PathWhiz

PathWhiz ID	Pathway	Meta Data
PW000115 View Pathway	disease Leigh Syndrome Homo sapiens Leigh Syndrome, also called Leigh Disease or infantile subacute necrotizing encephalopathy, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder that is caused by a mutation of any one of 75 different genes. Disruptions of the complexes I or IV are the most common reasons for Leigh syndrome. Complex IV is crucial in the electron transfer steps of oxidative phosphorylation, which is needed to provide energy to the mitochondria. This disorder is characterized by a large accumulation of lactate in the body. Symptoms of the disorder include diarrhea, dysphagia and vomiting. There is no cure for Leigh syndrome and the loss motor skills degenerate rapidly. It is estimated that Leigh syndrome affects 1 in 40,000 individuals. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 01, 2013 at 15:52 Last Updated: August 01, 2013 at 15:52
PW002397 View Pathway	metabolic Leloir Pathway Saccharomyces cerevisiae The pathway starts with the isomerization of Beta-D-galactose into Alpha-D-galactose through a galactose mutarotase. Alpha-D-galactose is then phosphorylated through an ATP dependent galactokinase resulting in the release of ADP, a hydrogen ion and alpha-D-galactose 1-phosphate. The latter compound reacts with UDP glucose which is the result of UTP reacting with alpha-D-glucose through a uridinephosphoglucose pyrophosphorylase. The reaction between alpha-D-galactose 1-phosphate and UDP glucose results in the release of glucose 1-phosphate and UDP-alpha-D-galactose. Glucose 1-phosphate can be further isomerized into glucose 6-phosphate, while UDP-alpha-D-galactose can be reverted into UDP glucose through a UDP-epimerase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: January 05, 2016 at 14:12 Last Updated: January 05, 2016 at 14:12
PW132552 View Pathway	metabolic Lemborexant Drug Metabolism Homo sapiens Lemborexant is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Lemborexant passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:23 Last Updated: September 21, 2023 at 22:23
PW146474 View Pathway	drug action Lemborexant Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:17 Last Updated: October 07, 2023 at 18:17
PW144602 View Pathway	drug action Lenalidomide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:00 Last Updated: October 07, 2023 at 14:00
PW176334 View Pathway	metabolic Lenalidomide Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:12 Last Updated: December 07, 2023 at 15:12
PW128523 View Pathway	drug action Lenvatinib Action Pathway Homo sapiens Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor used in the treatment of various cancers. It primarily targets the kinase activities of vascular endothelial growth factor (VEGF) receptors, including VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs, such as fibroblast growth factor receptors (FGFR1, 2, 3, and 4), the platelet-derived growth factor receptor alpha (PDGFRα), KIT, and RET, all of which play crucial roles in processes like angiogenesis, tumor growth, and cancer progression. Its approved indications include metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. Lenvatinib offers a targeted therapeutic approach for patients with limited treatment options. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Dorsa Yahya Rayat Created On: September 01, 2023 at 13:02 Last Updated: September 01, 2023 at 13:02
PW132436 View Pathway	metabolic Lenvatinib Drug Metabolism Homo sapiens Lenvatinib is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Lenvatinib passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:45 Last Updated: September 21, 2023 at 21:45
PW145958 View Pathway	drug action Lenvatinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:04 Last Updated: October 07, 2023 at 17:04
PW000300 View Pathway	drug action Lepirudin Action Pathway Homo sapiens Lepirudin (also known as Refludan) is an anticoagulant that can be used for inhibiting thrombin (prothrombin) irreversibly. Binding of thrombin can prevent formation of clot as well as thrombus. Lepirudin can also reduce thrombocytopenia and break up clot. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45