PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145208 View Pathway	drug action Diazoxide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:18 Last Updated: October 07, 2023 at 15:18
PW146632 View Pathway	drug action Dibekacin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:40 Last Updated: October 07, 2023 at 18:40
PW146613 View Pathway	drug action Dibenzepin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:38 Last Updated: October 07, 2023 at 18:38
PW126661 View Pathway	drug action Dibucaine Homo sapiens Dibucaine is an amide anesthetic used for local and regional anesthesia , it is one of the most potent and toxic long acting local anesthetics it is restricted mainly to spinal anesthesia. The mechanism of action is by blocking the initiation and conduction of nerve impulses, it disturbs the neuronal membrane permeabillity to sodium ions by inhibiting the sodium channel. By binding of dibucaine to the membrane it stabilizes it and inhibits the depolarization thus resulting in a failure to propagate an action potential and blocks conduction. Dibucaine ionized forms (salts) are not absorbed through intact skin, although nonionized (bases) and ionized forms are absorbed into the circulation if the skin is abraded. If too much dibucaine is administered this can lead to overdose, this can be seen through the following symptoms convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: February 10, 2022 at 16:37 Last Updated: February 10, 2022 at 16:37
PW000402 View Pathway	drug action Dibucaine Action Pathway Homo sapiens Dibucaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Dibucaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. For this to happen, the sodium channel must first become active so that so that gating mechanism is in the open state. Therefore dibucaine preferentially inhibits neurons that are actively firing. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW146993 View Pathway	metabolic Dibucaine Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:36 Last Updated: October 10, 2023 at 13:36
PW132300 View Pathway	metabolic Dichloralphenazone Drug Metabolism Homo sapiens Dichloralphenazone is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Dichloralphenazone passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:44 Last Updated: September 21, 2023 at 20:44
PW145439 View Pathway	drug action Dichloralphenazone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:50 Last Updated: October 07, 2023 at 15:50
PW145837 View Pathway	drug action Dichloroacetic acid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:47 Last Updated: October 07, 2023 at 16:47
PW146742 View Pathway	drug action Dichlorobenzene Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:56 Last Updated: October 07, 2023 at 18:56