PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176277 View Pathway	metabolic Norgestrel Predicted Metabolism Pathway Homo sapiens Metabolites of Norgestrel are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:32 Last Updated: December 04, 2023 at 14:32
PW128434 View Pathway	drug action Normethadone Action Pathway Homo sapiens Normethadone is an opioid antitussive used to treat a cough associated with inflamed mucosa. Normethadone binds to mu opioid receptors, stimulating the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as GABA is inhibited. Opioids close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability. This causes depression in the brain which inhibits the cough centre of the brain. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: August 28, 2023 at 18:32 Last Updated: August 28, 2023 at 18:32
PW146400 View Pathway	drug action Normethadone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:07 Last Updated: October 07, 2023 at 18:07
PW127940 View Pathway	drug action Nortriptyline Action Pathway Homo sapiens Nortriptyline is a tricyclic antidepressant used to treat major depression. Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA). This drug is also used off-label and it includes the treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome. Nortriptyline exerts antidepressant functions by inhibiting the reuptake of serotonin and norepinephrine in the neurons. It is possible by its binding to the sodium-dependent noradrenaline transporter and to the sodium-dependent serotonin transporter. This drug displays a more selective reuptake inhibition for noradrenaline, which may explain increased symptom improvement after nortriptyline therapy. As with other tricyclics, nortriptyline displays an affinity for other receptors including mACh receptors, histamine receptors, and 5-HT receptors, in addition to other receptors. This drug is administered as a tablet or as an oral solution. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 21, 2023 at 10:56 Last Updated: June 21, 2023 at 10:56
PW144658 View Pathway	drug action Nortriptyline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:08 Last Updated: October 07, 2023 at 14:08
PW176396 View Pathway	metabolic Nortriptyline Predicted Metabolism Pathway Homo sapiens Metabolites of Nortriptyline are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:46 Last Updated: December 07, 2023 at 16:46
PW145668 View Pathway	drug action Noscapine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:20 Last Updated: October 07, 2023 at 16:20
PW064693 View Pathway	signaling Notch Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: February 28, 2018 at 09:34 Last Updated: February 28, 2018 at 09:34
PW124223 View Pathway	signaling Notch signalling pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 14, 2020 at 02:59 Last Updated: October 14, 2020 at 02:59
PW064734 View Pathway	signaling notch1 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: May 10, 2018 at 01:17 Last Updated: May 10, 2018 at 01:17