PathWhiz

PathWhiz ID	Pathway	Meta Data
PW175982 View Pathway	metabolic Bimatoprost Predicted Metabolism Pathway new Homo sapiens Metabolites of Bimatoprost are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 12:59 Last Updated: November 29, 2023 at 12:59
PW132506 View Pathway	metabolic Binimetinib Drug Metabolism Homo sapiens Binimetinib is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Binimetinib passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:09 Last Updated: September 21, 2023 at 22:09
PW146477 View Pathway	drug action Binimetinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:17 Last Updated: October 07, 2023 at 18:17
PW146672 View Pathway	drug action Bioallethrin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:46 Last Updated: October 07, 2023 at 18:46
PW124412 View Pathway	metabolic Bioquímica kjhkjh BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Nuria Created On: January 03, 2021 at 14:27 Last Updated: January 03, 2021 at 14:27
PW122312 View Pathway	metabolic Biosynthesis of siderophore group nonribosomal peptide Lysinibacillus xylanilyticus t26 Siderophores are an important group of structurally diverse natural products that play key roles in ferric iron acquisition in most microorganisms. Two major pathways exist for siderophore biosynthesis. One is dependent on nonribosomal peptide synthetase (NRPS) multienzymes. The enzymology of several NRPS-dependent pathways to structurally diverse siderophores has been intensively studied for more than 10 years and is generally well understood. The other major pathway is NRPS-independent. It relies on a novel family of synthetase enzymes that until recently has received very little attention. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ng Ngashangva Created On: November 27, 2018 at 21:54 Last Updated: November 27, 2018 at 21:54
PW000760 View Pathway	metabolic Biosynthesis of Siderophore Group Nonribosomal Peptides Escherichia coli 2,3-Dihydroxybenzoate is created from chorismate through isochorismate and 2,3-dihydroxy-2,3-dihydrobenzoate. The biosynthesis of 2,3-dihydroxybenzoate starts from chorismate being converted into isochorismate through isochorismate synthase entC. The N-terminal isochorismate lyase domain of EntB adds hydrogen to the pyruvate group of isochorismate to create 2,3-dihydro-2,3-dihydroxybenzoate. this latter compound to 2,3-dihydroxybenzoate is then converted by the catalyzation of EntA dehydrogenase. This compound then interacts with L-serine and ATP through the enterobactin synthase protein complex resulting in the production of enterobactin. Enterobactin is exported into the periplasmic space through the enterobactin exporter entS. Enterobactin is then exported into the environment through the outer membrane protein TolC. In the environment, enterobactin reacts with iron to produce ferric enterobactin. It is then imported into the periplasmic space through a ferric enterobactin outer membrane transport complex. Ferric enterobactin continues it's journey and enters the cytoplasm via a ferric enterobactin ABC transporter. Once inside the cytoplasm, ferric enterobactin spontaneously releases the iron ion from the enterobactin. Alternatively, it can react with water through an enterochelin esterase resulting in the release of 2,3-dihydroxybenzoylserine, Fe3+, and hydrogen ions. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: January 25, 2015 at 21:28 Last Updated: January 25, 2015 at 21:28
PW122570 View Pathway	metabolic Biosynthesis of Siderophore Group Nonribosomal Peptides Pseudomonas aeruginosa 2,3-Dihydroxybenzoate is synthesized from chorismate via isochorismate and 2,3-dihydroxy-2,3-dihydrobenzoate. The biosynthesis of 2,3-dihydroxybenzoate starts from chorismate being synthesized into isochorismate through isochorismate synthase entC. The N-terminal isochorismate lyase domain of EntB hydrolyzes the pyruvate group of isochorismate to produce 2,3-dihydro-2,3-dihydroxybenzoate. The conversion of this latter compound to 2,3-dihydroxybenzoate is catalyzed by the EntA dehydrogenase. This compound then interacts with L-serine and ATP through the enterobactin synthase protein complex resulting in the production of enterobactin. Enterobactin is exported into the periplasmic space through the enterobactin exporter entS. Enterobactin is then exported into the environment through the outer membrane protein TolC. In the environment, enterobactin reacts with iron to produce ferric enterobactin. It is then imported into the periplasmic space through a ferric enterobactin outer membrane transport complex. Ferric enterobactin continues it's journey and enters the cytoplasm via a ferric enterobactin ABC transporter. Once inside the cytoplasm, ferric enterobactin spontaneously releases the iron ion from the enterobactin. Alternatively, it can react with water through an enterochelin esterase resulting in the release of 2,3-dihydroxybenzoylserine, Fe3+, and hydrogen ions. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 16:58 Last Updated: August 12, 2019 at 16:58
PW122264 View Pathway	metabolic Biosynthesis of type II polyketide backbone Bacteria Polyketide synthases (PKSs) are large (Mr 100- to 10,000-kDa) multienzyme systems that are responsible for the stepwise biosynthesis of extraordinarily complex natural products from simple 2-, 3-, and 4-carbon building blocks such as acetyl-CoA, propionyl-CoA, butyryl-CoA, and their activated derivatives, malonyl-, methylmalonyl-, and ethylmalonyl-CoA. These polyketide natural products are known to possess a wealth of pharmacologically important activities, including antimicrobial, antifungal, antiparasitic, antitumor, and immunosuppressive properties. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ng Ngashangva Created On: October 23, 2018 at 01:31 Last Updated: October 23, 2018 at 01:31
PW124142 View Pathway	metabolic Biosynthesis of type II polyketide backbone Paenibacillus peoriae IBSD35 Polyketide synthases (PKSs) are large (Mr 100- to 10,000-kDa) multienzyme systems that are responsible for the stepwise biosynthesis of extraordinarily complex natural products from simple 2-, 3-, and 4-carbon building blocks such as acetyl-CoA, propionyl-CoA, butyryl-CoA, and their activated derivatives, malonyl-, methylmalonyl-, and ethylmalonyl-CoA. These polyketide natural products are known to possess a wealth of pharmacologically important activities, including antimicrobial, antifungal, antiparasitic, antitumor, and immunosuppressive properties. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ng Ngashangva Created On: September 03, 2020 at 23:48 Last Updated: September 03, 2020 at 23:48