PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176193 View Pathway	metabolic Cladribine Predicted Metabolism Pathway Homo sapiens Metabolites of Cladribine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 12:32 Last Updated: December 04, 2023 at 12:32
PW000346 View Pathway	drug action Clarithromycin Action Pathway Homo sapiens Clarithromycin, is a macrolide antibiotic. It is used to treat many bacterial infections, from sinusitis to AIDS-related infections, and can be used along with anti-ulcer medications to treat stomach ulcers. The way this antibiotic works is by halting bacteria growth. It stops bacteria growth by binding to 50S ribosomal subunits or the 70S ribosome located on the bacteria, inhibits the movement of aminoacyl transfer-RNA and makes sure that the elongation of peptide chain does not occur. This ensures that RNA-mediated bacterial protein creation is blocked. This drug also blocks the isoenzyme CYP3A4, found in the liver, and P-glycoprotein. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW124277 View Pathway	drug action Clarithromycin Anti-bacterial Action Pathway Homo sapiens Clarithromycin is an oral antibiotic drug used for the treatment of bacterial infections including acute otitis media caused by H. influenzae, M. catarrhalis, or S. pneumoniae in patients with a history of type I penicillin hypersensitivity, pharyngitis and tonsillitis caused by susceptible Streptococcus pyogenes, respiratory tract infections including acute maxillary sinusitis, acute bacterial exacerbations of chronic bronchitis, mild to moderate community-acquired pneuomia, Legionnaires' disease, and pertussis, skin or skin structure infections, helicobacter pylori infection, duodenal ulcer disease, bartonella infections, early Lyme disease, and encephalitis caused by Toxoplasma gondii (in HIV infected patients in conjunction with pyrimethamine). Clarithromycin is metabolized in the liver to 14-OH clarithromycin by cytochrome P450 3A4 enzymes. Clarithromycin and 14-OH clarithromycin then penetrate the bacterial cell wall and act synergistically to inhibit protein synthesis. These compounds act by binding to domain V of the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome. This inhibits translocation of the aminoacyl transfer-RNA, preventing the addition of the next amino acid to the growing polypeptide chain. As a result, protein synthesis is inhibited, preventing bacterial growth and this may even kill the bacteria. Whether clarithromycin is bacteriostatic or bactericidal depends on the organism and the concentration used. Common side effects from taking clarithromycin include nausea, abdominal pain, diarrhea, dyspepsia, headache, dizziness, angioedema and rash. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: October 25, 2020 at 01:19 Last Updated: October 25, 2020 at 01:19
PW145297 View Pathway	drug action Clarithromycin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:29 Last Updated: October 07, 2023 at 15:29
PW146536 View Pathway	drug action Clascoterone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:26 Last Updated: October 07, 2023 at 18:26
PW176377 View Pathway	metabolic Clascoterone Predicted Metabolism Pathway Homo sapiens Metabolites of Clascoterone are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:29 Last Updated: December 07, 2023 at 16:29
PW065057 View Pathway	protein Classical Complement Pathway Homo sapiens The classical complement pathway is a pathway that is responsible for activating the complement system within the immune system. This pathway begins with the activation of antibodies IgM and IgG. Protein C3 is created, and after a series of reactions, cleaves the C5 protein. This brings phagocytes to the infected area and sets the stage for the coming together of the membrane attack complex (MAC). This complex targets the cell and creates an opening in the membrane, which leads to cell lysis and death. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: xuan cao Created On: July 30, 2018 at 11:04 Last Updated: July 30, 2018 at 11:04
PW122219 View Pathway	protein Classical Complement Pathway Rattus norvegicus The classical complement pathway is a pathway that is responsible for activating the complement system within the immune system. This pathway begins with the activation of antibodies IgM and IgG. Protein C3 is created, and after a series of reactions, cleaves the C5 protein. This brings phagocytes to the infected area and sets the stage for the coming together of the membrane attack complex (MAC). This complex targets the cell and creates an opening in the membrane, which leads to cell lysis and death. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 15:05 Last Updated: September 20, 2018 at 15:05
PW122171 View Pathway	protein Classical Complement Pathway Mus musculus The classical complement pathway is a pathway that is responsible for activating the complement system within the immune system. This pathway begins with the activation of antibodies IgM and IgG. Protein C3 is created, and after a series of reactions, cleaves the C5 protein. This brings phagocytes to the infected area and sets the stage for the coming together of the membrane attack complex (MAC). This complex targets the cell and creates an opening in the membrane, which leads to cell lysis and death. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 14:48 Last Updated: September 20, 2018 at 14:48
PW122195 View Pathway	protein Classical Complement Pathway Bos taurus The classical complement pathway is a pathway that is responsible for activating the complement system within the immune system. This pathway begins with the activation of antibodies IgM and IgG. Protein C3 is created, and after a series of reactions, cleaves the C5 protein. This brings phagocytes to the infected area and sets the stage for the coming together of the membrane attack complex (MAC). This complex targets the cell and creates an opening in the membrane, which leads to cell lysis and death. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 14:56 Last Updated: September 20, 2018 at 14:56