PathWhiz

PathWhiz ID	Pathway	Meta Data
PW124534 View Pathway	protein Ubiquitin–Proteasome Pathway 1613937577 Homo sapiens The ubiquitin-proteasome pathway is the pathway in which molecules, specifically proteins, are broken down into smaller molecules in the cytosol or in the nucleus.This pathway subsequently has effects in many other pathways and processes. This pathway uses 2 distinct steps. The first step is that the protein being broken down is tagged by multiple ubiquitin units attaching to the protein. The second step is that the protein that has been tagged degrades as it is catalyzed by the 26S proteasome. This pathway is important for DNA repair, regulating the amount of proteins, and the creation of antigen-peptide. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: February 21, 2021 at 12:59 Last Updated: February 21, 2021 at 12:59
PW146911 View Pathway	drug action Ubrogepant Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:20 Last Updated: October 07, 2023 at 19:20
PW176296 View Pathway	metabolic Ubrogepant Predicted Metabolism Pathway Homo sapiens Metabolites of Ubrogepant are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:51 Last Updated: December 04, 2023 at 14:51
PW145696 View Pathway	drug action Udenafil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:25 Last Updated: October 07, 2023 at 16:25
PW176414 View Pathway	metabolic Udenafil Predicted Metabolism Pathway Homo sapiens Metabolites of Udenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 17:01 Last Updated: December 07, 2023 at 17:01
PW124408 View Pathway	metabolic UDP-N-acetyl-D-Glucosamine Pseudomonas aeruginosa BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Marlon Yesid Cáceres Ortiz Created On: January 01, 2021 at 10:21 Last Updated: January 01, 2021 at 10:21
PW244655 View Pathway	metabolic Uliana1 Saccharomyces cerevisiae BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: May 07, 2024 at 03:49 Last Updated: May 07, 2024 at 03:49
PW145857 View Pathway	drug action Ulipristal Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:50 Last Updated: October 07, 2023 at 16:50
PW176158 View Pathway	metabolic Ulipristal Predicted Metabolism Pathway new Homo sapiens Metabolites of Ulipristal are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:23 Last Updated: November 29, 2023 at 14:23
PW127826 View Pathway	drug action Ulobetasol Action Pathway Homo sapiens Ulobetasol, also known as Halobetasol, is a highly potent corticosteroid used to treat corticosteroid-responsive dermatoses. This drug is available as a topical cream, foam, spray, or ointment. Ulobetasol is a glucocorticoid receptor agonist and is structurally related to clobetasol. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. This drug also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 06, 2023 at 16:00 Last Updated: June 06, 2023 at 16:00