Loading Pathway...
Error: Pathway image not found.
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Cytochrome P450
2C54
Cytochrome P450
2D9
Alcohol
dehydrogenase
[NADP(+)]
Short-chain
dehydrogenase/reductase
family 16C
member 6
Alcohol
dehydrogenase
[NADP(+)]
Steroid
21-hydroxylase
1,25-
dihydroxyvitamin
D(3)
24-hydroxylase,
mitochondrial
Steroid
21-hydroxylase
Cytochrome P450
2D9
3-beta-HSD 1
Steroid
21-hydroxylase
3-beta-HSD 1
Cytochrome P450
2C54
Steroid
21-hydroxylase
Cytochrome P450
2D9
Cytochrome P450
2D9
1,25-
dihydroxyvitamin
D(3)
24-hydroxylase,
mitochondrial
Steroid
21-hydroxylase
3-beta-HSD 1
3-beta-HSD 1
1,25-
dihydroxyvitamin
D(3)
24-hydroxylase,
mitochondrial
Steroid
21-hydroxylase
Cytochrome P450
2C39
Cytochrome P450
2C39
Cytochrome P450
2C39
Cytochrome P450
2C39
Cytochrome P450
2C39
Cytochrome P450
2C39
1,25-
dihydroxyvitamin
D(3)
24-hydroxylase,
mitochondrial
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Cytochrome P450
2D9
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Corticosteroid
11-beta-
dehydrogenase
isozyme 2
Corticosteroid
11-beta-
dehydrogenase
isozyme 2
Short-chain
dehydrogenase/reductase
family 42E
member 1
Cholesterol
Accumulation
Progesterone
Accumulation
Progesterone
11b,21-Dihydroxy-3,20-oxo-
5b-pregnan-18-al
NADPH
3a,11b,21-Trihydroxy-20-oxo-
5b-pregnan-18-al
NADP
NADP
Aldosterone
NADPH
18-Hydroxycorticosterone
O2
H2 O
Corticosterone
O2
H2 O
11b,21-Dihydroxy-5b-
pregnane-3,20-dione
Tetrahydrocorticosterone
NADP
NADPH
Accumulation
11-Dehydrocorticosterone
21-Hydroxy-5b-pregnane-
3,11,20-trione
NADP
3a,21-Dihydroxy-5b-pregnane-
11,20-dione
NADPH
NADP
NADPH
11b-Hydroxyprogesterone
21-Deoxycortisol
Cortisol
Accumulation
Deoxycorticosterone
21-Hydroxypregnenolone
NAD
NADH
Accumulation
Pregnenolone
NAD
NADH
17-Hydroxyprogesterone
Cortexolone
17a-Hydroxypregnenolone
NAD
NADH
NADH
17α,21-Dihydroxypregnenolone
NAD
20a,22b-Dihydroxycholesterol
4-
Methylpentanal
17a,20a-Dihydroxycholesterol
22b-Hydroxycholesterol
20α-Hydroxycholesterol
17a,21-Dihydroxy-5b-
pregnane-3,11,20-trione
NADP
Cortisone
NADPH
Tetrahydrocortisone
NADP
NADPH
Dihydrocortisol
NADP
NADPH
Tetrahydrocortisol
NADP
NADPH
O2
11b,17a,21-Trihydroxypreg-
nenolone
H2 O
NADPH
5a-Pregnane-3,20-dione
NADP
3a-Hydroxy-5b-pregnane-20-one
NADP
NADPH
NADP
NADPH
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Steroid
Biosynthesis
Adrenal Gland
Smooth Endoplasmic Reticulum
Smooth Endoplasmic Reticulum
ER Membrane
ER Membrane
ER Membrane
Mitochondrion
Mitochondrion
Mitochondrion
Mitochondrion
Intracellular Space
Extracellular Space
Inner mitochondria membrane
Outer mitochondria membrane
Endoplasmic Reticulum
Mitochondria
Endoplasmic Reticulum
Akr1a1
Akr1a1
Cyp2c54
Cyp2d9
Akr1a1
Sdr16c6
Akr1a1
Cyp21
Cyp24a1
Cyp21
Cyp2d9
Sdr42e1
Cyp21
Sdr42e1
Cyp2c54
Cyp21
Cyp2d9
Cyp2d9
Cyp24a1
Cyp21
Sdr42e1
Sdr42e1
Cyp24a1
Cyp21
Cyp2c39
Cyp2c39
Cyp2c39
Cyp2c39
Cyp2c39
Cyp2c39
Cyp24a1
Akr1a1
Akr1a1
Akr1a1
Akr1a1
Cyp2d9
Akr1a1
Akr1a1
Hsd11b2
Hsd11b2
Sdr42e1
Cholesterol
Accumulation
Progesterone
Accumulation
Progesterone
11b,21-
Dihydroxy-
3,20-oxo-5b-
pregnan-18-al
NADPH
3a,11b,21-
Trihydroxy-
20-oxo-5b-
pregnan-18-al
NADP
NADP
Aldosterone
NADPH
18-
Hydroxycorticosterone
Oxygen
Water
Corticosterone
Oxygen
Water
11b,21-
Dihydroxy-5b-
pregnane-
3,20-dione
Tetrahydrocorticosterone
NADP
NADPH
Accumulation
11-
Dehydrocorticosterone
21-Hydroxy-
5b-pregnane-
3,11,20- trione
NADP
3a,21-
Dihydroxy-5b-
pregnane-
11,20-dione
NADPH
NADP
NADPH
11b-
Hydroxyprogesterone
21-
Deoxycortisol
Cortisol
Accumulation
Deoxycorticosterone
21-
Hydroxypregnenolone
NAD
NADH
Accumulation
Pregnenolone
NAD
NADH
17-
Hydroxyprogesterone
Cortexolone
17a-
Hydroxypregnenolone
NAD
NADH
NADH
17α,21-
Dihydroxypregnenolone
NAD
20a,22b-
Dihydroxycholesterol
4-
Methylpentanal
17a,20a-
Dihydroxycholesterol
22b-
Hydroxycholesterol
20α-
Hydroxycholesterol
17a,21-
Dihydroxy-5b-
pregnane-
3,11,20- trione
NADP
Cortisone
NADPH
Tetrahydrocortisone
NADP
NADPH
Dihydrocortisol
NADP
NADPH
Tetrahydrocortisol
NADP
NADPH
Oxygen
11b,17a,21-
Trihydroxypreg-
nenolone
Water
NADPH
5a-Pregnane-
3,20-dione
NADP
3a-Hydroxy-
5b-pregnane-
20-one
NADP
NADPH
NADP
NADPH
Steroid
Biosynthesis
Akr1a1
Akr1a1
Cyp2c54
Cyp2d9
Akr1a1
Sdr16c6
Akr1a1
Cyp21
Cyp24a1
Cyp21
Cyp2d9
Sdr42e1
Cyp21
Sdr42e1
Cyp2c54
Cyp21
Cyp2d9
Cyp2d9
Cyp24a1
Cyp21
Sdr42e1
Sdr42e1
Cyp24a1
Cyp21
Cyp2c39
Cyp2c39
Cyp2c39
Cyp2c39
Cyp2c39
Cyp2c39
Cyp24a1
Akr1a1
Akr1a1
Akr1a1
Akr1a1
Cyp2d9
Akr1a1
Akr1a1
Hsd11b2
Hsd11b2
Sdr42e1
Lanol
Accumulation
Prgstrn
Accumulation
Prgstrn
NA
NADPH
T20OPal
NADP
NADP
Aldostr
NADPH
18-HCC
O2
H2 O
Cortcos
O2
H2 O
11B21D5
Tetrahy
NADP
NADPH
Accumulation
11dhccn
21-Hydr
NADP
321D5B
NADPH
NADP
NADPH
11Hprgt
21HOCrt
HC
Accumulation
Doct
21-Hpgn
NAD
NADH
Accumulation
Pregnen
NAD
NADH
17-OHP
Cortexo
17a-HP
NAD
NADH
NADH
17ADhp
NAD
OH2chol
4-MPnal
17aDhch
22b-HC
20a-HC
DHPRGT
NADP
Corlin
NADPH
TetraHC
NADP
NADPH
DHCort
NADP
NADPH
tetHCol
NADP
NADPH
O2
Trihpnn
H2 O
NADPH
P3D
NADP
3aH5bPO
NADP
NADPH
NADP
NADPH
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
PW000050
Adrenal Gland
Smooth Endoplasmic Reticulum
Smooth Endoplasmic Reticulum
ER Membrane
ER Membrane
ER Membrane
Mitochondrion
Mitochondrion
Mitochondrion
Mitochondrion
Intracellular Space
Extracellular Space
Inner mitochondria membrane
Outer mitochondria membrane
Endoplasmic Reticulum
Mitochondria
Endoplasmic Reticulum
Akr1a1
Akr1a1
Cyp2c54
Cyp2d9
Akr1a1
Sdr16c6
Akr1a1
Cyp21
Cyp24a1
Cyp21
Cyp2d9
Sdr42e1
Cyp21
Sdr42e1
Cyp2c54
Cyp21
Cyp2d9
Cyp2d9
Cyp24a1
Cyp21
Sdr42e1
Sdr42e1
Cyp24a1
Cyp21
Cyp2c39
Cyp2c39
Cyp2c39
Cyp2c39
Cyp2c39
Cyp2c39
Cyp24a1
Akr1a1
Akr1a1
Akr1a1
Akr1a1
Cyp2d9
Akr1a1
Akr1a1
Hsd11b2
Hsd11b2
Sdr42e1
Lanol
Accumulation
Prgstrn
Accumulation
Prgstrn
NA
NADPH
T20OPal
NADP
NADP
Aldostr
NADPH
18-HCC
O2
H2O
Cortcos
O2
H2O
11B21D5
Tetrahy
NADP
NADPH
Accumulation
11dhccn
21-Hydr
NADP
321D5B
NADPH
NADP
NADPH
11Hprgt
21HOCrt
HC
Accumulation
Doct
21-Hpgn
NAD
NADH
Accumulation
Pregnen
NAD
NADH
17-OHP
Cortexo
17a-HP
NAD
NADH
NADH
17ADhp
NAD
OH2chol
4-MPnal
17aDhch
22b-HC
20a-HC
DHPRGT
NADP
Corlin
NADPH
TetraHC
NADP
NADPH
DHCort
NADP
NADPH
tetHCol
NADP
NADPH
O2
Trihpnn
H2O
NADPH
P3D
NADP
3aH5bPO
NADP
NADPH
NADP
NADPH
PW000050