PathWhiz

PathWhiz ID	Pathway	Meta Data
PW002462 View Pathway	metabolic Porphyrin Metabolism Saccharomyces cerevisiae Porphyrins are organic compounds. Many porphyrins are involved in oxygen transportation. Porphyrin ring biosynthesis begins in the mitochondria and involves glycine and succinyl-CoA condensation by δ-aminolevulinic acid synthase (ALAS) to produce δ-aminolevulinic acid (ALA), also known as 5-aminolevulinic acid. ALA is then transported to the cytosol where it becomes dimerized by ALA dehydratase (also known as porphobilinogen synthase) to produce porphobilinogen. The pathway continues with the condensation of 4 molecules of porphobilinogen catalyzed by porphobilinogen deaminase (PBG deaminase, also called hydroxymethylbilane synthase or uroporphyrinogen I synthase) to produce hydroxymethylbilane. Hydroxymethylbilane may then be converted to uroporphyrinogen III, a heme intermediate, or it may be non-enzymatically cyclized to uroporphyrinogen I. In the cytosol, uroporphyrinogen I and III substituents become decarboxylated to become coproporphyrinogens. Coproporphyrinogen III is an important intermediate in the synthesis of heme. In the inner mitochondria, coproporphyrinogen III undergoes decarboxylation of 2 propionate residues producing protoporphyrinogen IX. Protoporphyrinogen IX oxidase converts protoporphyrinogen IX to protoporphyrin IX. The final reaction of heme synthesis is ferrochelatase catalyzing the insertion of iron into the ring, producing heme b. Heme is broken down when heme oxygenase opens the heme ring. This oxidation produces linear tetrapyrrole biliverdin, ferric iron (Fe3+), and carbon monoxide (CO). Biliverdin reductase then produces bilirubin. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: February 12, 2016 at 11:24 Last Updated: February 12, 2016 at 11:24
PW127399 View Pathway	drug action Posaconazole Action Pathway Homo sapiens Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. For prophylaxis of invasive Aspergillus and Candida infections in patients, 13 years of age and older, who are at high risk of developing these infections due to being severely immunocompromised as a result of procedures such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD), or due to hematologic malignancies with prolonged neutropenia from chemotherapy. Posaconazole is an antifungal agent structurally related to itraconazole. It is a drug derived from itraconzaole through the replacement of the chlorine substituents with flourine in the phenyl ring, as well as hydroxylation of the triazolone side chain. These modifications enhance the potency and spectrum of activity of the drug. Posaconazole can be either fungicial or fungistatic in action. Posaconazole binds to the enzyme lanosterol 14-alpha demethylase which inhibits the synthesis of 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol . Lanosterol 14-alpha demethylase is the enzyme that catalyzes the synthesis of 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol from lanosterol. With this enzyme inhibited ergosterol synthesis cannot occur which causes a significant low concentration of ergosterol in the fungal cell. Ergosterol is essential in maintaining membrane integrity in fungi. Without ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: January 05, 2023 at 12:00 Last Updated: January 05, 2023 at 12:00
PW145346 View Pathway	drug action Posaconazole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:37 Last Updated: October 07, 2023 at 15:37
PW176119 View Pathway	metabolic Posaconazole Predicted Metabolism Pathway new Homo sapiens Metabolites of Posaconazole are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:06 Last Updated: November 29, 2023 at 14:06
PW132164 View Pathway	metabolic Potassium acetate Drug Metabolism Homo sapiens Potassium acetate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Potassium acetate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 19:46 Last Updated: September 21, 2023 at 19:46
PW146820 View Pathway	drug action Potassium acetate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:07 Last Updated: October 07, 2023 at 19:07
PW145967 View Pathway	drug action Potassium alum Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:05 Last Updated: October 07, 2023 at 17:05
PW132297 View Pathway	metabolic Potassium aspartate Drug Metabolism Homo sapiens Potassium aspartate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Potassium aspartate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:43 Last Updated: September 21, 2023 at 20:43
PW146942 View Pathway	drug action Potassium aspartate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:24 Last Updated: October 07, 2023 at 19:24
PW132168 View Pathway	metabolic Potassium bicarbonate Drug Metabolism Homo sapiens Potassium bicarbonate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Potassium bicarbonate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 19:48 Last Updated: September 21, 2023 at 19:48