PathWhiz

PathWhiz ID	Pathway	Meta Data
PW127970 View Pathway	drug action Paroxetine Mechanism of Action Action Pathway (New) Homo sapiens Paroxetine is a selective serotonin reuptake inhibitor. It is used to manage major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Paroxetine selectively binds to the sodium dependent serotonin transporter (SERT) and blocks the recycling of serotonin from the synapse. As serotonin accumulates it enhances the serotonergic function of the 5-hydroxytryptamine 1A receptor leading to decreased anxiety and depressive moods. Lower serotonin concentrations in a depressed brain induces the upregulation of serotonergic receptors therefore by increasing the concentration of serotonin in the synapse, paroxetine in turn induces down regulation of the former upregulated serotonin receptors thereby restoring receptor concentration. Paroxetine has demonstrated a stronger inhibitory effect on serotonin reuptake than other members of the same drug class, including Citalopram, Fluoxetine, and Fluvoxamine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: June 26, 2023 at 10:10 Last Updated: June 26, 2023 at 10:10
PW128109 View Pathway	drug action Paroxetine Mechanism of Action Action Pathway New Homo sapiens Paroxetine is a selective serotonin reuptake inhibitor. It is used to manage major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Paroxetine selectively binds to the sodium dependent serotonin transporter (SERT) and blocks the recycling of serotonin from the synapse. As serotonin accumulates it enhances the serotonergic function of the 5-hydroxytryptamine 1A receptor leading to decreased anxiety and depressive moods. Lower serotonin concentrations in a depressed brain induces the upregulation of serotonergic receptors therefore by increasing the concentration of serotonin in the synapse, paroxetine in turn induces down regulation of the former upregulated serotonin receptors thereby restoring receptor concentration. Paroxetine has demonstrated a stronger inhibitory effect on serotonin reuptake than other members of the same drug class, including Citalopram, Fluoxetine, and Fluvoxamine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 18, 2023 at 14:26 Last Updated: July 18, 2023 at 14:26
PW176397 View Pathway	metabolic Paroxetine Predicted Metabolism Pathway Homo sapiens Metabolites of Paroxetine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:47 Last Updated: December 07, 2023 at 16:47
PW146578 View Pathway	drug action Parthenolide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:33 Last Updated: October 07, 2023 at 18:33
PW145731 View Pathway	drug action Pasireotide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:30 Last Updated: October 07, 2023 at 16:30
PW146718 View Pathway	drug action Patent Blue Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:52 Last Updated: October 07, 2023 at 18:52
PW176475 View Pathway	metabolic Patent Blue Predicted Metabolism Pathway Homo sapiens Metabolites of Patent Blue are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 12, 2023 at 16:06 Last Updated: December 12, 2023 at 16:06
PW122450 View Pathway	physiological Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: April 15, 2019 at 08:17 Last Updated: April 15, 2019 at 08:17
PW124347 View Pathway	disease Pathway in cancer Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: November 19, 2020 at 11:38 Last Updated: November 19, 2020 at 11:38
PW000974 View Pathway	metabolic PathWhiz Pt.2 - Video Learning Tutorials (Skeleton) Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: July 15, 2015 at 10:00 Last Updated: July 15, 2015 at 10:00