PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176457 View Pathway	metabolic Miconazole Predicted Metabolism Pathway Homo sapiens Metabolites of Miconazole are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 12, 2023 at 14:44 Last Updated: December 12, 2023 at 14:44
PW146768 View Pathway	drug action Microcrystalline cellulose Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:59 Last Updated: October 07, 2023 at 18:59
PW146634 View Pathway	drug action Micronomicin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:41 Last Updated: October 07, 2023 at 18:41
PW176271 View Pathway	metabolic Micronomicin Predicted Metabolism Pathway Homo sapiens Metabolites of Micronomicin are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:26 Last Updated: December 04, 2023 at 14:26
PW126588 View Pathway	drug action Midazolam Action Pathway Homo sapiens Midazolam is a short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. Midazolam allosterically binds on the benzodiazepine receptors in the post-synaptic GABA-A ligand-gated chloride channel in different sites of the central nervous system (CNS). This binding will result in an increase on the GABA inhibitory effects which is translated as an increase in the flow of chloride ions into the cell causing hyperpolarization and stabilization of the cellular plasma membrane. Benzodiazepine receptor associated GABA(a) receptors exist both peripherally and in the CNS, this activity consequently facilitates various effects like sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action. Midazolam is administered in a variety of ways including intravenous and intramuscular injection and as a buccal solution, BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 18, 2022 at 23:18 Last Updated: January 18, 2022 at 23:18
PW144795 View Pathway	drug action Midazolam Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:26 Last Updated: October 07, 2023 at 14:26
PW144342 View Pathway	drug action Midodrine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:26 Last Updated: October 07, 2023 at 13:26
PW128515 View Pathway	drug action Midostaurin Action Pathway Homo sapiens Midostaurin, marketed as Rydapt, is an antineoplastic agent employed in the treatment of high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). Primarily, it serves as a multitarget kinase inhibitor, particularly for adult patients with newly diagnosed AML who possess the FLT3 genetic mutation. Approved in April 2017, Midostaurin has demonstrated its ability to improve overall survival rates when used as an adjunct therapy alongside chemotherapeutic agents in AML patients. Its mechanism of action involves targeting multiple receptor tyrosine kinases, including protein kinase C alpha (PKCalpha), VEGFR2, KIT, PDGFR, and WT and/or mutant FLT3 tyrosine kinases. By inhibiting these kinases, Midostaurin disrupts signaling cascades that lead to malignancies such as AML and ASM, ultimately inducing apoptosis in leukemia cells and mast cells. Moreover, Midostaurin has shown effectiveness as a combination therapy during chemotherapy, further enhancing its therapeutic value. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Dorsa Yahya Rayat Created On: September 01, 2023 at 12:05 Last Updated: September 01, 2023 at 12:05
PW145721 View Pathway	drug action Midostaurin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:28 Last Updated: October 07, 2023 at 16:28
PW146661 View Pathway	drug action Mifamurtide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:44 Last Updated: October 07, 2023 at 18:44