PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128135 View Pathway	drug action Norethisterone Action Pathway Homo sapiens Norethisterone, also known as norethindrone, is a synthetic progestational hormone used for contraception, prevention of endometrial hyperplasia (hormone replacement therapy), and in the treatment of other hormone-related illnesses. This drug has the same action as endogenous progesterone but with greater potency. This drug acts by altering the cervical and endometrial function, as well as it inhibits the pituitary hormones, like the Follicle-stimulating hormone (FSH) and the Luteinizing hormone (LH) via binding to progesterone receptors that inhibits the Gonadotropin hormone-releasing hormone (GnRH) production in the hypothalamus. The low levels of LH and FSH result in the inhibition of the production of estrogen in the ovaries, thus inhibiting follicular maturation, ovulation, and corpus luteum development. Norethisterone has a low affinity for other steroid receptors, such as the androgen receptor and glucocorticoid receptor. Even if these affinities are low, it is thought that androgen receptor agonism is responsible for some of the adverse effects observed, like acne and serum lipid changes. This drug is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: July 21, 2023 at 12:23 Last Updated: July 21, 2023 at 12:23
PW176276 View Pathway	metabolic Norethisterone Predicted Metabolism Pathway Homo sapiens Metabolites of Norethisterone are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:32 Last Updated: December 04, 2023 at 14:32
PW146117 View Pathway	drug action Norethynodrel Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:27 Last Updated: October 07, 2023 at 17:27
PW128545 View Pathway	drug action Norfloxacin Action Pathway Haemophilus influenzae Norfloxacin is a broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine. Norfloxacin inhibits DNA gyrase (topoisomerase II) and topoisomerase IV. These proteins prevent supercoiling in bacterial DNA. The inhibition of DNA gyrase (topoisomerase II) and topoisomerase IV causes supercoiling of the bacterial DNA. This prevents DNA replication. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 01, 2023 at 21:31 Last Updated: September 01, 2023 at 21:31
PW145151 View Pathway	drug action Norfloxacin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:11 Last Updated: October 07, 2023 at 15:11
PW146584 View Pathway	drug action Norflurane Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:34 Last Updated: October 07, 2023 at 18:34
PW145055 View Pathway	drug action Norgestimate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:59 Last Updated: October 07, 2023 at 14:59
PW128121 View Pathway	drug action Norgestrel Action Pathway Homo sapiens Norgestrel is a synthetic progestin that has 2 stereoisomers, the active one is called levonorgestrel and the other one is dextronorgestrel. This drug is used in combination with ethinyl estradiol for oral contraception and prevention of pregnancy in women. Levonorgestrel (the active stereoisomer of norgestrel) binds the progesterone and estrogen receptors. Those receptors are found in the mammary glands, the hypothalamus, and in the pituitary gland. With this binding, levonorgestrel inhibits and downgrades the level of secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus. In consequence, this activity will lower the transcription rate of luteinizing hormone (LH) resulting in the inhibition of its normal surge needed for ovulation. This drug is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: July 20, 2023 at 11:55 Last Updated: July 20, 2023 at 11:55
PW146132 View Pathway	drug action Norgestrel Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:29 Last Updated: October 07, 2023 at 17:29
PW176277 View Pathway	metabolic Norgestrel Predicted Metabolism Pathway Homo sapiens Metabolites of Norgestrel are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:32 Last Updated: December 04, 2023 at 14:32