PathWhiz

PathWhiz ID	Pathway	Meta Data
PW012904 View Pathway	metabolic Plastoquinol-9 Biosynthesis Arabidopsis thaliana Plastoquinol-9 biosynthesis is a pathway that begins in the cytosol and endoplasmic reticulum and ends in the chloroplast by which L-tyrosine and geranylgeranyl diphosphate become plastoquinol-9, ubiquinone analogs and benzoquinone electron carriers. The subpathway that synthesizes homogentisate from L-tryptophan occurs in the cytosol. First, tryptophan aminotransferase uses a pyridoxal 5'-phosphate as a cofactor to convert L-tryptophan into 4-hydroxyphenylpyruvate. Second, 4-hydroxyphenylpyruvate dioxygenase uses Fe2+ as a cofactor to convert 4-hydroxyphenylpyruvate into homogentisate. The subpathway that synthesizes solanesyl diphosphate from geranylgeranyl diphosphate occurs in the endoplasmic reticulum and the single reaction is catalyzed by solanesyl diphosphate which requires a magnesium ion as a cofactor. Solanesyl diphosphate must then be transported out of the endoplasmic reticulum into the cytosol by a yet undiscovered solanesyl diphosphate transporter. The last two reactions are localized to the chloroplast inner membrane (coloured dark green in the image). First, homogentisate solanesyltransferase catalyzes the conversion of solanesyl diphosphate and homogentisate into 2-methyl-6-solanesyl-1,4-benzoquinol, requiring magnesium ion as a cofactor. Second, 2-methyl-6-phytyl-1,4-hydroquinone methyltransferase catalyzes the conversion of 2-methyl-6-solanesyl-1,4-benzoquinol into plastoquinol-9. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: February 23, 2017 at 02:18 Last Updated: February 23, 2017 at 02:18
PW120519 View Pathway	protein Platelet Amyloid Precursor Protein Pathway Homo sapiens Platelets are the first peripheral source of amyloid precursor protein (APP). They possess the proteolytic machinery to produce Aβ and fragments similar to those produced in neurons, and thus offer an ex-vivo model to study APP processing and changes associated with Alzheimer’s disease (AD). Platelet process APP mostly through the α-secretase pathway to release soluble APP (sAPP). They produce small amounts of Aβ, predominantly Aβ40 over Aβ42. sAPP and Aβ are stored in α-granules and are released upon platelet activation by thrombin and collagen, and agents inducing platelet degranulation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aidin Foroutannaddafi Created On: September 07, 2018 at 19:47 Last Updated: September 07, 2018 at 19:47
PW127876 View Pathway	drug action Plazomicin Action Pathway Homo sapiens Plazomicin, also known as Zemdri, is an antibiotic from the aminoglycoside family. This drug is mainly used to treat complicated urinary tract infections. This drug is a next-generation aminoglycoside, it is synthetically derived from Sisomicin. It was designed to evade all clinically relevant aminoglycoside-modifying enzymes, which contribute to the resistance mechanism for aminoglycoside therapy in many bacteria. This drug binds to bacterial 30S ribosomal subunit and inhibits protein synthesis. Aminoglycosides typically bind to the ribosomal aminoacyl-tRNA site (A-site) and induce a conformational change to further facilitate the binding between the rRNA and the antibiotic. This leads to codon misreading and mistranslation of mRNA during bacterial protein synthesis. Plazomicin actually binds and inhibits the 30S ribosomal protein S11. It is administered via an intravenous injection. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 14, 2023 at 11:26 Last Updated: June 14, 2023 at 11:26
PW146547 View Pathway	drug action Plazomicin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:28 Last Updated: October 07, 2023 at 18:28
PW176513 View Pathway	metabolic Plazomicin Predicted Metabolism Pathway Homo sapiens Metabolites of Plazomicin are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 13, 2023 at 13:25 Last Updated: December 13, 2023 at 13:25
PW127121 View Pathway	metabolic please work Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: September 29, 2022 at 14:28 Last Updated: September 29, 2022 at 14:28
PW146601 View Pathway	drug action Plecanatide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:36 Last Updated: October 07, 2023 at 18:36
PW132562 View Pathway	metabolic Plerixafor Drug Metabolism Homo sapiens Plerixafor is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Plerixafor passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:25 Last Updated: September 21, 2023 at 22:25
PW145810 View Pathway	drug action Plerixafor Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:43 Last Updated: October 07, 2023 at 16:43
PW145811 View Pathway	drug action Plicamycin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:43 Last Updated: October 07, 2023 at 16:43