PathWhiz

PathWhiz ID	Pathway	Meta Data
PW132364 View Pathway	metabolic Echothiophate Drug Metabolism Homo sapiens Echothiophate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Echothiophate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:14 Last Updated: September 21, 2023 at 21:14
PW145149 View Pathway	drug action Echothiophate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:10 Last Updated: October 07, 2023 at 15:10
PW126952 View Pathway	drug action Econazole Action Pathway Homo sapiens Econazole is a topical antifungal used to treat skin fungal infections such as athlete's foot, jock itch, and ringworm. It is a foam known as the brand name Ecoza, applied to the infected area. It is related to fluconazole, ketoconazole, itraconazole, and clotrimazole. Econazole inhibits the enzyme Cytochrome P450 51 or Lanosterol 14-alpha demethylase of yeast cells on the infected area. It does this by binding the free nitrogen atom located on the azole ring to an iron atom of Lanosterol 14-alpha demethylase. This enzyme catalyzes the reaction of lanosterol with 3 oxygen and 3 NADPH to become 4,4-Dimethylcholesta-8,14,24-trienol with byproducts of formic acid, 4 hydrogen ions, 4 water, and 3 NADP+. This reaction is the first step in the ergosterol biosynthesis pathway which is integral to cell membrane integrity. With this process inhibited by Fluconazole, the fungal cell cannot produce more fungi cells, and cannot keep the integrity of its own cell. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: May 25, 2022 at 11:09 Last Updated: May 25, 2022 at 11:09
PW145216 View Pathway	drug action Econazole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:19 Last Updated: October 07, 2023 at 15:19
PW251388 View Pathway	metabolic Ectoine degradation Serratia sp. FS14 Ectoine degradation utilizes ectoine, which is produced by bacteria to combat osmotic stress. Ectoine is catabolized in a sequence of enzymatic reactions to produce L-Aspartate or intermediates for Lysine production. The first step involves ectoine hydrolysis to N(alpha)-Acetyl-L-2,4-diaminobutyrate by ectoine hydrolase. N(alpha)-Acetyl-L-2,4-diaminobutyrate is then further degraded, resulting in intermediates that enter primary metabolic pathways for energy generation and biosynthesis of products such as amino acids. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: May 22, 2024 at 14:58 Last Updated: May 22, 2024 at 14:58
PW002487 View Pathway	metabolic ED Pseudomonas aeruginosa BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: February 27, 2016 at 19:34 Last Updated: February 27, 2016 at 19:34
PW124276 View Pathway	metabolic ED pathway Pseudomonas aeruginosa BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 24, 2020 at 09:26 Last Updated: October 24, 2020 at 09:26
PW146505 View Pathway	drug action Edaravone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:22 Last Updated: October 07, 2023 at 18:22
PW132251 View Pathway	metabolic Edetate calcium disodium anhydrous Drug Metabolism Homo sapiens Edetate calcium disodium anhydrous is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Edetate calcium disodium anhydrous passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:24 Last Updated: September 21, 2023 at 20:24
PW146859 View Pathway	drug action Edetate calcium disodium anhydrous Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:13 Last Updated: October 07, 2023 at 19:13