PathWhiz

Pathway Description

Pyruvate Decarboxylation to Acetyl-CoA

Escherichia coli O103:H2 str. 12009

Metabolic Pathway

The multi-enzyme complex catalyze three reactions that constitute a cycle, which is an essential source of acetyl-CoA. Pyruvate dehydrogenase E1 and dihydrolipoyllysine-residue acetyltransferase catalyzes pyruvic acid to acetyl-CoA and CO2. Acetyl-CoA is required for the TCA cycle. Lipoamide dehydrogenase reduces NAD+ to NADH.

References

Pyruvate Decarboxylation to Acetyl-CoA References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from PW002083

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Acetyl-CoA
		Carbon dioxide
		Coenzyme A
		Hydrogen Ion
		NAD
		NADH
		Pyruvic acid

Visualize Protein Data

		Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
		lipoamide dehydrogenase
		Pyruvate dehydrogenase E1 component

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