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Pathways

PathWhiz ID Pathway Meta Data

PW000317

Pw000317 View Pathway
drug action

Lansoprazole Action Pathway (old)

Homo sapiens
Lansoprazole, sold as Prevacid, is a proton pump inhibitor (PPI) class drug that suppresses the final step in gastric acid production. In this pathway, lansoprazole is taken orally and is oxidized in the stomach to form the active metabolite of lansoprazole. This active metabolite then binds covalently to the potassium-transporting ATPase protein subunits, found at the secretory surface of the gastric parietal cell, preventing any stimulus. Because the drug binds covalently, its effects are dose-dependent and last much longer than similar drugs that bind to the protein non-covalently. This is because additional ATPase enzymes must be created to replace the ones covalently bound by pantoprazole. Lansoprazole is used to manage gastroesophageal reflux disease, to prevent stomach ulcers, and can be used to help treat the effects of a H. pylori infection.

PW144573

Pw144573 View Pathway
drug action

Lansoprazole Drug Metabolism Action Pathway

Homo sapiens

PW000590

Pw000590 View Pathway
drug metabolism

Lansoprazole Metabolism Pathway (old)

Homo sapiens
Lansoprazole, sold as Prevacid, is a proton pump inhibitor (PPI) class drug that suppresses the final step in gastric acid production. In this pathway, lansoprazole is taken orally and is oxidized in the stomach to form the active metabolite of lansoprazole. This active metabolite then binds covalently to the potassium-transporting ATPase protein subunits, found at the secretory surface of the gastric parietal cell, preventing any stimulus. Because the drug binds covalently, its effects are dose-dependent and last much longer than similar drugs that bind to the protein non-covalently. This is because additional ATPase enzymes must be created to replace the ones covalently bound by pantoprazole. Lansoprazole is used to manage gastroesophageal reflux disease, to prevent stomach ulcers, and can be used to help treat the effects of a H. pylori infection.

PW132203

Pw132203 View Pathway
metabolic

Lanthanum carbonate Drug Metabolism

Homo sapiens
Lanthanum carbonate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Lanthanum carbonate passes through the liver and is then excreted from the body mainly through the kidney.

PW145799

Pw145799 View Pathway
drug action

Lanthanum carbonate Drug Metabolism Action Pathway

Homo sapiens

PW128491

Pw128491 View Pathway
drug action

Lapatinib Action Pathway

Homo sapiens
Lapatinib is an anti-cancer drug used to treat advanced or metastatic breast cancer whose tumors overexpress the human epidermal receptor type 2 (HER2) protein and have received prior therapy. It was approved by the FDA in 2007. This molecule is a tyrosine kinase inhibitor of the human epidermal growth factor receptor type 2 (HER2/ERBB2) and the epidermal growth factor receptor (HER1/EGFR/ERBB1). It acts by binding to the phosphorylation domain of the receptors, thus preventing the autophosphorylation when the ligand binds them. This inhibition results in the suppression of the cell growth signaling pathways. This drug is administered as an oral tablet.

PW145342

Pw145342 View Pathway
drug action

Lapatinib Drug Metabolism Action Pathway

Homo sapiens

PW176550

Pw176550 View Pathway
metabolic

Lapatinib Predicted Metabolism Pathway

Homo sapiens
Metabolites of Lapatinib are predicted with biotransformer.

PW146122

Pw146122 View Pathway
drug action

Lapyrium Drug Metabolism Action Pathway

Homo sapiens

PW146407

Pw146407 View Pathway
drug action

Laropiprant Drug Metabolism Action Pathway

Homo sapiens