Anileridine is an opioid analgesic that is most commonly used to treat pain varying from moderate to severe in intensity. Mainly in practice, it is to alleviate pain from narcotic substances as it acts upon the central nervous system to relieve pain one might experience from withdrawal. Anileridine is an analog of pethidine (another synthetic opioid pain medication that is a part of the class of phenylpiperidine). The mechanism of action is elicited by the binding of Anileridine with mu-opioid receptors that are coupled with Gi protein-coupled receptors. This causes the hydrolysis of GTP to GDP of the G protein leading to the downstream cascade of decreasing adenylate cyclase activity in turn decreasing available cAMP concentration. cAMP levels decreasing inhibits the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and norepinephrine, not only this but inhibiting the release of hormones such as vasopressin, somatostatin, insulin, and glucagon. Anileridine continues to elicit its inhibitory effects by causing hyperpolarization leading to reduced neuronal excitability by closing N-type voltage calcium channels and opening calcium-dependent inwardly rectifying potassium channels. These effects facilitate relaxation, reduces spasms of the larynx, and when using in conjunction with meperidine can reduce the amount of anesthetic needed to administer to supply patients with sufficient anesthesia. Administration of Anileridine is not limited to any one form it can be administered via intravenous, subcutaneous, inhalation, and so forth. It is metabolized by the hepatic system, any overexposure to Anileridine can result in dizziness, perspiration, dry mouth. difficulty with visual field, itching, euphoria, restlessness, nervousness, excitement, and experiencing a feeling of warmth.

Anileridine References