PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146274 View Pathway	drug action Sodium sulfide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:50 Last Updated: October 07, 2023 at 17:50
PW132208 View Pathway	metabolic Sodium tartrate Drug Metabolism Homo sapiens Sodium tartrate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Sodium tartrate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:08 Last Updated: September 21, 2023 at 20:08
PW146668 View Pathway	drug action Sodium tartrate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:45 Last Updated: October 07, 2023 at 18:45
PW132282 View Pathway	metabolic Sodium tetradecyl sulfate Drug Metabolism Homo sapiens Sodium tetradecyl sulfate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Sodium tetradecyl sulfate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:36 Last Updated: September 21, 2023 at 20:36
PW144587 View Pathway	drug action Sodium tetradecyl sulfate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:57 Last Updated: October 07, 2023 at 13:57
PW146743 View Pathway	drug action Sodium zirconium cyclosilicate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:56 Last Updated: October 07, 2023 at 18:56
PW127736 View Pathway	drug action Sofosbuvir Action Pathway Homo sapiens Sofosbuvir is a direct-acting antiviral agent used to treat specific hepatitis C virus in combination with other anti-viral drugs Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated endocytosis. The lipoviroparticles attach to LDL-R and SR-B1, and then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. The virus is internalized by clathrin-dependent endocytosis. RNA is released from the mature Hepatitis C virion and translated at the rough endoplasmic reticulum into a single Genome polyprotein. The genome polyprotein is cleaved by host and viral proteases into 10 viral proteins. The nucleocapsid protein core and the two envelope proteins E1 and E2 form the N terminus of the polyprotein and are the structural components of HCV virions. The precursor also gives rise to the viroporin p7 and six non-structural (NS) proteins. Sofosbuvir is an inhibitor of the Hepatitis C Virus (HCV) Nonstructural protein 5B, which is an RNA-dependent RNA polymerase. RNA polymerase is required for viral RNA replication and assembly of HCV virions. By binding to nonstructural protein 5B outside of the active site of the enzyme, dasabuvir induces a conformational change. Viral RNA replication complexes localize to lipid raft-containing, detergent-resistant membranes created by the viral protein NS4B. For full viral replication and maturation, nonstructural protein 5B is required so viral RNA replication cannot occur. Envelope glycoproteins are acquired through budding into the endoplasmic reticulum lumen. The immature, non-infective virions are released via the cellular golgi apparatus. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: May 29, 2023 at 16:19 Last Updated: May 29, 2023 at 16:19
PW145896 View Pathway	drug action Sofosbuvir Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:55 Last Updated: October 07, 2023 at 16:55
PW145460 View Pathway	drug action Solifenacin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:52 Last Updated: October 07, 2023 at 15:52
PW127978 View Pathway	drug action Solifenacin M3 Bladder Muscle Relaxation Action Pathway Homo sapiens Solifenacin is a muscarinic antagonist with antispasmodic properties used to treat urge urinary incontinence, urgency, and urinary frequency associated with an overactive bladder. It can be found under the brand name Vesicare. It has a long duration of action as it is usually taken once daily. Solifenacin is a competitive muscarinic receptor antagonist. Solifenacin's antagonism of the M3 receptor prevents contraction of the detrusor muscle, while antagonism of the M2 receptor may prevent contraction of smooth muscle in the bladder. Solifenacin works to decrease bladder activity by inhibiting contraction of the smooth muscle wall surrounding the bladder. As a potent and selective muscarinic receptor antagonist, solifenacin acts specifically at the M3 receptor site. Possible side effects of using solifenacin may include dry mouth, headache, dizziness, and vertigo. Solifenacine is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: June 26, 2023 at 12:12 Last Updated: June 26, 2023 at 12:12