PathWhiz

PathWhiz ID	Pathway	Meta Data
PW123664 View Pathway	metabolic Catecholamine Biosynthesis 1575851006 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Faith Inello Created On: December 08, 2019 at 17:24 Last Updated: December 08, 2019 at 17:24
PW123674 View Pathway	protein cav Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: January 01, 2020 at 20:50 Last Updated: January 01, 2020 at 20:50
PW026448 View Pathway	physiological CB1 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 15, 2017 at 02:37 Last Updated: June 15, 2017 at 02:37
PW124076 View Pathway	signaling CB1 Receptor Homo sapiens CB1 receptors can be found throughout the central and peripheral nervous system and have a range of effects on neurotransmitter release. They are part of the G-protein coupled receptor (GCPR) superfamily of heptihelical receptors and are one of the most abundant GPCR in the brain. This pathway illustrates a generic agonist binding to and activating a CB1 receptor. The resulting signaling pathway highlights cAMP signaling, which acts primarily through the inhibition of adenylyl cyclase to reduce protein kinase activity. This reduction influences current flow at voltage-dependent potassium channels, promoting the influx of ions into the presynaptic neuron. It also induces tyrosine phosphorylation of both FAK and FRNK (a distinct isoform of FAK). Activation of the receptor also inhibits calcium channels, reducing the flow of ions into the neuron. The combination of increased calcium and potassium within the synaptic cleft inhibits the proper polarization of the postsynaptic neuron, interrupting synaptic signalling. This leads to an analgesic effect, effectively preventing the propagation of pain signals. The activation of the CB1 receptor also activates MAPK, a serine kinase that is an essential part of the MAP signal transduction pathway. The MAPK signalling cascade is responsible for mediating a number of different cellular functions including adhesion and cell growth, which it achieves through regulating transcription and transcription. The effects of CB1 activation are broad, and the illustrated pathway serves as a general picture of its immediate cellular effects. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Alyssah Created On: August 13, 2020 at 14:57 Last Updated: August 13, 2020 at 14:57
PW124095 View Pathway	signaling CB2 Receptor Homo sapiens CB2 receptors are located throughout the peripheral nervous system, in immune cells, and in microglial cells within the brain stem. They are closely tied to immune responses, mediating inflammatory responses in the brain and throughout the body. CB2 receptors are G-protein coupled receptors and are especially critical in promoting chemotaxis through the release of chemokines. The main mechanism of action involves inhibiting adenylyl cyclase, which increases the concentration of cAMP in the cell. Through its coupling with G-proteins, CB2 inhibits calcium channels in the cell membrane, disrupting the flow of calcium ions into the cell and can further regulate calcium concentrations when acted upon by anandamide. However, CB2 seems to not have an effect on potassium channels, a marked difference from CB1 receptors. Activation of CB2 receptors also activates MAPK and its associated signalling pathway, which affects translation and transcription especially in relation to mitosis. CB2's most remarkable difference from CB1 is its effect on the release of chemokines. Depending on the ligand binding to it, CB2 can act either to promote or suppress the release of chemokines from the cell, enabling both inflammatory and anti-inflammatory responses. This versatility, combined with CB2's lack of psychotropic effects makes it a promising target for therapeutic treatments of a range of conditions. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Alyssah Created On: August 20, 2020 at 10:35 Last Updated: August 20, 2020 at 10:35
PW064729 View Pathway	metabolic CCM Escherichia coli BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: April 28, 2018 at 21:23 Last Updated: April 28, 2018 at 21:23
PW122205 View Pathway	protein CD40L Signalling Pathway Bos taurus CD40 is a part of the tumor necrosis factor (TNF) receptor superfamily. When bound to it’s main ligand CD40L, also known as CD154, CD40-CD40L interaction initializes the activation and proliferation of B lymphocytes or results in carcinoma cells apoptosis. CD40 can be expressed on many different cell surfaces such as endothelial cells, fibroblasts, hematopoietic progenitors, platelets, and basal epithelial cells. When combined with the variety of environments CD40 presenting cells can be in, the differing effects resulting from CD40 signalling is vast. However, one characteristic all CD40 mediated signalling has in common is that instead of using kinase to mediate signal transduction, signalling is performed through downstream adapter molecules. Some pathways activated by CD40-CD40L signalling include the activation of nuclear factor-κB, p38 mitogen activated protein kinase, c-Jun-NH2-kinase, signal transducers and activators of transcription, and phosphoinositide 3-kinase pathways. All of which ultimately help regulate alterations in gene expression. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 14:59 Last Updated: September 20, 2018 at 14:59
PW122229 View Pathway	protein CD40L Signalling Pathway Rattus norvegicus CD40 is a part of the tumor necrosis factor (TNF) receptor superfamily. When bound to it’s main ligand CD40L, also known as CD154, CD40-CD40L interaction initializes the activation and proliferation of B lymphocytes or results in carcinoma cells apoptosis. CD40 can be expressed on many different cell surfaces such as endothelial cells, fibroblasts, hematopoietic progenitors, platelets, and basal epithelial cells. When combined with the variety of environments CD40 presenting cells can be in, the differing effects resulting from CD40 signalling is vast. However, one characteristic all CD40 mediated signalling has in common is that instead of using kinase to mediate signal transduction, signalling is performed through downstream adapter molecules. Some pathways activated by CD40-CD40L signalling include the activation of nuclear factor-κB, p38 mitogen activated protein kinase, c-Jun-NH2-kinase, signal transducers and activators of transcription, and phosphoinositide 3-kinase pathways. All of which ultimately help regulate alterations in gene expression. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 15:07 Last Updated: September 20, 2018 at 15:07
PW122181 View Pathway	protein CD40L Signalling Pathway Mus musculus CD40 is a part of the tumor necrosis factor (TNF) receptor superfamily. When bound to it’s main ligand CD40L, also known as CD154, CD40-CD40L interaction initializes the activation and proliferation of B lymphocytes or results in carcinoma cells apoptosis. CD40 can be expressed on many different cell surfaces such as endothelial cells, fibroblasts, hematopoietic progenitors, platelets, and basal epithelial cells. When combined with the variety of environments CD40 presenting cells can be in, the differing effects resulting from CD40 signalling is vast. However, one characteristic all CD40 mediated signalling has in common is that instead of using kinase to mediate signal transduction, signalling is performed through downstream adapter molecules. Some pathways activated by CD40-CD40L signalling include the activation of nuclear factor-κB, p38 mitogen activated protein kinase, c-Jun-NH2-kinase, signal transducers and activators of transcription, and phosphoinositide 3-kinase pathways. All of which ultimately help regulate alterations in gene expression. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 14:51 Last Updated: September 20, 2018 at 14:51
PW090779 View Pathway	protein CD40L Signalling Pathway Homo sapiens CD40 is a part of the tumor necrosis factor (TNF) receptor superfamily. When bound to it’s main ligand CD40L, also known as CD154, CD40-CD40L interaction initializes the activation and proliferation of B lymphocytes or results in carcinoma cells apoptosis. CD40 can be expressed on many different cell surfaces such as endothelial cells, fibroblasts, hematopoietic progenitors, platelets, and basal epithelial cells. When combined with the variety of environments CD40 presenting cells can be in, the differing effects resulting from CD40 signalling is vast. However, one characteristic all CD40 mediated signalling has in common is that instead of using kinase to mediate signal transduction, signalling is performed through downstream adapter molecules. Some pathways activated by CD40-CD40L signalling include the activation of nuclear factor-κB, p38 mitogen activated protein kinase, c-Jun-NH2-kinase, signal transducers and activators of transcription, and phosphoinositide 3-kinase pathways. All of which ultimately help regulate alterations in gene expression. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Jonas Patron Created On: August 14, 2018 at 10:44 Last Updated: August 14, 2018 at 10:44