PathWhiz ID | Pathway | Meta Data |
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PW000317View Pathway |
drug action
Lansoprazole Action Pathway (old)Homo sapiens
Lansoprazole, sold as Prevacid, is a proton pump inhibitor (PPI) class drug that suppresses the final step in gastric acid production. In this pathway, lansoprazole is taken orally and is oxidized in the stomach to form the active metabolite of lansoprazole. This active metabolite then binds covalently to the potassium-transporting ATPase protein subunits, found at the secretory surface of the gastric parietal cell, preventing any stimulus. Because the drug binds covalently, its effects are dose-dependent and last much longer than similar drugs that bind to the protein non-covalently. This is because additional ATPase enzymes must be created to replace the ones covalently bound by pantoprazole. Lansoprazole is used to manage gastroesophageal reflux disease, to prevent stomach ulcers, and can be used to help treat the effects of a H. pylori infection.
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Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45 |
PW144573View Pathway |
drug action
Lansoprazole Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 13:56 Last Updated: October 07, 2023 at 13:56 |
PW000590View Pathway |
Lansoprazole Metabolism Pathway (old)Homo sapiens
Lansoprazole, sold as Prevacid, is a proton pump inhibitor (PPI) class drug that suppresses the final step in gastric acid production. In this pathway, lansoprazole is taken orally and is oxidized in the stomach to form the active metabolite of lansoprazole. This active metabolite then binds covalently to the potassium-transporting ATPase protein subunits, found at the secretory surface of the gastric parietal cell, preventing any stimulus. Because the drug binds covalently, its effects are dose-dependent and last much longer than similar drugs that bind to the protein non-covalently. This is because additional ATPase enzymes must be created to replace the ones covalently bound by pantoprazole. Lansoprazole is used to manage gastroesophageal reflux disease, to prevent stomach ulcers, and can be used to help treat the effects of a H. pylori infection.
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Creator: WishartLab Created On: September 11, 2013 at 22:33 Last Updated: September 11, 2013 at 22:33 |
PW132203View Pathway |
Lanthanum carbonate Drug MetabolismHomo sapiens
Lanthanum carbonate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Lanthanum carbonate passes through the liver and is then excreted from the body mainly through the kidney.
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Creator: Ray Kruger Created On: September 21, 2023 at 20:06 Last Updated: September 21, 2023 at 20:06 |
PW145799View Pathway |
drug action
Lanthanum carbonate Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 16:41 Last Updated: October 07, 2023 at 16:41 |
PW128491View Pathway |
drug action
Lapatinib Action PathwayHomo sapiens
Lapatinib is an anti-cancer drug used to treat advanced or metastatic breast cancer whose tumors overexpress the human epidermal receptor type 2 (HER2) protein and have received prior therapy. It was approved by the FDA in 2007. This molecule is a tyrosine kinase inhibitor of the human epidermal growth factor receptor type 2 (HER2/ERBB2) and the epidermal growth factor receptor (HER1/EGFR/ERBB1). It acts by binding to the phosphorylation domain of the receptors, thus preventing the autophosphorylation when the ligand binds them. This inhibition results in the suppression of the cell growth signaling pathways. This drug is administered as an oral tablet.
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Creator: Daphnee Created On: August 31, 2023 at 11:15 Last Updated: August 31, 2023 at 11:15 |
PW145342View Pathway |
drug action
Lapatinib Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 15:36 Last Updated: October 07, 2023 at 15:36 |
PW176550View Pathway |
Lapatinib Predicted Metabolism PathwayHomo sapiens
Metabolites of Lapatinib are predicted with biotransformer.
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Creator: Omolola Created On: December 14, 2023 at 11:48 Last Updated: December 14, 2023 at 11:48 |
PW146122View Pathway |
drug action
Lapyrium Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 17:27 Last Updated: October 07, 2023 at 17:27 |
PW146407View Pathway |
drug action
Laropiprant Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 18:07 Last Updated: October 07, 2023 at 18:07 |