl ethanolamine reacts with S-adenosylmethionine through a phosphatdylethanolamine N-methyltransferase resulting in the release of hydrogen ion and S-adenosylhomocysteine an a PE-NMe. The PE-NMe reacts with S'-adenosylmethionine through a phosphotidyl-N-methylethanolamine N-methyltransferase resulting in the release of hydrogen ion, s-adenosylhomocysteine and PE-NMe2. The PE-NMe2 reacts with s-adenosylmethionine through a phosphotidyl-N-methylethanolamine N-methyltransferase resuilting in the release of hydrogen ion, s-adenosylhomocysteine and PC

References

Phosphatidylcholine Biosynthesis References

Aktas M, Wessel M, Hacker S, Klusener S, Gleichenhagen J, Narberhaus F: Phosphatidylcholine biosynthesis and its significance in bacteria interacting with eukaryotic cells. Eur J Cell Biol. 2010 Dec;89(12):888-94. doi: 10.1016/j.ejcb.2010.06.013. Epub 2010 Jul 24.

Pubmed: 20656373

Bolognese CP, McGraw P: The isolation and characterization in yeast of a gene for Arabidopsis S-adenosylmethionine:phospho-ethanolamine N-methyltransferase. Plant Physiol. 2000 Dec;124(4):1800-13.

Pubmed: 11115895

Boumann HA, de Kroon AI: The contributions of biosynthesis and acyl chain remodelling to the molecular species profile of phosphatidylcholine in yeast. Biochem Soc Trans. 2005 Nov;33(Pt 5):1146-9. doi: 10.1042/BST20051146.

Pubmed: 16246068

Highlighted elements will appear in red.

Highlight Compounds

	Hydrogen Ion
	PC(14:0/14:0)
	PE(14:0/14:0)
	PE-NMe(14:0/14:0)
	PE-NMe2(14:0/14:0)
	S-Adenosylhomocysteine
	S-Adenosylmethionine

Highlight Proteins

	Phosphatidyl-N-methylethanolamine N-methyltransferase
	Phosphatidylethanolamine N-methyltransferase

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