PathWhiz

PathWhiz ID	Pathway	Meta Data
PW569128 View Pathway	metabolic Catabolism of salicylate esters (SalAR Operon activation) Prevotella shahii DSM 15611 = JCM 12083 The salAR operon in Acinetobacter sp. strain ADP1 is a sophisticated regulatory unit that plays a crucial role in the catabolism of salicylate, a compound that can originate from sources such as ethyl salicylate. When the concentration of salicylate in the environment reaches a high level, it acts as an inducer for the regulatory protein SalR. Upon its activation, SalR binds to the promoter region of the salAR operon, initiating the transcription of its genes. This process primarily enhances the expression of salA, which encodes salicylate hydroxylase. This enzyme catalyzes the conversion of salicylate into catechol, an important metabolic intermediate. Once produced, catechol is further processed by the catBCIJFD operon, which is integral to the subsequent degradation pathway. This operon facilitates the transformation of catechol into 3-Oxoadipate , which is then broken down into succinate. Succinate is a pivotal component that enters the tricarboxylic acid (TCA) cycle, thereby contributing to the organism’s energy production. Through this metabolic route, Acinetobacter sp. strain ADP1 not only efficiently utilizes salicylate and its derivatives as carbon sources but also integrates the breakdown products into its broader energy-generating pathways. This seamless transition from salicylate to catechol and subsequently to succinate underscores the intricacy and efficiency of metabolic regulation in responses to environmental cues, illustrating the organism's ability to adapt to diverse substrates and optimize its energy yield. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: March 12, 2025 at 20:15 Last Updated: March 12, 2025 at 20:15
PW569124 View Pathway	metabolic Catabolism of salicylate esters (SalDE Operon activation) Prevotella salivae DSM 15606 The salDE operon in Acinetobacter sp. strain ADP1 plays a critical role in the catabolism of ethyl salicylate, enabling the bacterium to utilize this aromatic ester as a carbon source. The operon is induced by the presence of ethyl salicylate through the action of the Arer protein, an aromatic-responsive transcriptional regulator. When ethyl salicylate is present in the environment, it binds to Arer, causing a conformational change that allows Arer to activate the transcription of the salDE operon. The operon encodes two key proteins: SalD, a transporter responsible for the uptake of ethyl salicylate into the cell, and SalE, an esterase that hydrolyzes ethyl salicylate into salicylate and ethanol. The salicylate produced by SalE serves as a critical inducer for the salAR operon, which encodes enzymes that further metabolize salicylate into catechol and ultimately feeding into the TCA cycle for energy production. Thus, the salDE operon acts as a crucial link between the transport and initial breakdown of ethyl salicylate and the activation of downstream metabolic pathways, enabling the bacterium to efficiently degrade and utilize this aromatic compound. The regulatory role of Arer ensures that the operon is expressed only when ethyl salicylate is available, optimizing the cell's metabolic response to environmental conditions. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: March 12, 2025 at 20:06 Last Updated: March 12, 2025 at 20:06
PW569126 View Pathway	metabolic Catabolism of salicylate esters (SalDE Operon activation) Prevotella pallens ATCC 700821 The salDE operon in Acinetobacter sp. strain ADP1 plays a critical role in the catabolism of ethyl salicylate, enabling the bacterium to utilize this aromatic ester as a carbon source. The operon is induced by the presence of ethyl salicylate through the action of the Arer protein, an aromatic-responsive transcriptional regulator. When ethyl salicylate is present in the environment, it binds to Arer, causing a conformational change that allows Arer to activate the transcription of the salDE operon. The operon encodes two key proteins: SalD, a transporter responsible for the uptake of ethyl salicylate into the cell, and SalE, an esterase that hydrolyzes ethyl salicylate into salicylate and ethanol. The salicylate produced by SalE serves as a critical inducer for the salAR operon, which encodes enzymes that further metabolize salicylate into catechol and ultimately feeding into the TCA cycle for energy production. Thus, the salDE operon acts as a crucial link between the transport and initial breakdown of ethyl salicylate and the activation of downstream metabolic pathways, enabling the bacterium to efficiently degrade and utilize this aromatic compound. The regulatory role of Arer ensures that the operon is expressed only when ethyl salicylate is available, optimizing the cell's metabolic response to environmental conditions. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: March 12, 2025 at 20:07 Last Updated: March 12, 2025 at 20:07
PW569125 View Pathway	metabolic Catabolism of salicylate esters (SalDE Operon activation) Prevotella oralis ATCC 33269 The salDE operon in Acinetobacter sp. strain ADP1 plays a critical role in the catabolism of ethyl salicylate, enabling the bacterium to utilize this aromatic ester as a carbon source. The operon is induced by the presence of ethyl salicylate through the action of the Arer protein, an aromatic-responsive transcriptional regulator. When ethyl salicylate is present in the environment, it binds to Arer, causing a conformational change that allows Arer to activate the transcription of the salDE operon. The operon encodes two key proteins: SalD, a transporter responsible for the uptake of ethyl salicylate into the cell, and SalE, an esterase that hydrolyzes ethyl salicylate into salicylate and ethanol. The salicylate produced by SalE serves as a critical inducer for the salAR operon, which encodes enzymes that further metabolize salicylate into catechol and ultimately feeding into the TCA cycle for energy production. Thus, the salDE operon acts as a crucial link between the transport and initial breakdown of ethyl salicylate and the activation of downstream metabolic pathways, enabling the bacterium to efficiently degrade and utilize this aromatic compound. The regulatory role of Arer ensures that the operon is expressed only when ethyl salicylate is available, optimizing the cell's metabolic response to environmental conditions. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: March 12, 2025 at 20:06 Last Updated: March 12, 2025 at 20:06
PW124315 View Pathway	metabolic Catabolismo de Pirimidinas (CV) Homo sapiens Ruta catóbólica de pirimidinas. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: November 06, 2020 at 20:20 Last Updated: November 06, 2020 at 20:20
PW124317 View Pathway	metabolic Catabolismo de Purinas (CV) Homo sapiens Catabolismo de purinas para obtener ácido úrico como producto final. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: November 06, 2020 at 21:10 Last Updated: November 06, 2020 at 21:10
PW124362 View Pathway	metabolic Catechol E. coli Escherichia coli BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: November 25, 2020 at 07:50 Last Updated: November 25, 2020 at 07:50
PW000017 View Pathway	metabolic Catecholamine Biosynthesis Homo sapiens The Catecholamine Biosynthesis pathway depicts the synthesis of catecholamine neurotransmitters. Catecholamines are chemical hormones released from the adrenal glands as a response to stress that activate the sympathetic nervous system. They are composed of a catechol group and are derived from amino acids. The commonly found catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. They are synthesized in catecholaminergic neurons by four enzymes, beginning with tyrosine hydroxylase (TH), which generates L-DOPA from tyrosine. The L-DOPA is then converted to dopamine via aromatic L-amino acid decarboxylase (AADC), which becomes norepinephrine via dopamine beta-hydroxylase (DBH); and finally is converted to epinephrine via phenylethanolamine N-methyltransferase (PNMT). BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 01, 2013 at 13:54 Last Updated: August 01, 2013 at 13:54
PW064582 View Pathway	metabolic Catecholamine Biosynthesis Mus musculus The Catecholamine Biosynthesis pathway depicts the synthesis of catecholamine neurotransmitters. Catecholamines are chemical hormones released from the adrenal glands as a response to stress that activate the sympathetic nervous system. They are composed of a catechol group and are derived from amino acids. The commonly found catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. They are synthesized in catecholaminergic neurons by four enzymes, beginning with tyrosine hydroxylase (TH), which generates L-DOPA from tyrosine. The L-DOPA is then converted to dopamine via aromatic L-amino acid decarboxylase (AADC), which becomes norepinephrine via dopamine beta-hydroxylase (DBH); and finally is converted to epinephrine via phenylethanolamine N-methyltransferase (PNMT). BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: January 21, 2018 at 20:36 Last Updated: January 21, 2018 at 20:36
PW123663 View Pathway	metabolic Catecholamine Biosynthesis 1575850739 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Faith Inello Created On: December 08, 2019 at 17:20 Last Updated: December 08, 2019 at 17:20