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Gastrin Gastrin/cholecystokinin type B receptor Histamine H2 receptor Somatostatin receptor type 2 Muscarinic acetylcholine receptor M1 H(+)/K(+) ATPase subunit Chloride anion exchanger Chloride anion exchanger KCNE2/KCNQ1 Channel Carbonic anhydrase 1 Acetylcholine Histamine Somatostatin Pirenzepine HCO3- HCO3- Cl- Cl- Cl- K+ K+ H+ H+ H2O CO2 G-Protein Signaling Cascade Stomach Lumen Gastric Parietal Cell Blood Vessel Pirenzepine is administered orally and absorbed through the gastrointestinal system, it then goes on to inhibit the muscarinic acetylcholine receptor. By inhibiting the muscarinic receptor this reduces activation of the G protein signaling cascade reducing the secretion of hydrogen ions into the stomach lumen. By doing this the acid content of the stomach is reduced allowing ulcers in the gastrointestinal system time to heal without further agitation.
Unknown CCKBR HRH2 SSTR2 CHRM1 ATP4A SLC26A3 SLC26A3 KCNE2 CA1 Acetylcholine Histamine Somatostatin Pirenzepine Hydrogen carbonate Hydrogen carbonate Chloride ion Chloride ion Chloride ion Potassium Potassium Hydrogen Ion Hydrogen Ion Water Carbon dioxide G-Protein Signaling Cascade
CCKBR HRH2 SSTR2 CHRM1 ATP4A SLC26A3 SLC26A3 KCNE2 CA1 ACh Hsm Somatos Pirenz HCO3- HCO3- Cl- Cl- Cl- K+ K+ H+ H+ H2O CO2 PW000728 Stomach Lumen Gastric Parietal Cell Blood Vessel Pirenzepine is administered orally and absorbed through the gastrointestinal system, it then goes on to inhibit the muscarinic acetylcholine receptor. By inhibiting the muscarinic receptor this reduces activation of the G protein signaling cascade reducing the secretion of hydrogen ions into the stomach lumen. By doing this the acid content of the stomach is reduced allowing ulcers in the gastrointestinal system time to heal without further agitation.
CCKBR HRH2 SSTR2 CHRM1 ATP4A SLC26A3 SLC26A3 KCNE2 CA1 ACh Hsm Somatos Pirenz HCO3 HCO3 Cl Cl Cl K+ K+ H+ H+ H2O CO2 PW000728