PathWhiz

PathWhiz ID	Pathway	Meta Data
PW144601 View Pathway	drug action Amikacin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:59 Last Updated: October 07, 2023 at 13:59
PW125985 View Pathway	drug action Amikacin Action Pathway (new) Homo sapiens Amikacin is a semi-synthetic aminoglycoside antibiotic that is used to treat infections caused by both positive and negative strains of Gram bacteria, as it is considered bacteriocidal. It is commonly administered intravenously or intramuscular injection, and is used to successfully treat bacterial infections caused by Pseudomonas species, Escherichia coli, species of indole-positive Proteus, indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter species. Amikacin enters the bacterial cell and interacts in the cytosol with the bacterial ribosome 30S subunit, this interferes with mRNA binding and tRNA acceptor sites which halts protein synthesis. With protein synthesis inhibited this leads to the formation of non-functional and defective peptides. The structure of Amikacin allows it to enter the body and minimize enzymatic deactivation, this is helpful as it reduces bacterial resistance to the drug. 94%-98% of Amikacin is eliminated by the kidneys, relatively unchanged within a 24 hour period. Patients with renal impairment have more difficulty clearing Amikacin and doses have to be adjusted accordingly so no harm comes to the patient. If Amikacin accumulates or too much is administered it can lead to nephrotoxicity, ototoxicity, and neuromuscular blockade. Caution should be taken by patients who are pregnant or breastfeeding as the possible effects of Amikacin on fetal development are unknown and could potentially be harmful. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: May 13, 2021 at 12:03 Last Updated: May 13, 2021 at 12:03
PW000351 View Pathway	drug action Amikacin Action Pathway Homo sapiens Amikacin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis. Amikacin binds irreversibly to the bacterial 30S ribosomal subunit protein and 16S rRNA and prevents the formation of the initiation complex with messenger RNA. More specifically, amikacin binds four nucleotides of the 16S rRNA and a single amino acid of protein S12. This interferes with the decoding site in the vicinity of nucleotide 1400 in 16S rRNA of the 30S subunit. This region interacts with the wobble base of the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so that incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides, and the breakup of polysomes into nonfunctional monosomes. Aminoglycosides are useful in treating infections from mycobacteria such as, tuberculosis, and aerobic Gram-negative bacteria including, Pseudomonas, Acinetobacter and Enterobacter. Aminoglycosides can also treat Gram-positive bacterial infections but are inferior to other available antibiotics. Aminoglycosides may be used in combination with penicillin type antibiotics. Aminoglycosides are not an effective treatment for anaerobic bacteria, fungi and viruses. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW145231 View Pathway	drug action Amifostine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:22 Last Updated: October 07, 2023 at 15:22
PW132337 View Pathway	metabolic Amifostine Drug Metabolism Homo sapiens Amifostine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Amifostine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:59 Last Updated: September 21, 2023 at 20:59
PW146416 View Pathway	drug action Amifampridine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:08 Last Updated: October 07, 2023 at 18:08
PW144416 View Pathway	drug action Amcinonide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:35 Last Updated: October 07, 2023 at 13:35
PW127753 View Pathway	drug action Amcinonide Action Pathway Homo sapiens Amcinonide is a topical corticosteroid used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Amcinonide is a selective glucocorticoid receptor (GC) agonist. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Amcinonide also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. Also, amcinonide has a weak affinity for the progesterone receptor, and virtually no affinity for the mineralocorticoid, estrogen, or androgen receptors. This molecule is administered as a topical cream or ointment. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: May 30, 2023 at 12:23 Last Updated: May 30, 2023 at 12:23
PW176362 View Pathway	metabolic Ambroxol Predicted Metabolism Pathway Homo sapiens Metabolites of Ambroxol are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:48 Last Updated: December 07, 2023 at 15:48
PW145766 View Pathway	drug action Ambroxol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:35 Last Updated: October 07, 2023 at 16:35