PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176393 View Pathway	metabolic Methylprednisone Predicted Metabolism Pathway Homo sapiens Metabolites of Methylprednisone are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:43 Last Updated: December 07, 2023 at 16:43
PW147113 View Pathway	metabolic Methylscopolamine Drug Metabolism Pathway Homo sapiens Gadoversetamide is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Gadoversetamide passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 11, 2023 at 09:29 Last Updated: October 11, 2023 at 09:29
PW145751 View Pathway	drug action Methyltestosterone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:33 Last Updated: October 07, 2023 at 16:33
PW132434 View Pathway	metabolic Methyprylon Drug Metabolism Homo sapiens Methyprylon is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Methyprylon passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:45 Last Updated: September 21, 2023 at 21:45
PW145196 View Pathway	drug action Methyprylon Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:17 Last Updated: October 07, 2023 at 15:17
PW132589 View Pathway	metabolic Methysergide Drug Metabolism Homo sapiens Methysergide is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Methysergide passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:31 Last Updated: September 21, 2023 at 22:31
PW144376 View Pathway	drug action Methysergide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:30 Last Updated: October 07, 2023 at 13:30
PW128456 View Pathway	drug action Methysergide Mechanism of Action Action Pathway Homo sapiens Methysergide is an ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle. Methysergide is a semisynthetic ergot alkaloid ergometrine derivative, introduced in pharmacotherapy for migraine prophylaxis as a specific serotonin (5HT) receptor antagonist. Methysergide is not just a 5HT2 antagonist, it is also a 5HT1 agonist. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 29, 2023 at 12:43 Last Updated: August 29, 2023 at 12:43
PW000712 View Pathway	drug action Metiamide Action Pathway Homo sapiens Metiamide is a histamine H2-receptor antagonist that can bind and inhibit histamine H2-receptor to prevent the histamine effects on basolateral memrbane in gastric parietal cell. Binding and inhibition of histamine H2-receptor can lead to decreased gastric acid secretion so that lowering gastric volume as well as acidity. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: June 23, 2014 at 05:37 Last Updated: June 23, 2014 at 05:37
PW124516 View Pathway	drug action Metiamide H2 Anti-Histamine Action Pathway Homo sapiens Metiamide is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epithelium. Ranitidine binds reversibly to the histamine H2 receptor blocking histamine from binding instead. This blocks the downstream Gs cascade which produces cyclic adenosine monophosphate (cAMP) which is an activator for the potassium-hydrogen ATPase pump (H+/K+ ATPase pump). The pump is responsible for secreting hydrogen ions into the stomach lumen increasing the acidity of the stomach environment. By blocking adenylate cyclase signalling pathway from the histamine H2 receptor less hydrogen ions are secreted into the stomach lumen increasing the pH. The less acidic environment doesn't irritate the stomach as much. The H+/K+ ATPase pump can still be activated through gastrin and acetylcholine through the phospholipase C signalling pathway, but blocking the adenylate cyclase pathway helps reduce the acidity. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Kristen Yee Created On: February 09, 2021 at 11:59 Last Updated: February 09, 2021 at 11:59