PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146970 View Pathway	drug action Bortezomib D-mannitol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:27 Last Updated: October 07, 2023 at 19:27
PW144319 View Pathway	drug action Bortezomib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:23 Last Updated: October 07, 2023 at 13:23
PW132542 View Pathway	metabolic Boscalid Drug Metabolism Homo sapiens Boscalid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Boscalid passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:20 Last Updated: September 21, 2023 at 22:20
PW146557 View Pathway	drug action Boscalid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:30 Last Updated: October 07, 2023 at 18:30
PW144676 View Pathway	drug action Bosentan Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:11 Last Updated: October 07, 2023 at 14:11
PW145726 View Pathway	drug action Bosutinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:29 Last Updated: October 07, 2023 at 16:29
PW032596 View Pathway	drug action Bosutinib Inhibition of BCR-ABL Action Pathway Homo sapiens Bosutinib is a tyrosine kinase inhibitor used to treat chronic myelogenous leukemia (CML), a cancer characterized by increased and unregulated growth of white blood cells in the bone marrow and the accumulation of these cells in the blood. The cause of CML pathophysiology is the BCR-ABL fusion protein - the result of a genetic abnormality known as the Philadelphia chromosome in which Abelson Murine Leukemia viral oncogene homolog 1 (ABL1) translocates within the Breakpoint Cluster Region (BCR) gene on chromosome 22. BCR-ABL is a cytoplasm-targeted constitutively active tyrosine kinase that activates several oncogenic pathways which promote increased cell proliferation and survival including the MAPK/ERK Pathway, the JAK-STAT Pathway, and the PI3K/Akt pathway. Bosutinib is considered a second generation BCR-ABL inhibitor (Imatinib being the progenitor) that inhibits BCR-ABL activity by binding a highly conserved ATP binding site to effectively lock the tyrosine kinase in an inactive conformation. As a result, phosphate is unable to be transferred from ATP to activate oncogenic signalling cascades. For greater detail, refer to the pathway titled BCR-ABL Action in CML Pathogenesis. Bosutinib is able to bind ABL with greater affinity than Imatinib, perhaps due to its ability to bind both inactive and intermediate conformations of the protein. It is therefore administered to patients with Imatinib resistance. Bosutinib may have a safer toxicity profile than both Imatinib and Dasatinib because it does not significantly inhibit the receptors KIT and PDGFR. Notably, Bosutinib is ineffective against the T315I mutation in BCR-ABL, and further research is necessary. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: August 16, 2017 at 00:50 Last Updated: August 16, 2017 at 00:50
PW128473 View Pathway	drug action Bovine Thrombin Action Pathway Homo sapiens Bovine thrombin is a coagulation factor also known under the brand name Thrombin-jmi, used to prevent bleeding during surgery. It is bovine thrombin that behaves like endogenous thrombin, converting fibrinogen to fibrin necessary for clot formation. The speed at which the clotting takes place is dependent on the concentration of bovine thrombin and fibrinogen present. It is metabolized in the same way as endogenous thrombin, it is inactivated by endogenous plasma inhibitors. It is administered as a topical and then cleared via thrombin inhibitor complexes and or through internalization and degradation by the endothelium. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 30, 2023 at 11:14 Last Updated: August 30, 2023 at 11:14
PW124024 View Pathway	metabolic Bradykinin Metabolism Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: July 29, 2020 at 13:49 Last Updated: July 29, 2020 at 13:49
PW124025 View Pathway	metabolic Bradykinin Metabolism 1596052791 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: July 29, 2020 at 13:59 Last Updated: July 29, 2020 at 13:59