PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176319 View Pathway	metabolic Alprazolam Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:02 Last Updated: December 07, 2023 at 15:02
PW144529 View Pathway	drug action Alprazolam Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:50 Last Updated: October 07, 2023 at 13:50
PW126589 View Pathway	drug action Alprazolam Action Pathway Homo sapiens Alprazolam is a triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Alprazolam is also indicated, either as a standard or extended-release formulation, for the treatment of panic disorder with or without agoraphobia in adults. Alprazolam may also be prescribed off-label for insomnia, premenstrual syndrome, and depression. . Alprazolam allosterically binds on the benzodiazepine receptors in the post-synaptic GABA-A ligand-gated chloride channel in different sites of the central nervous system (CNS). This binding will result in an increase on the GABA inhibitory effects which is translated as an increase in the flow of chloride ions into the cell causing hyperpolarization and stabilization of the cellular plasma membrane. Benzodiazepine receptor associated GABA(a) receptors exist both peripherally and in the CNS, this activity consequently facilitates various effects like sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 18, 2022 at 23:19 Last Updated: January 18, 2022 at 23:19
PW146731 View Pathway	drug action alpha-Tocopherol succinate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:54 Last Updated: October 07, 2023 at 18:54
PW146733 View Pathway	drug action alpha-Tocopherol acetate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:54 Last Updated: October 07, 2023 at 18:54
PW122524 View Pathway	metabolic alpha-Linolenic Acid Metabolism Arabidopsis thaliana alpha-Linolenic acid is a poly-unsaturated fatty acid with an 18-carbon chain and three cis double bonds. Its primary role in Arabidopsis thaliana is in being a precursor of the phytohormone jasmonic acid. Being a precursor for jasmonic acid, it plays a role in gene responses to feeding from insects. It is also a precursor to other molecules involved in defense signalling such as cis-3-hexenyl acetate. alpha-Linolenic acid itself modulates gene transcription in response to hyperosmotic salinity, heat acclimation, and oxidative stress. alpha-Linolenic acid is released from the hydrolysis of a phosphatidylcholine membrane lipid. It then has a hydroperoxy group added by a dioxygenase in either the 2, 9, or 13 position to form 2(R)-HPOT, 9(S)-HPOT, or 13(S)-HPOT respectively. The oxidation of alpha-linolenic acid to 13(S)-HPOT is the first step in the jasmonic acid synthesis and leads to that separate pathway. 2(R)-HPOT is formed in an oil body and undergoes a spontaneous decarboxylation to form a heptadecatrienal. 9(S)-HPOT, or 13(S)-HPOT are both formed in a chloroplast and cleaved by probable inactive linolenate hydroperoxide lyase to form an aldehyde and an oxo-carboxylic acid. The hexenal from 13(S)-HPOT is reduced by alcohol dehydrogenase class-P to form a hexenol, which undergoes an esterification with acetyl-CoA to form 3-hexenyl acetate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: William Created On: June 10, 2019 at 11:55 Last Updated: June 10, 2019 at 11:55
PW144275 View Pathway	drug action alpha-Linolenic acid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:05 Last Updated: October 07, 2023 at 13:05
PW146757 View Pathway	drug action alpha-Arbutin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:57 Last Updated: October 07, 2023 at 18:57
PW132280 View Pathway	metabolic alpha-Arbutin Drug Metabolism Homo sapiens alpha-Arbutin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. alpha-Arbutin passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:36 Last Updated: September 21, 2023 at 20:36
PW146772 View Pathway	drug action alpha-Amyl cinnamaldehyde Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:00 Last Updated: October 07, 2023 at 19:00